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Conserved domains on  [gi|240254313|ref|NP_176555|]
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ALBINO OR PALE-GREEN 13 [Arabidopsis thaliana]

Protein Classification

Mur ligase family protein( domain architecture ID 11433679)

Mur ligase family protein such as MurC, MurD, and MurE, which catalyze consecutive steps in the synthesis of peptidoglycan

CATH:  3.90.190.20|3.40.1190.10|3.40.1390.10
EC:  6.3.2.13
Gene Ontology:  GO:0005524|GO:0000287|GO:0009252|GO:0008765
PubMed:  11124264|28201974
SCOP:  4000234

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 267-749 1.13e-154

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 458.00  E-value: 1.13e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 267 GIQHDSRGVSAGDLFVCCLGS----ENFLSEADKRGAVAVVASKEIDIEDTlGCrALVIVEDTNAVLAALASSFYRHPSK 342
Cdd:COG0769    1 GITYDSRKVKPGDLFVALPGArvdgHDFIAQAIARGAVAVVTEAPGALLAA-GV-PVIVVPDPRAALALLAAAFYGHPSQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 343 NMSVIgvtgtdgkttttYLIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESLVMEA 422
Cdd:COG0769   79 KLKLIgvtgtngkttttYLLAQILRALGKKTGLIGTVGNGI-GGELIPSSLTT--PEALDLQRLLAEMVDAGVTHVVMEV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 423 SPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRmvDPERHRKVVNIDDPNAAFFVQqgNPNVPVVT 502
Cdd:COG0769  156 SSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQ--LGPGGAAVINADDPYGRRLAA--AAPARVIT 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 503 FAMENtKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCE 582
Cdd:COG0769  232 YGLKA-DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRME 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 583 LIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNEDPLDI 662
Cdd:COG0769  311 RVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAI 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 663 LDDMLSGIgwtmqeylkHGEHDYypplanghrLFLHDiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEKKEFYDDRE 742
Cdd:COG0769  391 IADILAGI---------PGAGKV---------LVIPD-RAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDRE 451


                 ....*..
gi 240254313 743 ECREALQ 749
Cdd:COG0769  452 VAREALA 458
 
Name Accession Description Interval E-value
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 267-749 1.13e-154

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 458.00  E-value: 1.13e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 267 GIQHDSRGVSAGDLFVCCLGS----ENFLSEADKRGAVAVVASKEIDIEDTlGCrALVIVEDTNAVLAALASSFYRHPSK 342
Cdd:COG0769    1 GITYDSRKVKPGDLFVALPGArvdgHDFIAQAIARGAVAVVTEAPGALLAA-GV-PVIVVPDPRAALALLAAAFYGHPSQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 343 NMSVIgvtgtdgkttttYLIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESLVMEA 422
Cdd:COG0769   79 KLKLIgvtgtngkttttYLLAQILRALGKKTGLIGTVGNGI-GGELIPSSLTT--PEALDLQRLLAEMVDAGVTHVVMEV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 423 SPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRmvDPERHRKVVNIDDPNAAFFVQqgNPNVPVVT 502
Cdd:COG0769  156 SSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQ--LGPGGAAVINADDPYGRRLAA--AAPARVIT 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 503 FAMENtKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCE 582
Cdd:COG0769  232 YGLKA-DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRME 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 583 LIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNEDPLDI 662
Cdd:COG0769  311 RVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAI 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 663 LDDMLSGIgwtmqeylkHGEHDYypplanghrLFLHDiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEKKEFYDDRE 742
Cdd:COG0769  391 IADILAGI---------PGAGKV---------LVIPD-RAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDRE 451


                 ....*..
gi 240254313 743 ECREALQ 749
Cdd:COG0769  452 VAREALA 458
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 262-749 1.73e-139

