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Conserved domains on  [gi|15219754|ref|NP_176257|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
75-327 1.88e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 1.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  75 LYVCLRFSHTGRSHRWFMLrEKNKSSGYVLAPIPIshsPSLHASSIVAVGSKIYKIGG--VMDGSSVSILDCW-----SH 147
Cdd:COG3055  25 VYVAGGLSGGSASNSFEVY-DPATNTWSELAPLPG---PPRHHAAAVAQDGKLYVFGGftGANPSSTPLNDVYvydpaTN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 148 RWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSYNpsKWMEVFDLKTETWEPVlcrSDRLTFESYHERTnnLLVDGKLY 227
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV--AWVEVYDPATGTWTQL---APLPTPRDHLAAA--VLPDGKIL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 228 IFWADKGVVYNPKDDTWDSLEVPEMDMCLTLFYCCVIENVLYDFFYEELDIkwYDTKARTWRSL--LNGMRElhkfvRHA 305
Cdd:COG3055 174 VIGGRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA--YDPATNTWTALgeLPTPRH-----GHA 246

                       250       260
                ....*....|....*....|..
gi 15219754 306 SVTladYGGKMvmfwdkFVASG 327
Cdd:COG3055 247 AVL---TDGKV------YVIGG 259
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 21-65 2.42e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.52  E-value: 2.42e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15219754  21 LIPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
75-327 1.88e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 1.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  75 LYVCLRFSHTGRSHRWFMLrEKNKSSGYVLAPIPIshsPSLHASSIVAVGSKIYKIGG--VMDGSSVSILDCW-----SH 147
Cdd:COG3055  25 VYVAGGLSGGSASNSFEVY-DPATNTWSELAPLPG---PPRHHAAAVAQDGKLYVFGGftGANPSSTPLNDVYvydpaTN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 148 RWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSYNpsKWMEVFDLKTETWEPVlcrSDRLTFESYHERTnnLLVDGKLY 227
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV--AWVEVYDPATGTWTQL---APLPTPRDHLAAA--VLPDGKIL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 228 IFWADKGVVYNPKDDTWDSLEVPEMDMCLTLFYCCVIENVLYDFFYEELDIkwYDTKARTWRSL--LNGMRElhkfvRHA 305
Cdd:COG3055 174 VIGGRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA--YDPATNTWTALgeLPTPRH-----GHA 246

                       250       260
                ....*....|....*....|..
gi 15219754 306 SVTladYGGKMvmfwdkFVASG 327
Cdd:COG3055 247 AVL---TDGKV------YVIGG 259
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 21-65 2.42e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.52  E-value: 2.42e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15219754  21 LIPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
PHA03098 PHA03098
kelch-like protein; Provisional
 119-288 6.65e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 6.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  119 SIVAVGSKIYKIGGVMDGSSVSILDCWSH---RWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSYNpSKWMEVFDLKT 195
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPgesKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDEL-LKTVECFSLNT 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  196 ETWEPVLCRSDRLTFESYHERTNNL-LVDGKLYIfwADKGVV-----YNPKDDTW---DSLEVPEMDMCLTLFYCCVIen 266
Cdd:PHA03098 416 NKWSKGSPLPISHYGGCAIYHDGKIyVIGGISYI--DNIKVYnivesYNPVTNKWtelSSLNFPRINASLCIFNNKIY-- 491

                        170       180
                 ....*....|....*....|....
gi 15219754  267 VLYDFFYEEL--DIKWYDTKARTW 288
Cdd:PHA03098 492 VVGGDKYEYYinEIEVYDDKTNTW 515
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-64 3.40e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 3.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15219754    22 IPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRF 64
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 159-201 5.03e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 5.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15219754   159 RDRPSANLIDGKIYVTGGCHRGsyNPSKWMEVFDLKTETWEPV 201
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN--QSLNSVEVYDPETNTWSKL 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 2.68e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 2.68e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15219754     25 LPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch smart00612
Kelch domain;
170-201 5.44e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 15219754    170 KIYVTGGCHRGsyNPSKWMEVFDLKTETWEPV 201
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPL 30
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
75-327 1.88e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 1.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  75 LYVCLRFSHTGRSHRWFMLrEKNKSSGYVLAPIPIshsPSLHASSIVAVGSKIYKIGG--VMDGSSVSILDCW-----SH 147
Cdd:COG3055  25 VYVAGGLSGGSASNSFEVY-DPATNTWSELAPLPG---PPRHHAAAVAQDGKLYVFGGftGANPSSTPLNDVYvydpaTN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 148 RWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSYNpsKWMEVFDLKTETWEPVlcrSDRLTFESYHERTnnLLVDGKLY 227
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV--AWVEVYDPATGTWTQL---APLPTPRDHLAAA--VLPDGKIL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 228 IFWADKGVVYNPKDDTWDSLEVPEMDMCLTLFYCCVIENVLYDFFYEELDIkwYDTKARTWRSL--LNGMRElhkfvRHA 305
Cdd:COG3055 174 VIGGRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA--YDPATNTWTALgeLPTPRH-----GHA 246

