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Conserved domains on  [gi|15220120|ref|NP_178153|]
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Cyclin A2;4 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-325 7.93e-98

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410265  Cd Length: 136  Bit Score: 289.69  E-value: 7.93e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQ 325
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 329-443 2.77e-65

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410210  Cd Length: 111  Bit Score: 205.18  E-value: 2.77e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTYK 408
Cdd:cd20506   1 PTIKTFLRRFLRAAQASVPD--LKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKF 443
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-325 7.93e-98

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 289.69  E-value: 7.93e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQ 325
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 329-443 2.77e-65

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 205.18  E-value: 2.77e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTYK 408
Cdd:cd20506   1 PTIKTFLRRFLRAAQASVPD--LKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKF 443
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 200-326 8.25e-52

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 170.78  E-value: 8.25e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120   200 DIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGIT 279
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15220120   280 CMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQI 326
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
183-450 2.69e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 168.80  E-value: 2.69e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 183 DIDSDDK-DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDW 261
Cdd:COG5024 165 DLDATDQeDPLMVPEYASDIFEYLLKLELIDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDR 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 262 FLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQIYTPTSKTFLRRFLRA 341
Cdd:COG5024 244 FLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 342 AqvsfpNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKwtLNQSSHPWNPTLEHYT-TYKASDLKASVHALQ 420
Cdd:COG5024 324 S-----DYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSR--KILSQNQWDRTLIHYSgNYTNPDLKPLNESNK 396

                       250       260       270
                ....*....|....*....|....*....|
gi 15220120 421 DLQLNTKGcSLNSIRMKYRQDKFKSVAVFS 450
Cdd:COG5024 397 ENLQNPSV-HHDAIFPKYPSPTFGKASSPT 425
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 329-451 7.01e-43

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 147.38  E-value: 7.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120   329 PTSKTFLRRFLRAAQVSfpnQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNqsSHPWNPTLEHYTTYK 408
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN--SPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 15220120   409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSVAVFSS 451
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPP 118
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 333-419 2.77e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.48  E-value: 2.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120    333 TFLRRFLRAAQVSFpnqslEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTY-KASD 411
Cdd:smart00385   1 DFLRRVCKALNLDP-----ETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEET--PPWTKELVHYTGYfTEEE 73


                   ....*...
gi 15220120    412 LKASVHAL 419
Cdd:smart00385  74 ILRMERLL 81
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 236-320 8.23e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 72.24  E-value: 8.23e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120    236 DWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDntYTRDQVLEME 315
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 15220120    316 SQVLK 320
Cdd:smart00385  79 RLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-325 7.93e-98

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 289.69  E-value: 7.93e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQ 325
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 197-324 2.31e-67

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 211.34  E-value: 2.31e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 197 YAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLL 276
Cdd:cd20504   2 YADDIYEYLRESELKHRPKPDYMRK-QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15220120 277 GITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20504  81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 329-443 2.77e-65

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 205.18  E-value: 2.77e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTYK 408
Cdd:cd20506   1 PTIKTFLRRFLRAAQASVPD--LKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKF 443
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 194-324 9.53e-60

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 191.59  E-value: 9.53e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 194 CSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRL 273
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSG-QPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220120 274 QLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20507  80 QLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 200-326 8.25e-52

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 170.78  E-value: 8.25e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120   200 DIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGIT 279
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15220120   280 CMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQI 326
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 179-324 5.37e-49

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 164.44  E-value: 5.37e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 179 PKFVDIDSDDKD-PLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVY 257
Cdd:cd20567   2 EPLPDIDEVDKNnPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQ-QPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220120 258 LIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20567  81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
183-450 2.69e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 168.80  E-value: 2.69e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 183 DIDSDDK-DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDW 261
Cdd:COG5024 165 DLDATDQeDPLMVPEYASDIFEYLLKLELIDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDR 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 262 FLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQIYTPTSKTFLRRFLRA 341
Cdd:COG5024 244 FLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 342 AqvsfpNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKwtLNQSSHPWNPTLEHYT-TYKASDLKASVHALQ 420
Cdd:COG5024 324 S-----DYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSR--KILSQNQWDRTLIHYSgNYTNPDLKPLNESNK 396

                       250       260       270
                ....*....|....*....|....*....|
gi 15220120 421 DLQLNTKGcSLNSIRMKYRQDKFKSVAVFS 450
Cdd:COG5024 397 ENLQNPSV-HHDAIFPKYPSPTFGKASSPT 425
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 190-324 5.48e-46

