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Conserved domains on  [gi|15217610|ref|NP_174628|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 7-432 3.08e-45

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 168.87  E-value: 3.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610    7 PLFLFVIFLRCLSStgaATCHPDDKAGLLAFKSGItQDPSGILSSWQKDIDCCSWYGIFClptIHGDRVTMMALDGNTdv 86
Cdd:PLN00113  10 PYLIFMLFFLFLNF---SMLHAEELELLLSFKSSI-NDPLKYLSNWNSSADVCLWQGITC---NNSSRVVSIDLSGKN-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   87 getfLSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFK-----------------------LPKLRTVYLENNRLSGP 143
Cdd:PLN00113  81 ----ISGKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgsIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  144 LPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASL 223
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  224 ApTLSTLEVGHNKLSGTIPDYLSRFELLSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFP--VLNSLGIEYLH 301
Cdd:PLN00113 236 T-SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPelVIQLQNLEILH 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  302 LSYNRF-----------------------------------------HLET------IPEWVTLSKFIYSLKLakcgIKM 334
Cdd:PLN00113 315 LFSNNFtgkipvaltslprlqvlqlwsnkfsgeipknlgkhnnltvlDLSTnnltgeIPEGLCSSGNLFKLIL----FSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  335 SLDHWMPADTSF---YHHIDFSENEISGSPIRFFNQMDFMVEFHAPGNKLQFDLGKLKFGI-FLKTLDLSRNLVFGKVPV 410
Cdd:PLN00113 391 SLEGEIPKSLGAcrsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMpSLQMLSLARNKFFGGLPD 470

                        490       500
                 ....*....|....*....|....
gi 15217610  411 TV--TRLQTLNLSQNHLCGKLPST 432
Cdd:PLN00113 471 SFgsKRLENLDLSRNQFSGAVPRK 494
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-432 3.08e-45

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 168.87  E-value: 3.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610    7 PLFLFVIFLRCLSStgaATCHPDDKAGLLAFKSGItQDPSGILSSWQKDIDCCSWYGIFClptIHGDRVTMMALDGNTdv 86
Cdd:PLN00113  10 PYLIFMLFFLFLNF---SMLHAEELELLLSFKSSI-NDPLKYLSNWNSSADVCLWQGITC---NNSSRVVSIDLSGKN-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   87 getfLSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFK-----------------------LPKLRTVYLENNRLSGP 143
Cdd:PLN00113  81 ----ISGKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgsIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  144 LPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASL 223
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  224 ApTLSTLEVGHNKLSGTIPDYLSRFELLSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFP--VLNSLGIEYLH 301
Cdd:PLN00113 236 T-SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPelVIQLQNLEILH 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  302 LSYNRF-----------------------------------------HLET------IPEWVTLSKFIYSLKLakcgIKM 334
Cdd:PLN00113 315 LFSNNFtgkipvaltslprlqvlqlwsnkfsgeipknlgkhnnltvlDLSTnnltgeIPEGLCSSGNLFKLIL----FSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  335 SLDHWMPADTSF---YHHIDFSENEISGSPIRFFNQMDFMVEFHAPGNKLQFDLGKLKFGI-FLKTLDLSRNLVFGKVPV 410
Cdd:PLN00113 391 SLEGEIPKSLGAcrsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMpSLQMLSLARNKFFGGLPD 470

                        490       500
                 ....*....|....*....|....
gi 15217610  411 TV--TRLQTLNLSQNHLCGKLPST 432
Cdd:PLN00113 471 SFgsKRLENLDLSRNQFSGAVPRK 494
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-361 1.82e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.27  E-value: 1.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 109 RLTNLRKITGSFPHFLFKLPKLRTVYLENNRLSGpLPANIGALSNLEILSVAGNRFSgSIPSSMSKLTSLLQLKLNGNRL 188
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQL 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 189 SGIfPDIFKSMRQLRFLDLSSNRFSgNLPSSIASLaPTLSTLEVGHNKLSgTIPDYLSRFELLSALNLSRNGYTGVVpmS 268
Cdd:COG4886 172 TDL-PEELGNLTNLKELDLSNNQIT-DLPEPLGNL-TNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLP--E 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 269 FANLTNIIFLDLSHNLLTGPFPVLNSLGIEYLHLSYNRF---HLETIPEWVTLSKFIYSLKLAKCGIKMSLDHWMPADTS 345
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLtdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                       250
                ....*....|....*.
gi 15217610 346 FYHHIDFSENEISGSP 361
Cdd:COG4886 326 LLLLLKGLLVTLTTLA 341
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-66 1.05e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 56.53  E-value: 1.05e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15217610    27 HPDDKAGLLAFKSGITqDPSGILSSW-QKDIDCCSWYGIFC 66
Cdd:pfam08263   1 LNDDGQALLAFKSSLN-DPPGALSSWnSSSSDPCSWTGVTC 40
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-286 2.19e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 2.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  99 LAKLHHLNeirLT--NLRKItGSFPHFlfklPKLRTVYLENNRLSgpLPANIGALSNLEILSVAGNRfsgsIpSSMSKLT 176
Cdd:cd21340   1 LKRITHLY---LNdkNITKI-DNLSLC----KNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQ----I-EKIENLE 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 177 SLLQLK---LNGNRLS---GifpdiFKSMRQLRFLDLSSNRFSGNL-----PSSIASLAPTLSTLEVGHNKLsgTIPDYL 245
Cdd:cd21340  66 NLVNLKklyLGGNRISvveG-----LENLTNLEELHIENQRLPPGEkltfdPRSLAALSNSLRVLNISGNNI--DSLEPL 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 15217610 246 SRFELLSALNLSRNGYTGVVPMS--FANLTNIIFLDLSHNLLT 286
Cdd:cd21340 139 APLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVC 181
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-432 3.08e-45

