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Conserved domains on  [gi|15227049|ref|NP_178389|]
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sucrose transporter 2 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPH_sucrose super family cl26211
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 59-580 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


The actual alignment was detected with superfamily member TIGR01301:

Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 529.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    59 SLVTLVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGS 138
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   139 FMISIAVIIIGFSADIGYLLGDSKEhcstfKGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNT--ANAV 216
Cdd:TIGR01301  82 ALVAFAVILIGFAADIGHLFGDNLD-----KKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   217 FCLWMAIGNILGFSAGASGKWQEWFPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEipftsnKPTRIQDSAP 296
Cdd:TIGR01301 157 FSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKE------NPLIGSDDFI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   297 llddlqskglehsklnngtangikyerVERDTDEQFGNSEnehqdetyvdgpgSVLVNLLTSLRHLPPAMHSVLIVMALT 376
Cdd:TIGR01301 231 ---------------------------NSEAAPPSKHGEE-------------AFFGELFGAFKYLPRPVWILLLVTCLN 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   377 WLSWFPFFLFDTDWMGREVYHGDPTgdslHMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGA-RVVWALSNFTV 455
Cdd:TIGR01301 271 WIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIVNIIL 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   456 FACMAGTAVISLMSLSDDkngieYIMRGNET------TRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIG 529
Cdd:TIGR01301 347 AICLAATVLVTYVAKNSR-----YYDGDGESlppptgIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMG 421

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15227049   530 VLNLAIVIPQMIVSLGAGPWDQLFGGGNLPAFVLASVAAFAAGVIALQRLP 580
Cdd:TIGR01301 422 VLNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
 
Name Accession Description Interval E-value
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 59-580 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 529.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    59 SLVTLVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGS 138
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   139 FMISIAVIIIGFSADIGYLLGDSKEhcstfKGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNT--ANAV 216
Cdd:TIGR01301  82 ALVAFAVILIGFAADIGHLFGDNLD-----KKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   217 FCLWMAIGNILGFSAGASGKWQEWFPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEipftsnKPTRIQDSAP 296
Cdd:TIGR01301 157 FSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKE------NPLIGSDDFI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   297 llddlqskglehsklnngtangikyerVERDTDEQFGNSEnehqdetyvdgpgSVLVNLLTSLRHLPPAMHSVLIVMALT 376
Cdd:TIGR01301 231 ---------------------------NSEAAPPSKHGEE-------------AFFGELFGAFKYLPRPVWILLLVTCLN 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   377 WLSWFPFFLFDTDWMGREVYHGDPTgdslHMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGA-RVVWALSNFTV 455
Cdd:TIGR01301 271 WIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIVNIIL 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   456 FACMAGTAVISLMSLSDDkngieYIMRGNET------TRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIG 529
Cdd:TIGR01301 347 AICLAATVLVTYVAKNSR-----YYDGDGESlppptgIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMG 421

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15227049   530 VLNLAIVIPQMIVSLGAGPWDQLFGGGNLPAFVLASVAAFAAGVIALQRLP 580
Cdd:TIGR01301 422 VLNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 63-577 6.65e-154

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 448.61  E-value: 6.65e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  63 LVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMIS 142
Cdd:cd17313   1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 143 IAVIIIGFSADIGYLLGDskehcstfkGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMA 222
Cdd:cd17313  81 LGLILIPNAADIGLALGD---------GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 223 IGNILGFSAGASGKWQEWFPFltsraccAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSapllddlq 302
Cdd:cd17313 152 LGGVLGYLLGAILWDHNWFGF-------ALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENP-------- 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 303 skglehsklnngtangikyerverdtdeqfgnsenehqdetyvdGPGSVLVNLLTSLRHLPPAMHSVLIVMALTWLSWFP 382
Cdd:cd17313 217 --------------------------------------------SLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFP 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 383 FFLFDTDWMGREVYHgdptGDSLHMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGARVVWALSNFTVFACMAGT 462
Cdd:cd17313 253 FELFFTDYMGEEVYH----GTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALM 328