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 419.15  E-value: 1.73e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 262 DVEITGIQHDSRGVSAGDLFVCCLGS----ENFLSEADKRGAVAVVASKEIDIEDTLgcrALVIVEDTNAVLAALASSFY 337
Cdd:PRK00139  12 PVEITGLTYDSRKVKPGDLFVALPGHkvdgRDFIAQAIANGAAAVVAEADGEAGTGV---PVIIVPDLRKALALLAAAFY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 338 RHPSKNMSVIgvtgtdgkttttYLIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTES 417
Cdd:PRK00139  89 GHPSDKLKLIgvtgtngktttaYLLAQILRLLGEKTALIGTLGNGI-GGELIPSGLTT--PDALDLQRLLAELVDAGVTY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 418 LVMEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFsrmvDPERHRKVVNIDDPNAAFFVQqgnpn 497
Cdd:PRK00139 166 AAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLF----SELGLAAVINADDEVGRRLLA----- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 498 vPVVTFAMENTKADVHPLKFELSLFETQVLVNTpqgilEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAV 577
Cdd:PRK00139 237 -LPDAYAVSMAGADLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 578 PGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNE 657
Cdd:PRK00139 311 PGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVTSDNPRSE 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 658 DPLDILDDMLSGIGWTmqeylkhgEHDyypplanghrlflhdiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEKKEF 737
Cdd:PRK00139 391 DPAAIIADILAGIYDV--------IED----------------RAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIP 446

                        490
                 ....*....|..
gi 240254313 738 YDDREECREALQ 749
Cdd:PRK00139 447 FDDREVAREALA 458
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 262-741 5.92e-126

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 384.36  E-value: 5.92e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  262 DVEITGIQHDSRGVSAGDLFVCCLG----SENFLSEADKRGAVAVVASKEIDIEDTLGCraLVIVEDTNAVLAALASSFY 337
Cdd:TIGR01085   1 DLEVTGLTLDSREVKPGDLFVAIKGthvdGHDFIHDAIANGAVAVVVERDVDFYVAPVP--VIIVPDLRHALSSLAAAFY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  338 RHPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGVRTGMFSTVSCYIHGDNKLDTPNATMNPDAVLVQSLMAKMLHNGTES 417
Cdd:TIGR01085  79 GHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIKNPAALTTPEALTLQSTLAEMVEAGAQY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  418 LVMEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRmvDPERHRKVVNIDDPNAAFFVQ--QGN 495
Cdd:TIGR01085 159 AVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTE--LGLKRFAVINLDDEYGAQFVKrlPKD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  496 PNVPVVTFAMENTKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVG-APLEDIVRGVEEV 574
Cdd:TIGR01085 237 ITVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKF 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  575 DAVPGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNP 654
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDNP 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  655 RNEDPLDILDDMLSGIGwTMQEYlkHGEHDyypplanghrlflhdiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEK 734
Cdd:TIGR01085 397 RGEDPEQIIADILAGIS-EKEKV--VIIAD----------------RRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGE 457


                  ....*..
gi 240254313  735 KEFYDDR 741
Cdd:TIGR01085 458 TIPFDDR 464
Mur_ligase_M pfam08245
Mur ligase middle domain;
360-557 1.42e-41

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 150.53  E-value: 1.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  360 YLIKSLYEAMGvrtGMFSTVscyihGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESLVMEASPQELALGK-CDEVDFD 438
Cdd:pfam08245  12 ELIAAILSLAG---GVIGTI-----GTYIGKSGNTT--NNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRlSGLLKPD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  439 IAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQ-GNPNVPVVTFAMENtKADVHPLKF 517
Cdd:pfam08245  82 IAVFTNISPDHLDFHGTMENYAKAKAELFEGL--PEDGIAVINADDPYGAFLIAKlKKAGVRVITYGIEG-EADLRAANI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 240254313  518 ELSLFETQV-LVNTPQGILEISSGLLGRHNIYNILAAVAVG 557
Cdd:pfam08245 159 ELSSDGTSFdLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 267-749 1.13e-154

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 458.00  E-value: 1.13e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 267 GIQHDSRGVSAGDLFVCCLGS----ENFLSEADKRGAVAVVASKEIDIEDTlGCrALVIVEDTNAVLAALASSFYRHPSK 342
Cdd:COG0769    1 GITYDSRKVKPGDLFVALPGArvdgHDFIAQAIARGAVAVVTEAPGALLAA-GV-PVIVVPDPRAALALLAAAFYGHPSQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 343 NMSVIgvtgtdgkttttYLIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESLVMEA 422
Cdd:COG0769   79 KLKLIgvtgtngkttttYLLAQILRALGKKTGLIGTVGNGI-GGELIPSSLTT--PEALDLQRLLAEMVDAGVTHVVMEV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 423 SPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRmvDPERHRKVVNIDDPNAAFFVQqgNPNVPVVT 502
Cdd:COG0769  156 SSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQ--LGPGGAAVINADDPYGRRLAA--AAPARVIT 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 503 FAMENtKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCE 582
Cdd:COG0769  232 YGLKA-DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRME 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 583 LIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNEDPLDI 662
Cdd:COG0769  311 RVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAI 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 663 LDDMLSGIgwtmqeylkHGEHDYypplanghrLFLHDiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEKKEFYDDRE 742
Cdd:COG0769  391 IADILAGI---------PGAGKV---------LVIPD-RAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDRE 451