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 168.87  E-value: 3.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610    7 PLFLFVIFLRCLSStgaATCHPDDKAGLLAFKSGItQDPSGILSSWQKDIDCCSWYGIFClptIHGDRVTMMALDGNTdv 86
Cdd:PLN00113  10 PYLIFMLFFLFLNF---SMLHAEELELLLSFKSSI-NDPLKYLSNWNSSADVCLWQGITC---NNSSRVVSIDLSGKN-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   87 getfLSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFK-----------------------LPKLRTVYLENNRLSGP 143
Cdd:PLN00113  81 ----ISGKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgsIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  144 LPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASL 223
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  224 ApTLSTLEVGHNKLSGTIPDYLSRFELLSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFP--VLNSLGIEYLH 301
Cdd:PLN00113 236 T-SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPelVIQLQNLEILH 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  302 LSYNRF-----------------------------------------HLET------IPEWVTLSKFIYSLKLakcgIKM 334
Cdd:PLN00113 315 LFSNNFtgkipvaltslprlqvlqlwsnkfsgeipknlgkhnnltvlDLSTnnltgeIPEGLCSSGNLFKLIL----FSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  335 SLDHWMPADTSF---YHHIDFSENEISGSPIRFFNQMDFMVEFHAPGNKLQFDLGKLKFGI-FLKTLDLSRNLVFGKVPV 410
Cdd:PLN00113 391 SLEGEIPKSLGAcrsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMpSLQMLSLARNKFFGGLPD 470

                        490       500
                 ....*....|....*....|....
gi 15217610  411 TV--TRLQTLNLSQNHLCGKLPST 432
Cdd:PLN00113 471 SFgsKRLENLDLSRNQFSGAVPRK 494
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-361 1.82e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.27  E-value: 1.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 109 RLTNLRKITGSFPHFLFKLPKLRTVYLENNRLSGpLPANIGALSNLEILSVAGNRFSgSIPSSMSKLTSLLQLKLNGNRL 188
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQL 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 189 SGIfPDIFKSMRQLRFLDLSSNRFSgNLPSSIASLaPTLSTLEVGHNKLSgTIPDYLSRFELLSALNLSRNGYTGVVpmS 268
Cdd:COG4886 172 TDL-PEELGNLTNLKELDLSNNQIT-DLPEPLGNL-TNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLP--E 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 269 FANLTNIIFLDLSHNLLTGPFPVLNSLGIEYLHLSYNRF---HLETIPEWVTLSKFIYSLKLAKCGIKMSLDHWMPADTS 345
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLtdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                       250
                ....*....|....*.
gi 15217610 346 FYHHIDFSENEISGSP 361
Cdd:COG4886 326 LLLLLKGLLVTLTTLA 341
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-272 9.41e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.87  E-value: 9.41e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   91 LSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGAlSNLEILSVAGNRFSGSIPS 170
Cdd:PLN00113 416 FSGELPSEFTKLPLVYFLDISN-NNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPR 493

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  171 SMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASLaPTLSTLEVGHNKLSGTIPDYLSRFEL 250
Cdd:PLN00113 494 KLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEM-PVLSQLDLSQNQLSGEIPKNLGNVES 572

                        170       180
                 ....*....|....*....|..
gi 15217610  251 LSALNLSRNGYTGVVPMSFANL 272
Cdd:PLN00113 573 LVQVNISHNHLHGSLPSTGAFL 594
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-290 3.12e-27