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 463 AVISlmslsddkngieyimrgnetTRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIGVLNLAIVIPQMIV 542
Cdd:cd17313 329 ALVH--------------------NVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILV 388

                       490       500       510
                ....*....|....*....|....*....|....*
gi 15227049 543 SLGAGPWDqlFGGGNLPAFVLASVAAFAAGVIALQ 577
Cdd:cd17313 389 SLLAGPII--DVKGYGTVFPVAAVASFLSLVGALF 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
70-576 8.62e-28

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 116.54  E-value: 8.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  70 AAGVQFGWALQLSLLTP-YIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMISIAVIII 148
Cdd:COG2211  19 DLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIPLALSFVLL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 149 GFSADIGYllgdskehcstfkgtrTRAAVVFIIGFWLLDLANNTVQGPARALLADLSG-PDQRNTANAVFCLWMAIGNIL 227
Cdd:COG2211  99 FTAPDLSP----------------TGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 228 GFSAGasgkwqewfPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSapllddlqskgle 307
Cdd:COG2211 163 ASVLP---------PPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES------------- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 308 hsklnngtangikyerverdtdeqfgnsenehqdetyvdgpgsvlvnlLTSLRHLPPAMHsVLIVMALTWLSW------F 381
Cdd:COG2211 221 ------------------------------------------------LKALLKNRPFLL-LLLAYLLFFLALalvaalL 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 382 PFFLfdTDWMGREvyhgdptgdslhmelydqgVREGALGLLLNSVVLGISSFLIEPMCQRMGARVVWALSNFTVFACMAG 461
Cdd:COG2211 252 LYYF--KYVLGLS-------------------AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 462 TAVISLMSLsddkngieyimrgnettrTAAVIVFALLGFPLAITYSVPFSVTAEVtADSGGGQ------GLAIGVLNLAI 535
Cdd:COG2211 311 LFFLGPGNL------------------WLLLVLAALAGIGLGAILVLPWAMLADV-VDYDEWKtgrrreGLYFGIFTFAI 371

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 15227049 536 VIPQMIVSLGAGPWDQLFG-------------GGNLPAFVLASVAAFAAGVIAL 576
Cdd:COG2211 372 KLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLL 425
MFS_1 pfam07690
Major Facilitator Superfamily;
67-290 9.31e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.18  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    67 CTVAAGVQFGWALQLSLLTPYI-QTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRpFILVGSFMISIAV 145
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRR-VLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   146 IIIGFSADIgyllgdskehcstfkgtrtraaVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMAIGN 225
Cdd:pfam07690  77 LLLLFASSL----------------------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227049   226 ILGFSAGAsgkwqewfpFLTSRaccaacGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTR 290
Cdd:pfam07690 135 ALGPLLGG---------LLASL------FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
 
Name Accession Description Interval E-value
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 59-580 0e+00

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 529.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    59 SLVTLVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGS 138
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   139 FMISIAVIIIGFSADIGYLLGDSKEhcstfKGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNT--ANAV 216
Cdd:TIGR01301  82 ALVAFAVILIGFAADIGHLFGDNLD-----KKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   217 FCLWMAIGNILGFSAGASGKWQEWFPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEipftsnKPTRIQDSAP 296
Cdd:TIGR01301 157 FSFFMAIGNVLGYAAGAYSGLYKIFPFTKTEACGVSCANLKSCFLIDIILLAILTYIALSAVKE------NPLIGSDDFI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   297 llddlqskglehsklnngtangikyerVERDTDEQFGNSEnehqdetyvdgpgSVLVNLLTSLRHLPPAMHSVLIVMALT 376
Cdd:TIGR01301 231 ---------------------------NSEAAPPSKHGEE-------------AFFGELFGAFKYLPRPVWILLLVTCLN 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   377 WLSWFPFFLFDTDWMGREVYHGDPTgdslHMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGA-RVVWALSNFTV 455
Cdd:TIGR01301 271 WIAWFPFILFDTDWMGREVYGGSVN----QGAKYDDGVRAGAFGLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIVNIIL 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   456 FACMAGTAVISLMSLSDDkngieYIMRGNET------TRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIG 529
Cdd:TIGR01301 347 AICLAATVLVTYVAKNSR-----YYDGDGESlppptgIKASALIVFAILGIPLAITYSIPFALASIRSSNLGAGQGLSMG 421

