|
Name |
Accession |
Description |
Interval |
E-value |
| PRP40 |
COG5104 |
Splicing factor [RNA processing and modification]; |
185-810 |
1.72e-48 |
|
Splicing factor [RNA processing and modification];
Pssm-ID: 227435 [Multi-domain] Cd Length: 590 Bit Score: 182.59 E-value: 1.72e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 185 QSASDWQEHTSADGRKYYYNKRTKQSNWEKPLELMTPLERADASTVWKEFTTPEGKKYYYNKVTKESKWTIPEDLKLARE 264
Cdd:COG5104 12 EARSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPERKKVEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 265 QAQlasEKTSLSeagstplSHHAASSSDLAVStvtsvvpstssaltghssspiqaglavpvtrppsvapvtptsgaisdt 344
Cdd:COG5104 92 IAE---QKHDER-------SMIGGNGNDMAIT------------------------------------------------ 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 345 eattikgdnlssrgaddsnDGATAQNNEAENKEMSVNGKANlspagDKANVEEpmvyATKQEAKAAFKSLLESVNVHSDW 424
Cdd:COG5104 114 -------------------DHETSEPKYLLGRLMSQYGITS-----TKDAVYR----LTKEEAEKEFITMLKENQVDSTW 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 425 TWEQTLKEIVHDKRYGALRTLGERKQAFNEYLGQRKKVEAEERRRRQKKAREEFVKMLEECEELSSSLKWSKAMSLFEND 504
Cdd:COG5104 166 PIFRAIEELRDPRYWMVDTDPLWRKDLFKKYFENQEKDQREEEENKQRKYINEFCKMLAGNSHIKYYTDWFTFKSIFSKH 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 505 QRFKAVDRPRDREDLFDNYIVELERKEREKAAEEHRQYMADYRKFLETCDYiKAGTQWRKIQDRLEDDDR------CSCL 578
Cdd:COG5104 246 PYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGKHMGGTALGRLEEVLRSLGS-ETFIIWLLNHYVFDSVVRylknkeMKPL 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 579 EKIDRLIGFEEYILDLEKEEEELKRVEKEHVRRAERKNRDAFRTLLEEHVAAGILTAKTYWLDYCIELKDLPQYQAVASN 658
Cdd:COG5104 325 DRKDILFSFIRYVRRLEKELLSAIEERKAAAAQNARHHRDEFRTLLRKLYSEGKIYYRMKWKNAYPLIKDDPRFLNLLGR 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 659 TsGSTPKDLFEDVTEELEKQYHEDKSYVKDAMKSRKISMVSSWLFEDFKSAISE-----DLSTQQISDINLKLIYDDLVG 733
Cdd:COG5104 405 T-GSSPLDLFFDFIVDLENMYGFARRSYERETRTGQISPTDRRAVDEIFEAIAEkkeegEIKFDKVDKEDISLIVDGLIK 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 734 RVKEKEEKEARKLQRLAEEFTNLLHTFKEITVA-------SNWEDSKQLVEESQEYRSIGDE-SVSQGLFE----EYITS 801
Cdd:COG5104 484 QRNEKIQQKLQNERRILEQKKHYFWLLLQRTYTktgkpkpSTWDLASKELGESLEYKALGDEdNIRRQIFEdfkpESSAP 563
|
....*....