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 115.33  E-value: 3.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   91 LSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRFSGSIPS 170
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQD-NSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  171 SmSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASlAPTLSTLEVGHNKLSGTIPDYLSRFEL 250
Cdd:PLN00113 471 S-FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSS-CKKLVSLDLSHNQLSGQIPASFSEMPV 548

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 15217610  251 LSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFP 290
Cdd:PLN00113 549 LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-242 5.71e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.66  E-value: 5.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   85 DVGETFLSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFlFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRF 164
Cdd:PLN00113 434 DISNNNLQGRINSRKWDMPSLQMLSLAR-NKFFGGLPDS-FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15217610  165 SGSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASLApTLSTLEVGHNKLSGTIP 242
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVE-SLVQVNISHNHLHGSLP 588
PLN03150 PLN03150
hypothetical protein; Provisional
 118-193 2.42e-15

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 78.32  E-value: 2.42e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217610  118 GSFPHFLFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRLSGIFP 193
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-323 2.02e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 2.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  94 TISPLLAKLHHLNEIRLTNlRKITgSFPHFLFKLPKLRTVYLENNRLSgPLPANIGALSNLEILSVAGNRFSgSIPSsMS 173
Cdd:COG4886 173 DLPEELGNLTNLKELDLSN-NQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLPE-LG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 174 KLTSLLQLKLNGNRLSGIFPdiFKSMRQLRFLDLSSNRFSGNLPSSIASLAPTLSTLEvghNKLSGTIPDYLSRFELLSA 253
Cdd:COG4886 248 NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL---LLLLLNLLELLILLLLLTT 322

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 254 LNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFPVLNSLGIEYLHLSYNRFHLETIPEWVTLSKFIY 323
Cdd:COG4886 323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-442 2.13e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 2.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  83 NTDVGETFLSGTISPLLAKLHHLNEIRLTNLRKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGN 162
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 163 RFSG--SIPSSMSKLTSLLQLKLNGNRLsgifpdiFKSMRQLRFLDLSSNRFSgNLPSSIASLaPTLSTLEVGHNKLSgT 240
Cdd:COG4886  81 LLSLllLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLT-DLPEELANL-TNLKELDLSNNQLT-D 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 241 IPDYLSRFELLSALNLSRNGYTGvVPMSFANLTNIIFLDLSHNLLT---GPFPVLNSLgiEYLHLSYNRfhLETIPEWVT 317
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITdlpEPLGNLTNL--EELDLSGNQ--LTDLPEPLA 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 318 LSKFIYSLKLAKCGIKmsldhWMPADTSFYH--HIDFSENEISGSPirFFNQMDFMVEFHAPGNKL-QFDLGKLKFGIFL 394
Cdd:COG4886 226 NLTNLETLDLSNNQLT-----DLPELGNLTNleELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLtDLKLKELELLLGL 298

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 15217610 395 KTLDLSRNLVFGKVPVTVTRLQTLNLSQNHLCGKLPSTKFPASAFVDN 442
Cdd:COG4886 299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 109-242 3.57e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 3.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  109 RLTNL----RKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLN 184
Cdd:PLN00113 476 RLENLdlsrNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217610  185 GNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASLAPTLSTLE-----VGHNKLSGTIP 242
Cdd:PLN00113 556 QNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAgnidlCGGDTTSGLPP 618
PLN03150 PLN03150
hypothetical protein; Provisional
 166-242 6.26e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 64.45  E-value: 6.26e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15217610  166 GSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASLApTLSTLEVGHNKLSGTIP 242
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLT-SLRILNLNGNSLSGRVP 507
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-66 1.05e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 56.53  E-value: 1.05e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15217610    27 HPDDKAGLLAFKSGITqDPSGILSSW-QKDIDCCSWYGIFC 66
Cdd:pfam08263   1 LNDDGQALLAFKSSLN-DPPGALSSWnSSSSDPCSWTGVTC 40
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
106-314 9.85e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 9.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  106 NEIRLTNLRKITGSFPHFLFKlpKLRTVYLENNRLSGpLPANIGAlsNLEILSVAGNRFSgSIPSSM------------- 172
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPE--QITTLILDNNELKS-LPENLQG--NIKTLYANSNQLT-SIPATLpdtiqemelsinr 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  173 -----SKLTSLLQ-LKLNGNRLSGIfPDIFKSmrQLRFLDLSSNRFSG---NLPSSI--------------ASLAPTLST 229
Cdd:PRK15370 253 itelpERLPSALQsLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTlpaHLPSGIthlnvqsnsltalpETLPPGLKT 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  230 LEVGHNKLSgTIPDYLSrfELLSALNLSRNGYTgVVPMSFAnlTNIIFLDLSHNLLTGpFPVLNSLGIEYLHLSYNrfHL 309
Cdd:PRK15370 330 LEAGENALT-SLPASLP--PELQVLDVSKNQIT-VLPETLP--PTITTLDVSRNALTN-LPENLPAALQIMQASRN--NL 400