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15227049   530 VLNLAIVIPQMIVSLGAGPWDQLFGGGNLPAFVLASVAAFAAGVIALQRLP 580
Cdd:TIGR01301 422 VLNLAIVIPQIIVSLGSGPWDQLFGGGNLPAFVVGAVAAFVSGLLALILLP 472
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 63-577 6.65e-154

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 448.61  E-value: 6.65e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  63 LVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMIS 142
Cdd:cd17313   1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 143 IAVIIIGFSADIGYLLGDskehcstfkGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMA 222
Cdd:cd17313  81 LGLILIPNAADIGLALGD---------GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 223 IGNILGFSAGASGKWQEWFPFltsraccAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSapllddlq 302
Cdd:cd17313 152 LGGVLGYLLGAILWDHNWFGF-------ALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENP-------- 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 303 skglehsklnngtangikyerverdtdeqfgnsenehqdetyvdGPGSVLVNLLTSLRHLPPAMHSVLIVMALTWLSWFP 382
Cdd:cd17313 217 --------------------------------------------SLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFP 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 383 FFLFDTDWMGREVYHgdptGDSLHMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGARVVWALSNFTVFACMAGT 462
Cdd:cd17313 253 FELFFTDYMGEEVYH----GTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALM 328

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 463 AVISlmslsddkngieyimrgnetTRTAAVIVFALLGFPLAITYSVPFSVTAEVTADSGGGQGLAIGVLNLAIVIPQMIV 542
Cdd:cd17313 329 ALVH--------------------NVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILV 388

                       490       500       510
                ....*....|....*....|....*....|....*
gi 15227049 543 SLGAGPWDqlFGGGNLPAFVLASVAAFAAGVIALQ 577
Cdd:cd17313 389 SLLAGPII--DVKGYGTVFPVAAVASFLSLVGALF 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
70-576 8.62e-28

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 116.54  E-value: 8.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  70 AAGVQFGWALQLSLLTP-YIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMISIAVIII 148
Cdd:COG2211  19 DLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIPLALSFVLL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 149 GFSADIGYllgdskehcstfkgtrTRAAVVFIIGFWLLDLANNTVQGPARALLADLSG-PDQRNTANAVFCLWMAIGNIL 227
Cdd:COG2211  99 FTAPDLSP----------------TGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 228 GFSAGasgkwqewfPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSapllddlqskgle 307
Cdd:COG2211 163 ASVLP---------PPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES------------- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 308 hsklnngtangikyerverdtdeqfgnsenehqdetyvdgpgsvlvnlLTSLRHLPPAMHsVLIVMALTWLSW------F 381
Cdd:COG2211 221 ------------------------------------------------LKALLKNRPFLL-LLLAYLLFFLALalvaalL 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 382 PFFLfdTDWMGREvyhgdptgdslhmelydqgVREGALGLLLNSVVLGISSFLIEPMCQRMGARVVWALSNFTVFACMAG 461
Cdd:COG2211 252 LYYF--KYVLGLS-------------------AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 462 TAVISLMSLsddkngieyimrgnettrTAAVIVFALLGFPLAITYSVPFSVTAEVtADSGGGQ------GLAIGVLNLAI 535
Cdd:COG2211 311 LFFLGPGNL------------------WLLLVLAALAGIGLGAILVLPWAMLADV-VDYDEWKtgrrreGLYFGIFTFAI 371

