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Conserved domains on  [gi|30692706|ref|NP_174523|]
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nitrate transporter 1.5 [Arabidopsis thaliana]

Protein Classification

NRT1/PTR family MFS transporter( domain architecture ID 13024510)

NRT1/PTR (nitrate transporter/peptide transporter) family major facilitator superfamily (MFS) transporter is a proton-coupled transporter that facilitates the transport of one or more from a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
41-580 0e+00

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 753.44  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17419   1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17419  81 IGLLLLTLSSALPSLRPPQCGDGDLKCPPASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASKSAFFS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFYR---------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17419 213 -----------------------------------------------------------------EVKCILRLLPIWLST 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgSKGITELHRMGIGLV 440
Cdd:cd17419 228 IIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGH-PKGITELQRMGIGLV 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYRLKYADKSC-THCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMS 519
Cdd:cd17419 307 IGILAMVVAALVEIQRLKVARPSNlDDPTSPSPLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMAS 386
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30692706 520 MSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17419 387 VALGNYLSSLLVTIVNKVTTKDGSPGWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICAKW 447
 
Name Accession Description Interval E-value
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
41-580 0e+00

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 753.44  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17419   1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17419  81 IGLLLLTLSSALPSLRPPQCGDGDLKCPPASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASKSAFFS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFYR---------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17419 213 -----------------------------------------------------------------EVKCILRLLPIWLST 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgSKGITELHRMGIGLV 440
Cdd:cd17419 228 IIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGH-PKGITELQRMGIGLV 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYRLKYADKSC-THCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMS 519
Cdd:cd17419 307 IGILAMVVAALVEIQRLKVARPSNlDDPTSPSPLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMAS 386
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30692706 520 MSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17419 387 VALGNYLSSLLVTIVNKVTTKDGSPGWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICAKW 447
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
156-547 3.08e-88

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 279.20  E-value: 3.08e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   156 TMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEgysKIAFFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTG 235
Cdd:pfam00854  33 ALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRR---RSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAV 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   236 SAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSSveaplrgreemydgdseGKNASVNTGRRIVHTDEFKFLD 315
Cdd:pfam00854 110 GMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWNKV-----------------KLNGSSAGIKKLHWLDWARELD 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   316 KAAYITArdldDKKQDSVNPWrlCPVTQVEEVKCILRLMPIWLCTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASM 395
Cdd:pfam00854 173 ALIILGI----VVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGSFEIPPAQF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   396 SSFDILSVALFIFLYRRVLEPVANRFkkngSKGITELHRMGIGLVIAVIAMIAAGIVECYRLKYAdkSCTHCDGSSSLSI 475
Cdd:pfam00854 247 QAFNAILVLIFIPIFDRLVYPLGRKC----TGGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTG--PEFPIAQEVPISV 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30692706   476 FWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGNFVSSLLVTMVVKISTEDHMPGWI 547
Cdd:pfam00854 321 LWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNVLGAYGWL 392
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
52-582 7.35e-36

