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Conserved domains on  [gi|15218445|ref|NP_175036|]
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Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

Protein Classification

PLP-dependent aminotransferase family protein; bifunctional SDR family oxidoreductase/aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme( domain architecture ID 10010750)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation| bifunctional extended SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase/aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02263 PLN02263
serine decarboxylase
 15-482 0e+00

serine decarboxylase


:

Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 1023.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   15 TLIEKLDILSDDFDPTAVVTEPLPP-PVTNGIGADKGGGGGEREMVLGRNIHTTSLAVTEPEVNDEFTGDKEAYMASVLA 93
Cdd:PLN02263   1 HLPEKLEILSVDIDPDLLVSDPLPVaTYNVAVVAEYGDLGGEREIVLGRNVHTTCLAVTEPEADDEFTGDKEAYMASVLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   94 RYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWEIERDDYWGYITNC 173
Cdd:PLN02263  81 RYRKTLVERTKHHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWEIEKNEYWGYITNC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  174 GTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDKPAILNVNIGTTV 253
Cdd:PLN02263 161 GTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMECVKVDTLVSGEIDCADFKAKLLANKDKPAIINVNIGTTV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  254 KGAVDDLDLVIKTLEECGFSHDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQITRMEHIK 333
Cdd:PLN02263 241 KGAVDDLDLVIKTLEECGFSQDRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRMEHIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  334 VLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 413
Cdd:PLN02263 321 VLSSNVEYLASRDATIMGSRNGHAPIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  414 DEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLVKHRLIWYEDGS-QPPCLASEVGTNNCICPAHK 482
Cdd:PLN02263 401 DEEFVRRWQLACQGNIAHVVVMPSVTIEKLDYFLKELVEKRSTWYPDGKvQPPCVAKDVGEENCLCSLHK 470
 
Name Accession Description Interval E-value
PLN02263 PLN02263
serine decarboxylase
 15-482 0e+00

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 1023.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   15 TLIEKLDILSDDFDPTAVVTEPLPP-PVTNGIGADKGGGGGEREMVLGRNIHTTSLAVTEPEVNDEFTGDKEAYMASVLA 93
Cdd:PLN02263   1 HLPEKLEILSVDIDPDLLVSDPLPVaTYNVAVVAEYGDLGGEREIVLGRNVHTTCLAVTEPEADDEFTGDKEAYMASVLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   94 RYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWEIERDDYWGYITNC 173
Cdd:PLN02263  81 RYRKTLVERTKHHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWEIEKNEYWGYITNC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  174 GTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDKPAILNVNIGTTV 253
Cdd:PLN02263 161 GTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMECVKVDTLVSGEIDCADFKAKLLANKDKPAIINVNIGTTV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  254 KGAVDDLDLVIKTLEECGFSHDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQITRMEHIK 333
Cdd:PLN02263 241 KGAVDDLDLVIKTLEECGFSQDRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRMEHIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  334 VLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 413
Cdd:PLN02263 321 VLSSNVEYLASRDATIMGSRNGHAPIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  414 DEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLVKHRLIWYEDGS-QPPCLASEVGTNNCICPAHK 482
Cdd:PLN02263 401 DEEFVRRWQLACQGNIAHVVVMPSVTIEKLDYFLKELVEKRSTWYPDGKvQPPCVAKDVGEENCLCSLHK 470
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 151-453 4.83e-41

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 152.68  E-value: 4.83e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 151 VLDWFARLWEIErDDYWGYITNCGTEGNLHGILVGREMF-------------PDGILYASRESHYSVFKAARMYRMECE- 216
Cdd:COG0076 112 VVRWLADLLGLP-EGAGGVFTSGGTEANLLALLAARDRAlarrvraeglpgaPRPRIVVSEEAHSSVDKAARLLGLGRDa 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 217 --KVDTLMSGEIDCDDLRKKL---LANKDKPAILNVNIGTTVKGAVDDLDLVIKTLEECGFshdrfYIHCDGAlFGLMM- 290
Cdd:COG0076 191 lrKVPVDEDGRMDPDALEAAIdedRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGL-----WLHVDAA-YGGFAl 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 291 ------PFVKRAPKVTfnkpigSVSVSGHKFVGCPMPCGVQITR--MEHIKVLSSNVEYLASRDA--------TIMGSRN 354
Cdd:COG0076 265 pspelrHLLDGIERAD------SITVDPHKWLYVPYGCGAVLVRdpELLREAFSFHASYLGPADDgvpnlgdyTLELSRR 338

