BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 163 YTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQ-NEDFLIHrlaLLQ 240
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYtGELElSEENVEE---LLA 77

                ....*
gi 15222771 241 AAEKY 245
Cdd:cd18186  78 AADKL 82

hypothetical protein; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15222771  151 VTSLGRMLTESIYTDITINASDGS-IGAHRAVLAARSPVFRSMFLHDLKEKEL-SEINVLDMPLDACQAFLSYIY 223
Cdd:PHA02713  13 VSNISNLLDDDILCDVIITIGDGEeIKAHKTILAAGSKYFRTLFTTPMIIRDLvTRVNLQMFDKDAVKNIVQYLY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 163 YTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQ-NEDFLIHrlaLLQ 240
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYtGELElSEENVEE---LLA 77

                ....*
gi 15222771 241 AAEKY 245
Cdd:cd18186  78 AADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQNedfl 232
Cdd:cd18279   9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYtGKAPN---- 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15222771 233 IHRLA--LLQAAEKYDIADLKEACHLSLLDDIDTKN 266
Cdd:cd18279  85 LDKMAddLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNiQNEDFLI 233
Cdd:cd18344  14 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTG-KAPHLHS 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15222771 234 HRLA--LLQAAEKYDIADLKEACHLSLLDDIDTKN 266
Cdd:cd18344  93 HSMAcdVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 165 DITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQnedflihrlallqaae 243
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYsGRIA---------------- 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15222771 244 kydiadlkeachlsllddIDTKNVLERLQNAYLYQLPELKASCMRYLVK 292
Cdd:cd18247  85 ------------------IDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGN--IQNEDF 231
Cdd:cd18280   5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDelPDDVEP 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 15222771 232 LIHRLA---------LLQAAEKYDIADLKEAC 254
Cdd:cd18280  85 AGSDSSsldttmaqhLLAAADRYALERLRLLC 116

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 156 RMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNIQNEDFLIHR 235
Cdd:cd18286  10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVNL 89

                        90       100
                ....*....|....*....|....*..
gi 15222771 236 LALLQAAEKYDIADLKEACHLSLLDDI 262
Cdd:cd18286  90 GELLSLADMYGLDGLKDVVAYTLRRDY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 153 SLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQ---- 227
Cdd:cd18287  12 DIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRLTltdl 91

                        90       100
                ....*....|....*....|....*.
gi 15222771 228 NEDFLIHRLALlqaAEKYDIADLKEA 253
Cdd:cd18287  92 KEDVLLDVLGL---AHQYGFEELEAA 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 159 TESIYTDITINASDGSI-GAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYG--------NIQne 229
Cdd:cd18252  17 LDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTsqiciterNVQ-- 94

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15222771 230 dflihrlALLQAAEKYDIADLKEACHLSLLDDIDTKNVL 268
Cdd:cd18252  95 -------SLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 162 IYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYG-NIQ-NEDfliHRLALL 239
Cdd:cd18265  22 TFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGgGLRiQED---NVESVL 98

                        90
                ....*....|....*
gi 15222771 240 QAAEKYDIADLKEAC 254
Cdd:cd18265  99 EASDLLQVSKLREAC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 153 SLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQNEDF 231
Cdd:cd18237  11 VMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYtARISVNSN 90

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15222771 232 LIHrlALLQAAEKYDIADLKEACHLSLLDDIDTKNVL 268
Cdd:cd18237  91 NVQ--SLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 151 VTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY------- 223
Cdd:cd18253   6 LQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYtgkvkit 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15222771 224 -GNIQnedflihrlALLQAAEKYDIADLKEACHLSLLDDIDTKN 266
Cdd:cd18253  86 tENVQ---------YLFETSSLFQISPLRDACAKFLEEQLDPCN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 151 VTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEIN--------VLDMPLDAcqAFLSYI 222
Cdd:cd18254  10 LTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNfhdslhpeVLELLLDF--AYSSRI 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15222771 223 YGNIQNEDflihrlALLQAAEKYDIADLKEACHLSLLDDIDTKNVL 268
Cdd:cd18254  88 IINEENAE------SLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 149 TAVTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEIN--------VLDMPLDacQAFLS 220
Cdd:cd18267  26 SVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNfhdsihpeVLELLLD--YAYSS 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15222771 221 YIYGNIQNEDflihrlALLQAAEKYDIADLKEACHLSLLDDIDTKNVL 268
Cdd:cd18267 104 RVIINEENAE------SLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 160 ESIYTDITINASDG-SIGAHRAVLAARSPVFRSMFLHDLKEK-------ELSE-INVLDMPLDACQAFLSYIY-GNIqne 229
Cdd:cd18310  15 DLFYSDAEIIVEGGrPVPVHRCILAARSPFFRDIFASAKAEGantkpklELRElIPGGIVGYDAFMLVLSYLYsGRL--- 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15222771 230 dflihRLALLQAAEKYDiadlKEACHLSLLDDIDTknVLERLQNAYLYQLPELKASCMRYLVKF 293
Cdd:cd18310  92 -----RLVPKEGSACVD----SDCWHVACRPAVDF--ALEVLYAASVFQIPELVSLFQRRLLDF 144

