|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
24-478 |
5.10e-165 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 473.98 E-value: 5.10e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 24 ELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDLLT 103
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 104 LSLHRMVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLA 183
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 184 AVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKrvsgdgdggsttmvavvAQSSSVMELVGGL 263
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKA-----------------TWGGFSREAFRGW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 264 GPLMRVAVPSCLGICLEWWWYEIVIVMGGYLEnPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARL 343
Cdd:cd13132 224 GPFLKLAIPSALMLCLEWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 344 AANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLG 423
Cdd:cd13132 303 AAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLV 382
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 15217599 424 SFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACVVSILYAVLaRTDWEGEAVK 478
Cdd:cd13132 383 AYYLIGLPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIIL-RTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
25-464 |
1.68e-51 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 180.73 E-value: 1.68e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLLTL 104
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 105 SLHRMVVILLMASLPISLL-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLA 183
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 184 AVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVW-VSGMLQKRVSGDGDGGSTtmvavvaqsssvmelvgg 262
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFrKRSLLRLRLRDLRPDRKI------------------ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 263 LGPLMRVAVPSCLGICLEWW-WYEIVIVMGGYLENpklAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKA 341
Cdd:COG0534 228 LKRILRIGLPAGLQQLAESLgFLVLNALVARLGTA---AVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 342 RLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVN 421
Cdd:COG0534 305 RRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 15217599 422 LGSFYFVGTPVAVGLAFwLKIGFSGLWFGLLSAQA-ACVVSILY 464
Cdd:COG0534 385 LLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVlRALLLLLR 427
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
24-451 |
1.28e-48 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 173.45 E-value: 1.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 24 ELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFtNITGYSVMVGLASGLEPVCSQAYGSKNWDLLT 103
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL-WFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 104 LSLHRMVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLA 183
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 184 AVAFHVPLNYWLVMvKHWGVP-----GVAIASVVTNLIMVVLLVGYVWvSGMLQKRVSGDGDGGSTTMVAVVAqsssvme 258
Cdd:cd13131 160 ALVLNIPLNYVLIF-GKFGLPalggaGAGLATAIVYWLMFLALAFYIR-RHKRFRRYRLFARFWRPDWARLKE------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 259 lvgglgpLMRVAVPSCLGICLEWWWYEIVIVMGGYLENpkLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRP 338
Cdd:cd13131 231 -------LLRLGLPIGLTIFFEVSLFAAVALLMGRLGT--TVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 339 YKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGA 418
Cdd:cd13131 302 ADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPF 381
|
410 420 430
....*....|....*....|....*....|...
gi 15217599 419 HVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGL 451
Cdd:cd13131 382 LLALISYWGIGLPLGYLLAFTTGLGAFGVWIGL 414
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
48-392 |
4.33e-46 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 163.96 E-value: 4.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 48 VSVLFLGRLGSLELAGGALSiGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLLWINL 127
Cdd:TIGR00797 15 VDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVGYFF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 128 GPIML-FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLNYWLVMVKH--WGVP 204
Cdd:TIGR00797 94 IDPLLsLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIFGKFgfLGIV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 205 GVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSGDgdggsttmvavvaqsssVMELVGGLGPLMRVAVPSCLGICLEWWWY 284
Cdd:TIGR00797 174 GAALATVISYWLMFLLLLYYIKKAKKIGLKWEGL-----------------LKPDWEVLKRLLKLGLPIAFRVILESLSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 285 EIVIVMGGYLEnpKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTV 364
Cdd:TIGR00797 237 ALLALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314
|
330 340
....*....|....*....|....*...