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 15227049 536 VIPQMIVSLGAGPWDQLFG-------------GGNLPAFVLASVAAFAAGVIAL 576
Cdd:COG2211 372 KLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLL 425
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 75-576 1.48e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.21  E-value: 1.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  75 FGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCtskygRRRPFILVGSFMISIAVIIIGFSADI 154
Cdd:cd06174  10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFALGALLFAFAPSF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 155 GyllgdskehcstfkgtrtraavVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMAIGNILGfsagas 234
Cdd:cd06174  85 W----------------------LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILG------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 235 gkwqewfPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSAPLLDDlqskglehsklnng 314
Cdd:cd06174 137 -------PLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------------- 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 315 tangikyerverdtdeqfgnsenehqdetyvdgpgsvlvnlLTSLRHLPPAMhSVLIVMALTWLSWFPFFLFDTDWMgre 394
Cdd:cd06174 196 -----------------------------------------LKRVLKNPGLW-LLLLAIFLVNLAYYSFSTLLPLFL--- 230

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 395 vyhgdptgdslhMELYDQGVREGALGLLLNSVVLGISSFLIEPMCQRMGARVVWALsnFTVFACMAGTAVISLMslsddk 474
Cdd:cd06174 231 ------------LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL--IGLLLMALGLALLLLA------ 290

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 475 ngieyimrgneTTRTAAVIVFALLGFPLAITYSVPFSVTAEVTadSGGGQGLAIGVLNLAIVIPQMIVSLGAGPWDQLFG 554
Cdd:cd06174 291 -----------PSLLLLLLLLLLLGFGLGGLLPLSFALIAELF--PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357

                       490       500
                ....*....|....*....|..
gi 15227049 555 GGNLpAFVLASVAAFAAGVIAL 576
Cdd:cd06174 358 GLTG-AFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 67-290 8.38e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 60.67  E-value: 8.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  67 CTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPfILVGSFMISIAVI 146
Cdd:cd17325   2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRL-LLLGLLLLAVSTL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 147 IIGFSADIGYLLgdskehcstfkgtrtraAVVFIIGFWlldlanNTVQGPAR-ALLADLSGPDQRNTANAVFCLWMAIGN 225
Cdd:cd17325  77 LFAFATSYWQLL-----------------LARFLQGLA------SAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGF 133

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227049 226 ILGFSAGAsgkwqewfpFLTSRaccaacGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTR 290
Cdd:cd17325 134 LIGPLLGG---------LLADA------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 63-278 4.14e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.74  E-value: 4.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  63 LVLSCTVAAGVQFGWALQLSLLTPYIQTL-GISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRPfILVGSFMI 141
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDR----IGRKPL-ILIGLLLS 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 142 SIAVIIIGFSADIGYLlgdskehcstfkgtrtraavvfIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWM 221
Cdd:cd17325 276 AVALLLLPLATSFWLL----------------------LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227049 222 AIGNILGFSAGAsgkwqewfpFLTSRaccaacGNLKAAFLLAVVFLTICTLVTIYFA 278
Cdd:cd17325 334 SLGMVLGPLLGG---------FLYDA------FGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
60-233 3.25e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 3.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  60 LVTLVLSCTVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPFiLVGSF 139
Cdd:COG2814   9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGRRRVL-LLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 140 MISIAVIIIGFSADIGYLLgdskehcstfkgtrtraAVVFIIGFwlldlANNTVQGPARALLADLSGPDQRNTANAVFCL 219
Cdd:COG2814  84 LFALGSLLCALAPSLWLLL-----------------AARFLQGL-----GAGALFPAALALIADLVPPERRGRALGLLGA 141

                       170
                ....*....|....
gi 15227049 220 WMAIGNILGFSAGA 233
Cdd:COG2814 142 GLGLGPALGPLLGG 155
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 65-302 3.86e-07

