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Conserved domains on  [gi|145337144|ref|NP_176566|]
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nucleolar protein [Arabidopsis thaliana]

Protein Classification

nucleolar RNA-associated family protein( domain architecture ID 13691717)

nucleolar RNA-associated protein (NRAP) family protein such as nucleolar protein 6 (NOL6) that is involved in RNA binding, localization, and ribosome biogenesis; it interacts with pre-rRNA primary transcripts to facilitate ribosome assembly within the nucleolus

CATH:  3.30.460.10|3.30.70.3030
Gene Ontology:  GO:0003723|GO:0042255|GO:0005730|GO:0032040
PubMed:  11895476
SCOP:  4004203|4005371|4005372|4005373|4005375|4005376

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 740-904 2.07e-57

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465419  Cd Length: 157  Bit Score: 194.71  E-value: 2.07e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   740 FPVYAPVARLAKRWVSAHLFSGCLAEEAIELLVAYLFLTPLPLGVPSSRINGFLRFLRLLADYEWMFYPLIVDINNDFGR 819
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   820 NDEKEINDNFMSSRKgyeEDKQNISSAMFLAAPYDKASEAWTSTSPNLLEQKRLVAYARSSANvlskmVLQEHNDSVQWE 899
Cdd:pfam17406   81 EDIKEIETRFEAWRK---SDPAMNHTALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALK-----LLEEQGGGLDVK 152


                   ....*
gi 145337144   900 CLFRT 904
Cdd:pfam17406  153 SLFRP 157
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 381-537 2.11e-53

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465417  Cd Length: 159  Bit Score: 183.62  E-value: 2.11e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   381 YPVKYDHCIRLQLKGKTAVSLSGFCLDK----ECWRLYEQKVHSLLLEGLGDRAKSIRVVWRNTnqDWHVES-GLSVLDR 455
Cdd:pfam17404    1 PLLRFDLVLRIPLPLSASLLSKFGPLEKidfiGFENALLRKLYSLLKRALGDRAKLIHIQLPSP--SWSISKrKPSPANP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   456 EPLFIGISVSStEKAYRTVDIGPDAENKIEALRFRKFWGEKSDLRRFKDGRISESTVWETQQWTKHLIMKQIVEYILKRH 535
Cdd:pfam17404   79 SSILIGLLLNP-ENAFRLVDHGPSAEDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSERLIVEQIVKYILKRH 157


                   ..
gi 145337144   536 LS 537
Cdd:pfam17404  158 LG 159
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 545-737 1.40e-49

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465418  Cd Length: 201  Bit Score: 174.33  E-value: 1.40e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   545 QLVDQLDFSLNYGGKDPISLSGNLVQAYEVLSKCLREIEGIPLKVSSVQSLDSALRFTSVFPPEPHPVAcekidsrrlqk 624
Cdd:pfam17405    1 QFDSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA----------- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   625 lipSCIPAMEVMIQLEGSGNWPMDDLAVEKTKSAFLLKIAESLQN-VKGIPCTATEDNVDVFIG-----------GYAFR 692
Cdd:pfam17405   70 ---AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESkNSGYKARVGLDNSIPPILnqafldvlypsGYVFR 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 145337144   693 LRILHERGLSLVKREIGVDPV---------KHVSSTDKMLFIRSQHASMINGLQ 737
Cdd:pfam17405  147 LRIHHDREETLLERQLKDKGLaryqreeaaEALAKYKRRFIHLPRHTQAIQTLC 200
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 98-233 1.37e-47

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


:

Pssm-ID: 461061  Cd Length: 144  Bit Score: 166.21  E-value: 1.37e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144    98 VDLLVHLPKECFYEKDYMNHRYHAKRCLYLCVIEKHLLSSSSIE---KVVWSTLHNEARKPVLVVFPAKKLDQFPG--FS 172
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFSKskFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145337144   173 IRLIPSATS-LFSVAKLSISRNNVRSVTAD--GVPEPTPTYNSSILEDMFLEENSEFLKKTFSE 233
Cdd:pfam03813   81 IRIIPCAPSgLFPLSKLLPSKNNIRPATDSeeTTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 239-378 3.59e-42

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 150.83  E-value: 3.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   239 DALILLKIWARQRSSIYV-HDCLNGFLISVILSYL------ATHSKINKALSALDIFRVTLDFIATSKLWERGLYLPPQS 311
Cdd:pfam17403    4 DACILLKVWLRQRGFGSSsKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFKSDS 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145337144   312 EIrvSKEEKMQFRELFPVVICDSSTFVNLAFRMTSVGFLELQDEASLTLKCMEKLRDGGFEEIFMTK 378
Cdd:pfam17403   84 DS--KYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 906-1044 3.15e-13