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 140.72  E-value: 7.35e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  52 GLATL---------AFFGVGVNLVLFLTRVLQQ-----NNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQV 117
Cdd:COG3104  15 GLYTLfftemwerfSFYGMRAILVLYLTASLADgglglSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAILLGGI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 118 IFVIGlsslslssYMFLIRPRGcgdevtpcgshsmmeITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegysKIA 197
Cdd:COG3104  95 LMALG--------HFLLALPGG---------------VTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPR----RDA 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 198 FFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGtprYRYFKPTG----NPLSRFCQVLVAATK 273
Cdd:COG3104 148 GFTIFYMGINIGAFLAPLLCGYLGEKYGWHYGFGAAAIGMLIGLIIFLLG---RKYLGDIGlepdNPLSKKERLIAVALG 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 274 KSSVEAPLRGreemydgdsegknasVNTGRRIVHTdeFKFLDKAAYITARDLDDKKQDSvnpwrlcpvtqvEEVKCILRL 353
Cdd:COG3104 225 ALLLVLVLAG---------------LLSNANIANY--LLYVIAIIAYFIFILRSKKLTK------------EERKRLLAI 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 354 MPIWLCTIIYSVVFTQMAS---LFVEQgaAMNTSVSDFKIPPASMSSFDilsvALFIFlyrrVLEPV-ANRFKKNGSKGI 429
Cdd:COG3104 276 LILFLFSIVFWALYEQAGTslnLFADR--NVDRSLFGFEIPPSWFQSLN----PLFII----ILAPVfAALWTKLGKRGK 345
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 430 --TELHRMGIGLVIAVIAMIAAGIvecyrlkyadkSCTHCDGSSSLSIFWQAPQYSLIGASEVFMY-VGqLEFFNAQTPD 506
Cdd:COG3104 346 epSTPTKFALGLLLLGLGFLVMAL-----------AALLAGAGGKVSPLWLVLAYLLLTIGELCLSpVG-LSMITKLAPA 413
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30692706 507 GLKSFGSALCMMSMSMGNFVSSLLVTMvvkISTEDHMPgwiprnlnkghldrFYFLLAALTSIDLVVYIACAKWYK 582
Cdd:COG3104 414 RFAGQMMGLWFLATALGNLLAGLLAGL---YAVPGYTA--------------YFLLLGGIALVAGVVLLLLSPKLR 472
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
58-453 6.64e-25

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 109.46  E-value: 6.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706    58 FFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSLSLSSYMFLirp 137
Cdd:TIGR00926   3 YYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSS--- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   138 rgcgdevtpcgSHSMMEITMFyFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSkiaFFSYFYLALNLGSLFSNTI- 216
Cdd:TIGR00926  80 -----------GHPLHDLLDL-LGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSR---FFSFFYFAINAGSLISTIIt 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   217 ------LGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSsveaplrgreemydg 290
Cdd:TIGR00926 145 pilrgdVGCFGCQDCYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKR--------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   291 dseGKNASvntGRRIVHtdefkFLDKAAYITARDLddkkqdsvnpwrlcpvtqVEEVKCILRLMPIWLCTIIYSVVFTQM 370
Cdd:TIGR00926 210 ---FSTRS---EHWPLH-----WLDYAKDKHDIRM------------------IRSTKRLLRVLVLFIPLPMFWALFDQQ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   371 ASLFVEQGAAMNTSVSDFKIPPASMSSFDILsvaLFIFLYRRVLEPVANRFKKNGSKgITELHRMGIGLVIAVIAMIAAG 450
Cdd:TIGR00926 261 GSRWTLQATRMDGDVGGFEIQPDQMQVVNPL---LILIFVPIFDYIVYPAIAKCGTR-FTSLRKMAVGGLLAALSFFVAA 336

                  ...
gi 30692706   451 IVE 453
Cdd:TIGR00926 337 LVQ 339
PRK15462 PRK15462
dipeptide permease;
56-257 3.30e-15

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 78.45  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   56 LAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlsslslssYMFLi 135
Cdd:PRK15462  23 FSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIG--------HVVL- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  136 rprgCGDEVTPcgshsmmeiTMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegysKIAFFSYFYLALNLGSLFSNT 215
Cdd:PRK15462  94 ----GASEIHP---------SFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPR----RDGGFSLMYAAGNVGSIIAPI 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 30692706  216 ILGYFEDEGMWALGFWASTGSAIIGLILFLVGTpryRYFKPT 257
Cdd:PRK15462 157 ACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGN---RHFTHT 195
 
Name Accession Description Interval E-value
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
41-580 0e+00