gi 15217599 365 ILKERWAGLFTGYEPLKVLVASVMPIVG 392
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
34-194 |
1.19e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 113.81 E-value: 1.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 34 PITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVIL 113
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 114 LMASLPISLL-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLN 192
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 15217599 193 YW 194
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-472 |
4.42e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 116.47 E-value: 4.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSiGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDLLTL 104
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 105 SLHRMVVILLMASLPISLLWINLGP-IMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLA 183
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 184 AVAFHVPLNYWLVMVK----HWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRvsgdgdggsttmvAVVAQSSSVMEL 259
Cdd:cd13133 163 MVVVNIVLDYALIFGKlgfpAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRF-------------GLRRAWRFDREL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 260 vggLGPLMRVAVPSCLGICLE---WWWYEIVIVMGGylenpKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAG 336
Cdd:cd13133 230 ---LRRILRLGLPSGLQFFLDvgaFTVFFLLIGRLG-----TTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 337 RPYKA----RLAANVALACAFVVGALnvawTVILKERWAGLFTGY---EPLKVLVASVMPIVGLCELGNCPQTTGCGILR 409
Cdd:cd13133 302 RPDLAmrvtRRGLKLALAYMLLLGIL----FLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALR 377
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217599 410 GTGRPAVGAHVNLGSFYFVGTPVAVgLAFWLKIGFSGLWFGLLsAQAACVVSILYAVLARTDW 472
Cdd:cd13133 378 GAGDTRFVMLAELIVAWLYLLPPAY-LLVVLGAGLAGAWTVET-VYVIVLALIFLLRFRSGKW 438
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
26-472 |
1.13e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 114.92 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLLTLS 105
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 106 LHRMVVILLMASLPISLL-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAA 184
Cdd:cd13137 80 LGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 185 VAFHVPLNYWLVMVK----HWGVPGVAIASVVTNLIMVVLLVgYVWVSGMLQKRVSGDGDGGSTTM---VAVVAQSSSVM 257
Cdd:cd13137 160 NVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLL-FLLLRGRLPIKISFKGFRLDRKIikkLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 258 ELVGGLGPLMRVAVPSCLGIclewwwyeivivmggylenpkLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGR 337
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGT---------------------AALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 338 PYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVG 417
Cdd:cd13137 298 PDEARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPP 377
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 15217599 418 AHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACVVsILYAVLARTDW 472
Cdd:cd13137 378 LIINLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAI-LLLYRFRKGKW 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
23-464 |
4.00e-26 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 110.67 E-value: 4.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 23 EELKELWAMVLPI-------TAMNclvyvraVVSVLFLGRLGSLELAGGAL--SIGFTNITGysvMVGLASGLEPVCSQA 93
Cdd:PRK01766 9 SEARQLLALALPIllaqvaqTAMG-------FVDTVMAGGVSATDLAAVAIgtSIWLPVILF---GHGLLLALTPIVAQL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 94 YGSKNWDLLTLSLHRMVVILLMASLPI-SLLWINLGPIMLFMGQNPEITATAAEY---CLYALPDLLtntLLQPLRVYLR 169
Cdd:PRK01766 79 NGAGRRERIAHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYL---LYQVLRSFID 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 170 SQRVTKPMMWCTLAAVAFHVPLNYWLVMVKhWGVP-----GVAIASVVTNLIMVVLLVGYVWVSGMLQKrvsgdgdggST 244
Cdd:PRK01766 156 GLGKTKPTMVIGFLGLLINIPLNYIFIYGK-FGFPelggvGCGVATAIVYWVMFLAMLIYIKRARRFRD---------FR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 245 TMVAVVAQSSSVmelvggLGPLMRVAVPSCLGICLEWWWYEIVIVMGGYLENpkLAVAATGILIQTTSLMYTVPMALAGC 324
Cdd:PRK01766 226 LFKGLYKPDWAV------IKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPLGT--VTVAAHQIALNFSSLLFMLPLSLAMA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 325 VSARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTG 404
Cdd:PRK01766 298 LTIRVGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIG 377
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 405 CGILRGTGRPAVGAHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACVVSILY 464
Cdd:PRK01766 378 SGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
33-467 |
2.55e-25 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 108.18 E-value: 2.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 33 LPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITGYSVMvGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVI 112
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGV-GLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 113 LLMASLPISLL-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPL 191
Cdd:cd12082 81 AILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 192 NYWLVM---VKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSGDGDGGSTTMvavvaqsssvmelvgglGPLMR 268
Cdd:cd12082 161 DPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELL-----------------RRLLR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 269 VAVPSCLGICLEWWWYEIVIVMGGYLeNPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANVA 348
Cdd:cd12082 224 IGLPSAIQNSLLSLGLLIIVAIVAAF-GGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 349 LACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLGSFYFV 428
Cdd:cd12082 303 LLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVV 382
|
410 420 430
....*....|....*....|....*....|....*....
gi 15217599 429 GTPVAVgLAFWLKIGFSGLWFGLLSAQAACVVSILYAVL 467
Cdd:cd12082 383 RLPLAY-VLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
26-453 |
3.00e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 104.89 E-value: 3.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNItGYSVMVGLASGLEPVCSQAYGSKNWDLLTLS 105
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 106 LHRMVVILLMASLPISLLWINLGPIML-FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAA 184
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLrLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 185 VAFHVPLNYWLVM----VKHWGVPGVAIASVVTNLIMVVLLVGYVWvsgmlqkrvsgdgdggsTTMVAVVAQSSSVMELV 260
Cdd:cd13134 162 NILNIVGNYLLIFgwfgLPKLGVAGVAISTVISRAVGLVLLFILLF-----------------RKLKIRFRLKDLRPFPK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 261 GGLGPLMRVAVPSCLGICLewWWYEIVIVMGGYLENPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYK 340
Cdd:cd13134 225 KLLKKILKIGLPSAGEELS--YNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDE 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 341 ARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHV 420
Cdd:cd13134 303 AYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLI 382
|
410 420 430
....*....|....*....|....*....|...