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465420  Cd Length: 128  Bit Score: 67.33  E-value: 3.15e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   906 LNNYDAVILLHRDKLPYPRRLlfpselnqgkhVARGKASRLFNpfmspgdlkRSHEELKNKLMVDFEPTKCLLSGLQEEF 985
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLSSA-----------PGILSKSKFKN---------LDLRLTSDKLRVGFDPVQLLVRELNRKY 60

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145337144   986 G-TLKPWYDHIGGDAIGLTWNKHNSKKR--------ERDEEEEEEEESNPMEMLKAVGEMGKGLVRDI 1044
Cdd:pfam17407   61 GdTILFFYDKYGGNVIGGLWNPAVLKPRkfkvnlgyNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 740-904 2.07e-57

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 194.71  E-value: 2.07e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   740 FPVYAPVARLAKRWVSAHLFSGCLAEEAIELLVAYLFLTPLPLGVPSSRINGFLRFLRLLADYEWMFYPLIVDINNDFGR 819
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   820 NDEKEINDNFMSSRKgyeEDKQNISSAMFLAAPYDKASEAWTSTSPNLLEQKRLVAYARSSANvlskmVLQEHNDSVQWE 899
Cdd:pfam17406   81 EDIKEIETRFEAWRK---SDPAMNHTALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALK-----LLEEQGGGLDVK 152


                   ....*
gi 145337144   900 CLFRT 904
Cdd:pfam17406  153 SLFRP 157
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 381-537 2.11e-53

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 183.62  E-value: 2.11e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   381 YPVKYDHCIRLQLKGKTAVSLSGFCLDK----ECWRLYEQKVHSLLLEGLGDRAKSIRVVWRNTnqDWHVES-GLSVLDR 455
Cdd:pfam17404    1 PLLRFDLVLRIPLPLSASLLSKFGPLEKidfiGFENALLRKLYSLLKRALGDRAKLIHIQLPSP--SWSISKrKPSPANP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   456 EPLFIGISVSStEKAYRTVDIGPDAENKIEALRFRKFWGEKSDLRRFKDGRISESTVWETQQWTKHLIMKQIVEYILKRH 535
Cdd:pfam17404   79 SSILIGLLLNP-ENAFRLVDHGPSAEDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSERLIVEQIVKYILKRH 157


                   ..
gi 145337144   536 LS 537
Cdd:pfam17404  158 LG 159
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 545-737 1.40e-49

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 174.33  E-value: 1.40e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   545 QLVDQLDFSLNYGGKDPISLSGNLVQAYEVLSKCLREIEGIPLKVSSVQSLDSALRFTSVFPPEPHPVAcekidsrrlqk 624
Cdd:pfam17405    1 QFDSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA----------- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   625 lipSCIPAMEVMIQLEGSGNWPMDDLAVEKTKSAFLLKIAESLQN-VKGIPCTATEDNVDVFIG-----------GYAFR 692
Cdd:pfam17405   70 ---AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESkNSGYKARVGLDNSIPPILnqafldvlypsGYVFR 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 145337144   693 LRILHERGLSLVKREIGVDPV---------KHVSSTDKMLFIRSQHASMINGLQ 737
Cdd:pfam17405  147 LRIHHDREETLLERQLKDKGLaryqreeaaEALAKYKRRFIHLPRHTQAIQTLC 200
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 98-233 1.37e-47

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 166.21  E-value: 1.37e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144    98 VDLLVHLPKECFYEKDYMNHRYHAKRCLYLCVIEKHLLSSSSIE---KVVWSTLHNEARKPVLVVFPAKKLDQFPG--FS 172
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFSKskFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145337144   173 IRLIPSATS-LFSVAKLSISRNNVRSVTAD--GVPEPTPTYNSSILEDMFLEENSEFLKKTFSE 233
Cdd:pfam03813   81 IRIIPCAPSgLFPLSKLLPSKNNIRPATDSeeTTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 239-378 3.59e-42

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 150.83  E-value: 3.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   239 DALILLKIWARQRSSIYV-HDCLNGFLISVILSYL------ATHSKINKALSALDIFRVTLDFIATSKLWERGLYLPPQS 311
Cdd:pfam17403    4 DACILLKVWLRQRGFGSSsKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFKSDS 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145337144   312 EIrvSKEEKMQFRELFPVVICDSSTFVNLAFRMTSVGFLELQDEASLTLKCMEKLRDGGFEEIFMTK 378
Cdd:pfam17403   84 DS--KYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 906-1044 3.15e-13

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 67.33  E-value: 3.15e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   906 LNNYDAVILLHRDKLPYPRRLlfpselnqgkhVARGKASRLFNpfmspgdlkRSHEELKNKLMVDFEPTKCLLSGLQEEF 985
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLSSA-----------PGILSKSKFKN---------LDLRLTSDKLRVGFDPVQLLVRELNRKY 60

