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Conserved domains on  [gi|15219197|ref|NP_178003|]
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D-mannose binding lectin protein with Apple-like carbohydrate-binding domain-containing protein [Arabidopsis thaliana]

Protein Classification

G-type lectin S-receptor-like serine/threonine-protein kinase family protein; G-type lectin S-receptor-like serine/threonine-protein kinase; G-type lectin S-receptor-like serine/threonine-protein kinase family protein( domain architecture ID 10032985)

G-type lectin S-receptor-like serine/threonine-protein kinase is involved in abiotic stress response, allowing the plant to adapt to continuously changing environmental factors; contains a highly conserved serine/threonine protein kinase catalytic domain, a G-type lectin region, and a PAN/APPLE-like domain

Gene Ontology:  GO:0030246|GO:0006468|GO:0005524
PubMed:  27933379

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B_lectin cd00028
Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat ...
 43-165 1.96e-28

Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically recognize diverse carbohydrates and mediate a wide variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein turnover, and innate immune responses.


:

Pssm-ID: 237995  Cd Length: 116  Bit Score: 108.55  E-value: 1.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197  43 TEYDASYRFLNSPNQnfftiPFQLMFYNTTPSAyvlALRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAEL 122
Cdd:cd00028   1 SNPLSSGQTLVSSGS-----LFELGFFKLIMQS---RDYNLILYKGSSRTVVWVANRDNPSGSSCTLTLQSDGNLVIYDG 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15219197 123 NGQVKWQTNTAN-KGVTGFQILPNGNMVLHDKHGKFVWQSFDHP 165
Cdd:cd00028  73 SGTVVWSSNTTRvNGNYVLVLLDDGNLVLYDSDGNFLWQSFDYP 116
PAN_APPLE super family cl00112
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 370-454 4.19e-08

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


The actual alignment was detected with superfamily member cd01098:

Pssm-ID: 469620  Cd Length: 84  Bit Score: 50.51  E-value: 4.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197 370 TTQFCSGGKgkavNYYKIVGVEHFTGPYVNDGQGPTSVNDCKAKCDRDCKCLGYFYKEKDKKCLLAPLLGTLIKDAN-TS 448
Cdd:cd01098   1 TPLNCGGDG----STDGFLKLPDVKLPDNASAITAISLEECREACLSNCSCTAYAYNNGSGGCLLWNGLLNNLRSLSsGG 76


                ....*.
gi 15219197 449 SVAYIK 454
Cdd:cd01098  77 GTLYLR 82
 
Name Accession Description Interval E-value
B_lectin cd00028
Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat ...
 43-165 1.96e-28

Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically recognize diverse carbohydrates and mediate a wide variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein turnover, and innate immune responses.


Pssm-ID: 237995  Cd Length: 116  Bit Score: 108.55  E-value: 1.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197  43 TEYDASYRFLNSPNQnfftiPFQLMFYNTTPSAyvlALRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAEL 122
Cdd:cd00028   1 SNPLSSGQTLVSSGS-----LFELGFFKLIMQS---RDYNLILYKGSSRTVVWVANRDNPSGSSCTLTLQSDGNLVIYDG 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15219197 123 NGQVKWQTNTAN-KGVTGFQILPNGNMVLHDKHGKFVWQSFDHP 165
Cdd:cd00028  73 SGTVVWSSNTTRvNGNYVLVLLDDGNLVLYDSDGNFLWQSFDYP 116
B_lectin smart00108
Bulb-type mannose-specific lectin;
43-164 3.14e-26

Bulb-type mannose-specific lectin;


Pssm-ID: 214519 [Multi-domain]  Cd Length: 114  Bit Score: 102.39  E-value: 3.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197     43 TEYDASYRFLNSPNQnfftiPFQLMFYNTTPSAyvlaLRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAEL 122
Cdd:smart00108   1 SNTLSSGQTLVSGNS-----LFELGFFTLIMQN----DYNLILYKSSSRTVVWVANRDNPVSDSCTLTLQSDGNLVLYDG 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 15219197    123 NGQVKWQTNTA-NKGVTGFQILPNGNMVLHDKHGKFVWQSFDH 164
Cdd:smart00108  72 DGRVVWSSNTTgANGNYVLVLLDDGNLVIYDSDGNFLWQSFDY 114
B_lectin pfam01453
D-mannose binding lectin; These proteins include mannose-specific lectins from plants as well ...
 94-185 3.32e-24

D-mannose binding lectin; These proteins include mannose-specific lectins from plants as well as bacteriocins from bacteria.


Pssm-ID: 460217  Cd Length: 105  Bit Score: 96.40  E-value: 3.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197    94 IWDANRNNPVGDNS-TLSFGRNGNLVLAELNGQVKWQTNTANKGVTG--FQILPNGNMVLHD--KHGKFVWQSFDHPTDT 168
Cdd:pfam01453   3 VWVANRDNPINDSSgVLTISNDGNLVLLNGSNSVVWSTNNSSSSANNtvAQLLDSGNLVLSDdsNSGNVLWQSFDHPTDT 82

                          90       100
                  ....*....|....*....|.
gi 15219197   169 LLVGQSL---KVNGVN-KLVS 185
Cdd:pfam01453  83 LLPGMKLgwnKRTGLNrRLTS 103
PAN_AP_plant cd01098
Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted ...
 370-454 4.19e-08

Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted glycoproteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions. S-receptor protein kinases and S-locus glycoproteins are involved in sporophytic self-incompatibility response in Brassica, one of probably many molecular mechanisms, by which hermaphrodite flowering plants avoid self-fertilization.