gi 15217599 421 NLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLS 453
Cdd:cd13134 383 GIISMWGISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
272-425 |
2.64e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 96.10 E-value: 2.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 272 PSCLGICLEWWWYEIVIVMGGYLenPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANVALAC 351
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217599 352 AFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLGSF 425
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-464 |
2.37e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 99.46 E-value: 2.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 33 LPITAMNCLVYVRAVVSVLFLGRLGSLElAGGALSIG------FTNITgysvmVGLASGLEPVCSQAYGSKNWDLLTLSL 106
Cdd:cd13138 10 LPLLLSNLLQQLYNLVDLLIVGQFLGVA-ALAAVSNGspiiflLTAIG-----MGLSMGGTILISQYIGAKDEEKAKKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 107 HRMVVILLMASLPISLL-WINLGPIMLFMGQNPEITATAAEY---CLYALPDLLTNTLLQPLrvyLRSQRVTKPMMWCTL 182
Cdd:cd13138 84 GTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYlriCFLGIPFIFGYNAYSAI---LRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 183 AAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSG--MLQKRVSGDGDGGSTTMVAVVAQSSSVMELV 260
Cdd:cd13138 161 IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKlpFKLSLKDFRFDKEILKEILKIGLPSALQQSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 261 GGLGplmRVAVPSclgiclewwwyeIVIVMGgylenpKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYK 340
Cdd:cd13138 241 VSIS---FLIINS------------IVNSYG------VVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIER 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 341 ARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHV 420
Cdd:cd13138 300 AKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMII 379
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 15217599 421 NLGSFYFVGTPVAVGLAFWLKIGFSGLWFG-LLSAQAACVVSILY 464
Cdd:cd13138 380 SILRLWLVRIPLAYLLSRLTGLGLFGIWLAmPISNILSAIICIIY 424
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
24-470 |
1.32e-19 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 91.34 E-value: 1.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 24 ELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGAL---SIGFTNItgysVMVGLASGLEPVCSQAYGSKNWD 100
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgaaSYSFVSI----FCVGVIAAVGTLVAIRHGAGDIE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 101 LLT-LSLHRMVVILLMASLPISLLWiNLGPIMLFMGQNPEITATAAEYCL---YALPDLLTntlLQPLRVYLRSQRVTKP 176
Cdd:PRK00187 84 GATrLAQAGLWLAWLLALVAALLLW-NLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLS---FMALRGFTSALGRAGP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 177 MMWCTLAAVAFHVPLNYwlVMVKHW------GVPGVAIASVVTNLIMVVLLVGYV-WVSGMLQKRVSgdgDGGSTTMVAV 249
Cdd:PRK00187 160 VMVISLAGAVANLLLNY--ALIEGWfglpklGLMGIGLVTALVSNGMALALALYIrRHPAYAAYPLR---KGLSRPSRAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 250 VAQsssvmelvgglgpLMRVAVPSCLGICLEWWWYEIVIVMGGYLENPKLAvaATGILIQTTSLMYTVPMALAGCVSARV 329
Cdd:PRK00187 235 LRE-------------LWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLA--AHQIALQIVSVAFMVPVGLSYAVTMRV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 330 GNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFT-----GYEPLKVLVASVMPIVGLCELGNCPQTTG 404
Cdd:PRK00187 300 GQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIA 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217599 405 CGILRGTGRPAVGAHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACVVSILYAVLART 470
Cdd:PRK00187 380 MGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTLAFEWKT 445
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
28-464 |
3.91e-18 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 86.41 E-value: 3.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 28 LWAMVLPITAMNCLVYVRAVVSVLFLGRL-GSLELAGGALSIGFTN-ITGYSVMVGLASGlePVCSQAYGSKNWD----L 101
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREkanrI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 102 LTLSLhrmVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCT 181
Cdd:cd13143 84 FSTAL---LLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 182 LAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSGDGDGGSTTMVAVVA--QSSSVMEL 259
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILAlgFPSFLMQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 260 VGGLGPLMrvavpsclgiclewwwyeIVIVMGGYLENpkLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPY 339
Cdd:cd13143 241 SSSVVTIV------------------LNLTLLGYGGD--IGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYD 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 340 KARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAH 419
Cdd:cd13143 301 RVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAAL 380
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 15217599 420 VNLGSFYFVGTPVAVGLAFWLkiGFSGLWFGLLSAQAACVVSILY 464
Cdd:cd13143 381 LSLLRQGLFLIPLLLILPRLF--GLDGIWLAFPLAEILTLLLALI 423
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
23-224 |
5.57e-16 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 79.80 E-value: 5.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 23 EELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLL 102
Cdd:COG0534 226 KILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 103 TLSLHRMVVILLMASLPISLL-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCT 181
Cdd:COG0534 305 RRAARLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15217599 182 LAA-VAFHVPLNYWLVMVkHWGVPGVAIASVVTNLIMVVLLVGY 224
Cdd:COG0534 385 LLRlWLVRLPLAYLLAFL-GLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
26-358 |
1.76e-12 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 69.13 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSL-ELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLLTL 104
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 105 SLHRMVVILLMASLPISLLWINL-GPIMLFMGQNPEITATAAEYC---LYALPDLLTNTLLQPlrvYLRSQRVTKPMMWC 180
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLlALALLLLGASAAVAALARQYLrirILGAPAVLLNYVATG---WFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 181 TLAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWvsgmlqKRVSGDGdggsttmvavvAQSSSVMELV 260
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLR------RRVRLLG-----------KSLSRRLPSK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 261 GGLGPLMRVAVP-----SCLGICLEWwwyeIVIVMGGYLENpklAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGA 335
Cdd:cd13136 222 AALKRLFKLNRDifirtLALLAAFLF----FTALAARLGDV---ILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGA 294
|
330 340
....*....|....*....|...
