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Conserved domains on  [gi|79376494|ref|NP_177197|]
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NOSIC domain protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nop super family cl38058
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
 55-163 1.30e-35

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


The actual alignment was detected with superfamily member pfam01798:

Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 123.33  E-value: 1.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79376494    55 LVDIENEIVIVQNFIRDKYRVKFQELELLVPHPIDYARVVKRIGNE-MDLKLVDLEGLLPSAMIMVLLVTALTTKGNQLP 133
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNDrEDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 79376494   134 EDVLLKTIDACDRALDLDSARKKVLEFVDC 163
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLES 110
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
 55-163 1.30e-35

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 123.33  E-value: 1.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79376494    55 LVDIENEIVIVQNFIRDKYRVKFQELELLVPHPIDYARVVKRIGNE-MDLKLVDLEGLLPSAMIMVLLVTALTTKGNQLP 133
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNDrEDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 79376494   134 EDVLLKTIDACDRALDLDSARKKVLEFVDC 163
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLES 110
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
 48-99 2.88e-17

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 71.04  E-value: 2.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 79376494     48 IVDCKQLLVDIENEIVIVQNFIRDKYRVKFQELELLVPHPIDYARVVKRIGN 99
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
 55-163 1.30e-35

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 123.33  E-value: 1.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79376494    55 LVDIENEIVIVQNFIRDKYRVKFQELELLVPHPIDYARVVKRIGNE-MDLKLVDLEGLLPSAMIMVLLVTALTTKGNQLP 133
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNDrEDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 79376494   134 EDVLLKTIDACDRALDLDSARKKVLEFVDC 163
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLES 110
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
 48-99 2.88e-17

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 71.04  E-value: 2.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 79376494     48 IVDCKQLLVDIENEIVIVQNFIRDKYRVKFQELELLVPHPIDYARVVKRIGN 99
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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