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Conserved domains on  [gi|15218629|ref|NP_177436|]
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toll/interleukin-1 receptor-like protein [Arabidopsis thaliana]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 10481568)

toll/interleukin-1 receptor (TIR) domain-containing protein adopts a flavodoxin fold and may play a role in signal transduction as a phosphorylation-independent conformational switch protein

CATH:  3.40.50.10140
Gene Ontology:  GO:0007165|GO:0005515
PubMed:  34868065
SCOP:  4003648

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
9-171 1.68e-77

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 228.40  E-value: 1.68e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629     9 YDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVTIM 88
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    89 DFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSGDDDSKLVDKIANEISN 168
Cdd:pfam01582  81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFWKKIAYDISN 160

                  ...
gi 15218629   169 KKT 171
Cdd:pfam01582 161 KLN 163
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
9-171 1.68e-77

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 228.40  E-value: 1.68e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629     9 YDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVTIM 88
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    89 DFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSGDDDSKLVDKIANEISN 168
Cdd:pfam01582  81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFWKKIAYDISN 160

                  ...
gi 15218629   169 KKT 171
Cdd:pfam01582 161 KLN 163
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
1-169 1.11e-45

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 160.04  E-value: 1.11e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629     1 MSSHTATK----YDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDkELENGQRFSPELKSPIEVSRFAVVVVSENYAA 76
Cdd:PLN03210    1 MASSSSSSrnwvYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYAS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    77 SSWCLDELVTIMDFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSG--DD 154
Cdd:PLN03210   80 SSWCLNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQnwPN 159
                         170
                  ....*....|....*
gi 15218629   155 DSKLVDKIANEISNK 169
Cdd:PLN03210  160 EAKMIEEIANDVLGK 174
TIR smart00255
Toll - interleukin 1 - resistance;
8-141 4.07e-35

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 119.74  E-value: 4.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629      8 KYDVFLSFRGH-DTRHNFISFLYKELVRRSIRTFKDDKELenGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVT 86
Cdd:smart00255   1 EYDVFISYSGKeDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15218629     87 IMDF-EKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASRE-DPEKVLKWRQALT 141
Cdd:smart00255  79 ALENaLEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWpEDEKEQFWKKALY 135
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
9-104 5.91e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 50.50  E-value: 5.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629   9 YDVFLSFRGHDtRHnFISFLYKELVRRSIRTFKDDKELEN--GQRFSPELkSPI--EVSRFAVVVVSENYAASSWCLDEL 84
Cdd:COG4916   1 YDVALSFAGED-RE-FVERVAEALKARGIKVFYDENEEAElwGKDLDEYL-QDIyrSESRFVVVFLSKDYVEKKWTGLER 77
                        90       100
                ....*....|....*....|.
gi 15218629  85 VTIMD-FEKKGSITVMPIFYG 104
Cdd:COG4916  78 RAALArAMQRKKEYILPIRLD 98
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
9-171 1.68e-77

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 228.40  E-value: 1.68e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629     9 YDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVTIM 88
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    89 DFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSGDDDSKLVDKIANEISN 168
Cdd:pfam01582  81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFWKKIAYDISN 160

                  ...
gi 15218629   169 KKT 171
Cdd:pfam01582 161 KLN 163
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
1-169 1.11e-45

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 160.04  E-value: 1.11e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629     1 MSSHTATK----YDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDkELENGQRFSPELKSPIEVSRFAVVVVSENYAA 76
Cdd:PLN03210    1 MASSSSSSrnwvYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYAS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    77 SSWCLDELVTIMDFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSG--DD 154
Cdd:PLN03210   80 SSWCLNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQnwPN 159
                         170
                  ....*....|....*
gi 15218629   155 DSKLVDKIANEISNK 169
Cdd:PLN03210  160 EAKMIEEIANDVLGK 174
TIR smart00255
Toll - interleukin 1 - resistance;
8-141 4.07e-35

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 119.74  E-value: 4.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629      8 KYDVFLSFRGH-DTRHNFISFLYKELVRRSIRTFKDDKELenGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVT 86
Cdd:smart00255   1 EYDVFISYSGKeDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15218629     87 IMDF-EKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASRE-DPEKVLKWRQALT 141
Cdd:smart00255  79 ALENaLEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWpEDEKEQFWKKALY 135
PLN03194 PLN03194
putative disease resistance protein; Provisional
2-111 1.37e-17

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 76.01  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    2 SSHTATKYDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCL 81
Cdd:PLN03194  20 SSSSAKPCDVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCL 99
                         90       100       110
                 ....*....|....*....|....*....|
gi 15218629   82 DELVTIMDFEKKgsitVMPIFYGVEPNHVR 111
Cdd:PLN03194 100 HELALIMESKKR----VIPIFCDVKPSQLR 125
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
11-109 3.73e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 62.72  E-value: 3.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629    11 VFLSFRGHDtrHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVTIMDf 90
Cdd:pfam13676   1 VFISYAGED--RAWAEWLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77
                          90
                  ....*....|....*....
gi 15218629    91 EKKGSITVMPIFYGVEPNH 109
Cdd:pfam13676  78 DPEGRKRLIPVRLECDLEL 96
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
9-104 5.91e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 50.50  E-value: 5.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218629   9 YDVFLSFRGHDtRHnFISFLYKELVRRSIRTFKDDKELEN--GQRFSPELkSPI--EVSRFAVVVVSENYAASSWCLDEL 84
Cdd:COG4916   1 YDVALSFAGED-RE-FVERVAEALKARGIKVFYDENEEAElwGKDLDEYL-QDIyrSESRFVVVFLSKDYVEKKWTGLER 77
                        90       100
                ....*....|....*....|.
gi 15218629  85 VTIMD-FEKKGSITVMPIFYG 104
Cdd:COG4916  78 RAALArAMQRKKEYILPIRLD 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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