gi 15217599 336 GRPYKARLAANVALACAFVVGAL 358
Cdd:cd13136 295 GDRKAARRVARRLLQWGLGLGVL 317
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-472 |
5.14e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 67.60 E-value: 5.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAggALSIGFTNI-TGYSVMVGLASGLEPVCSQAYGSKNWDLLT 103
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVA--APSISWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 104 LSLHRMVVILLMASLPISLL-WINLGPIML-FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCT 181
Cdd:cd13142 88 KVAGQTFSFVIILSLILAVLgYILSRPLLLlLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 182 LAAVAFHVPLNYWLVM----VKHWGVPGVAIASVVTNLIMVVLLVGYvwvsgMLQKRVsgdgdGGSTTMVAVVAQSSSVM 257
Cdd:cd13142 168 FGSVLLNVILDPLLIFgigpFPGLGVAGAALATVISRGIAAVIGLYL-----LFKGRV-----GLKISLRDLKPDWEWLK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 258 ELVgglgplmRVAVPSCLGICLEWWWYEIVIVMGGYLenPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGR 337
Cdd:cd13142 238 KIF-------RIGLPSSIEQSARALGFTVMTALVAGF--GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQ 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 338 PYKARLAANVALACAFVVGALNVAWTVILKERWAGLFT--------GYEPLKVlVASVMPIVGLCELGNcpqttgcGILR 409
Cdd:cd13142 309 IDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFIndpevikeGADFLRI-VAPSFPFFGLFQVIN-------GAFR 380
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217599 410 GTGRPAVGAHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGL-LSAQAACVVSILYavLARTDW 472
Cdd:cd13142 381 GSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMaISNIVAALIALAW--FKRGTW 442
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
23-226 |
8.11e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 64.02 E-value: 8.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 23 EELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLL 102
Cdd:cd13138 222 EILKEILKIGLPSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFA-FLPPSAIGQAVSTFVAQNIGAGKIERA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 103 TLSLHRMVVILLMASLPISLLWINLGP-IMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLR-SQRVTKPMMWC 180
Cdd:cd13138 301 KKGLRTGIIISLIIGLIIILLVFFFAPqLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRgLGKTKFPMIIS 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217599 181 TLAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVW 226
Cdd:cd13138 381 ILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYR 426
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
28-222 |
3.48e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 55.34 E-value: 3.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 28 LWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGgALSIGFtNITGYSVMVG--LASGLEPVCSQAYGSKNWDLLTLS 105
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVG-IYSAAY-RLASLLLLLItaLSQVLFPRLSRLLAEGDREELRRL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 106 LHRMVVILLMASLPISL-LWINLGPIMLFMGqnPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAA 184
Cdd:COG2244 253 YRKALRLLLLLGLPLALgLALLAPPLLSLLF--GPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG 330
|
170 180 190
....*....|....*....|....*....|....*...
gi 15217599 185 VAFHVPLNYWLVmvKHWGVPGVAIASVVTNLIMVVLLV 222
Cdd:COG2244 331 AVLNLVLNLLLI--PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-414 |
4.79e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 55.22 E-value: 4.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGgALSIGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDL--- 101
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAA-VGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEark 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 102 ---------LTLSLHRMVVILLMASLPISLLwiNLGpimlfmgqNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQR 172
Cdd:cd13140 83 yarnalqlnLLLGILYGLLLLLFAKPLIGFF--NLG--------DAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 173 VTKPMMWCTLAAVAFHVPLNYWLV----MVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSgdgdggsttmvA 248
Cdd:cd13140 153 DSKTPFIINAIGLVLNIILDPLLIfgfgPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIR-----------I 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 249 VVAQSSSVMELVgglgplMRVAVPSCLGICLewwwYEIV-IVMGGYLEN-PKLAVAATGILIQTTSLMYTVPMALAGCVS 326
Cdd:cd13140 222 LKRPDRKYIKEI------LKLGLPVALQSIL----FALIsMILARIIASfGPVAIAAQKVGSQIESISWMTAEGFSTALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 327 ARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGyEPLKVLVASV-MPIVGLCELGNCPQTTGC 405
Cdd:cd13140 292 AFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIP-DPETIAIGVDyLRILGFSQLFMCLEITTT 370
|
....*....