                 ....*
gi 15217610  310 ETIPE 314
Cdd:PRK15370 401 VRLPE 405
PLN03150 PLN03150
hypothetical protein; Provisional
 91-172 2.39e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 2.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610   91 LSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRFSGSIPS 170
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSG-NSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508


                 ..
gi 15217610  171 SM 172
Cdd:PLN03150 509 AL 510
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-286 2.19e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 2.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  99 LAKLHHLNeirLT--NLRKItGSFPHFlfklPKLRTVYLENNRLSgpLPANIGALSNLEILSVAGNRfsgsIpSSMSKLT 176
Cdd:cd21340   1 LKRITHLY---LNdkNITKI-DNLSLC----KNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQ----I-EKIENLE 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 177 SLLQLK---LNGNRLS---GifpdiFKSMRQLRFLDLSSNRFSGNL-----PSSIASLAPTLSTLEVGHNKLsgTIPDYL 245
Cdd:cd21340  66 NLVNLKklyLGGNRISvveG-----LENLTNLEELHIENQRLPPGEkltfdPRSLAALSNSLRVLNISGNNI--DSLEPL 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 15217610 246 SRFELLSALNLSRNGYTGVVPMS--FANLTNIIFLDLSHNLLT 286
Cdd:cd21340 139 APLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVC 181
PLN03150 PLN03150
hypothetical protein; Provisional
 237-296 3.68e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.59  E-value: 3.68e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  237 LSGTIPDYLSRFELLSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFPvlNSLG 296
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP--ESLG 487
LRR_8 pfam13855
Leucine rich repeat;
152-212 2.21e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15217610   152 SNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRF 212
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 181-301 2.44e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610  181 LKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIaslaptlstlevghnklsGTIPDylsrfelLSALNLSRNG 260
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSL------------------GSITS-------LEVLDLSYNS 477

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15217610  261 YTGVVPMSFANLTNIIFLDLSHNLLTGPFPVlnSLGIEYLH 301
Cdd:PLN03150 478 FNGSIPESLGQLTSLRILNLNGNSLSGRVPA--ALGGRLLH 516
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 115-286 2.14e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 2.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 115 KITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGAL---SNLEILSVAGNRFSGSIpsSMSKLTSLLQLKLNgnrlsgi 191
Cdd:cd00116  68 RGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRG--LRLLAKGLKDLPPA------- 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217610 192 fpdifksmrqLRFLDLSSNRFSGNLPSSIASLAP---TLSTLEVGHNKLSGTIPDYLSR----FELLSALNLSRNGYT-- 262
Cdd:cd00116 139 ----------LEKLVLGRNRLEGASCEALAKALRanrDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGLTde 208

                       170       180
                ....*....|....*....|....*.
gi 15217610 263 GVVPMS--FANLTNIIFLDLSHNLLT 286
Cdd:cd00116 209 GASALAetLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
225-285 4.42e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 4.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15217610   225 PTLSTLEVGHNKLSGTIPDYLSRFELLSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLL 285
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-188 7.15e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.15e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15217610   128 PKLRTVYLENNRLSGPLPANIGALSNLEILSVAGNRFSGSIPSSMSKLTSLLQLKLNGNRL 188
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 394-453 1.13e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217610  394 LKTLDLSRNLVFGKVPVTV---TRLQTLNLSQNHLCGKLPS---------TKFpasAFVDNKCLCGFP-LSPC 453
Cdd:PLN03150 468 LEVLDLSYNSFNGSIPESLgqlTSLRILNLNGNSLSGRVPAalggrllhrASF---NFTDNAGLCGIPgLRAC 537
LRR_8 pfam13855
Leucine rich repeat;
181-237 3.69e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15217610   181 LKLNGNRLSGIFPDIFKSMRQLRFLDLSSNRFSGNLPSSIASLaPTLSTLEVGHNKL 237
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
251-307 1.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15217610   251 LSALNLSRNGYTGVVPMSFANLTNIIFLDLSHNLLTGPFPV----LNSLgiEYLHLSYNRF 307
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPSL--RYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 83-151 9.75e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.26  E-value: 9.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15217610   83 NTDVGETFLSGTISPLLAKLHHLNEIRLTNlRKITGSFPHFLFKLPKLRTVYLENNRLSGPLPANIGAL 151
Cdd:PLN03150 446 SINLSGNSIRGNIPPSLGSITSLEVLDLSY-NSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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