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 753.44  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17419   1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17419  81 IGLLLLTLSSALPSLRPPQCGDGDLKCPPASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASKSAFFS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFYR---------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17419 213 -----------------------------------------------------------------EVKCILRLLPIWLST 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgSKGITELHRMGIGLV 440
Cdd:cd17419 228 IIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGH-PKGITELQRMGIGLV 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYRLKYADKSC-THCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMS 519
Cdd:cd17419 307 IGILAMVVAALVEIQRLKVARPSNlDDPTSPSPLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMAS 386
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30692706 520 MSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17419 387 VALGNYLSSLLVTIVNKVTTKDGSPGWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICAKW 447
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
45-580 0e+00

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 564.55  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  45 IVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLS 124
Cdd:cd17351   2 PFILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 125 SLSLSSYMFLIRPRGCGDEvTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFSYFYL 204
Cdd:cd17351  82 LLTLSASVPSLRPPPCNPD-SPCEPASSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDETDPKEKKQKPSFFNWFYF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 205 ALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveaplrgr 284
Cdd:cd17351 161 SINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVAGTPFYR-------------------------------- 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 285 eemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCTIIYS 364
Cdd:cd17351 209 -------------------------------------------------------------EVKCLLRLLPIWATTILLS 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 365 VVFTQMASLFVEQGAAMN-TSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSkGITELHRMGIGLVIAV 443
Cdd:cd17351 228 TVYAQMQTFFVQQGLTMDrRLGGSFEIPAASLSVFSTLFVLLFIPLYDRVFVPFARRYTGNPR-GITPLQRIGIGLVLSI 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 444 IAMIAAGIVECYRLKYADKSCT--HCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMS 521
Cdd:cd17351 307 LAMAVAALVEVKRLRVARAHGLldSPTGVVPMSVFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIA 386
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30692706 522 MGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17351 387 LGNFLSSALVTIVNKITGKGGGPGWLPNNLNKGRLDYFYWLLAVLSAVNFLVFLVCAKW 445
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
41-582 6.16e-151

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 442.86  E-value: 6.16e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17417   1 WKACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCgdeVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17417  81 LGLVLLTLSASLPSLKPPEC---NGTCSKASTLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQKSSFFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17417 158 WWYFSICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRY--------------------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtQVEEVKCILRLMPIWLCT 360
Cdd:cd17417 211 --------------------------------------------------------------KVEEVKLVLRLIPIWFTT 228
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSV-SDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSkGITELHRMGIGL 439
Cdd:cd17417 229 LVFTVVFAQSPTFFTKQGVTMDRTIgPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPR-GITLLQRIGIGM 307
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 440 VIAVIAMIAAGIVECYRLKYA-DKSCTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMM 518
Cdd:cd17417 308 FLSILAMVIAALVEMKRLKVAkEHGLISPKATVPMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLS 387
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30692706 519 SMSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKWYK 582
Cdd:cd17417 388 VFGVGSFLSSFLISIVDKITSSSGGQSWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYV 451
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
41-582 1.98e-141

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 418.41  E-value: 1.98e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17418   1 WKACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVTPcgSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17418  81 IGMVLLTLSASVPGLKPASCIGSLCP--PATSVQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPKEKVRKSSFFN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17418 159 WFYFSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFFGTPLYR---------------------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17418 211 -----------------------------------------------------------------EVKILIRLLPIWASG 225
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgSKGITELHRMGIGLV 440
Cdd:cd17418 226 IVFATVYSQMSTMFVQQGRTMDRMGGNFEIPPASLSLFDTLSVLIWVPIYDRFIVPLVRKFTGH-ERGFTQLQRMGIGLF 304
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYRLKYADKSCTHCDGSS-SLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMS 519
Cdd:cd17418 305 ISVLSMVAAAIVEIVRLQLARTHNLVESGPPvPMSIFWQIPQYFLIGAAEVFTFIGQLEFFYDQSPDAMRSLCSALSLLT 384
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30692706 520 MSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKWYK 582
Cdd:cd17418 385 TALGNYLSSLIVTLVTYVTTKGGKPGWIPDNLNNGHLDYFFWLLASLSFLNILVYLWIAKRYT 447
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
41-580 1.22e-125