gi 79359944 802 LQEKAKEKE 810
Cdd:COG5104 564 TAESATANL 572
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
406-455 |
9.85e-15 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 69.02 E-value: 9.85e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 79359944 406 EAKAAFKSLLESVNVHSDWTWEQTLKEIVHDKRYGALRTLGERKQAFNEY 455
Cdd:pfam01846 1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
472-526 |
1.02e-10 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 57.97 E-value: 1.02e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 79359944 472 KKAREEFVKMLEECEELSSSLKWSKAMSLFENDQRFKAVDRPRDREDLFDNYIVE 526
Cdd:smart00441 1 EEAKEAFKELLKEHEVITPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHIEE 55
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
188-217 |
4.46e-09 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 52.53 E-value: 4.46e-09
10 20 30
....*....|....*....|....*....|
gi 79359944 188 SDWQEHTSADGRKYYYNKRTKQSNWEKPLE 217
Cdd:cd00201 2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
71-336 |
9.19e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 46.62 E-value: 9.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 71 TSSSQAVSVP---YIQTNKILT--SGSTQPQPNAPPMTGFATsGPPFSSPytfVPSSYPQQQPTSLVQ-----PNSQMHV 140
Cdd:PRK10263 327 TTATQSWAAPvepVTQTPPVASvdVPPAQPTVAWQPVPGPQT-GEPVIAP---APEGYPQQSQYAQPAvqynePLQQPVQ 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 141 AGVPPAANTWPVPVNQSTSLVSPVQQTGQQTPVAVSTDPGNLTPQSASD----WQEHTSADGRKYYYNKRTKQSNWEKPl 216
Cdd:PRK10263 403 PQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEqqstFAPQSTYQTEQTYQQPAAQEPLYQQP- 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 217 ELMTPLERADASTVWKEFTTPEGKKYYYNKVTKeskwtipedlKLAREQAQLASEKTSLSEAGSTPLSHHAASSSDLA-- 294
Cdd:PRK10263 482 QPVEQQPVVEPEPVVEETKPARPPLYYFEEVEE----------KRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVaa 551
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 79359944 295 ---VSTVTSVVPSTSSALTGHSSSPIQAGLAVPVTRPPSVAPVTP 336
Cdd:PRK10263 552 vppVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANSGGPRP 596
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
27-156 |
3.06e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 27 PAASQPFH--PYGHVPPnvqsqppqySQPIQQQQLFPVRPGQPVHITsssQAVSVPYIQTNKILTSGSTQPQPNAP-PMT 103
Cdd:pfam03154 398 PLSSLSTHhpPSAHPPP---------LQLMPQSQQLPPPPAQPPVLT---QSQSLPPPAASHPPTSGLHQVPSQSPfPQH 465
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 79359944 104 GFATSGPPF----SSPYTFVPSSYPQQQPTSLVQPNSQMHVagvpPAANTWPVPVNQ 156
Cdd:pfam03154 466 PFVPGGPPPitppSGPPTSTSSAMPGIQPPSSASVSSSGPV----PAAVSCPLPPVQ 518
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRP40 |
COG5104 |
Splicing factor [RNA processing and modification]; |
185-810 |
1.72e-48 |
|
Splicing factor [RNA processing and modification];
Pssm-ID: 227435 [Multi-domain] Cd Length: 590 Bit Score: 182.59 E-value: 1.72e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 185 QSASDWQEHTSADGRKYYYNKRTKQSNWEKPLELMTPLERADASTVWKEFTTPEGKKYYYNKVTKESKWTIPEDLKLARE 264
Cdd:COG5104 12 EARSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPERKKVEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 265 QAQlasEKTSLSeagstplSHHAASSSDLAVStvtsvvpstssaltghssspiqaglavpvtrppsvapvtptsgaisdt 344
Cdd:COG5104 92 IAE---QKHDER-------SMIGGNGNDMAIT------------------------------------------------ 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 345 eattikgdnlssrgaddsnDGATAQNNEAENKEMSVNGKANlspagDKANVEEpmvyATKQEAKAAFKSLLESVNVHSDW 424
Cdd:COG5104 114 -------------------DHETSEPKYLLGRLMSQYGITS-----TKDAVYR----LTKEEAEKEFITMLKENQVDSTW 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 425 TWEQTLKEIVHDKRYGALRTLGERKQAFNEYLGQRKKVEAEERRRRQKKAREEFVKMLEECEELSSSLKWSKAMSLFEND 504
