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Conserved domains on  [gi|15224013|ref|NP_177285|]
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F-box associated ubiquitination effector family protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10550066)

F-box protein is the substrate-recognition component of an SCF (Skp1-cullin-F-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FBA_3 pfam08268
F-box associated domain;
27-160 5.12e-22

F-box associated domain;


:

Pssm-ID: 285468  Cd Length: 125  Bit Score: 86.57  E-value: 5.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013    27 GLCKGGFLYYGADESNSDKSVVVSFNVSSEEFSVIELPEEVKIDHRWRLVNYNGEVALVddsefdfgivkEPNGNGVFEL 106
Cdd:pfam08268   1 GICINGVLYYGAWTSDNSKSVIVSFDVRSEKFDFIKLPVPLANDLSSTLINYKGKLAVV-----------SHTSDGGIEL 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15224013   107 WVRNETD-GTWWRNCIEIPHWEQH-VGNMEFFFKGTIGTGELVFAQDSVIERSFYV 160
Cdd:pfam08268  70 WVLEDAEkHEWSKKIFVLPPSHEHlVDNTDLSVVGTTRTGEIILVLPSTLSKPFYV 125
 
Name Accession Description Interval E-value
FBA_3 pfam08268
F-box associated domain;
27-160 5.12e-22

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 86.57  E-value: 5.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013    27 GLCKGGFLYYGADESNSDKSVVVSFNVSSEEFSVIELPEEVKIDHRWRLVNYNGEVALVddsefdfgivkEPNGNGVFEL 106
Cdd:pfam08268   1 GICINGVLYYGAWTSDNSKSVIVSFDVRSEKFDFIKLPVPLANDLSSTLINYKGKLAVV-----------SHTSDGGIEL 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15224013   107 WVRNETD-GTWWRNCIEIPHWEQH-VGNMEFFFKGTIGTGELVFAQDSVIERSFYV 160
Cdd:pfam08268  70 WVLEDAEkHEWSKKIFVLPPSHEHlVDNTDLSVVGTTRTGEIILVLPSTLSKPFYV 125
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
8-168 9.74e-11

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 58.91  E-value: 9.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013     8 ESNSWRVITCKHDHSPVT-EGLCKGGFLYYGA-DESNSDKSVVVSFNVSSEEFSV-IELPEEVKIDHRWR-LVNYNGEVA 83
Cdd:TIGR01640  78 GSNSWRTIECSPPHHPLKsRGVCINGVLYYLAyTLKTNPDYFIVSFDVSSERFKEfIPLPCGNSDSVDYLsLINYKGKLA 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013    84 LvddsefdfgiVKEPNGNGVFELWVRNET-DGTWWRNC-IEIPHWEQHVGNMefFFKGTIGTGELVFAQDSviERSFYVV 161
Cdd:TIGR01640 158 V----------LKQKKDTNNFDLWVLNDAgKQEWSKLFtVPIPPLPDLVDDN--FLSGFTDKGEIVLCCED--ENPFYIF 223

                  ....*..
gi 15224013   162 YYDTVTQ 168
Cdd:TIGR01640 224 YYNVGEN 230
 
Name Accession Description Interval E-value
FBA_3 pfam08268
F-box associated domain;
27-160 5.12e-22

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 86.57  E-value: 5.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013    27 GLCKGGFLYYGADESNSDKSVVVSFNVSSEEFSVIELPEEVKIDHRWRLVNYNGEVALVddsefdfgivkEPNGNGVFEL 106
Cdd:pfam08268   1 GICINGVLYYGAWTSDNSKSVIVSFDVRSEKFDFIKLPVPLANDLSSTLINYKGKLAVV-----------SHTSDGGIEL 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15224013   107 WVRNETD-GTWWRNCIEIPHWEQH-VGNMEFFFKGTIGTGELVFAQDSVIERSFYV 160
Cdd:pfam08268  70 WVLEDAEkHEWSKKIFVLPPSHEHlVDNTDLSVVGTTRTGEIILVLPSTLSKPFYV 125
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
8-168 9.74e-11

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 58.91  E-value: 9.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013     8 ESNSWRVITCKHDHSPVT-EGLCKGGFLYYGA-DESNSDKSVVVSFNVSSEEFSV-IELPEEVKIDHRWR-LVNYNGEVA 83
Cdd:TIGR01640  78 GSNSWRTIECSPPHHPLKsRGVCINGVLYYLAyTLKTNPDYFIVSFDVSSERFKEfIPLPCGNSDSVDYLsLINYKGKLA 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224013    84 LvddsefdfgiVKEPNGNGVFELWVRNET-DGTWWRNC-IEIPHWEQHVGNMefFFKGTIGTGELVFAQDSviERSFYVV 161
Cdd:TIGR01640 158 V----------LKQKKDTNNFDLWVLNDAgKQEWSKLFtVPIPPLPDLVDDN--FLSGFTDKGEIVLCCED--ENPFYIF 223

                  ....*..
gi 15224013   162 YYDTVTQ 168
Cdd:TIGR01640 224 YYNVGEN 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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