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Conserved domains on  [gi|145336750|ref|NP_175849|]
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resistance to peronospora parasitica protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10549656)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 229-412 2.69e-17

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 229 LRKLKNLEILDLSYNNrFNNNILPFINAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGPM-QGLTHLKK 307
Cdd:PLN00113 208 LGQMKSLKWIYLGYNN-LSGEIPYEIGGLTSLNHLDLVYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIpPSIFSLQK 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 308 LKALDLSNNVFS-SIMELqvVCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:PLN00113 286 LISLDLSDNSLSgEIPEL--VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDL 363

                        170       180
                 ....*....|....*....|....*...
gi 145336750 387 LDNNFTGFF--SFDPLANLTKLKVFKLS 412
Cdd:PLN00113 364 STNNLTGEIpeGLCSSGNLFKLILFSNS 391
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 130-174 1.51e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 39.20  E-value: 1.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145336750  130 ERVALLDFKKywmSITqesDLDYVFPTWNNDTkSDCCQWESIMCN 174
Cdd:pfam08263   4 DGQALLAFKS---SLN---DPPGALSSWNSSS-SDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 229-412 2.69e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 229 LRKLKNLEILDLSYNNrFNNNILPFINAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGPM-QGLTHLKK 307
Cdd:PLN00113 208 LGQMKSLKWIYLGYNN-LSGEIPYEIGGLTSLNHLDLVYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIpPSIFSLQK 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 308 LKALDLSNNVFS-SIMELqvVCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:PLN00113 286 LISLDLSDNSLSgEIPEL--VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDL 363

                        170       180
                 ....*....|....*....|....*...
gi 145336750 387 LDNNFTGFF--SFDPLANLTKLKVFKLS 412
Cdd:PLN00113 364 STNNLTGEIpeGLCSSGNLFKLILFSNS 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
227-406 1.80e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 227 KSLRKLKNLEILDLSYNNRfnNNILPFINAATSLTSLSLQNNSMEgPFPfEEIKDLTNLKLLDLSRNILKGPMQGLTHLK 306
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQL--TDLPEELGNLTNLKELDLSNNQIT-DLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 307 KLKALDLSNNVFSSIMELqvvCEMKNLWELDLRENKfVGQLPlCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:COG4886  229 NLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQ-LTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        170       180
                 ....*....|....*....|
gi 145336750 387 LDNNFTGFFSFDPLANLTKL 406
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTL 323
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 211-367 1.05e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 211 ELSAGLNGF-VDNVEGYKSLRKLKNLEILDLSyNNRFNNNILPFINAA-----TSLTSLSLQNNSMEGPFPF---EEIKD 281
Cdd:cd00116   85 ELDLSDNALgPDGCGVLESLLRSSSLQELKLN-NNGLGDRGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEalaKALRA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 282 LTNLKLLDLSRNILKGP-----MQGLTHLKKLKALDLSNNVFSSImELQVVCE----MKNLWELDLRENKF--VGQLPLC 350
Cdd:cd00116  164 NRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDE-GASALAEtlasLKSLEVLNLGDNNLtdAGAAALA 242

                        170       180
                 ....*....|....*....|
gi 145336750 351 LGRLN---KLRVLDLSSNQL 367
Cdd:cd00116  243 SALLSpniSLLTLSLSCNDI 262
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 130-174 1.51e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 39.20  E-value: 1.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145336750  130 ERVALLDFKKywmSITqesDLDYVFPTWNNDTkSDCCQWESIMCN 174
Cdd:pfam08263   4 DGQALLAFKS---SLN---DPPGALSSWNSSS-SDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
258-316 6.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 6.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145336750  258 TSLTSLSLQNNSME--GPFPFeeiKDLTNLKLLDLSRNILKG-PMQGLTHLKKLKALDLSNN 316
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAF---KGLSNLKVLDLSNNLLTTlSPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 229-412 2.69e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 229 LRKLKNLEILDLSYNNrFNNNILPFINAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGPM-QGLTHLKK 307
Cdd:PLN00113 208 LGQMKSLKWIYLGYNN-LSGEIPYEIGGLTSLNHLDLVYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIpPSIFSLQK 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 308 LKALDLSNNVFS-SIMELqvVCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:PLN00113 286 LISLDLSDNSLSgEIPEL--VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDL 363