                 ....*..
gi 240254313 743 ECREALQ 749
Cdd:COG0769  452 VAREALA 458
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 262-749 1.73e-139

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 419.15  E-value: 1.73e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 262 DVEITGIQHDSRGVSAGDLFVCCLGS----ENFLSEADKRGAVAVVASKEIDIEDTLgcrALVIVEDTNAVLAALASSFY 337
Cdd:PRK00139  12 PVEITGLTYDSRKVKPGDLFVALPGHkvdgRDFIAQAIANGAAAVVAEADGEAGTGV---PVIIVPDLRKALALLAAAFY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 338 RHPSKNMSVIgvtgtdgkttttYLIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTES 417
Cdd:PRK00139  89 GHPSDKLKLIgvtgtngktttaYLLAQILRLLGEKTALIGTLGNGI-GGELIPSGLTT--PDALDLQRLLAELVDAGVTY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 418 LVMEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFsrmvDPERHRKVVNIDDPNAAFFVQqgnpn 497
Cdd:PRK00139 166 AAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLF----SELGLAAVINADDEVGRRLLA----- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 498 vPVVTFAMENTKADVHPLKFELSLFETQVLVNTpqgilEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAV 577
Cdd:PRK00139 237 -LPDAYAVSMAGADLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 578 PGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNE 657
Cdd:PRK00139 311 PGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVTSDNPRSE 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 658 DPLDILDDMLSGIGWTmqeylkhgEHDyypplanghrlflhdiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEKKEF 737
Cdd:PRK00139 391 DPAAIIADILAGIYDV--------IED----------------RAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIP 446

                        490
                 ....*....|..
gi 240254313 738 YDDREECREALQ 749
Cdd:PRK00139 447 FDDREVAREALA 458
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 262-741 5.92e-126

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 384.36  E-value: 5.92e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  262 DVEITGIQHDSRGVSAGDLFVCCLG----SENFLSEADKRGAVAVVASKEIDIEDTLGCraLVIVEDTNAVLAALASSFY 337
Cdd:TIGR01085   1 DLEVTGLTLDSREVKPGDLFVAIKGthvdGHDFIHDAIANGAVAVVVERDVDFYVAPVP--VIIVPDLRHALSSLAAAFY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  338 RHPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGVRTGMFSTVSCYIHGDNKLDTPNATMNPDAVLVQSLMAKMLHNGTES 417
Cdd:TIGR01085  79 GHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIKNPAALTTPEALTLQSTLAEMVEAGAQY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  418 LVMEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRmvDPERHRKVVNIDDPNAAFFVQ--QGN 495
Cdd:TIGR01085 159 AVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTE--LGLKRFAVINLDDEYGAQFVKrlPKD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  496 PNVPVVTFAMENTKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVG-APLEDIVRGVEEV 574
Cdd:TIGR01085 237 ITVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKF 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  575 DAVPGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNP 654
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDNP 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  655 RNEDPLDILDDMLSGIGwTMQEYlkHGEHDyypplanghrlflhdiRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEGEK 734
Cdd:TIGR01085 397 RGEDPEQIIADILAGIS-EKEKV--VIIAD----------------RRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGE 457


                  ....*..
gi 240254313  735 KEFYDDR 741
Cdd:TIGR01085 458 TIPFDDR 464
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 265-749 5.28e-101