                       250       260
                ....*....|....*....|..
gi 15219754 306 SVTladYGGKMvmfwdkFVASG 327
Cdd:COG3055 247 AVL---TDGKV------YVIGG 259
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 21-65 2.42e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.52  E-value: 2.42e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15219754  21 LIPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
106-247 2.40e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 66.72  E-value: 2.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 106 PIPISHSpslhasSIVAVGSKIYKIGGVMDGSSVSILDCW---SHRWLEAPSMQM-ERDRPSANLIDGKIYVTGGC--HR 179
Cdd:COG3055  10 PTPRSEA------AAALLDGKVYVAGGLSGGSASNSFEVYdpaTNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFtgAN 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15219754 180 GSYNPSKWMEVFDLKTETWEPVlcrsdrLTFESYHERTNNLLVDGKLYIF--WADKGV-----VYNPKDDTWDSL 247
Cdd:COG3055  84 PSSTPLNDVYVYDPATNTWTKL------APMPTPRGGATALLLDGKIYVVggWDDGGNvawveVYDPATGTWTQL 152
PHA03098 PHA03098
kelch-like protein; Provisional
 119-288 6.65e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 6.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  119 SIVAVGSKIYKIGGVMDGSSVSILDCWSH---RWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSYNpSKWMEVFDLKT 195
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPgesKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDEL-LKTVECFSLNT 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  196 ETWEPVLCRSDRLTFESYHERTNNL-LVDGKLYIfwADKGVV-----YNPKDDTW---DSLEVPEMDMCLTLFYCCVIen 266
Cdd:PHA03098 416 NKWSKGSPLPISHYGGCAIYHDGKIyVIGGISYI--DNIKVYnivesYNPVTNKWtelSSLNFPRINASLCIFNNKIY-- 491

                        170       180
                 ....*....|....*....|....
gi 15219754  267 VLYDFFYEEL--DIKWYDTKARTW 288
Cdd:PHA03098 492 VVGGDKYEYYinEIEVYDDKTNTW 515
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
149-335 2.01e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.86  E-value: 2.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 149 WLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSynPSKWMEVFDLKTETWEPVlcrsDRLTFESYHErTNNLLVDGKLYI 228
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGS--ASNSFEVYDPATNTWSEL----APLPGPPRHH-AAAVAQDGKLYV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 229 F---------WA--DKGVVYNPKDDTWDslEVPEMDMCLTLFYCCVIENVLYDF--FYEELDIKW---YDTKARTWRSL- 291
Cdd:COG3055  76 FggftganpsSTplNDVYVYDPATNTWT--KLAPMPTPRGGATALLLDGKIYVVggWDDGGNVAWvevYDPATGTWTQLa 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15219754 292 -LNGMRElhkfvrHASVTLAdYGGKMVmfwdkfVASG-DGLGFHKT 335
Cdd:COG3055 154 pLPTPRD------HLAAAVL-PDGKIL------VIGGrNGSGFSNT 186
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-64 3.40e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 3.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15219754    22 IPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRF 64
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PHA03098 PHA03098
kelch-like protein; Provisional
 104-201 2.69e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.38  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  104 LAPIPISHSpslhASSIVAVGSKIYKIGG------VMDGSSVSILDCWSHRWLEAPSMQMERDRPSANLIDGKIYVTGGC 177
Cdd:PHA03098 421 GSPLPISHY----GGCAIYHDGKIYVIGGisyidnIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD 496

                         90       100
                 ....*....|....*....|....
gi 15219754  178 HRGSYNpsKWMEVFDLKTETWEPV 201
Cdd:PHA03098 497 KYEYYI--NEIEVYDDKTNTWTLF 518
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 24-63 2.92e-06