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 155.92  E-value: 5.48e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDD-QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVS 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20568  80 LNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 183-324 9.07e-46

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 156.54  E-value: 9.07e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 183 DIDSDDKDPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWF 262
Cdd:cd20560  22 DDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRK-QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRF 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15220120 263 LHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20560 101 LSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 183-324 2.21e-45

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 154.72  E-value: 2.21e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 183 DIDSD-DKDPLLCSLYAPDIYYNLRVAELKRRPfPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDW 261
Cdd:cd20508   1 DIDEEnSDDPFQVSEYAKDIFDYMKEREEKFVV-PDYLEK-QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15220120 262 FLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20508  79 YLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 197-324 5.90e-44

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 150.59  E-value: 5.90e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 197 YAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLL 276
Cdd:cd20561   4 YHEDIHTYLREMEVKCKPKVGYMKK-QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15220120 277 GITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20561  83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 329-451 7.01e-43

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 147.38  E-value: 7.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120   329 PTSKTFLRRFLRAAQVSfpnQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNqsSHPWNPTLEHYTTYK 408
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN--SPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 15220120   409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSVAVFSS 451
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPP 118
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 190-324 1.59e-41

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 144.24  E-value: 1.59e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtqRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDG--KEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20566  79 RKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 194-324 1.64e-39

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 138.86  E-value: 1.64e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 194 CSLYAPDIYYNLRVAELKRRPFPDFMEKtqRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRL 273
Cdd:cd20565   1 CSEYVKDIYAYLRQLEEEQAVRPKYLEG--QEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKML 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220120 274 QLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSF 324
Cdd:cd20565  79 QLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 199-320 1.77e-32

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 120.11  E-value: 1.77e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 199 PDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLH-GNYVERQRLQLLG 277
Cdd:cd20519   6 EEVWDLMLKKEELYKRDRDFLNR-HPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLStQTNVPKTQLQLIG 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15220120 278 ITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLK 320
Cdd:cd20519  85 ITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILK 127
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 231-326 1.63e-30

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 113.57  E-value: 1.63e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 231 RGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQ 310
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 15220120 311 VLEMESQVLKHFSFQI 326
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 329-448 3.81e-28

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 107.78  E-value: 3.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQvsfPNQslEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSShPWNPTLEHYTTYK 408
Cdd:cd20511   1 PTPYVFLVRFLKAAQ---SDK--KLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTP-EWTSTLEFHTGYS 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSVAV 448
Cdd:cd20511  75 ESQLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVAL 114
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 230-320 7.23e-28

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 106.26  E-value: 7.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 230 MRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRD 309
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                        90
                ....*....|.
gi 15220120 310 QVLEMESQVLK 320
Cdd:cd20536  81 QICNLECIILT 91
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 329-446 7.22e-25

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 98.45  E-value: 7.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSfpnqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSshPWNPTLEHYTTYK 408
Cdd:cd20509   1 PLPLHFLRRFSKAGGAD-----AQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEP--EWTPTLEHYSTYS 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSV 446
Cdd:cd20509  74 EEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 228-319 1.26e-24

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 97.39  E-value: 1.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 228 ETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYT 307
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                        90
                ....*....|..
gi 15220120 308 RDQVLEMESQVL 319
Cdd:cd20521  81 YEDVVRMMGEIV 92
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 329-443 1.33e-24

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 97.75  E-value: 1.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNQSLEMeflanYLTELTLMDY-PFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTY 407
Cdd:cd20505   1 PTSNWFLERFLKHSNADEKTKSLAM-----YLCELSLIDAdPYLKYLPSVIAAAAVCLANHTLGN--EVWPQKLARSTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220120 408 KASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKF 443
Cdd:cd20505  74 SLEDLLPCLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 329-447 9.82e-24

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 95.43  E-value: 9.82e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNQSLemeflANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSShpWNPTLEHYTTYK 408
Cdd:cd20510   1 PLSYRFLRRYAKCARASMETLTL-----ARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGE--WTPTLEYYSGYS 73

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220120 409 ASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSVA 447
Cdd:cd20510  74 AEDLLPLVRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVA 112
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 230-320 6.77e-23

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 94.14  E-value: 6.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 230 MRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWF-LHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTR 308
Cdd:cd20580  42 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSE 121

                        90
                ....*....|..
gi 15220120 309 DQVLEMESQVLK 320
Cdd:cd20580 122 DDILDMELIILK 133
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 191-320 2.29e-22

