RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).

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gi 15217947 176 DFGSRMSNI------------NFGPVLSVRIPNQKEQVYGFVSFANAETVTTILDQENPHLIGESPVNVT 233
Cdd:cd12458   1 IYLTFPAESsfteedvstyfsSFGPVQDVRIPYQQKRMFGFVTFANAETVKTILAEGNPHFICDSRVLVK 70

RNA recognition motif (RRM) found in Arabidopsis thaliana zinc finger CCCH domain-containing protein 46 (AtC3H46) and similar proteins; This subfamily corresponds to the RRM domain in AtC3H46, a putative RNA-binding protein that contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a CCCH class of zinc finger, typically C-X8-C-X5-C-X3-H. It may possess ribonuclease activity.

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gi 15217947 176 DFGSRMSNI------------NFGPVLSVRIPNQKEQVYGFVSFANAETVTTILDQENPHLIGESPVNVT 233
Cdd:cd12458   1 IYLTFPAESsfteedvstyfsSFGPVQDVRIPYQQKRMFGFVTFANAETVKTILAEGNPHFICDSRVLVK 70

RNA recognition motif (RRM) found in Arabidopsis thaliana zinc finger CCCH domain-containing protein 46 (AtC3H46) and similar proteins; This subfamily corresponds to the RRM domain in AtC3H46, a putative RNA-binding protein that contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a CCCH class of zinc finger, typically C-X8-C-X5-C-X3-H. It may possess ribonuclease activity.

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gi 15217947 176 DFGSRMSNI------------NFGPVLSVRIPNQKEQVYGFVSFANAETVTTILDQENPHLIGESPVNVT 233
Cdd:cd12458   1 IYLTFPAESsfteedvstyfsSFGPVQDVRIPYQQKRMFGFVTFANAETVKTILAEGNPHFICDSRVLVK 70

RNA recognition motif (RRM) found in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE; This subfamily corresponds to the RRM domain of two Deleted in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE. BOULE is the founder member of the family and DAZL arose from BOULE in an ancestor of vertebrates. The DAZ gene subsequently originated from a duplication transposition of the DAZL gene. Invertebrates contain a single DAZ homolog, BOULE, while vertebrates, other than catarrhine primates, possess both BOULE and DAZL genes. The catarrhine primates possess BOULE, DAZL, and DAZ genes. The family members encode closely related RNA-binding proteins that are required for fertility in numerous organisms. These proteins contain an RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a varying number of copies of a DAZ motif, believed to mediate protein-protein interactions. DAZL and BOULE contain a single copy of the DAZ motif, while DAZ proteins can contain 8-24 copies of this repeat. Although their specific biochemical functions remain to be investigated, DAZL proteins may interact with poly(A)-binding proteins (PABPs), and act as translational activators of specific mRNAs during gametogenesis.

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gi 15217947 186 FGPVLSVRIPNQKEQV---YGFVSFANAETVTTILDQENPHLIGESPVNVTAA 235
Cdd:cd12412  26 FGKVKDVKIIKDRAGVskgYGFVTFETQEDAEKIQKWGANLVFKGKKLNVGPA 78