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Conserved domains on  [gi|42563215|ref|NP_177553|]
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Rhomboid-related intramembrane serine protease family protein [Arabidopsis thaliana]

Protein Classification

rhomboid family intramembrane serine protease( domain architecture ID 10002186)

rhomboid family intramembrane serine protease is a membrane-bound protein that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchor

CATH:  1.20.1540.10
EC:  3.4.21.-|3.4.21.105
Gene Ontology:  GO:0008270|GO:0004252|GO:0006508|GO:0016020
MEROPS:  S54
PubMed:  11672525|22035660|24099005
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 117-293 3.68e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 72.58  E-value: 3.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 117 VVFGLVIANAAVFTMWRVLgkdNMWMVKNFMLSRYSFMTGRIHTLITSGFSHVGATHIILNMMGLCYFGARIARSFGPRY 196
Cdd:COG0705   5 VTLALIALNVLVFLLQLLL---GGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 197 LLKLYFAGALGGSVFFLSSHALSVISLkgqrvvpkdqlkvpigkLGANGPVYAITLLDMLLYPKVTTY-FGLMLRVPVFA 275
Cdd:COG0705  82 FLLLYLLSGLGGGLLQLLFSPGSGYPL-----------------VGASGAIFGLLGALLVLGPRRRVLlLFIPIPALLFL 144

                       170
                ....*....|....*...
gi 42563215 276 GIYsLGLNIIKMLEGKNN 293
Cdd:COG0705 145 LVW-LLLGLLFGLLGGGG 161
 
Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 117-293 3.68e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 72.58  E-value: 3.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 117 VVFGLVIANAAVFTMWRVLgkdNMWMVKNFMLSRYSFMTGRIHTLITSGFSHVGATHIILNMMGLCYFGARIARSFGPRY 196
Cdd:COG0705   5 VTLALIALNVLVFLLQLLL---GGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 197 LLKLYFAGALGGSVFFLSSHALSVISLkgqrvvpkdqlkvpigkLGANGPVYAITLLDMLLYPKVTTY-FGLMLRVPVFA 275
Cdd:COG0705  82 FLLLYLLSGLGGGLLQLLFSPGSGYPL-----------------VGASGAIFGLLGALLVLGPRRRVLlLFIPIPALLFL 144

                       170
                ....*....|....*...
gi 42563215 276 GIYsLGLNIIKMLEGKNN 293
Cdd:COG0705 145 LVW-LLLGLLFGLLGGGG 161
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 156-223 1.25e-10

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 58.77  E-value: 1.25e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563215   156 GRIHTLITSGFSHVGATHIILNMMGLCYFGARIARSFGPRYLLKLYFAGALGGSVFFLSSHALSVISL 223
Cdd:pfam01694   5 GQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSV 72
 
Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 117-293 3.68e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 72.58  E-value: 3.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 117 VVFGLVIANAAVFTMWRVLgkdNMWMVKNFMLSRYSFMTGRIHTLITSGFSHVGATHIILNMMGLCYFGARIARSFGPRY 196
Cdd:COG0705   5 VTLALIALNVLVFLLQLLL---GGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563215 197 LLKLYFAGALGGSVFFLSSHALSVISLkgqrvvpkdqlkvpigkLGANGPVYAITLLDMLLYPKVTTY-FGLMLRVPVFA 275
Cdd:COG0705  82 FLLLYLLSGLGGGLLQLLFSPGSGYPL-----------------VGASGAIFGLLGALLVLGPRRRVLlLFIPIPALLFL 144

                       170
                ....*....|....*...
gi 42563215 276 GIYsLGLNIIKMLEGKNN 293
Cdd:COG0705 145 LVW-LLLGLLFGLLGGGG 161
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 156-223 1.25e-10

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 58.77  E-value: 1.25e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563215   156 GRIHTLITSGFSHVGATHIILNMMGLCYFGARIARSFGPRYLLKLYFAGALGGSVFFLSSHALSVISL 223
Cdd:pfam01694   5 GQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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