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 333.21  E-value: 5.28e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 265 ITGIQHDSRGVSAGDLFVCCLGSEN----FLSEADKRGAVAVVAskEIDIEDTLG-CRALVI-VEDTNAVLAALASSFYR 338
Cdd:PRK11929  29 TADLRLDSREVQPGDLFVACRGAASdgraFIDQALARGAAAVLV--EAEGEDQVAaADALVLpVADLRKALGELAARWYG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 339 HPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGVRTGMFSTVScYIHGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESL 418
Cdd:PRK11929 107 RPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLG-ARLDGRLIPGSLTT--PDAIILHRILARMRAAGADAV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 419 VMEASPQELALGKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQGNPNV 498
Cdd:PRK11929 184 AMEASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKL--PGLGAAVINADDPAAARLLAALPRGL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 499 PVVTFAmENTKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVP 578
Cdd:PRK11929 262 KVGYSP-QNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVP 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 579 GRCELIDEE---QAFGVIVDHANTPDGLSRLLDSIRELK---PRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSD 652
Cdd:PRK11929 341 GRMERVGPTagaQGPLVVVDYAHTPDALAKALTALRPVAqarNGRLVCVFGCGGDRDKGKRPEMGRIAAELADRVVVTSD 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 653 NPRNEDPLDILDDMLSGIGWTMQeylkhgehdyypplanghrLFLHDIRRVAVRCAVAMGEEGDMVVVAGKGHEAYQLEG 732
Cdd:PRK11929 421 NPRSEAPEAIIDQILAGIPAGAR-------------------VFVISDRAEAIRQAIWMAAPGDVILIAGKGHETYQEIG 481

                        490
                 ....*....|....*..
gi 240254313 733 EKKEFYDDREECREALQ 749
Cdd:PRK11929 482 GRKLFFDDREWARRALL 498
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
258-734 7.76e-63

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 218.37  E-value: 7.76e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 258 YGDLDVEITGIQHDSRGVSAGDLFVCCLG--SENFLSEADKRGAVAVVASKEIDIEDTLgcralVIVEDTNAVLAALASS 335
Cdd:PRK14022  27 YNYSGVQFDDISYDSRTADEGTLFFAKGAyfKHKFLQNAITQGLKLYVSEKDYEVGIPQ-----VIVPDIKKAMSLIAME 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 336 FYRHPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGvRTGMFSTVSCYIHGDNKLDTPNATmnPDAVLVQSLMAKMLHNGT 415
Cdd:PRK14022 102 FYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLH-KPAMLSTMNTTLDGETFFKSALTT--PESLDLFKMMAEAVDNGM 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 416 ESLVMEASPQELALGKCDEVDFDIAVFTNLTRENTDF--RGTDEEYRDAEAKLF--SRMVdperhrkVVNIDDPNAAFFV 491
Cdd:PRK14022 179 THLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLLMenSKAV-------VVNSDMDHFSELL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 492 QQGNPnVPVVTFAM--ENTKADVHPLKFELSLfetqvlvnTPQGILEISsgLLGRHNIYNILAAvavGIAV---GAPLED 566
Cdd:PRK14022 252 EQVTP-QEHDFYGIdsENQIMASNAFSFEATG--------KLAGTYDIQ--LIGKFNQENAMAA---GLAClrlGASLED 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 567 IVRGVEEvDAVPGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDV 646
Cdd:PRK14022 318 IQKGIAQ-TPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYL 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 647 T-MLTSDNPRNEDPLDILDDMLSGIGWTMQEYLKHGEhdyypplanghrlflhdirrvAVRCAVAMGE-EGDMVVVAGKG 724
Cdd:PRK14022 397 QvILTADDPNNEDPKMITQEIASHITHPVEIIDDRAE---------------------AIKHAMSITEgPGDAVIIAGKG 455

                        490
                 ....*....|.
gi 240254313 725 HEAYQ-LEGEK 734
Cdd:PRK14022 456 ADAYQiVPGHR 466
Mur_ligase_M pfam08245
Mur ligase middle domain;
360-557 1.42e-41

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 150.53  E-value: 1.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  360 YLIKSLYEAMGvrtGMFSTVscyihGDNKLDTPNATmnPDAVLVQSLMAKMLHNGTESLVMEASPQELALGK-CDEVDFD 438
Cdd:pfam08245  12 ELIAAILSLAG---GVIGTI-----GTYIGKSGNTT--NNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRlSGLLKPD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  439 IAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQ-GNPNVPVVTFAMENtKADVHPLKF 517
Cdd:pfam08245  82 IAVFTNISPDHLDFHGTMENYAKAKAELFEGL--PEDGIAVINADDPYGAFLIAKlKKAGVRVITYGIEG-EADLRAANI 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 240254313  518 ELSLFETQV-LVNTPQGILEISSGLLGRHNIYNILAAVAVG 557
Cdd:pfam08245 159 ELSSDGTSFdLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 240-623 2.83e-32