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 52.61  E-value: 3.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  65 LSCTVAAGVQFGWalqlsLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMISIA 144
Cdd:cd17332   9 FGNNLIFQIVSTY-----LLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 145 VIIIgFsadigyllgdskehcSTFKGTRTRAAVVFIIGFWLLDLANNTVQGPARALLADLSG-PDQRNTANAvfcLWMAI 223
Cdd:cd17332  84 FVLL-F---------------TTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDdPEERTSLTS---WRMFF 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 224 GNILGFSAGASgkwqewFPFLTSRA--CCAACGNLKAAFLLAVVFLtICTLVTIYFAKEIPftsNKPTRIQDSAPLLDDL 301
Cdd:cd17332 145 ATIGGLLVTVL------PPPLVAYFggGNASRGYFLTALIIGIIGI-ILLLICFFGTRERV---VPPEEEKSKLPLLKSL 214


                .
gi 15227049 302 Q 302
Cdd:cd17332 215 K 215
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-282 1.05e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 1.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  60 LVTLVLSCTVAAGVQFGWALQLSLLTPYI-QTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPFILVGS 138
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD----RLGRRRKLVLAIG 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 139 FMISIAVIIIGFSADIGYLLgdskehcstfkgtrtrAAVVFIIGFwlldlANNTVQGPARALLADLSGPDQRNTAnavfc 218
Cdd:COG2271 255 LLLAALALLLLALLPSPALA----------------IALLFLAGF-----GLGGAFGLLWALAAELFPKKARGTA----- 308

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227049 219 lwMAIGNILGFSAGASGKWqeWFPFLTSRAccaacgNLKAAFLLAVVFLTICTLVTIYFAKEIP 282
Cdd:COG2271 309 --SGLVNTFGFLGGALGPL--LVGYLLDAT------GYQAAFLLLAALALLAALLALLLLRETR 362
MFS_1 pfam07690
Major Facilitator Superfamily;
67-290 9.31e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.18  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    67 CTVAAGVQFGWALQLSLLTPYI-QTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRpFILVGSFMISIAV 145
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRR-VLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   146 IIIGFSADIgyllgdskehcstfkgtrtraaVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWMAIGN 225
Cdd:pfam07690  77 LLLLFASSL----------------------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227049   226 ILGFSAGAsgkwqewfpFLTSRaccaacGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTR 290
Cdd:pfam07690 135 ALGPLLGG---------LLASL------FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 69-301 9.81e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 48.07  E-value: 9.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    69 VAAGVqFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTSKYGRRRPFILVGSFMISIAVIII 148
Cdd:pfam13347   7 LAAGI-KYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   149 GFSADIGYLLgdskehcstfkgtrtrAAVVFIIGFWLLDLANNTVQGPARALLADLS-GPDQRNTANAVFCLWMAIGnIL 227
Cdd:pfam13347  86 FTPPELGRAP----------------LFIWLLATYILLRIAYTFFEIPYWSLGPELTrDYDERTSLTSYRSFFSVGG-GL 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227049   228 GFSAGASGkwqewFPFLTSRACCAACGNLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTRIQDSAPLLDDL 301
Cdd:pfam13347 149 LAAALAFP-----LVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDML 217
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
62-227 1.14e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  62 TLVLSCTVAAGVQFGWALQLSLLTPYIQT-LGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRpFILVGSFM 140
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADR----FGRRR-LLLIGLLL 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 141 ISIAVIIIGFSAdigyllgdskehcstfkgtrtrAAVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLW 220
Cdd:COG2814 283 LALGLLLLALAG----------------------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340


                ....*..
gi 15227049 221 MAIGNIL 227
Cdd:COG2814 341 FFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
68-228 2.68e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.64  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049    68 TVAAGVQFGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPFILVGSFMISIAVII 147
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049   148 IGFSADIGYLLGdskehcstfkgtrtrAAVVFIIGFwlldlANNTVQGPARALLADLSGPDQRNTANAVFCLWMAIGNIL 227
Cdd:pfam07690 283 LLLSLTLSSLWL---------------LLALLLLGF-----GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342


                  .
gi 15227049   228 G 228
Cdd:pfam07690 343 G 343
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 89-148 3.10e-05