Pssm-ID: 238531  Cd Length: 84  Bit Score: 50.51  E-value: 4.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197 370 TTQFCSGGKgkavNYYKIVGVEHFTGPYVNDGQGPTSVNDCKAKCDRDCKCLGYFYKEKDKKCLLAPLLGTLIKDAN-TS 448
Cdd:cd01098   1 TPLNCGGDG----STDGFLKLPDVKLPDNASAITAISLEECREACLSNCSCTAYAYNNGSGGCLLWNGLLNNLRSLSsGG 76


                ....*.
gi 15219197 449 SVAYIK 454
Cdd:cd01098  77 GTLYLR 82
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 405-434 7.58e-03

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 35.25  E-value: 7.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15219197    405 TSVNDCKAKC-DRDCKCLGYFYKEKDKKCLL 434
Cdd:smart00473  25 ASLEECASKClNSNCSCRSFTYNNGTKGCLL 55
 
Name Accession Description Interval E-value
B_lectin cd00028
Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat ...
 43-165 1.96e-28

Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically recognize diverse carbohydrates and mediate a wide variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein turnover, and innate immune responses.


Pssm-ID: 237995  Cd Length: 116  Bit Score: 108.55  E-value: 1.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197  43 TEYDASYRFLNSPNQnfftiPFQLMFYNTTPSAyvlALRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAEL 122
Cdd:cd00028   1 SNPLSSGQTLVSSGS-----LFELGFFKLIMQS---RDYNLILYKGSSRTVVWVANRDNPSGSSCTLTLQSDGNLVIYDG 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15219197 123 NGQVKWQTNTAN-KGVTGFQILPNGNMVLHDKHGKFVWQSFDHP 165
Cdd:cd00028  73 SGTVVWSSNTTRvNGNYVLVLLDDGNLVLYDSDGNFLWQSFDYP 116
B_lectin smart00108
Bulb-type mannose-specific lectin;
43-164 3.14e-26

Bulb-type mannose-specific lectin;


Pssm-ID: 214519 [Multi-domain]  Cd Length: 114  Bit Score: 102.39  E-value: 3.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197     43 TEYDASYRFLNSPNQnfftiPFQLMFYNTTPSAyvlaLRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAEL 122
Cdd:smart00108   1 SNTLSSGQTLVSGNS-----LFELGFFTLIMQN----DYNLILYKSSSRTVVWVANRDNPVSDSCTLTLQSDGNLVLYDG 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 15219197    123 NGQVKWQTNTA-NKGVTGFQILPNGNMVLHDKHGKFVWQSFDH 164
Cdd:smart00108  72 DGRVVWSSNTTgANGNYVLVLLDDGNLVIYDSDGNFLWQSFDY 114
B_lectin pfam01453
D-mannose binding lectin; These proteins include mannose-specific lectins from plants as well ...
 94-185 3.32e-24

D-mannose binding lectin; These proteins include mannose-specific lectins from plants as well as bacteriocins from bacteria.


Pssm-ID: 460217  Cd Length: 105  Bit Score: 96.40  E-value: 3.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197    94 IWDANRNNPVGDNS-TLSFGRNGNLVLAELNGQVKWQTNTANKGVTG--FQILPNGNMVLHD--KHGKFVWQSFDHPTDT 168
Cdd:pfam01453   3 VWVANRDNPINDSSgVLTISNDGNLVLLNGSNSVVWSTNNSSSSANNtvAQLLDSGNLVLSDdsNSGNVLWQSFDHPTDT 82

                          90       100
                  ....*....|....*....|.
gi 15219197   169 LLVGQSL---KVNGVN-KLVS 185
Cdd:pfam01453  83 LLPGMKLgwnKRTGLNrRLTS 103
PAN_AP_plant cd01098
Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted ...
 370-454 4.19e-08

Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted glycoproteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions. S-receptor protein kinases and S-locus glycoproteins are involved in sporophytic self-incompatibility response in Brassica, one of probably many molecular mechanisms, by which hermaphrodite flowering plants avoid self-fertilization.


Pssm-ID: 238531  Cd Length: 84  Bit Score: 50.51  E-value: 4.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219197 370 TTQFCSGGKgkavNYYKIVGVEHFTGPYVNDGQGPTSVNDCKAKCDRDCKCLGYFYKEKDKKCLLAPLLGTLIKDAN-TS 448
Cdd:cd01098   1 TPLNCGGDG----STDGFLKLPDVKLPDNASAITAISLEECREACLSNCSCTAYAYNNGSGGCLLWNGLLNNLRSLSsGG 76


                ....*.
gi 15219197 449 SVAYIK 454
Cdd:cd01098  77 GTLYLR 82
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 405-434 7.58e-03

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 35.25  E-value: 7.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15219197    405 TSVNDCKAKC-DRDCKCLGYFYKEKDKKCLL 434
Cdd:smart00473  25 ASLEECASKClNSNCSCRSFTYNNGTKGCLL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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