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 130.61  E-value: 2.83e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 240 KMCLAELLDeskVVPISVYGDLDVEITGIQHDSRGVSAGDLFVCcLGSEN-----FLSEADKRGAVAVVASKEIDIEDtl 314
Cdd:COG0770    2 LLTLAEIAE---ATGGRLIGDPDLVVTGVSTDSRKIKPGDLFVA-LKGERfdghdFVAQALAKGAAAALVSRPLPADL-- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 315 gcrALVIVEDTNAVLAALASsFYRHPSkNMSVIgvtgtdgkttttylikslyeamGVrTG-----------------MFS 377
Cdd:COG0770   76 ---PLIVVDDTLKALQQLAA-AHRARF-NIPVI----------------------AI-TGsngktttkemlaavlstKGK 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 378 TVScyihgdnkldTP---N---------ATMNPDavlvqslmakmlhngTESLVMEAS---PQELA-LgkCDEVDFDIAV 441
Cdd:COG0770  128 VLA----------TPgnfNneigvpltlLRLPED---------------HEFAVLEMGmnhPGEIAyL--ARIARPDIAV 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 442 FTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQGNPNVpvVTFAMENtKADVHPLKFELSL 521
Cdd:COG0770  181 ITNIGPAHLEGFGSLEGIARAKGEIFEGL--PPGGVAVLNADDPLLAALAERAKARV--LTFGLSE-DADVRAEDIELDE 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 522 FETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDEEQAFGVIVD--HANt 599
Cdd:COG0770  256 DGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDsyNAN- 334

                        410       420
                 ....*....|....*....|....*.
gi 240254313 600 PDGLSRLLDSIRELKP--RRIItVIG 623
Cdd:COG0770  335 PDSMKAALDVLAQLPGggRRIA-VLG 359
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 270-623 2.52e-28

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 118.52  E-value: 2.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  270 HDSRGVSAGDLFVCCLGSE----NFLSEADKRGAVAVVASKEIDIEDTLgcrALVIVEDTNAVLAALASSFYRHPS---- 341
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERfdghDFVEQALAAGAVAVVVDREVGPDNGL---PQILVDDTLEALQALARAKRAKFSgkvi 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  342 -----------KNMsvigvtgtdgkttttyliksLYEAMGVRTGMFSTvscyihgdnkldtpNATMNPDAVLVQSLMakM 410
Cdd:TIGR01143  78 gitgssgktttKEM--------------------LAAILSHKYKVFAT--------------PGNFNNEIGLPLTLL--R 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  411 LHNGTESLVME--AS-PQELALgKCDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNA 487
Cdd:TIGR01143 122 APGDHDYAVLEmgAShPGEIAY-LAEIAKPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQGL--KENGIAVINADDPAF 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  488 AFFvQQGNPNVPVVTFAMENtkADVHPLKFELSLF-ETQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLED 566
Cdd:TIGR01143 199 ADL-AKRLPNRNILSFGFEG--GDFVAKDISYSALgSTSFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEE 275

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 240254313  567 IVRGVEEVDAVPGRCElIDEEQAFGVIVDHAN-TPDGLSRLLDSIRELKPRRIItVIG 623
Cdd:TIGR01143 276 IAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNaNPDSMRAALDALARFPGKKIL-VLG 331
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 217-627 9.12e-20

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 94.77  E-value: 9.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 217 DHQFEFDlDDFGESKARIVEPKFKMCLAELLDESKVVPIsvyGDLDVEITGIQHDSRGVSAGDLFVCCLGsEN-----FL 291
Cdd:PRK11929 482 GRKLFFD-DREWARRALLARISSTLIKLRAAKGGSNSLQ---INSLPHAGAVSTDSRSVGRGELFVALRG-ENfdghdYL 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 292 SEADKRGAVAVVASKEIDIEDTLGcralVIVEDTNAVLAALASSFYRHPSKnmSVIGVTGTDGKTTTTYLIKslyeamgv 371
Cdd:PRK11929 557 PQAFAAGACAAVVERQVADVDLPQ----IVVDDTRAALGRLATAWRARFSL--PVVAITGSNGKTTTKEMIA-------- 622