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 355 GHApLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNE-LSSTVVF-----ERPKDEEFVRRWQ--LACQ 426
Cdd:COG0076 339 FRA-LKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPpELNIVCFrykpaGLDEEDALNYALRdrLRAR 417

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 15218445 427 GDIA------------HVVVM-PSVTIEKLDNFLKDLVKH 453
Cdd:COG0076 418 GRAFlsptkldgrvvlRLVVLnPRTTEDDVDALLDDLREA 457
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 105-453 2.57e-31

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 123.47  E-value: 2.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 105 NHLGYPYNLDFDyGALGQLQHFSINNLGDPFIESnygvhsrP----FEVGVLDWFARLWEIERDDYWGYITNCGTEGNLH 180
Cdd:cd06450   1 FLAGFVTTMDPP-ALLLEMLTSAKNAIDFTWDES-------PaateMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 181 GILVGR------------EMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLL---ANKDKPAIL 245
Cdd:cd06450  73 ALLAARdrarkrlkagggRGIDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDedkAEGLNPIMV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 246 NVNIGTTVKGAVDDLDLVIKTLEEcgfsHDrFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQ 325
Cdd:cd06450 153 VATAGTTDTGAIDPLEEIADLAEK----YD-LWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAV 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 326 ITRMehikvlssnveylasrdatimgsrnghapLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLRE-AGISAMLNELS 404
Cdd:cd06450 228 LVRA-----------------------------LKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAdPGFELLGEPNL 278

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15218445 405 STVVFeRPKDEEFV--------------RRWQLA--CQGDIAH---VVVMPSVTIEKLDNFLKDLVKH 453
Cdd:cd06450 279 SLVCF-RLKPSVKLdelnydlsdrlnerGGWHVPatTLGGPNVlrfVVTNPLTTRDDADALLEDIERA 345
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
148-395 8.75e-22

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 96.72  E-value: 8.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   148 EVGVLDWFARLWEIERDDYW----GYITNCGTEGNLHGILVGR-EMFPDG----------------ILYASRESHYSVFK 206
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGqeggGVLQPGSSESNLLALLAARtKWIKRMkaagkpadssgilaklVAYTSDQAHSSIEK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   207 AARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDK---PAILNVNIGTTVKGAVDDLDLVIKTLEEcgfsHDrFYIHCDG 283
Cdd:pfam00282 161 AALYGGVKLREIPSDDNGKMRGMDLEKAIEEDKENgliPFFVVATLGTTGSGAFDDLQELGDICAK----HN-LWLHVDA 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   284 ALFG--LMMPFV----KRAPKVTfnkpigSVSVSGHKFVGCPMPCGVQITRMEH--IKVLSSNVEYLAS-------RDAT 348
Cdd:pfam00282 236 AYGGsaFICPEFrhwlFGIERAD------SITFNPHKWMLVLLDCSAVWVKDKEalQQAFQFNPLYLGHtdsaydtGHKQ 309

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 15218445   349 IMGSRNGHApLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAG 395
Cdd:pfam00282 310 IPLSRRFRI-LKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG 355
 
Name Accession Description Interval E-value
PLN02263 PLN02263
serine decarboxylase
 15-482 0e+00

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 1023.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   15 TLIEKLDILSDDFDPTAVVTEPLPP-PVTNGIGADKGGGGGEREMVLGRNIHTTSLAVTEPEVNDEFTGDKEAYMASVLA 93
Cdd:PLN02263   1 HLPEKLEILSVDIDPDLLVSDPLPVaTYNVAVVAEYGDLGGEREIVLGRNVHTTCLAVTEPEADDEFTGDKEAYMASVLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   94 RYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWEIERDDYWGYITNC 173
Cdd:PLN02263  81 RYRKTLVERTKHHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWEIEKNEYWGYITNC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  174 GTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDKPAILNVNIGTTV 253
Cdd:PLN02263 161 GTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMECVKVDTLVSGEIDCADFKAKLLANKDKPAIINVNIGTTV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  254 KGAVDDLDLVIKTLEECGFSHDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQITRMEHIK 333
Cdd:PLN02263 241 KGAVDDLDLVIKTLEECGFSQDRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRMEHIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  334 VLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 413
Cdd:PLN02263 321 VLSSNVEYLASRDATIMGSRNGHAPIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFERPK 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  414 DEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLVKHRLIWYEDGS-QPPCLASEVGTNNCICPAHK 482
Cdd:PLN02263 401 DEEFVRRWQLACQGNIAHVVVMPSVTIEKLDYFLKELVEKRSTWYPDGKvQPPCVAKDVGEENCLCSLHK 470
PLN03032 PLN03032
serine decarboxylase; Provisional
 81-454 0e+00