gi 15217599 406 GILRGTGRP 414
Cdd:cd13140 371 GAFNGLGRT 379
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
81-454 |
5.23e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 55.10 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 81 GLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLLWINLG-PIMLFMGQNPEITATAAEYCLYALPDLLTNT 159
Cdd:cd13146 65 GIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAePLLQLLGAKGLLLEYALEYFYYSLPGVPFIM 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 160 LLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVgYVWVSGMLQKRVSgdg 239
Cdd:cd13146 145 LIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLL-YVFLIGKSNVTIH--- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 240 dggsttmVAVVAQSSSVMElvgglgPLMRVAVPSCLG---ICLEWWWYEIVIVmggylENPKLAVAATGILIQTTSLMYT 316
Cdd:cd13146 221 -------IKLSNISSSVIV------EILRVGLPQMLLqliSSISFLIYNRIII-----DIDPVAMTAFTLVGRLDQFILI 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 317 VPMALAGCVSARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCEL 396
Cdd:cd13146 283 PIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALP 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15217599 397 GNCPQTTGCGILRGTGRPAVGAHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSA 454
Cdd:cd13146 363 FVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSA 420
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
26-375 |
9.22e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 54.22 E-value: 9.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAG-GALSIGFTNITGysVMVGLASGLEPVCSQAYGSKNWDLLTL 104
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAvGNVTTPFNTITG--FLGSISIGFTILGSQSVGAKDIKRIND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 105 SLHRMVVILLMASLPISLLWINLGPIML-FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLA 183
Cdd:cd13135 79 YAISSIVYNSIIGVILFLLWLFGARIIFvLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 184 AVAFHVPLNYWLVMvKHWGVP-----GVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSGDGDGGS--TTMVAVVAQSSSV 256
Cdd:cd13135 159 KNLLNVILDYVLIF-GNFGFPrlgiiGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKAniRPYKFTIKLGLPL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 257 M--ELVGGLGPLMRVAVPSCLGIclewwwyeivIVMGGYLenpklavaatgILIQTTSLMYTVPMALAGCVSARVGNELG 334
Cdd:cd13135 238 GgeEFLWNIGNLAVIRILNRIGE----------LALGIYT-----------LVFGIENIVLMPMYGYSSAALTLVGESIG 296
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15217599 335 AGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFT 375
Cdd:cd13135 297 KKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFT 337
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
25-226 |
2.04e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 53.24 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVV-SVLFLGRLGSLELAGGALSIGFTNITGYS---VMVG------LASGLEPVCSQAY 94
Cdd:cd13124 223 LKELLSYAIPITLSSLILPLLQLIdSFTVPRRLQAAGLSESEATALYGILTGRAqplVQLPtviataLSTSLVPAISEAY 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 95 GSKNWDLLTLSLHRMVVILLMASLPISL-LWINLGPIMLFMGQNPEITATAAEYCLYALPdlltNTLLQPLRVYLRSQRV 173
Cdd:cd13124 303 AKGDKKELRRRINQALRLTLLIGLPAAVgLAVLAEPINTLLFGDSEGGLILQILAPSILF----LSLQQVTAAILQGLGK 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15217599 174 TKPMMWCTLAAVAFHVPLNYWLVMvkHWGVPGVAIASVVTNLIMVVLLVGYVW 226
Cdd:cd13124 379 VKIPVINLLIGLLVKIVLNYVLIP--IFGIYGAAIATVIGFLVAALLNLRALK 429
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-465 |
2.95e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 49.52 E-value: 2.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 47 VVSVLFLGRLGSLELAGGALS--IGFTNItgySVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLLW 124
Cdd:cd13145 30 VVDTFFAGKISTEALAALSLSfpIFFIII---AIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 125 INLGPIML-FMGQNPEITATAAEY---CLYALPDLLTNTLLQPLrvyLRSQRVTKPMMWCTLAAVAFHVPLNYWLVMVKH 200
Cdd:cd13145 107 LFAAPPLFrLLGAEGDYLDLALEYmdvIFAGSIFFLLNFGLNGI---LNAQGDTKSYRNFLIIGFFLNIILDPLFIFGGG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 201 W----GVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRvsgdgdggsttmvavvaqssSVMELVGGLGP---LMRVAVPS 273
Cdd:cd13145 184 GipamGVSGIALATIISQFIGMFYLLYKVRKSGIISGC--------------------RLRDFIPRLDVykeILKQGFPA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 274 CLGIclewwwyeIVIVMGGYL------ENPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANV 347
Cdd:cd13145 244 SLNM--------MTIGLGIFVityfvgQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 348 ALACAFVVGALNVAWTVILKERWAGLFT----------GYEPLKVLVASVMPIVGLCelgncpqttgCGILRGTGRPAVG 417
Cdd:cd13145 316 ALKYGFVIMVVATVFLLFFAEPLMSLFTndpaviaigaGYLRIDALIFYAYVVLFIS----------VSVLQGLKRPIFA 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 15217599 418 AHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQ-AACVVSILYA 465
Cdd:cd13145 386 LWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVwSAAIIALLYT 434
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
16-277 |
3.28e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 49.76 E-value: 3.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 16 PTLPQVIEELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGslelAGG--ALSIGFT-NITGYSV-MVGLASGLEPVCS 91
Cdd:COG0728 212 PRFDLRDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLP----EGSvsALYYADRlYQLPLGLfGVAIGTALLPRLS 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 92 QAYGSKNWDLLTLSLHRMVVILLMASLPISL-LWINLGPIMLFMGQNPEITATAAEY-----CLYA--LPDLLTNTLLQp 163