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 372 rtgmfSTVSCYIHGDNKLDTPnATMNPDAVLVQSLMAkmLHNGTESLVMeaspqELALGKCDEVDF-------DIAVFTN 444
Cdd:PRK11929 623 -----AILAAWQGEDRVLATE-GNFNNEIGVPLTLLR--LRAQHRAAVF-----ELGMNHPGEIAYlaaiaapTVALVTN 689

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 445 LTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQGNPNVpVVTFAMeNTKADVHPLKF--ELSLF 522
Cdd:PRK11929 690 AQREHQEFMHSVEAVARAKGEIIAAL--PEDGVAVVNGDDPYTAIWAKLAGARR-VLRFGL-QPGADVYAEKIakDISVG 765

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 523 E---TQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDEEQAFGVIVDHANT 599
Cdd:PRK11929 766 EaggTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTYNA 845

                        410       420
                 ....*....|....*....|....*....
gi 240254313 600 -PDGLSRLLDSIRELKPRRIITVIGCEGE 627
Cdd:PRK11929 846 nPDSMRAAIDVLAELPNGPRALVLGDMLE 874
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 577-663 5.18e-18

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 79.31  E-value: 5.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  577 VPGRCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRN 656
Cdd:pfam02875   1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYPRA 80


                  ....*..
gi 240254313  657 EDPLDIL 663
Cdd:pfam02875  81 EDPGAII 87
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 438-621 4.95e-17

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 84.35  E-value: 4.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 438 DIAVFTNLTRENTDFRGTDEEYRDAeaklFSRMVD--PERHRKVVNIDDPNAAFFVQQgnPNVPVVTFAmENTKADVHPL 515
Cdd:COG0773  173 DIAVVTNIEADHLDIYGDLEAIKEA----FHEFARnvPFYGLLVLCADDPGLRELLPR--CGRPVITYG-FSEDADYRAE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 516 KFELSLFETQVLVNTP-QGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDEEQAFGVIV 594
Cdd:COG0773  246 NIRIDGGGSTFDVLRRgEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVID 325

                        170       180
                 ....*....|....*....|....*...
gi 240254313 595 DHANTPDGLSRLLDSIRELKP-RRIITV 621
Cdd:COG0773  326 DYAHHPTEIAATLAAAREKYPdRRLVAV 353
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 432-586 6.06e-17

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 83.98  E-value: 6.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 432 CDEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAFFVQQGNPNVpvVTFAMEntkad 511
Cdd:COG0771  169 TPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQ--TPDDYAVLNADDPLTRALAEEAKARV--VPFSLK----- 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 240254313 512 vHPLKFELSLFETQVLVNTP-QGILEISS-GLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDE 586
Cdd:COG0771  240 -EPLEGGAGLEDGKLVDRASgEELLPVDDlRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAE 315
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 410-599 9.41e-13

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 70.83  E-value: 9.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  410 MLHNGTESLVMEASPQELALGKcdEVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvdPERHRKVVNIDDPNAAF 489
Cdd:TIGR01087 145 LDQEGAELYVLELSSFQLETTE--SLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQ--TEGDVAVLNADDPRFAR 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  490 FVQQGNPNVpvVTFAMENtkadvhPLKFELSLFETQVLVntPQGILEISsgLLGRHNIYNILAAVAVGIAVGAPLEDIVR 569
Cdd:TIGR01087 221 LAQKSKAQV--IWFSVEK------DAERGLCIRDGGLYL--KPNDLEGS--LLGLHNAENILAAIALAKSLGLNLEAILE 288

                         170       180       190
                  ....*....|....*....|....*....|
gi 240254313  570 GVEEVDAVPGRCELIDEEQAFGVIVDHANT 599
Cdd:TIGR01087 289 ALRSFKGLPHRLEYVGQKNGVHFYNDSKAT 318
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 524-580 2.67e-12