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 378.33  E-value: 1.22e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17413   1 WKSAALILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVT-PCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFF 199
Cdd:cd17413  81 LGVLVLTLSTTLPSLRPPPCNHTTShHCEPASGIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFDENDPKERKLMSYFF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 200 SYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNplsrfcqvlvaatkkssvea 279
Cdd:cd17413 161 NRFFFCISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVFLAGTKRYRFKKSIGS-------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 280 plrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvTQVEEVKCILRLMPIWLC 359
Cdd:cd17413 221 --------------------------------------------------------------TQVEEVKMVVRMLPIWAT 238
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 360 TIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKkNGSKGITELHRMGIGL 439
Cdd:cd17413 239 TILFWTVYAQMTTFSVEQAETMDRNIGSFEIPPASMAVFLVATILLTTAVYDRVIVPLCRKLT-GHPQGLTTLQRIGVGL 317
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 440 VIAVIAMIAAGIVECYRLKYAdKSCTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMS 519
Cdd:cd17413 318 VFSCLAMAVAALVELKRLRIA-HAHGKPVKTVPMSVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGMKSMSTGLFLST 396
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30692706 520 MSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17413 397 LSLGFFVSSFLVSIVNRVTGKSHPHGWLADNLNKGRLDYFYWLLAVLSALNFVIFLVFAKW 457
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
41-580 5.03e-105

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 324.79  E-value: 5.03e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFV 120
Cdd:cd17415   1 WKTMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 121 IGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFS 200
Cdd:cd17415  81 LGMVLLTISAILPSLRPPPCNGHEVCACQASSAQLSILYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQTWNFFN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 201 YFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17415 161 WYYFCMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLYR---------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17415 213 -----------------------------------------------------------------ELKSIIRMLPIWAAG 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVS-DFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSkGITELHRMGIGL 439
Cdd:cd17415 228 ILLVTASSQQHTFSIQQARTMNRHLTpSFQIPPASMSVFGILSLLTTVPLYDRVLMPVARKFTGNER-GITFLQRMGIGL 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 440 VIAVIAMIAAGIVECYRLKYADKS--CTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCM 517
Cdd:cd17415 307 FISILATVVAAFVEVKRKSVAANHglLDRPHATVPISVFWLVPQYILHGIAEAFMSIGHLEFFYDQSPESMRSTATALFW 386
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30692706 518 MSMSMGNFVSSLLVTMVVKISTEDHMpGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17415 387 STISLGSYLSTLLVTLVHKETSRGGR-WWLPNNLNRGRLDYFYWLVAVLQAVNLVYFLICARW 448
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
47-581 7.45e-104

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 321.52  E-value: 7.45e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  47 ILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlssl 126
Cdd:cd17416   4 IIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLG---- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 127 slssyMFLI---------RPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIA 197
Cdd:cd17416  80 -----MVLLtltaaipslRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKRGLES 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 198 FFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssv 277
Cdd:cd17416 155 FFNWYYFTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 278 eaplrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqVEEVKCILRLMPIW 357
Cdd:cd17416 210 ------------------------------------------------------------------VEDLKSLIRVIPIW 223
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 358 LCTIIYSVVFTQMASLFVEQGAAMNTSV-SDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGsKGITELHRMG 436
Cdd:cd17416 224 STGIILSLAMAQQMSLTVLQALVMDRHLgPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITGRG-RGLTLLQRVG 302
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 437 IGLVIAVIAMIAAGIVECYRLKYADkscTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALC 516
Cdd:cd17416 303 IGIVFSILSMAVAAIVERKRRKTAL---TQGNGTSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLF 379
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30692706 517 MMSMSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKWY 581
Cdd:cd17416 380 SLGMGVASYLSSALISAVHRTTGRGGGGSWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
43-580 2.86e-99