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 92.63  E-value: 2.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 191 PLLCSLYAPDIYYNLRVAELKRRPFPDFMEKtQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNY-VE 269
Cdd:cd20579   4 PVLGWANRDEVWKNMLNKDKTYLRDKNFLQK-HPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLK 320
Cdd:cd20579  83 KTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMK 133
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 329-423 4.20e-22

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 90.06  E-value: 4.20e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAqvsfpNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQsSHPWNPTLEHYTTYK 408
Cdd:cd20537   1 PTPLSFLRRYLSLL-----GLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGE-PPPSPQLLQLVTGYS 74

                        90
                ....*....|....*
gi 15220120 409 ASDLKASVHALQDLQ 423
Cdd:cd20537  75 ENDLQECAKELLELL 89
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 203-321 8.93e-22

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 91.21  E-value: 8.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 203 YNLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCML 282
Cdd:cd20515  28 QNLLSLEERYLPSASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLF 107

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220120 283 IASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKH 321
Cdd:cd20515 108 LASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTK 146
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 230-324 6.99e-20

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 84.19  E-value: 6.99e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 230 MRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEI--HAPRIEEFCFITDN-TY 306
Cdd:cd20528   6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLNRYLCNsVY 85

                        90
                ....*....|....*...
gi 15220120 307 TRDQVLEMESQVLKHFSF 324
Cdd:cd20528  86 SKQEYLQMELLILEFFQW 103
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 333-419 2.77e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.48  E-value: 2.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120    333 TFLRRFLRAAQVSFpnqslEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTY-KASD 411
Cdd:smart00385   1 DFLRRVCKALNLDP-----ETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEET--PPWTKELVHYTGYfTEEE 73


                   ....*...
gi 15220120    412 LKASVHAL 419
Cdd:smart00385  74 ILRMERLL 81
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 208-319 5.33e-17

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 77.71  E-value: 5.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 208 AELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKY 287
Cdd:cd20573  32 AEETCLPSVSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKM 111

                        90       100       110
                ....*....|....*....|....*....|..
gi 15220120 288 EEIHAPRIEEFCFITDNTYTRDQVLEMESQVL 319
Cdd:cd20573 112 KETIPLTAEKLCIYTDNSIRPEELLQMELLVL 143
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 204-319 7.70e-17

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 77.34  E-value: 7.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 204 NLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLI 283
Cdd:cd20575  29 NLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLL 108

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220120 284 ASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVL 319
Cdd:cd20575 109 ASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVL 144
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 329-448 3.38e-16

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 74.85  E-value: 3.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSfpnqsLEMEFLANYLTELTLMDY-PFLKFLPSIIAASAVFLAKWTLNQssHPWNPTLEHYTTY 407
Cdd:cd20563   1 PTINQFLLQYLKRHEVC-----EKTENLAMYVAELSLLEVdPFLKYLPSLTAAAAYCLANYTVNK--VFWPETLAAFTGY 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15220120 408 KASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKFKSVAV 448
Cdd:cd20563  74 SLSEIVPCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSL 114
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 236-320 8.23e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 72.24  E-value: 8.23e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120    236 DWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDntYTRDQVLEME 315
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 15220120    316 SQVLK 320
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 190-319 2.19e-15

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 73.10  E-value: 2.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 190 DPLLcsLYAPDIYYNLRVAELKRRPFPDFMEKTQRDVTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVE 269
Cdd:cd20574  17 DPNL--LYDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTR 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220120 270 RQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVL 319
Cdd:cd20574  95 KCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVL 144
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 334-449 3.41e-15

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 71.49  E-value: 3.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 334 FLRRFLRAAqvsfpNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSshPWNPTLEHYTTYKASDLK 413
Cdd:cd20512   5 FLRRISKAD-----DYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRG--DWNDNLVHYSGYTESQLI 77

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15220120 414 ASVHA-LQDLQLNTKgcSLNSIRMKYRQDKFKSVAVF 449
Cdd:cd20512  78 PCADImLEYLVKPIK--HHDAFFKKYSSKKFLKASIF 112
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 234-320 7.17e-15

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 70.11  E-value: 7.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 234 LVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHA--PRIEEFCFITDNTYTRDQV 311
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81


                ....*....
gi 15220120 312 LEMESQVLK 320
Cdd:cd20559  82 IQMEMHILN 90
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 329-443 2.63e-14

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 68.70  E-value: 2.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNQSLEMeflanYLTELTLMDY-PFLKFLPSIIAASAVFLAKWTLNQSShpWNPTLEHYTTY 407
Cdd:cd20564   1 PTINQFLTQYFLHQQANCKVESLSM-----FLGELSLIDAdPYLKYLPSVIAAAAFHLALYTVTGQS--WPESLVQKTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220120 408 KASDLKASVHALQDLQLNTKGCSLNSIRMKYRQDKF 443
Cdd:cd20564  74 TLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 334-412 3.23e-12