                        170       180
                 ....*....|....*....|....*...
gi 145336750 387 LDNNFTGFF--SFDPLANLTKLKVFKLS 412
Cdd:PLN00113 364 STNNLTGEIpeGLCSSGNLFKLILFSNS 391
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 227-393 9.67e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 9.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 227 KSLRKLKNLEILDLSYNNR-------------------FNNN----ILPFINAATSLTSLSLQNNSMEGPFPFEEIKdLT 283
Cdd:PLN00113 350 KNLGKHNNLTVLDLSTNNLtgeipeglcssgnlfklilFSNSlegeIPKSLGACRSLRRVRLQDNSFSGELPSEFTK-LP 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 284 NLKLLDLSRNILKGPMQGLT-HLKKLKALDLSNNVFSSimELQVVCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDL 362
Cdd:PLN00113 429 LVYFLDISNNNLQGRINSRKwDMPSLQMLSLARNKFFG--GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                        170       180       190
                 ....*....|....*....|....*....|.
gi 145336750 363 SSNQLNGNLPSTFNRLESLEYLSLLDNNFTG 393
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
227-406 1.80e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 227 KSLRKLKNLEILDLSYNNRfnNNILPFINAATSLTSLSLQNNSMEgPFPfEEIKDLTNLKLLDLSRNILKGPMQGLTHLK 306
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQL--TDLPEELGNLTNLKELDLSNNQIT-DLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLT 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 307 KLKALDLSNNVFSSIMELqvvCEMKNLWELDLRENKfVGQLPlCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:COG4886  229 NLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQ-LTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        170       180
                 ....*....|....*....|
gi 145336750 387 LDNNFTGFFSFDPLANLTKL 406
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
187-414 1.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 187 ASNLKENSLLNISLLHPFEEVRSLELSAGLNGFVDNVEGYKSLRKLKNLEILDLSYNNRFNNNILPFINAATSLTSLSLQ 266
Cdd:COG4886   25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 267 NNsmegpfpfEEIKDLTNLKLLDLSRNILKGPMQGLTHLKKLKALDLSNNVFSSIMElqVVCEMKNLWELDLRENKfVGQ 346
Cdd:COG4886  105 GN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQ-LTD 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145336750 347 LPLCLGRLNKLRVLDLSSNQLNgNLPSTFNRLESLEYLSLLDNNFTGFfsFDPLANLTKLKVFKLSST 414
Cdd:COG4886  174 LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETLDLSNN 238
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 156-415 3.91e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 3.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 156 TWNndTKSDCCQWESIMCNPTSgRLIRLHVGASNLKENSLLNISLLhPFEEVRSLELSAGLNGFVDNVEGYKSlrklkNL 235
Cdd:PLN00113  50 NWN--SSADVCLWQGITCNNSS-RVVSIDLSGKNISGKISSAIFRL-PYIQTINLSNNQLSGPIPDDIFTTSS-----SL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 236 EILDLSyNNRFNNNILPfiNAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGPMQG-LTHLKKLKALDLS 314
Cdd:PLN00113 121 RYLNLS-NNNFTGSIPR--GSIPNLETLDLSNNMLSGEIP-NDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLA 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 315 NNVFSSIMELQvVCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSLLDNNFTGF 394
Cdd:PLN00113 197 SNQLVGQIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275

                        250       260
                 ....*....|....*....|.
gi 145336750 395 FSfDPLANLTKLKVFKLSSTS 415
Cdd:PLN00113 276 IP-PSIFSLQKLISLDLSDNS 295
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
227-416 1.23e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 227 KSLRKLKNLEILDLSYNNRfnNNILPFINAATSLTSLSLQNNSMEgPFPfEEIKDLTNLKLLDLSRNILKgPMQGLTHLK 306
Cdd:COG4886  176 EELGNLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQLT-DLP-EPLANLTNLETLDLSNNQLT-DLPELGNLT 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 307 KLKALDLSNNVFSSIMELqvvCEMKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSL 386
Cdd:COG4886  251 NLEELDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                        170       180       190
                 ....*....|....*....|....*....|
gi 145336750 387 LDNNFTGFFSFDPLANLTKLKVFKLSSTSD 416
Cdd:COG4886  328 LLLKGLLVTLTTLALSLSLLALLTLLLLLN 357
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 255-423 6.64e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 255 NAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGPMQG--LTHLKKLKALDLSNNVFSSIMELQVVcemKN 332
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKIS-SAIFRLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSIPRGSI---PN 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 333 LWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTfnrlesleylslldnnftgffsfdpLANLTKLKVFKLS 412
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS-------------------------LTNLTSLEFLTLA 196