Cdd:COG0728 288 RAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVgLIVLAEPIVRLLFERGAFTAEDTALtalalAAYAlgLPAFALVKVLA- 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 164 lRVYLrSQRVTKPMMWCTLAAVAFHVPLNYWLVmvKHWGVPGVAIASVVTNLIMVVLLVGYvwvsgmLQKRVSGDGDGG- 242
Cdd:COG0728 367 -RAFY-ARQDTRTPVRIAVIAVVVNIVLNLLLV--PPLGHAGLALATSLSALVNALLLLVL------LRRRLGGLPLRGi 436
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 15217599 243 ----------STTMVAVVAQSSSVMELVGGLGPLMRVAVPSCLGI 277
Cdd:COG0728 437 lrtllklllaSLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLIL 481
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
23-234 |
8.12e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 48.26 E-value: 8.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 23 EELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLL 102
Cdd:cd13131 226 ARLKELLRLGLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLL-FMVPLGISMAATVRVGFALGAGDPADA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 103 TL-SLHRMVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEY----CLYALPDLLTNTLLQPLRVYlrsQRVTKPM 177
Cdd:cd13131 305 RRaGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLlvfaALFQLFDGIQVVAAGALRGY---KDTRVPF 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 178 MwctLAAVAFHV---PLNYWLVMVKHWGVPGVAIASVVTnLIMVVLLVGYVWVsgMLQKR 234
Cdd:cd13131 382 L---LALISYWGiglPLGYLLAFTTGLGAFGVWIGLIIG-LALAAILLLWRFR--RLQRR 435
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
26-225 |
2.63e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 46.54 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSiGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDLLTLS 105
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLA-GNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 106 LHRMVVILLMASLPISLLWINLG-PIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAA 184
Cdd:cd13141 90 FNQSLLLAAVLGLVVLVLGYLFGrLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILA 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15217599 185 VAFHVPLNYWLV----MVKHWGVPGVAIASVVTNLIMVVLLVGYV 225
Cdd:cd13141 170 VLLNIILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYF 214
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
88-221 |
5.47e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.61 E-value: 5.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 88 PVCSQAYGsKNWDLLTLSLHRMVVILLMASLPISLLWINLGP--IMLFMGQNPEITATAaeycLYAL-PDLLTNTLLQPL 164
Cdd:cd13128 268 PRISELYK-NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEpiITLLFGEEYLPAALV----LQILaWGFLFIFLNGIF 342
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15217599 165 RVYLRSQRVTKPMMWCTLAAVAFHVPLNYWLVMvkHWGVPGVAIASVVTNLIMVVLL 221
Cdd:cd13128 343 GSILQAIGKQKLTLKILLIGALLNVILNLLLIP--KYGIIGAAIATLISEFIIFILL 397
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
25-221 |
6.24e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.20 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAggALSIG-----FTNITGYSVMVGLASglepVCSQAYGSKNW 99
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALA--AYQIGlriesLAFMPGFGFSMAAST----LVGQNLGAGDP 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 100 DLLTLSLHRMVVI--LLMASLPIsLLWINLGPIMLFMGQNPEITATAAEYclyalpdLLTNTLLQPLRVY-------LRS 170
Cdd:cd13137 299 DEARRYGKRALRLgvLFMGLLGL-LLFIFAPPLASLFTPDPEVIELGVLY-------LRIVALSQPFLAIsfvlsgaLRG 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15217599 171 QRVTKPMMWCTLAAV-AFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLL 221
Cdd:cd13137 371 AGDTRPPLIINLISMwLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILL 422
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
300-490 |
1.38e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 44.36 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 300 AVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEP 379
Cdd:COG0534 42 ALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 380 LKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLGSFyFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACV 459
Cdd:COG0534 122 VLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN-VLNIVLDPLLIFGGGLGVAGAALATVISQAVSA 200
|
170 180 190
....*....|....*....|....*....|.
gi 15217599 460 VSILYAVLARTDWEGEAVKAMRLTSLEMRKV 490
Cdd:COG0534 201 LLLLYYLFRKRSLLRLRLRDLRPDRKILKRI 231
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
80-221 |
2.24e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.60 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 80 VGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLLWINLG-PIMLFMGQNPEITATAAEYCLYAL----PD 154
Cdd:cd13123 269 VAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAePIVRLLFERGAFTAEDTLMTASALaayaLG 348
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15217599 155 LLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLNYWLVmvKHWGVPGVAIASVVTNLIMVVLL 221
Cdd:cd13123 349 LPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLI--KPLGHVGLALATSLSAWVNALLL 413
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
63-226 |
2.59e-04 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 43.44 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 63 GGALSIGFTNITGYSVMV------GLASGLEPVCSQAYGSKNWDlltlSLHRMVVILLMASLPISLLWI---NLGP---I 130
Cdd:PRK09575 265 GSALTVGAYAIVGYLMVLyylvaeGIAEGMQPPVSYYFGARQYD----NIKKLLKLAMKVTVLAGIAWVlllNLFPetmI 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 131 MLFMGQNPEITATAA---EYCLYALPdllTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLNYwlVMVKHWGVPGVA 207
Cdd:PRK09575 341 ALFNSGDSELIAETIvgiRLHLFAMF---LDGFLVLASAYFMAVNQGGKALFISIGNMLIQLPFLF--ILPKWLGVDGVW 415
|
170
....*....|....*....