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 63.37  E-value: 3.23e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15220120 334 FLRRFLRAAQVSfpnqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSShpWNPTLEHYTTYKASDL 412
Cdd:cd20569   6 FLRRASKIGEVD-----VEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGE--WTPTLQHYMSYTEESL 77
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 334-442 3.80e-12

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 62.98  E-value: 3.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 334 FLRRFLRAAQVSfpnqsLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSshPWNPTLEHYTTYKASDLK 413
Cdd:cd20570   6 FLRRASKAGSAD-----VEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGG--KWSLTQQYYTGYTEDDLK 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 15220120 414 ASVH--ALQDLQLNTKGCSLNSIRMKYRQDK 442
Cdd:cd20570  79 PIMQhmAKNVVKVNEGLTKHVAVKNKYASSK 109
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 234-317 1.11e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 60.50  E-value: 1.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 234 LVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHaPRIEEFCFITDntYTRDQVLE 313
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELP-RTLKEIAKVSG--VSEKELRK 78


                ....
gi 15220120 314 MESQ 317
Cdd:cd00043  79 AEKE 82
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 355-458 1.75e-10

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 58.02  E-value: 1.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 355 FLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQsSHPWNPTLEHYTTYKASDLKASVHAL------QDLQLNTKG 428
Cdd:cd20522   1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQ-ALPWPSQLEEFTGFSLEDLLSCVLHLhkkcfhEDSPKDYRN 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 15220120 429 CSLNSIRMKYRQDKFKSVA---VFSSGELPDKL 458
Cdd:cd20522  80 VSLTAVKQRYEDERFLSISkikVMSYEELCALL 112
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 329-419 2.88e-10

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 56.99  E-value: 2.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAAQVSFPNQSLE-----------MEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSShPW 397
Cdd:cd20529   1 PTPAHFLEYYLSQGVLFVDDHDGLpsellekvkeyVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSP-TW 79

                        90       100
                ....*....|....*....|..
gi 15220120 398 NPTLEHYTTYKASDLKASVHAL 419
Cdd:cd20529  80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 226-324 4.99e-09

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 53.33  E-value: 4.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 226 VTETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEEIHAPRIEEFCFITDNT 305
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                        90
                ....*....|....*....
gi 15220120 306 YTRDQVLEMESQVLKHFSF 324
Cdd:cd20517  81 FTNLELINQEKDILEALKW 99
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 329-396 1.21e-08

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 52.52  E-value: 1.21e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 329 PTSKTFLRRFLRAA--QVSFPNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLAKWTLNQSSHP 396
Cdd:cd20721   1 PTILTFLRMYIERLslESGAAHASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAW 70
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 231-298 1.14e-06

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 46.93  E-value: 1.14e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220120 231 RGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQR---LQLLGITCMLIASKYEEIHAPRIEEF 298
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDL 72
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 329-386 8.24e-05

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 41.56  E-value: 8.24e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15220120 329 PTSKTFLRRF----LRAAQVSFPNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFLA 386
Cdd:cd20722   1 PTLQFFLEHFsslrLENRELSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELA 62
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 235-289 5.41e-04

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 39.22  E-value: 5.41e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15220120 235 VDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKYEE 289
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNE 60
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 329-385 1.40e-03

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 38.03  E-value: 1.40e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15220120 329 PTSKTFLRRFLRAAQV-----------SFPNQSLEMEFLANYLTELTLMDYPFLKFLPSIIAASAVFL 385
Cdd:cd20520   2 PTPNSWLNLYLQLAQLnpppkendsafLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYL 69
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 230-320 6.83e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 35.95  E-value: 6.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220120 230 MRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLHGNYVERQRLQLLGITCMLIASKY--EEIHAPRIEEFCFITDNTYT 307
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|...
gi 15220120 308 RDQVLEMESQVLK 320
Cdd:cd20583  81 VSDMMRMEKIILE 93
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 328-386 8.57e-03

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 35.37  E-value: 8.57e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220120 328 TPTSktFLRRFLRAaqvsFPNQSLEMEFLANYLTEL--TLMDYPFLKFLPSIIAASAVFLA 386
Cdd:cd20544   2 TPFS--FLDYFISK----IGLSDSREELLSRATELLlsTTKDIRFLEYRPSVIAAAAILCA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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