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 310.11  E-value: 2.86e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  43 AGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIG 122
Cdd:cd17414   3 AAFFVLVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 123 LSSLSLSSYMFLIRPRGCGDEVTP-CGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFSY 201
Cdd:cd17414  83 LILLTVQAHIPSLQPPSCNSLGDLtCKEPSGSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPKGRRQLSSFFNW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 202 FYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveapl 281
Cdd:cd17414 163 YYFSFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVFVAGTPFYR----------------------------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 282 rgreemydgdsegknasvntgrrivhtdeFKfldkaayitardlddkkqdsvnpwrlcpvTQVEEVKCILRLMPIWLCTI 361
Cdd:cd17414 214 -----------------------------NK-----------------------------TQVEEVKIVLKMLPIFACTI 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 362 IYSVVFTQMASLFVEQGAAMNTSVS-DFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSkGITELHRMGIGLV 440
Cdd:cd17414 236 ILNCILAQLQTFSVQQGSTMNRTKIgSFNIPPASLQAIPVIFMLILVPLYDHLLVPFARKITGHES-GITHLQRIGIGLV 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYRLKYAdKSCTHCDGSSSL--SIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMM 518
Cdd:cd17414 315 LSTLSMVVAALVETKRKKVA-VENGLLNSKENLpiSIFWIALQFLILGISDMFTAVGLLEFFYTESPSSMRSLGTALTWC 393
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30692706 519 SMSMGNFVSSLLVTMVVKISTEDHMPGWI-PRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd17414 394 SYSFGFYLSSVLVSVVNKVTGSGGHGGWLlGENLNRDRLDLFYWLLCVLSTINFLNYLFWARR 456
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
156-547 3.08e-88

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 279.20  E-value: 3.08e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   156 TMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEgysKIAFFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTG 235
Cdd:pfam00854  33 ALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRR---RSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAV 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   236 SAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSSveaplrgreemydgdseGKNASVNTGRRIVHTDEFKFLD 315
Cdd:pfam00854 110 GMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWNKV-----------------KLNGSSAGIKKLHWLDWARELD 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   316 KAAYITArdldDKKQDSVNPWrlCPVTQVEEVKCILRLMPIWLCTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASM 395
Cdd:pfam00854 173 ALIILGI----VVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGSFEIPPAQF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   396 SSFDILSVALFIFLYRRVLEPVANRFkkngSKGITELHRMGIGLVIAVIAMIAAGIVECYRLKYAdkSCTHCDGSSSLSI 475
Cdd:pfam00854 247 QAFNAILVLIFIPIFDRLVYPLGRKC----TGGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTG--PEFPIAQEVPISV 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30692706   476 FWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGNFVSSLLVTMVVKISTEDHMPGWI 547
Cdd:pfam00854 321 LWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNVLGAYGWL 392
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
44-580 3.47e-69

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 230.40  E-value: 3.47e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  44 GIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGL 123
Cdd:cd06175   1 CAMILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 124 SSLSLSSYMFLIRPRGCGDEVtpCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPkegySKI-AFFSYF 202
Cdd:cd06175  81 AILTVSTIPPGLRPLRCNPSH--CEQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDERGP----SKTqSFFNWF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 203 YLALNLGSLFSNTILGYFEDEGMWALGFwastgsaiiglilflvGTPryryfkptgnplsrFCQVLVAatkkssveaplr 282
Cdd:cd06175 155 YFCINVGSLLAMLGTPYIQDNVGWAAAY----------------GIP--------------FVAILLA------------ 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 283 greemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvTQVEEVKCILRLMPIWLCTII 362
Cdd:cd06175 193 -----------------------------------------------------------LVVFEVKQLLRALPLFAFCIL 213
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 363 YSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVanrFKKNGsKGITELHRMGIGLVIA 442
Cdd:cd06175 214 FWTVYAQMTTSYVLQALTLVRSTGLFTIPPASMQAFNPILLLLLIPVLDKVVYPL---IRRYG-VGLSPLTKIGLGFFFG 289
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 443 VIAMIAAGIVECYRLKYADKSCTHCDGSSsLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSM 522
Cdd:cd06175 290 SLSMFVAGFLELKRLNTAHAHGPVVTTSP-LSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGF 368
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 30692706 523 GNFVSSLLVTMVVKISTEDhmpgWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKW 580
Cdd:cd06175 369 GSFFGSVLVTLVSKPTDGA----HIADDLNKGVLTNFFFLLAVLAALNFLIFLLVSRK 422
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
47-585 6.99e-47