gi 15217599 208 IASVVTNLIMVVLLVGYVW 226
Cdd:PRK09575 416 LAMPLSNIALSLVVAPMLW 434
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
26-467 |
4.24e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 42.91 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGgalsIGF-TNItgYSVMVGLASGL----EPVCSQAYGSKNWD 100
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAA----IGFvFPL--FMIIIGLGNGLgagaSSAISRRIGAKDKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 101 LLTLSLHRMVVILLMASLPISL-LWINLGPIMLFMGQNpEITATAAEY----CLYALPDLLTNTLLQPLRVYLRSQRVTK 175
Cdd:cd13147 83 GADNAAVHSILLGLIISIILTIvLLPFLEPILVLMGAG-EVLDLAVDYgriiFLGSIFLIFNNVAYGILRGEGDTKRAMY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 176 PMMWCTLAAVAFHVPLNYWLvmvkHWGVPGVAIASVVTNLIMVVLLVGYVWVsgmlqKRvsgdgdggSTTMVAVVAQSSS 255
Cdd:cd13147 162 AMVAGSILNIILDPIFIYTL----GLGIAGAAWATVISMLISSLVLLYWFFV-----KK--------DTYVSLSLKNFKF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 256 VMELVGGlgpLMRVAVP--------SCLGICLEWWwyeIVIVMGGYlenpKLAVAATGILIqtTSLMYTVPMALAGCVSA 327
Cdd:cd13147 225 DKKIVKD---ILKVGIPasleqlimSVLMIILNLI---LVIVAGTD----GVAVYTAGWRI--VSFAIIPLIGIATAVTS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 328 RVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYE---PLKVLVASVMPIVGLCELGNCPQTTG 404
Cdd:cd13147 293 VTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEesaHLAPEIVAFLRIMCLFLPFVPFGMMS 372
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15217599 405 CGILRGTGRPAVGAHVN-LGSFYFVgTPVAVGLAFWLKIGFSGLWFGL-LSAQAACVVSILYAVL 467
Cdd:cd13147 373 SSMFQGIGKGLTSLIITiLRELIFQ-VLFAYLFAIVLGLGLFGVWWGIvLGNAIGSIVGYLWARL 436
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
25-455 |
4.52e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 42.68 E-value: 4.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAggalSIGFTNITGY---SVMVGLASGLEPVCSQAYGSKNWDL 101
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLflnSLTIGLGIGASAVISRAIGAGDRNK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 102 L-TLSLHRMVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEYC--------LYALPDLLTNTLlqplRVYLRSQR 172
Cdd:cd13149 84 AkRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMaiwylglvFLVLPMVGNAII----RATGDTKR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 173 VTKPMMWCTLAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQkrvsgdgdggSTTMVAVVAQ 252
Cdd:cd13149 160 PSLVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRLI----------DFSEPSLKAL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 253 SSSVMEL--VGGLGPLMRVAVPSCLGIclewwwyeIVIVMGGYLENpklAVAATGILIQTTSLMYTVPMALAGCVSARVG 330
Cdd:cd13149 230 FRSWKDIlsIGIPAALSNILTPLSAAF--------ITALVATYGPA---AVAAFGVATRIESFAFIIVMALSSALGPFVG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 331 NELGAGRPYKARLAANVALACAFVVGAlnVAWTV-ILKERW-AGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGIL 408
Cdd:cd13149 299 QNWGAGQYERVQEGLKISLKFSLIYGA--ILGIVlALFAGWlASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASF 376
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 15217599 409 RGTGRPAVGAHVNLGSFYFVGTPVAVgLAFWLkIGFSGLWFGLLSAQ 455
Cdd:cd13149 377 NALGKPLYSLGLNLIRVFLLYIPLAY-VGSHL-LGFAGVFIGALAGN 421
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
54-226 |
7.87e-04 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 41.78 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 54 GRLGSLELAGGALSIGFTNITGYsVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLL-WINLGPIML 132
Cdd:cd13136 253 ARLGDVILAANQILLQFWLLSSY-FLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLfFLGGEPIIR 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 133 FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLnyWLVMVKHWGVPGVAIASVV 212
Cdd:cd13136 332 LFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPL--LFLLVPLWGNHGLWLALIL 409
|
170
....*....|....
