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Conserved domains on  [gi|15226931|ref|NP_178337|]
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phloem protein 2-B6 [Arabidopsis thaliana]

Protein Classification

PP2 family F-box protein( domain architecture ID 17779824)

PP2 (Phloem protein 2) family F-box protein is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0030246|GO:0019005|GO:0005515
PubMed:  12529520|31898225|11178263|11077244
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP2 pfam14299
Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in ...
 135-303 2.67e-54

Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances.


:

Pssm-ID: 464128  Cd Length: 151  Bit Score: 173.93  E-value: 2.67e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   135 KKCVLLAAKELWITGGNNPEYWQWIELCESSFEKVPELLNNRSFQMGGSMSTQILSLGTHYSVYIVYKIKDERHGLRDLP 214
Cdd:pfam14299   1 KKCYMLSARALSITWGDDPRYWRWIPLPESRFSEVAELLQVCWLEIRGKIDTRMLSPGTTYSAYFVFKLGDSSYGWDDVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   215 IQVGVGFKGqeMPKQFICFDESTdktkewpkkklmkskKRGDGWMEAEIGDF-FNDGGLMGfdEVEVSIVDVTSPNLKCG 293
Cdd:pfam14299  81 VEFSVSVGS--SSKRFVCLRRPK---------------EREDGWMEIELGEFvVNEGGEDG--EVEFSLYEVKGGHWKGG 141

                         170
                  ....*....|
gi 15226931   294 VMIEGIEFRP 303
Cdd:pfam14299 142 LIVEGIEIRP 151
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 45-90 4.88e-22

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438933  Cd Length: 46  Bit Score: 86.87  E-value: 4.88e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15226931  45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKFLP 90
Cdd:cd22162   1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVWERFLP 46
 
Name Accession Description Interval E-value
PP2 pfam14299
Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in ...
 135-303 2.67e-54

Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances.


Pssm-ID: 464128  Cd Length: 151  Bit Score: 173.93  E-value: 2.67e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   135 KKCVLLAAKELWITGGNNPEYWQWIELCESSFEKVPELLNNRSFQMGGSMSTQILSLGTHYSVYIVYKIKDERHGLRDLP 214
Cdd:pfam14299   1 KKCYMLSARALSITWGDDPRYWRWIPLPESRFSEVAELLQVCWLEIRGKIDTRMLSPGTTYSAYFVFKLGDSSYGWDDVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   215 IQVGVGFKGqeMPKQFICFDESTdktkewpkkklmkskKRGDGWMEAEIGDF-FNDGGLMGfdEVEVSIVDVTSPNLKCG 293
Cdd:pfam14299  81 VEFSVSVGS--SSKRFVCLRRPK---------------EREDGWMEIELGEFvVNEGGEDG--EVEFSLYEVKGGHWKGG 141

                         170
                  ....*....|
gi 15226931   294 VMIEGIEFRP 303
Cdd:pfam14299 142 LIVEGIEIRP 151
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 45-90 4.88e-22

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 86.87  E-value: 4.88e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15226931  45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKFLP 90
Cdd:cd22162   1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVWERFLP 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 45-87 8.06e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 42.14  E-value: 8.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15226931    45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEK 87
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
48-88 1.44e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15226931     48 LPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKF 88
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
PP2 pfam14299
Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in ...
 135-303 2.67e-54

Phloem protein 2; Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances.


Pssm-ID: 464128  Cd Length: 151  Bit Score: 173.93  E-value: 2.67e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   135 KKCVLLAAKELWITGGNNPEYWQWIELCESSFEKVPELLNNRSFQMGGSMSTQILSLGTHYSVYIVYKIKDERHGLRDLP 214
Cdd:pfam14299   1 KKCYMLSARALSITWGDDPRYWRWIPLPESRFSEVAELLQVCWLEIRGKIDTRMLSPGTTYSAYFVFKLGDSSYGWDDVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226931   215 IQVGVGFKGqeMPKQFICFDESTdktkewpkkklmkskKRGDGWMEAEIGDF-FNDGGLMGfdEVEVSIVDVTSPNLKCG 293
Cdd:pfam14299  81 VEFSVSVGS--SSKRFVCLRRPK---------------EREDGWMEIELGEFvVNEGGEDG--EVEFSLYEVKGGHWKGG 141

                         170
                  ....*....|
gi 15226931   294 VMIEGIEFRP 303
Cdd:pfam14299 142 LIVEGIEIRP 151
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 45-90 4.88e-22

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 86.87  E-value: 4.88e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15226931  45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKFLP 90
Cdd:cd22162   1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVWERFLP 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 45-87 8.06e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 42.14  E-value: 8.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15226931    45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEK 87
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 45-88 2.99e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 2.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15226931    45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKF 88
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 46-80 4.61e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.73  E-value: 4.61e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15226931  46 DDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQ 80
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 44-88 4.11e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 37.58  E-value: 4.11e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15226931  44 PFDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKF 88
Cdd:cd20090   1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRI 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
48-88 1.44e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15226931     48 LPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKF 88
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 43-89 1.84e-03

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 35.85  E-value: 1.84e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15226931  43 SPFDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIWEKFL 89
Cdd:cd22085   1 PLLNHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFL 47
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 45-85 4.32e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 34.62  E-value: 4.32e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15226931  45 FDDLPEDCISNIISFTSPRDVCVSASVSKSFAHAVQCDSIW 85
Cdd:cd22118   1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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