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 730.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   81 TGDKEAYMASVLARYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWE 160
Cdd:PLN03032   1 TGERDAYMADILASYDKLLAEKSSVHFGYPYNLDFDYGELSQLMKYSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  161 IERDDYWGYITNCGTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKD 240
Cdd:PLN03032  81 LEKDEYWGYITTCGTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTLPSGEIDYDDLERALAKNRD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  241 KPAILNVNIGTTVKGAVDDLDLVIKTLEECGFSHDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPM 320
Cdd:PLN03032 161 KPAILNVNIGTTVKGAVDDLDRILRILKELGYTEDRFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  321 PCGVQITRMEHIKVLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAML 400
Cdd:PLN03032 241 PCGVALTRKKHVKALSQNVEYLNSRDATIMGSRNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAGLTCRL 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15218445  401 NELSSTVVFERPKDEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLVKHR 454
Cdd:PLN03032 321 NELSSTVVFERPMDEAFIKKWQLACEGDIAHVVVMPNVTVEKLDEFVEELVEVR 374
PRK02769 PRK02769
histidine decarboxylase; Provisional
 92-451 1.43e-169

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 482.62  E-value: 1.43e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   92 LARYRKTLVERTKNHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRPFEVGVLDWFARLWEIERDDYWGYIT 171
Cdd:PRK02769  11 IEDFWLYLRHNQYFNVGYPEAADFDYSALKRFFSFSINNCGDPYSKSNYPLNSFDFERDVMNFFAELFKIPFNESWGYIT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  172 NCGTEGNLHGILVGREMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDKPAILNVNIGT 251
Cdd:PRK02769  91 NGGTEGNLYGCYLARELFPDGTLYYSKDTHYSVSKIARLLRIKSRVITSLPNGEIDYDDLISKIKENKNQPPIIFANIGT 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  252 TVKGAVDDLDLVIKTLEECGFshDRFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQITRMEH 331
Cdd:PRK02769 171 TMTGAIDNIKEIQEILKKIGI--DDYYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFIGSPMPCGIVLAKKKY 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  332 IKVLSSNVEYLASRDATIMGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFER 411
Cdd:PRK02769 249 VERISVDVDYIGSRDQTISGSRNGHTALLLWAAIRSLGSKGLRQRVQHCLDMAQYAVDRLQANGIPAWRNPNSITVVFPC 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 15218445  412 PkDEEFVRRWQLACQGDIAHVVVMPSVTIEKLDNFLKDLV 451
Cdd:PRK02769 329 P-SERIWKKWHLATSGNQAHIITMPHHNKQQIDSLIDELI 367
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 151-453 4.83e-41

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 152.68  E-value: 4.83e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 151 VLDWFARLWEIErDDYWGYITNCGTEGNLHGILVGREMF-------------PDGILYASRESHYSVFKAARMYRMECE- 216
Cdd:COG0076 112 VVRWLADLLGLP-EGAGGVFTSGGTEANLLALLAARDRAlarrvraeglpgaPRPRIVVSEEAHSSVDKAARLLGLGRDa 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 217 --KVDTLMSGEIDCDDLRKKL---LANKDKPAILNVNIGTTVKGAVDDLDLVIKTLEECGFshdrfYIHCDGAlFGLMM- 290
Cdd:COG0076 191 lrKVPVDEDGRMDPDALEAAIdedRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGL-----WLHVDAA-YGGFAl 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 291 ------PFVKRAPKVTfnkpigSVSVSGHKFVGCPMPCGVQITR--MEHIKVLSSNVEYLASRDA--------TIMGSRN 354
Cdd:COG0076 265 pspelrHLLDGIERAD------SITVDPHKWLYVPYGCGAVLVRdpELLREAFSFHASYLGPADDgvpnlgdyTLELSRR 338

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 355 GHApLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAGISAMLNE-LSSTVVF-----ERPKDEEFVRRWQ--LACQ 426
Cdd:COG0076 339 FRA-LKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPpELNIVCFrykpaGLDEEDALNYALRdrLRAR 417

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 15218445 427 GDIA------------HVVVM-PSVTIEKLDNFLKDLVKH 453
Cdd:COG0076 418 GRAFlsptkldgrvvlRLVVLnPRTTEDDVDALLDDLREA 457
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 105-453 2.57e-31