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 150 AVTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQ- 227
Cdd:cd18235   8 AFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYtAEIQv 87

                        90       100
                ....*....|....*....|....*..
gi 15222771 228 NEDfliHRLALLQAAEKYDIADLKEAC 254
Cdd:cd18235  88 TEE---NVQVLLPAANLLQLTDVRDAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 153 SLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHD-LKEKELSEInVLDMPlDACQA----FLSYIY-GNI 226
Cdd:cd18292   7 DIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEI-ELVED-PECAAvfekFLRYLYtGQI 84

                        90       100       110
                ....*....|....*....|....*....|.
gi 15222771 227 QnedflIHR---LALLQAAEKYDIADLKEAC 254
Cdd:cd18292  85 S-----VNLetaLPLLMLADKYNVTDLKQLC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 174 SIGAHRAVLAARSPVFRSMFLHDLKEKElSEINVLDMPLDACQAFLSYIYGN-IQNE-DfliHRLALLQAAEKYDIADLK 251
Cdd:cd18282  22 RIPAHKYVLATGSSVFYAMFYGGLAENK-NEIEIPDVEPAAFLNLLRYLYCDeIDLEpD---TVLATLYAAKKYLVPHLA 97

                ...
gi 15222771 252 EAC 254
Cdd:cd18282  98 RAC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 150 AVTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQN 228
Cdd:cd18338   8 AFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYtAEIQV 87

                        90       100
                ....*....|....*....|....*.
gi 15222771 229 EDFLIHrlALLQAAEKYDIADLKEAC 254
Cdd:cd18338  88 TEENVQ--VLLPAAGLLQLQDVKKTC 111

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15222771 163 YTDITINASDGSIGAHRAVLAARSPVFRSMFLhDLKEKELSEINVLDMPLDACQAFLSYIY 223
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIY 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 165 DITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY--------GNIQNedflihrl 236
Cdd:cd18249  25 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYtsqitveeGNVQT-------- 96

                        90       100       110
                ....*....|....*....|....*....|..
gi 15222771 237 aLLQAAEKYDIADLKEACHLSLLDDIDTKNVL 268
Cdd:cd18249  97 -LLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNiqnedfli 233
Cdd:cd18340  18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTS-------- 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15222771 234 hrlallqaaekyDIAdlkeachlsllddIDTKNVLERLQNAYLYQLPELKASCMRYLVK 292
Cdd:cd18340  90 ------------EIE-------------ITEQNVQDIFAAANMFQIPSIFTVCVSFLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY 223
Cdd:cd18269  18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 177 AHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQN-EDFLIHRLALLQAAEKYDIADLKEAC 254
Cdd:cd18297  26 AHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtGGVESlDVAQDDALELLRAASFFQLDGLKRHC 105

                        90
                ....*....|..
gi 15222771 255 HLSLLDDIDTKN 266
Cdd:cd18297 106 EILLSQQIDLDN 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 154 LGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNIQNEDFLI 233
Cdd:cd18360   1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIL 80

                        90       100
                ....*....|....*....|...
gi 15222771 234 HRLALLQAAEKYDIADLKEACHL 256
Cdd:cd18360  81 QAMALLICAEMYQVSRLQHICEL 103

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222771 164 TDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIY-GNIQnedfLIHRLA--LLQ 240
Cdd:cd18352  14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYtGSVD----ITNDIAkdLLR 89

                        90       100
                ....*....|....*....|....*..
gi 15222771 241 AAEKYDIADLKEACHLSLLDDIDTKNV 267
Cdd:cd18352  90 AADQYLLEGLKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15222771 177 AHRAVLAARSPVFRSMFLHDLKEKElSEINVLDMPLDACQAFLSYIYGN-IQNEDFLIhrLALLQAAEKYDIADLKEAC 254
Cdd:cd18349  26 AHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPDVEPAAFLILLKYMYSDeIDLEADTV--LATLYAAKKYIVPALAKAC 101