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145337144   986 G-TLKPWYDHIGGDAIGLTWNKHNSKKR--------ERDEEEEEEEESNPMEMLKAVGEMGKGLVRDI 1044
Cdd:pfam17407   61 GdTILFFYDKYGGNVIGGLWNPAVLKPRkfkvnlgyNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 740-904 2.07e-57

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 194.71  E-value: 2.07e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   740 FPVYAPVARLAKRWVSAHLFSGCLAEEAIELLVAYLFLTPLPLGVPSSRINGFLRFLRLLADYEWMFYPLIVDINNDFGR 819
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLLGHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLTA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   820 NDEKEINDNFMSSRKgyeEDKQNISSAMFLAAPYDKASEAWTSTSPNLLEQKRLVAYARSSANvlskmVLQEHNDSVQWE 899
Cdd:pfam17406   81 EDIKEIETRFEAWRK---SDPAMNHTALFVATPYDPSGSAWTRRGPSKVVAARLTALAKAALK-----LLEEQGGGLDVK 152


                   ....*
gi 145337144   900 CLFRT 904
Cdd:pfam17406  153 SLFRP 157
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 381-537 2.11e-53

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 183.62  E-value: 2.11e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   381 YPVKYDHCIRLQLKGKTAVSLSGFCLDK----ECWRLYEQKVHSLLLEGLGDRAKSIRVVWRNTnqDWHVES-GLSVLDR 455
Cdd:pfam17404    1 PLLRFDLVLRIPLPLSASLLSKFGPLEKidfiGFENALLRKLYSLLKRALGDRAKLIHIQLPSP--SWSISKrKPSPANP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   456 EPLFIGISVSStEKAYRTVDIGPDAENKIEALRFRKFWGEKSDLRRFKDGRISESTVWETQQWTKHLIMKQIVEYILKRH 535
Cdd:pfam17404   79 SSILIGLLLNP-ENAFRLVDHGPSAEDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSERLIVEQIVKYILKRH 157


                   ..
gi 145337144   536 LS 537
Cdd:pfam17404  158 LG 159
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 545-737 1.40e-49

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 174.33  E-value: 1.40e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   545 QLVDQLDFSLNYGGKDPISLSGNLVQAYEVLSKCLREIEGIPLKVSSVQSLDSALRFTSVFPPEPHPVAcekidsrrlqk 624
Cdd:pfam17405    1 QFDSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLA----------- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   625 lipSCIPAMEVMIQLEGSGNWPMDDLAVEKTKSAFLLKIAESLQN-VKGIPCTATEDNVDVFIG-----------GYAFR 692
Cdd:pfam17405   70 ---AYSPPIDVVLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESkNSGYKARVGLDNSIPPILnqafldvlypsGYVFR 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 145337144   693 LRILHERGLSLVKREIGVDPV---------KHVSSTDKMLFIRSQHASMINGLQ 737
Cdd:pfam17405  147 LRIHHDREETLLERQLKDKGLaryqreeaaEALAKYKRRFIHLPRHTQAIQTLC 200
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 98-233 1.37e-47

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 166.21  E-value: 1.37e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144    98 VDLLVHLPKECFYEKDYMNHRYHAKRCLYLCVIEKHLLSSSSIE---KVVWSTLHNEARKPVLVVFPAKKLDQFPG--FS 172
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdllKVSFSYLNGDPLKPILVLRPKKTEGKFSKskFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145337144   173 IRLIPSATS-LFSVAKLSISRNNVRSVTAD--GVPEPTPTYNSSILEDMFLEENSEFLKKTFSE 233
Cdd:pfam03813   81 IRIIPCAPSgLFPLSKLLPSKNNIRPATDSeeTTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 239-378 3.59e-42

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 150.83  E-value: 3.59e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   239 DALILLKIWARQRSSIYV-HDCLNGFLISVILSYL------ATHSKINKALSALDIFRVTLDFIATSKLWERGLYLPPQS 311
Cdd:pfam17403    4 DACILLKVWLRQRGFGSSsKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFKSDS 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145337144   312 EIrvSKEEKMQFRELFPVVICDSSTFVNLAFRMTSVGFLELQDEASLTLKCMEKLRDGGFEEIFMTK 378
Cdd:pfam17403   84 DS--KYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 906-1044 3.15e-13

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 67.33  E-value: 3.15e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337144   906 LNNYDAVILLHRDKLPYPRRLlfpselnqgkhVARGKASRLFNpfmspgdlkRSHEELKNKLMVDFEPTKCLLSGLQEEF 985
Cdd:pfam17407    1 LEDYDFVIHLKPKALPRLSSA-----------PGILSKSKFKN---------LDLRLTSDKLRVGFDPVQLLVRELNRKY 60

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145337144   986 G-TLKPWYDHIGGDAIGLTWNKHNSKKR--------ERDEEEEEEEESNPMEMLKAVGEMGKGLVRDI 1044
Cdd:pfam17407   61 GdTILFFYDKYGGNVIGGLWNPAVLKPRkfkvnlgyNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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