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 123.47  E-value: 2.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 105 NHLGYPYNLDFDyGALGQLQHFSINNLGDPFIESnygvhsrP----FEVGVLDWFARLWEIERDDYWGYITNCGTEGNLH 180
Cdd:cd06450   1 FLAGFVTTMDPP-ALLLEMLTSAKNAIDFTWDES-------PaateMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 181 GILVGR------------EMFPDGILYASRESHYSVFKAARMYRMECEKVDTLMSGEIDCDDLRKKLL---ANKDKPAIL 245
Cdd:cd06450  73 ALLAARdrarkrlkagggRGIDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDedkAEGLNPIMV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 246 NVNIGTTVKGAVDDLDLVIKTLEEcgfsHDrFYIHCDGALFGLMMPFVKRAPKVTFNKPIGSVSVSGHKFVGCPMPCGVQ 325
Cdd:cd06450 153 VATAGTTDTGAIDPLEEIADLAEK----YD-LWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAV 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445 326 ITRMehikvlssnveylasrdatimgsrnghapLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLRE-AGISAMLNELS 404
Cdd:cd06450 228 LVRA-----------------------------LKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAdPGFELLGEPNL 278

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15218445 405 STVVFeRPKDEEFV--------------RRWQLA--CQGDIAH---VVVMPSVTIEKLDNFLKDLVKH 453
Cdd:cd06450 279 SLVCF-RLKPSVKLdelnydlsdrlnerGGWHVPatTLGGPNVlrfVVTNPLTTRDDADALLEDIERA 345
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
148-395 8.75e-22

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 96.72  E-value: 8.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   148 EVGVLDWFARLWEIERDDYW----GYITNCGTEGNLHGILVGR-EMFPDG----------------ILYASRESHYSVFK 206
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGqeggGVLQPGSSESNLLALLAARtKWIKRMkaagkpadssgilaklVAYTSDQAHSSIEK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   207 AARMYRMECEKVDTLMSGEIDCDDLRKKLLANKDK---PAILNVNIGTTVKGAVDDLDLVIKTLEEcgfsHDrFYIHCDG 283
Cdd:pfam00282 161 AALYGGVKLREIPSDDNGKMRGMDLEKAIEEDKENgliPFFVVATLGTTGSGAFDDLQELGDICAK----HN-LWLHVDA 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445   284 ALFG--LMMPFV----KRAPKVTfnkpigSVSVSGHKFVGCPMPCGVQITRMEH--IKVLSSNVEYLAS-------RDAT 348
Cdd:pfam00282 236 AYGGsaFICPEFrhwlFGIERAD------SITFNPHKWMLVLLDCSAVWVKDKEalQQAFQFNPLYLGHtdsaydtGHKQ 309

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 15218445   349 IMGSRNGHApLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKDRLREAG 395
Cdd:pfam00282 310 IPLSRRFRI-LKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG 355
PLN02590 PLN02590
probable tyrosine decarboxylase
 118-389 1.05e-03

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 41.62  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  118 GALGQLQHFSINNLGDPFIESNYGVHsrpFEVGVLDWFARLWEIErdDYW-------GYITNCGTEGNLHGIL------- 183
Cdd:PLN02590 145 GFLGEMLNAGLSVVGFTWLTSPAATE---LEIIVLDWLAKLLQLP--DHFlstgnggGVIQGTGCEAVLVVVLaardril 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  184 --VGREMFPDGILYASRESHYSVFKAARMYRMECE-----KVDTLMSGEIDCDDLRKKL---LANKDKPAILNVNIGTTV 253
Cdd:PLN02590 220 kkVGKTLLPQLVVYGSDQTHSSFRKACLIGGIHEEnirllKTDSSTNYGMPPESLEEAIshdLAKGFIPFFICATVGTTS 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  254 KGAVDDLDLVIKTLEECGfshdrFYIHCDGALFG--LMMPFVKRAPKVTFNKpiGSVSVSGHKFVGCPMPCGVQIT--RM 329
Cdd:PLN02590 300 SAAVDPLVPLGNIAKKYG-----IWLHVDAAYAGnaCICPEYRKFIDGIENA--DSFNMNAHKWLFANQTCSPLWVkdRY 372

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218445  330 EHIKVLSSNVEYL----ASRDATI------MGSRNGHAPLFLWYTLNRKGYKGFQKEVQKCLRNAHYLKD 389
Cdd:PLN02590 373 SLIDALKTNPEYLefkvSKKDTVVnykdwqISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFED 442
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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