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 43.75  E-value: 2.92e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15219754  24 SLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSgEIYR 63
Cdd:cd22143   4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLALP-ELWR 42
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 159-201 5.03e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 5.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15219754   159 RDRPSANLIDGKIYVTGGCHRGsyNPSKWMEVFDLKTETWEPV 201
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN--QSLNSVEVYDPETNTWSKL 42
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 22-63 6.95e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.86  E-value: 6.95e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15219754    22 IPSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYR 63
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWR 42
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 24-57 2.12e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.89  E-value: 2.12e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 15219754  24 SLPEELILSILARVSRLSYRSLSLVCKRFHSLLT 57
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 2.68e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 2.68e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15219754     25 LPEELILSILARVSRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 22-55 1.37e-04

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 38.99  E-value: 1.37e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15219754  22 IPSLPEELILSILARVSRLSYR-SLSLVCKRFHSL 55
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRnSCSLVCKRWYRL 35
PHA02790 PHA02790
Kelch-like protein; Provisional
 106-176 1.79e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 43.49  E-value: 1.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15219754  106 PIPISHSPSLHASSIVAvGSKIYKIGGVMDGSSVsilDCWSH---RWLEAPSMQMERDRPSANLIDGKIYVTGG 176
Cdd:PHA02790 301 PIPPMNSPRLYASGVPA-NNKLYVVGGLPNPTSV---ERWFHgdaAWVNMPSLLKPRCNPAVASINNVIYVIGG 370
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 23-58 2.15e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 38.21  E-value: 2.15e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15219754  23 PSLPEELILSILARVSRLSYRSLSLVCKRFHSLLTS 58
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
104-192 2.41e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 42.45  E-value: 2.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754 104 LAPIPISHSpslhASSIVAVGSKIYKIGGVMDGSS-VSILDCWSHRWLEAPSMQMERDRPSANLIDGKIYVTGGCHRGSY 182
Cdd:COG3055 190 LAPLPTARA----GHAAAVLGGKILVFGGESGFSDeVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGV 265

                        90
                ....*....|..
gi 15219754 183 NPSKW--MEVFD 192
Cdd:COG3055 266 RTPLVtsAEVYD 277
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 119-156 5.06e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 5.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15219754   119 SIVAVGSKIYKIGGVMDG---SSVSILDCWSHRWLEAPSMQ 156
Cdd:pfam01344   6 GVVVVGGKIYVIGGFDGNqslNSVEVYDPETNTWSKLPSMP 46
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 23-63 3.37e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 35.30  E-value: 3.37e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15219754  23 PSLPEELILSILarvSRLSYRSLS---LVCKRFHSLLTSGEIYR 63
Cdd:cd22139   2 LCLPDELWLHIF---SFLSPKDLCqvaLVCRRFNRLASDESLWK 42
PHA03098 PHA03098
kelch-like protein; Provisional
 118-245 4.23e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.98  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15219754  118 SSIVAVGSKIYKIGGVMDG----SSVSILDCWSHRWLEAPSMQMERDRPSANLIDGKIYVTGG-CHRGSYNPSKWMEVFD 192
Cdd:PHA03098 383 PCVVNVNNLIYVIGGISKNdellKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGiSYIDNIKVYNIVESYN 462

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15219754  193 LKTETWepvlcrsdrlTFESY--HERTNNLL--VDGKLYIFWADKGV-------VYNPKDDTWD 245
Cdd:PHA03098 463 PVTNKW----------TELSSlnFPRINASLciFNNKIYVVGGDKYEyyineieVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
170-201 5.44e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 15219754    170 KIYVTGGCHRGsyNPSKWMEVFDLKTETWEPV 201
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPL 30
F-box_FBXW9 cd22135
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ...
 24-65 5.50e-03

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438907  Cd Length: 45  Bit Score: 34.56  E-value: 5.50e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15219754  24 SLPEELILSILARV-SRLSYRSLSLVCKRFHSLLTSGEIYRFR 65
Cdd:cd22135   3 SLPPELLLHICSYLdARFVLHVLPLVCKTFRDILSDETTWRIR 45
Kelch_6 pfam13964
Kelch motif;
159-201 7.22e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 7.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15219754   159 RDRPSANLIDGKIYVTGGCHRGSyNPSKWMEVFDLKTETWEPV 201
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNAS-PALNKLEVYNPLTKSWEEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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