Cdd:COG5104 166 PIFRAIEELRDPRYWMVDTDPLWRKDLFKKYFENQEKDQREEEENKQRKYINEFCKMLAGNSHIKYYTDWFTFKSIFSKH 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 505 QRFKAVDRPRDREDLFDNYIVELERKEREKAAEEHRQYMADYRKFLETCDYiKAGTQWRKIQDRLEDDDR------CSCL 578
Cdd:COG5104 246 PYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGKHMGGTALGRLEEVLRSLGS-ETFIIWLLNHYVFDSVVRylknkeMKPL 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 579 EKIDRLIGFEEYILDLEKEEEELKRVEKEHVRRAERKNRDAFRTLLEEHVAAGILTAKTYWLDYCIELKDLPQYQAVASN 658
Cdd:COG5104 325 DRKDILFSFIRYVRRLEKELLSAIEERKAAAAQNARHHRDEFRTLLRKLYSEGKIYYRMKWKNAYPLIKDDPRFLNLLGR 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 659 TsGSTPKDLFEDVTEELEKQYHEDKSYVKDAMKSRKISMVSSWLFEDFKSAISE-----DLSTQQISDINLKLIYDDLVG 733
Cdd:COG5104 405 T-GSSPLDLFFDFIVDLENMYGFARRSYERETRTGQISPTDRRAVDEIFEAIAEkkeegEIKFDKVDKEDISLIVDGLIK 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 734 RVKEKEEKEARKLQRLAEEFTNLLHTFKEITVA-------SNWEDSKQLVEESQEYRSIGDE-SVSQGLFE----EYITS 801
Cdd:COG5104 484 QRNEKIQQKLQNERRILEQKKHYFWLLLQRTYTktgkpkpSTWDLASKELGESLEYKALGDEdNIRRQIFEdfkpESSAP 563
|
....*....
gi 79359944 802 LQEKAKEKE 810
Cdd:COG5104 564 TAESATANL 572
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
406-455 |
9.85e-15 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 69.02 E-value: 9.85e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 79359944 406 EAKAAFKSLLESVNVHSDWTWEQTLKEIVHDKRYGALRTLGERKQAFNEY 455
Cdd:pfam01846 1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
473-523 |
1.31e-13 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 65.94 E-value: 1.31e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 79359944 473 KAREEFVKMLEECEeLSSSLKWSKAMSLFENDQRFKAVDRPRDREDLFDNY 523
Cdd:pfam01846 1 KAREAFKELLKEHK-ITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
472-526 |
1.02e-10 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 57.97 E-value: 1.02e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 79359944 472 KKAREEFVKMLEECEELSSSLKWSKAMSLFENDQRFKAVDRPRDREDLFDNYIVE 526
Cdd:smart00441 1 EEAKEAFKELLKEHEVITPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHIEE 55
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
188-217 |
4.46e-09 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 52.53 E-value: 4.46e-09
10 20 30
....*....|....*....|....*....|
gi 79359944 188 SDWQEHTSADGRKYYYNKRTKQSNWEKPLE 217
Cdd:cd00201 2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| WW |
pfam00397 |
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ... |
188-215 |
1.77e-08 |
|
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.
Pssm-ID: 459800 [Multi-domain] Cd Length: 30 Bit Score: 50.58 E-value: 1.77e-08
10 20
....*....|....*....|....*...
gi 79359944 188 SDWQEHTSADGRKYYYNKRTKQSNWEKP 215
Cdd:pfam00397 3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
406-458 |
6.85e-08 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 49.88 E-value: 6.85e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 79359944 406 EAKAAFKSLLESVNV-HSDWTWEQTLKEIVHDKRYGALRTLGERKQAFNEYLGQ 458
Cdd:smart00441 2 EAKEAFKELLKEHEViTPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHIEE 55
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
231-258 |
9.16e-08 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 48.68 E-value: 9.16e-08
10 20
....*....|....*....|....*...
gi 79359944 231 WKEFTTPEGKKYYYNKVTKESKWTIPED 258
Cdd:cd00201 4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| WW |
pfam00397 |
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ... |
231-256 |
1.02e-07 |
|
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.