                        170
                 ....*....|.
gi 145336750 413 STSDMLQIKTE 423
Cdd:PLN00113 197 SNQLVGQIPRE 207
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 211-367 1.05e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 211 ELSAGLNGF-VDNVEGYKSLRKLKNLEILDLSyNNRFNNNILPFINAA-----TSLTSLSLQNNSMEGPFPF---EEIKD 281
Cdd:cd00116   85 ELDLSDNALgPDGCGVLESLLRSSSLQELKLN-NNGLGDRGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEalaKALRA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 282 LTNLKLLDLSRNILKGP-----MQGLTHLKKLKALDLSNNVFSSImELQVVCE----MKNLWELDLRENKF--VGQLPLC 350
Cdd:cd00116  164 NRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDE-GASALAEtlasLKSLEVLNLGDNNLtdAGAAALA 242

                        170       180
                 ....*....|....*....|
gi 145336750 351 LGRLN---KLRVLDLSSNQL 367
Cdd:cd00116  243 SALLSpniSLLTLSLSCNDI 262
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-341 2.12e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 229 LRKLKNLEILDLSYNN--RFNNnilpfINAATSLTSLSLQNNSMEGPFPFEE----IKDLTN-LKLLDLSRNILKGpMQG 301
Cdd:cd21340   64 LENLVNLKKLYLGGNRisVVEG-----LENLTNLEELHIENQRLPPGEKLTFdprsLAALSNsLRVLNISGNNIDS-LEP 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145336750 302 LTHLKKLKALDLSNNVFSSIMEL-QVVCEMKNLWELDLREN 341
Cdd:cd21340  138 LAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 263-373 5.37e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.13  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 263 LSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNILKGpmqglthlkklkALDLSnnvFSSIMELQVvcemknlweLDLRENK 342
Cdd:PLN03150 423 LGLDNQGLRGFIP-NDISKLRHLQSINLSGNSIRG------------NIPPS---LGSITSLEV---------LDLSYNS 477

                         90       100       110
                 ....*....|....*....|....*....|.
gi 145336750 343 FVGQLPLCLGRLNKLRVLDLSSNQLNGNLPS 373
Cdd:PLN03150 478 FNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508
PLN03150 PLN03150
hypothetical protein; Provisional
 215-297 5.76e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 5.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 215 GLNGFVDNvegykSLRKLKNLEILDLSyNNRFNNNILPFINAATSLTSLSLQNNSMEGPFPfEEIKDLTNLKLLDLSRNI 294
Cdd:PLN03150 429 GLRGFIPN-----DISKLRHLQSINLS-GNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLRILNLNGNS 501


                 ...
gi 145336750 295 LKG 297
Cdd:PLN03150 502 LSG 504
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-367 4.91e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750 229 LRKLKNLEILDLsYNNRFNNniLPFINAATSLTSLSLQNNsmegpfpfeeikdltnlklldlsrNILKgpMQGLTHLKKL 308
Cdd:cd21340   20 LSLCKNLKVLYL-YDNKITK--IENLEFLTNLTHLYLQNN------------------------QIEK--IENLENLVNL 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145336750 309 KALDLSNNVFSSIMELQvvcEMKNLWELDLRENKFVGQLPLC------LGRLNKLRVLDLSSNQL 367
Cdd:cd21340   71 KKLYLGGNRISVVEGLE---NLTNLEELHIENQRLPPGEKLTfdprslAALSNSLRVLNISGNNI 132
PLN03150 PLN03150
hypothetical protein; Provisional
 330-393 8.93e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 8.93e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145336750 330 MKNLWELDLRENKFVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSLLDNNFTG 393
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 130-174 1.51e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 39.20  E-value: 1.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145336750  130 ERVALLDFKKywmSITqesDLDYVFPTWNNDTkSDCCQWESIMCN 174
Cdd:pfam08263   4 DGQALLAFKS---SLN---DPPGALSSWNSSS-SDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
258-316 6.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 6.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145336750  258 TSLTSLSLQNNSME--GPFPFeeiKDLTNLKLLDLSRNILKG-PMQGLTHLKKLKALDLSNN 316
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAF---KGLSNLKVLDLSNNLLTTlSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 228-275 2.80e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 2.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 145336750 228 SLRKLKNLEILDLSYNnRFNNNILPFINAATSLTSLSLQNNSMEGPFP 275
Cdd:PLN03150 461 SLGSITSLEVLDLSYN-SFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
283-367 3.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336750  283 TNLKLLDLSRNILKG-PMQGLTHLKKLKALDLSNNVFSSImelqvvcemknlweldlrenkfvgqLPLCLGRLNKLRVLD 361
Cdd:pfam13855   1 PNLRSLDLSNNRLTSlDDGAFKGLSNLKVLDLSNNLLTTL-------------------------SPGAFSGLPSLRYLD 55


                  ....*.
gi 145336750  362 LSSNQL 367
Cdd:pfam13855  56 LSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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