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Conserved domains on  [gi|22330150|ref|NP_175446|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 200-442 1.01e-72

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 230.45  E-value: 1.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   200 EWWFEDMTNLSPKIILKLVMIIGAykTNIKSLVLTRFLLHYLKTKLQTKSRTT----TELMRNKLEYSDLADTAVRGVIS 275
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKS--KGMKPEVIGEALMHYAKKWLPGLSRSSsssaSRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   276 AGTrTFSCRKLFWILRVLSSFSLSRESRIGLETLIGEMLEQATLDDLLISARGSrESGFYNVDLvirllKVfvknreeee 355
Cdd:pfam03000  79 EKG-SVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSG-EETLYDVDL-----KV--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   356 eesrernmkeiGKLIDKYLREISPDQNLKVPKFLGVAESLPDSARDCFDGVYRAIDIYLQSHPNLTPQDRTEICRCLNYK 435
Cdd:pfam03000 143 -----------AKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQ 211


                  ....*..
gi 22330150   436 KLTMETC 442
Cdd:pfam03000 212 KLSLEAC 218
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 4-104 2.27e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 66.20  E-value: 2.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   4 LNDLKINLNGQyTFFLNQNVISKYSGSLRKMIKQSKKKRNKkkriiTIEINDFPGGPDGFELVSRFCYhNGEILIDVSNV 83
Cdd:cd18312   9 PSDITVRVGNT-TFHLHKFPLCSKSGYFKRLASSSSESDPS-----EIELNDFPGGAEAFELVAKFCY-GMPINLTATNV 81

                        90       100
                ....*....|....*....|.
gi 22330150  84 STLYCCSVFLGMSEKFCFSNL 104
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNL 102
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 200-442 1.01e-72

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 230.45  E-value: 1.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   200 EWWFEDMTNLSPKIILKLVMIIGAykTNIKSLVLTRFLLHYLKTKLQTKSRTT----TELMRNKLEYSDLADTAVRGVIS 275
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKS--KGMKPEVIGEALMHYAKKWLPGLSRSSsssaSRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   276 AGTrTFSCRKLFWILRVLSSFSLSRESRIGLETLIGEMLEQATLDDLLISARGSrESGFYNVDLvirllKVfvknreeee 355
Cdd:pfam03000  79 EKG-SVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSG-EETLYDVDL-----KV--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   356 eesrernmkeiGKLIDKYLREISPDQNLKVPKFLGVAESLPDSARDCFDGVYRAIDIYLQSHPNLTPQDRTEICRCLNYK 435
Cdd:pfam03000 143 -----------AKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQ 211


                  ....*..
gi 22330150   436 KLTMETC 442
Cdd:pfam03000 212 KLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-104 2.27e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 66.20  E-value: 2.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   4 LNDLKINLNGQyTFFLNQNVISKYSGSLRKMIKQSKKKRNKkkriiTIEINDFPGGPDGFELVSRFCYhNGEILIDVSNV 83
Cdd:cd18312   9 PSDITVRVGNT-TFHLHKFPLCSKSGYFKRLASSSSESDPS-----EIELNDFPGGAEAFELVAKFCY-GMPINLTATNV 81

                        90       100
                ....*....|....*....|.
gi 22330150  84 STLYCCSVFLGMSEKFCFSNL 104
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNL 102
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 200-442 1.01e-72

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 230.45  E-value: 1.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   200 EWWFEDMTNLSPKIILKLVMIIGAykTNIKSLVLTRFLLHYLKTKLQTKSRTT----TELMRNKLEYSDLADTAVRGVIS 275
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKS--KGMKPEVIGEALMHYAKKWLPGLSRSSsssaSRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   276 AGTrTFSCRKLFWILRVLSSFSLSRESRIGLETLIGEMLEQATLDDLLISARGSrESGFYNVDLvirllKVfvknreeee 355
Cdd:pfam03000  79 EKG-SVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSG-EETLYDVDL-----KV--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   356 eesrernmkeiGKLIDKYLREISPDQNLKVPKFLGVAESLPDSARDCFDGVYRAIDIYLQSHPNLTPQDRTEICRCLNYK 435
Cdd:pfam03000 143 -----------AKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQ 211


                  ....*..
gi 22330150   436 KLTMETC 442
Cdd:pfam03000 212 KLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-104 2.27e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 66.20  E-value: 2.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330150   4 LNDLKINLNGQyTFFLNQNVISKYSGSLRKMIKQSKKKRNKkkriiTIEINDFPGGPDGFELVSRFCYhNGEILIDVSNV 83
Cdd:cd18312   9 PSDITVRVGNT-TFHLHKFPLCSKSGYFKRLASSSSESDPS-----EIELNDFPGGAEAFELVAKFCY-GMPINLTATNV 81

                        90       100
                ....*....|....*....|.
gi 22330150  84 STLYCCSVFLGMSEKFCFSNL 104
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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