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 69.67  E-value: 2.67e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 240254313 524 TQVLVNTPQGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGR 580
Cdd:PRK10773 261 TEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGR 317
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 264-337 7.19e-11

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 58.78  E-value: 7.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  264 EITGIQHDSRGVSAGDLFVCCLGSE----NFLSEADKRGAVAVVASKE-----IDIEDTLGCRALVI-VEDTNAVLAALA 333
Cdd:pfam01225   1 EIHFVGIDGRGMSPGALFLALKGYRvdgsDFIESLIALGAAAVVGHDAannisPDNPELEAAKVPGIpVIDRREALAELA 80


                  ....
gi 240254313  334 SSFY 337
Cdd:pfam01225  81 AAFY 84
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 355-622 2.27e-08

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 57.32  E-value: 2.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  355 KTTTTYLIKSLYEAMGvrtgmfstvscyihgdnkLDTpnatmnpdAVLVQSLMAKMLHN----GTESLVMEAspqelalg 430
Cdd:TIGR01082 110 KTTTTAMIAVILKEAG------------------LDP--------TVVVGGLVKEAGTNarlgSGEYLVAEA-------- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  431 kcDEVD--F-----DIAVFTNLTRENTDFRGTD-EEYRDAeaklFSRMVD--PERHRKVVNIDDPNAAFFVQqgNPNVPV 500
Cdd:TIGR01082 156 --DESDasFlhlqpNVAIVTNIEPDHLDTYGSSfERLKAA----FEKFIHnlPFYGLAVICADDPVLRELVP--KATEQV 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313  501 VTFAMENTKADVHPLKFELSLFETQVLVNTP-QGILEISSGLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPG 579
Cdd:TIGR01082 228 ITYGGSGEDADYRAENIQQSGAEGKFSVRGKgKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKR 307

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 240254313  580 RCELIDEEQAFGVIVDHANTPDGLSRLLDSIRELKP-RRIITVI 622
Cdd:TIGR01082 308 RFEILGEFGGVLLIDDYAHHPTEIKATLKAARQGYPdKRIVVVF 351
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 439-612 2.34e-06

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 50.74  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 439 IAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMvDPERHrKVVNIDDPNAAFFVQQGNPNVpvVTFAMENtkadvhplKFE 518
Cdd:PRK14106 179 VGCILNITPDHLDRHKTMENYIKAKARIFENQ-RPSDY-TVLNYDDPRTRSLAKKAKARV--IFFSRKS--------LLE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 519 LSLF--ETQVLVNTPQGILEISS----GLLGRHNIYNILAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDEEQAFGV 592
Cdd:PRK14106 247 EGVFvkNGKIVISLGGKEEEVIDideiFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKF 326

                        170       180
                 ....*....|....*....|.
gi 240254313 593 IVDHANT-PDGLSRLLDSIRE 612
Cdd:PRK14106 327 INDSKGTnPDAAIKALEAYET 347
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 361-583 4.00e-03

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 40.52  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 361 LIKSLYEAMGVRTGMFSTVSCYIhGDNKLDTPNAT---------MNPDavlVQslmAKMLHNGTESLVMEAspqeLALGK 431
Cdd:PRK14016 497 LIAHILKLSGKRVGMTTTDGVYI-DGRLIDKGDCTgpksarrvlMNPD---VE---AAVLETARGGILREG----LAYDR 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 432 CDevdfdIAVFTNLTRENTDFRGTDEEyrDAEAKLFSRMVD---PERHrKVVNIDDPNAA-----------FFVQqgNPN 497
Cdd:PRK14016 566 CD-----VGVVTNIGEDHLGLGGINTL--EDLAKVKRVVVEavkPDGY-AVLNADDPMVAamaerckgkviFFSM--DPD 635

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254313 498 VPVV---------TFAMENTKADVHPLKFELSLFETQVLVNTPQGILeissgllgRHNIYNILAAVAVGIAVGAPLEDIV 568
Cdd:PRK14016 636 NPVIaehraqggrAVYVEGDYIVLAEGGWEIRIISLADIPLTLGGKA--------GFNIENALAAIAAAWALGIDIELIR 707

                        250
                 ....*....|....*....
gi 240254313 569 RGVE----EVDAVPGRCEL 583
Cdd:PRK14016 708 AGLRtfvsDAAQAPGRFNL 726
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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