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 46.48  E-value: 3.10e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227049  89 QTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKCTS--KYGRRRPFILVGSFMISIAVIII 148
Cdd:cd17491  28 LVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGcgKYGRRKSWHLIGTICVLLSFPFI 89
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 83-232 3.65e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.40  E-value: 3.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  83 LLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskyGRRRPFILVGSFMISIAVIIIGFSADIGYLLgdsk 162
Cdd:cd17478  18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADR-----KPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL---- 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 163 ehcstfkgtrtraAVVFIIGFwlldlaNNTVQGPARALLADLSGPDQRNTANAVFclwMAIGNiLGFSAG 232
Cdd:cd17478  89 -------------LLVALAGI------GSAAFHPEGARLASQAAGGRRGLAMSIF---SVGGN-LGFALG 135
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 99-290 4.79e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 45.91  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  99 SFIWLCGPITGLVVQPFVGIWSDKctskYGRRRPFILVGSFMISIAVIIIGFSADIGYLLGdskehcstfkgtrtraAVV 178
Cdd:COG2270  55 GYALAIAGLLVALLAPVLGAIADR----SGRKKPFLAFFTLLGVLATAALFFVAPGGLWLG----------------LLL 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 179 FIIGFWLLDLANNtvqgPARALLADLSGPDQRNTANAVFclWmAIGNILGFSAGASG----KWQEWFPFLTSRAccaacg 254
Cdd:COG2270 115 FVLANIGFEGSLV----FYNAFLPDIATPEEIGRVSGLG--W-ALGYLGGVLLLLINlalfLKPEAFGLPDAGE------ 181

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15227049 255 NLKAAFLLAVVFLTICTLVTIYFAKEIPFTSNKPTR 290
Cdd:COG2270 182 AVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPR 217
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 65-277 6.15e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 6.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  65 LSCTVAAGVQFGWALQLSLLTPYIQTLGISHAfsSFIWLCGPITGLVVQPFVGIWSDKctskyGRRRPFILVGSFMISIA 144
Cdd:cd17489 198 PPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVYAIALLLSRPFSGKLSDR-----KGPKTVIIPGLLLLALG 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 145 VIIIGFSADIGYLLGdskehcstfkgtrtrAAVVFIIGFWLLDLANNtvqgparALLADLSGPDQRNTANAVFCLWMAIG 224
Cdd:cd17489 271 LLLLSFAGSPWMLLL---------------AAVLYGLGFGLLFPALQ-------ALAVDLVPPHRRGAANGTFFIFFDLG 328

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15227049 225 niLGFSAGASGKWQEWFPFltsraccaacgnlKAAFLLAVVFLTICTLVTIYF 277
Cdd:cd17489 329 --IGLGGLLLGLVAELFGY-------------RAMFLLAAVVVLLALVLYIFL 366
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 82-290 6.15e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.61  E-value: 6.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  82 SLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRPFILVGSFMISIAVIIIGFSADIGyllgds 161
Cdd:cd17370  20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDR----TGKRKPLVILGYGLSALAKPLLALAGSWQ------ 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 162 kehcstfkgtrtrAAVVFIIgfwlLDLANNTVQGPAR-ALLADLSGPDQRNTAnavFCLWMA---IGNILGfsagasgkw 237
Cdd:cd17370  90 -------------LVLLLRI----LERLGKGIRTPPRdALLADATPPSGRGKA---FGLHRAldtLGAVLG--------- 140