Pssm-ID: 459800 [Multi-domain] Cd Length: 30 Bit Score: 48.66 E-value: 1.02e-07
10 20
....*....|....*....|....*.
gi 79359944 231 WKEFTTPEGKKYYYNKVTKESKWTIP 256
Cdd:pfam00397 5 WEERWDPDGRVYYYNHETGETQWEKP 30
|
|
| WW |
smart00456 |
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ... |
190-215 |
1.17e-07 |
|
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.
Pssm-ID: 197736 [Multi-domain] Cd Length: 33 Bit Score: 48.37 E-value: 1.17e-07
10 20
....*....|....*....|....*.
gi 79359944 190 WQEHTSADGRKYYYNKRTKQSNWEKP 215
Cdd:smart00456 6 WEERKDPDGRPYYYNHETKETQWEKP 31
|
|
| WW |
smart00456 |
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ... |
231-258 |
3.73e-07 |
|
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.
Pssm-ID: 197736 [Multi-domain] Cd Length: 33 Bit Score: 47.21 E-value: 3.73e-07
10 20
....*....|....*....|....*...
gi 79359944 231 WKEFTTPEGKKYYYNKVTKESKWTIPED 258
Cdd:smart00456 6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
71-336 |
9.19e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 46.62 E-value: 9.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 71 TSSSQAVSVP---YIQTNKILT--SGSTQPQPNAPPMTGFATsGPPFSSPytfVPSSYPQQQPTSLVQ-----PNSQMHV 140
Cdd:PRK10263 327 TTATQSWAAPvepVTQTPPVASvdVPPAQPTVAWQPVPGPQT-GEPVIAP---APEGYPQQSQYAQPAvqynePLQQPVQ 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 141 AGVPPAANTWPVPVNQSTSLVSPVQQTGQQTPVAVSTDPGNLTPQSASD----WQEHTSADGRKYYYNKRTKQSNWEKPl 216
Cdd:PRK10263 403 PQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEqqstFAPQSTYQTEQTYQQPAAQEPLYQQP- 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 217 ELMTPLERADASTVWKEFTTPEGKKYYYNKVTKeskwtipedlKLAREQAQLASEKTSLSEAGSTPLSHHAASSSDLA-- 294
Cdd:PRK10263 482 QPVEQQPVVEPEPVVEETKPARPPLYYFEEVEE----------KRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVaa 551
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 79359944 295 ---VSTVTSVVPSTSSALTGHSSSPIQAGLAVPVTRPPSVAPVTP 336
Cdd:PRK10263 552 vppVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANSGGPRP 596
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
251-389 |
9.95e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 9.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 251 SKWTIPEDLKLAREQAQLASEKTSLSEAGSTPLSHHAASSSDLAV------STVTSVVPSTSSALTGHSSSPIQAglAVP 324
Cdd:pfam17823 73 TKGTSAAHLNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAaassspSSAAQSLPAAIAALPSEAFSAPRA--AAC 150
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79359944 325 VTrPPSVAPVTPTSGAISDTEATTIKGDNLSSRGADDSNDGATAQNNEAenkemSVNGKANLSPA 389
Cdd:pfam17823 151 RA-NASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA-----ASSAPATLTPA 209
|
|
| PHA03369 |
PHA03369 |
capsid maturational protease; Provisional |
76-377 |
2.52e-04 |
|
capsid maturational protease; Provisional
Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 44.99 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 76 AVSVPYIQTNKILTSGSTQPQPNAPPMTGFATSGPPFSSPYTFVPSSYPQQQPTSLVQPNSQMHVAGVPPAANTWPVPVN 155
Cdd:PHA03369 363 AAKVAVIAAPQTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGPVPPQPTN 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 156 QSTSLVSPVQQ--TGQQTPVAVSTDPGNLTPQSASDWQEHTSAdgRKYyynkRTKQSNWEKPLELMTPLERADASTVwKE 233
