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Conserved domains on  [gi|15221890|ref|NP_175874|]
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AGAMOUS-like 85 [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 734)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 20-62 1.92e-15

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member cd00265:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 77  Bit Score: 66.81  E-value: 1.92e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15221890  20 ELSILCGAEVAFLGYSCSGKPYTFGSPSFQAVAERFLNREASS 62
Cdd:cd00265  33 ELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSS 75
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 20-62 1.92e-15

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 66.81  E-value: 1.92e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15221890  20 ELSILCGAEVAFLGYSCSGKPYTFGSPSFQAVAERFLNREASS 62
Cdd:cd00265  33 ELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSS 75
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
19-43 3.33e-08

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 47.42  E-value: 3.33e-08
                          10        20
                  ....*....|....*....|....*
gi 15221890    19 NELSILCGAEVAFLGYSCSGKPYTF 43
Cdd:pfam00319  24 SELSVLCGAEVAVIVFSPTGKLYTF 48
MADS smart00432
MADS domain;
19-46 3.93e-06

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 42.16  E-value: 3.93e-06
                           10        20
                   ....*....|....*....|....*...
gi 15221890     19 NELSILCGAEVAFLGYSCSGKPYTFGSP 46
Cdd:smart00432  32 HELSVLCDAEVALIVFSPTGKLYEFASP 59
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 20-62 1.92e-15

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 66.81  E-value: 1.92e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15221890  20 ELSILCGAEVAFLGYSCSGKPYTFGSPSFQAVAERFLNREASS 62
Cdd:cd00265  33 ELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSS 75
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 19-46 2.73e-10

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 52.90  E-value: 2.73e-10
                        10        20
                ....*....|....*....|....*...
gi 15221890  19 NELSILCGAEVAFLGYSCSGKPYTFGSP 46
Cdd:cd00120  32 SELSVLCDAEVAVIVFSPSGKLYEFWSS 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
19-43 3.33e-08

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 47.42  E-value: 3.33e-08
                          10        20
                  ....*....|....*....|....*
gi 15221890    19 NELSILCGAEVAFLGYSCSGKPYTF 43
Cdd:pfam00319  24 SELSVLCGAEVAVIVFSPTGKLYTF 48
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 19-55 4.58e-07

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 45.33  E-value: 4.58e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15221890  19 NELSILCGAEVAFLGYSCSGKPYTFG-SPSFQAVAERF 55
Cdd:cd00266  32 SELSTLCGAEVAVIVYSPSGKLYVFWpSSEVEGVISRF 69
MADS smart00432
MADS domain;
19-46 3.93e-06

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 42.16  E-value: 3.93e-06
                           10        20
                   ....*....|....*....|....*...
gi 15221890     19 NELSILCGAEVAFLGYSCSGKPYTFGSP 46
Cdd:smart00432  32 HELSVLCDAEVALIVFSPTGKLYEFASP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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