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15227049 238 qewfPFLTSRACCAACGNLKAAFLLAVV--FLTICTLVTIYFAKEIPFTSNKPTR 290
Cdd:cd17370 141 ----PLLAALLLYLLGGNYRTIFLLAAIpaLLALLILLFVVKEYPRPPKLRKKSK 191
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 75-228 2.04e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  75 FGWALQLSLLTPYI-QTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRrPFILVGSFMISIAVIIIGFSAD 153
Cdd:cd17329  13 LGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR----FGRK-PVMLAGLLLRALGFALLGFAHS 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227049 154 IgyllgdskehcstfkgtrtraaVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFC----LWMAIGNILG 228
Cdd:cd17329  88 P----------------------WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYwainLGVAIGPLLG 144
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 84-158 5.73e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.59  E-value: 5.73e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227049  84 LTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRRPFILVGSFMISIAVIIIGFSADIGYLL 158
Cdd:cd17490  19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDR----IGKRKLFIIIGLLFTVLASLIMILFPSPWGLL 89
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 75-228 1.06e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 41.44  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  75 FGWALQLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDKctskYGRRrPFILVGSFMISIAVIIIGFSADI 154
Cdd:cd17390  10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDV----VGRR-PVLLICLLLTALGYVLLGFSTSL 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227049 155 gYLLGDSKEHCSTFKGTrtraavvfiigfwlldlanntvQGPARALLADLSGPDQRNTANAVFCLWMAIGNILG 228
Cdd:cd17390  85 -ALLFLSRIPLGIFKHT----------------------QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILG 135
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 75-228 1.10e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  75 FGWALQLSLLTPYIQ---TLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGrRRPFILVGSFMISIAVIIIGFS 151
Cdd:cd17330  10 LGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSD----RYG-RKPVLLLSLAGSAVSYVLLGLS 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227049 152 adigyllgdskehcstfkgtrtRAAVVFIIGFWLLDLANNTVqGPARALLADLSGPDQRNTANAVFCLWMAIGNILG 228
Cdd:cd17330  85 ----------------------RNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILG 138
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 112-233 1.90e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.95  E-value: 1.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 112 VQPFVGIWSDKCTSKYGRRRPFILVGSFMISIAVIIIGFSAdigYLLGdskehcstfkGTRTRAAVVF-IIGFWLLDLAN 190
Cdd:cd06176  51 LRVWIGHRSDTHPLRGYRRTPYIWLGMLLLALGLALAPFAA---LLLA----------GAAFWLGLALaVLAFLLYGIGV 117

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15227049 191 NTVQGPARALLADLSGPDQRntANAVFCLWMAIgnILGFSAGA 233
Cdd:cd06176 118 GAAGTAFLALLADLTPEERR--PRAVTVVWTML--ILGIIVTA 156
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
63-277 5.10e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 5.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  63 LVLSCTVAAGVQFGWALQLSLLtpYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPFILVGSFMIS 142
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RIGGRRVLLIVFALMAL 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 143 IAVIIIGFSADIgyllgdskehcstfkgtrtraaVVFIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANA-VFCLWM 221
Cdd:COG2223 284 GLLLLALALGSL----------------------WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGlVGAAGG 341

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15227049 222 AIGNILGFSAGASGKWQewfpfltsraccaacGNLKAAFLLAVVFLTICTLVTIYF 277
Cdd:COG2223 342 LGGFLGPLLFGALLDAT---------------GSYTAAFLVFAVLALVALVLTLLL 382
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 62-228 6.64e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 6.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  62 TLVLSCTVAAGVQFGWalqLSLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRpFILVGSFMI 141
Cdd:cd17477 192 LALLGAFVAGFLEGAF---YSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD----RFDRRR-VLLGCALLG 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049 142 SIAVIIIGFSADIGYLLgdskehcstfkgtrtraavvfIIGFWLLDLANNTVQGPARALLADLSGPDQRNTANAVFCLWM 221
Cdd:cd17477 264 ALAALLLPLVPGLPLAL---------------------LVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLY 322


                ....*..
gi 15227049 222 AIGNILG 228
Cdd:cd17477 323 GLGSVIG 329
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
60-159 8.44e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 8.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227049  60 LVTLVLSCTVAAGVQFGWALqlsLLTPYIQTLGISHAFSSFIWLCGPITGLVVQPFVGIWSDkctsKYGRRRPFILVGSF 139
Cdd:COG2223   7 LLLATLAFFLAFGVWYLWSV---LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD----RFGPRRVLLIGLLL 79

                        90       100
                ....*....|....*....|
gi 15227049 140 MIsIAVIIIGFSADIGYLLG 159
Cdd:COG2223  80 LG-IGLLLLALAVSYWLLLL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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