Cdd:PHA03369 443 PYVMPISMANMvyPGHPQEHGHERKRKRGGELKEELIETLKLV--KKL----KEEQESLAKELEATAHKSEIKKIAE-SE 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 234 FTTPEGKKYYYNKVTKESKWTIPEDLKLAREQAQLASEKTSLSEAGSTPLSHHAASSSDLAVS--TVTSVVPSTSSALTG 311
Cdd:PHA03369 516 FKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTlaAAAGQGSDTAEALAG 595
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79359944 312 ------HSSSPIQAGL-----AVPVTrPPSVAPVTPTSGAISDTEATTIKGdnlssrgaddSNDGATAQNNEAENKE 377
Cdd:PHA03369 596 aietllTQASAQPAGLslpapAVPVN-ASTPASTPPPLAPQEPPQPGTSAP----------SLETSLPQQKPVLSKG 661
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
72-200 |
4.95e-04 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 43.48 E-value: 4.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 72 SSSQAVSVPyIQTNKILTSGSTQPQPNAPPMTGFATSGPPFSSPytfvPSSYPQQQPTSLVQPNSqmhvAGVPPAANTWP 151
Cdd:PRK10856 155 SQNSGQSVP-LDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATA----PAPAVDPQQNAVVAPSQ----ANVDTAATPAP 225
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 79359944 152 VPV-NQSTSLVSPVQQTGQQTPVAvstDPGNLTPQ-SASDWQEHTSADGRK 200
Cdd:PRK10856 226 AAPaTPDGAAPLPTDQAGVSTPAA---DPNALVMNfTADCWLEVTDATGKK 273
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
5-184 |
1.09e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 5 PPQSSgtqfRPMVPGQ-QGQHFVPAASQPFHPYGHVPPNVQSQPPQYSQPIQQQQLFPVRPGQPVHITSSSQAVSVPYIQ 83
Cdd:PHA03247 2592 PPQSA----RPRAPVDdRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA 2667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 84 TNKILTSGSTQP-----QPNAPPMTGFATS--GPPFSSPytfVPSSYPQQQPTSLVQPNSQMHVAGVPPAANTWPVPVNQ 156
Cdd:PHA03247 2668 RRLGRAAQASSPpqrprRRAARPTVGSLTSlaDPPPPPP---TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744
|
170 180
....*....|....*....|....*...
gi 79359944 157 STSLVSPVQQTGQQTPVAVSTDPGNLTP 184
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
615-670 |
2.96e-03 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 36.67 E-value: 2.96e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 79359944 615 KNRDAFRTLLEEHVaagiLTAKTYWLDYCIELKDLPQYQAVasnTSGSTPKDLFED 670
Cdd:pfam01846 1 KAREAFKELLKEHK----ITPYSTWSEIKKKIENDPRYKAL---LDGSEREELFED 49
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
27-156 |
3.06e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 27 PAASQPFH--PYGHVPPnvqsqppqySQPIQQQQLFPVRPGQPVHITsssQAVSVPYIQTNKILTSGSTQPQPNAP-PMT 103
Cdd:pfam03154 398 PLSSLSTHhpPSAHPPP---------LQLMPQSQQLPPPPAQPPVLT---QSQSLPPPAASHPPTSGLHQVPSQSPfPQH 465
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 79359944 104 GFATSGPPF----SSPYTFVPSSYPQQQPTSLVQPNSQMHVagvpPAANTWPVPVNQ 156
Cdd:pfam03154 466 PFVPGGPPPitppSGPPTSTSSAMPGIQPPSSASVSSSGPV----PAAVSCPLPPVQ 518
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
88-184 |
5.71e-03 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 39.86 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79359944 88 LTSGSTQPQPNAPPmtGFATSGPPFSSPYTFVPSSYPQQQPTSLVQPNSQMHVAGVPPAANTWPVPVNQSTSLV------ 161
Cdd:pfam05956 58 LADLSPPKRSATPP--ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTkksgsh 135
|
90 100
....*....|....*....|....*..
gi 79359944 162 ----SPVQQTGQQTPVAVSTDPGNLTP 184
Cdd:pfam05956 136 ktqkSPVRIPFMQTPTKQTGLPRNPSP 162
|
|
| |