gi 15217599 213 TNLIMVVLLVGYVW 226
Cdd:cd13136 410 FMLLRGLTLALRLP 423
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-469 |
9.08e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 41.83 E-value: 9.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 46 AVVSVLFLGRLGSLELAggalSIGFTNIT---GYSVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISL 122
Cdd:cd13139 34 AVVDLYFVSRLGALAIA----TVGLTESVltiVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLGVALSLILSI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 123 L-WINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLN----YWLVM 197
Cdd:cd13139 110 LgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILDplfiFGLGP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 198 VKHWGVPGVAIASVVTNLIMVVLLVGYV-WVSGMLQKRVSgdgdggstTMVAVVAQSSSVMEL-VGGLGPLMrvaVPSCL 275
Cdd:cd13139 190 IPAMGVTGAAIATTIGRSIGVLYQLYHLfKGKGRIQIRRR--------HLKLDWAIIKKIIKIaVGGILQFL---IASSS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 276 giclewwWYEIVIVMGGYLENpklAVAATGILIQTtsLMYTVPMA--LAGCVSARVGNELGAGRPYKARLAANVALACAF 353
Cdd:cd13139 259 -------WIFLVRIIAEFGST---ALAGYTIAIRI--IMFALLPAwgLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 354 V-VGALNVAWtVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLGSFYFVGTPV 432
Cdd:cd13139 327 VfLGIVSLVF-FLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPL 405
|
410 420 430
....*....|....*....|....*....|....*..
gi 15217599 433 AVGLAFWLKIGFSGLWFGLLSAQAacVVSILYAVLAR 469
Cdd:cd13139 406 AYLLARHLNLGPKGVFIAIPIAET--VLAIAAIILFR 440
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
63-226 |
2.84e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 40.19 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 63 GGALSIGFTNITGYSVMV------GLASGLEPVCSQAYGSKNWDLLTLSLHR-MVVILLMASLPISLLWINLGPIMLFMG 135
Cdd:cd13143 257 GGDIGVAAFGIVTRILTFlflpliGLSQGLQPIIGYNYGAGNYDRVKQALKLaLIVALIYGLVLFLILLLFPEQIVSLFT 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 136 QNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAA-VAFHVPLnyWLVMVKHWGVPGVAIASVVTN 214
Cdd:cd13143 337 DDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRqGLFLIPL--LLILPRLFGLDGIWLAFPLAE 414
|
170
....*....|..
gi 15217599 215 LIMVVLLVGYVW 226
Cdd:cd13143 415 ILTLLLALILLK 426
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
31-394 |
3.19e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 39.95 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 31 MVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITGYSVMVGLASGLEPVCSQAYGS-KNWDLLTLSLHrM 109
Cdd:cd13148 17 LALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAMGGGVSSAIARALGAgDRERAEALVWH-A 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 110 VVILLMASLPISLLWINLGPIML-FMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFH 188
Cdd:cd13148 96 LVIALAGGLVFSLLFLLFGPALYrLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAVVQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 189 VPLNYWLVM----VKHWGVPGVAIASVVTNLIMVVLLVGYVWvsgmlqkrvSGDgdggsttmvavvaqssSVMELVGGLG 264
Cdd:cd13148 176 IPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLA---------SGR----------------SRLRLRLRAL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 265 PL--------MRVAVPSCLGICLEwwwYEIVIVMGGYLEN-PKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGA 335
Cdd:cd13148 231 RLerrlfrdiLRVGLLAALSPLQT---NLTVLLLTGLVGRfGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15217599 336 GRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLC 394
Cdd:cd13148 308 GQIARARRIAWTGALMAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPF 366
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
26-234 |
7.49e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 38.95 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 26 KELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGaLSIGFTnITGYSVMVGL-----ASGLepvCSQAYGSKNWD 100
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGG-VAVGAT-ATSFLFMLLLflrmsTTGL---TAQAFGAKNPQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 101 LLTLSLHRMVVILLMASLPISLLWINLGPIML-FMGQNPEITATAAEYC---LYALPDLLTNTLLqpLRVYLRSQRVTKP 176
Cdd:PRK10367 84 ALARALVQPLLLALGAGALIALLRTPLIDLALhIVGGSEAVLEQARRFLeirWLSAPASLANLVL--LGWLLGVQYARAP 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 15217599 177 MMWCTLAAVaFHVPLNYWLVMVKHWGVPGVAIASVVTNliMVVLLVGYVWVSGMLQKR 234
Cdd:PRK10367 162 VILLVVGNI-LNIVLDLWLVMGLHMNVQGAALATVIAE--YATLLIGLLMVRKVLKLR 216
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
25-152 |
8.30e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 38.38 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217599 25 LKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITgYSVMVGLASGLEPVCSQAYGSKNWDLLTL 104
Cdd:TIGR00797 215 LKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPKRAKE 293
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15217599 105 SLHRMVVI-LLMASLPISLLWINLGPIMLFMGQNPEITATAAEYCLYAL 152
Cdd:TIGR00797 294 VARVALKLsLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| |