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 170.49  E-value: 6.99e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  47 ILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSl 126
Cdd:cd17347   7 IVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHIV- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 127 slssyMFLirprgcgDEVTPCGSHSMMeitMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEgyskIA-FFSYFYLA 205
Cdd:cd17347  86 -----LAV-------TAIPPLGPPHVW---GLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHL----LArFFSWFYFA 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 206 LNLGSLFSnTIL-------GYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssve 278
Cdd:cd17347 147 INAGSLLS-TFLtpilradVQFGGHDCYPLAFGVPGVLMAVATLVFWLGRKHYK-------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 279 aplrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWL 358
Cdd:cd17347 200 -------------------------------------------------------------------DVKALLRVLVLFI 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 359 CTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgskgITELHRMGIG 438
Cdd:cd17347 213 PLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIP----LTPLRKMGVG 288
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 439 LVIAVIAMIAAGIVE------CYRLKYADKSCTHCDGS-SSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSF 511
Cdd:cd17347 289 MILAALAFVIAGFLQlridggLPGQPDPGEVTTFEDIEpNSVSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSV 368
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30692706 512 GSALCMMSMSMGNfvssLLVTMVVKISTEDHMPGwiprnlnkghldrFYFLLAALTSIDLVVYIACAKWYKPIQ 585
Cdd:cd17347 369 VQAAWLLTVALGN----LIVVIVAELIQFSSQAA-------------EYFFFAGLMLVVAVVFALLARFYKYVT 425
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
52-582 7.35e-36

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 140.72  E-value: 7.35e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  52 GLATL---------AFFGVGVNLVLFLTRVLQQ-----NNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQV 117
Cdd:COG3104  15 GLYTLfftemwerfSFYGMRAILVLYLTASLADgglglSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAILLGGI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 118 IFVIGlsslslssYMFLIRPRGcgdevtpcgshsmmeITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegysKIA 197
Cdd:COG3104  95 LMALG--------HFLLALPGG---------------VTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPR----RDA 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 198 FFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGtprYRYFKPTG----NPLSRFCQVLVAATK 273
Cdd:COG3104 148 GFTIFYMGINIGAFLAPLLCGYLGEKYGWHYGFGAAAIGMLIGLIIFLLG---RKYLGDIGlepdNPLSKKERLIAVALG 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 274 KSSVEAPLRGreemydgdsegknasVNTGRRIVHTdeFKFLDKAAYITARDLDDKKQDSvnpwrlcpvtqvEEVKCILRL 353
Cdd:COG3104 225 ALLLVLVLAG---------------LLSNANIANY--LLYVIAIIAYFIFILRSKKLTK------------EERKRLLAI 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 354 MPIWLCTIIYSVVFTQMAS---LFVEQgaAMNTSVSDFKIPPASMSSFDilsvALFIFlyrrVLEPV-ANRFKKNGSKGI 429
Cdd:COG3104 276 LILFLFSIVFWALYEQAGTslnLFADR--NVDRSLFGFEIPPSWFQSLN----PLFII----ILAPVfAALWTKLGKRGK 345
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 430 --TELHRMGIGLVIAVIAMIAAGIvecyrlkyadkSCTHCDGSSSLSIFWQAPQYSLIGASEVFMY-VGqLEFFNAQTPD 506
Cdd:COG3104 346 epSTPTKFALGLLLLGLGFLVMAL-----------AALLAGAGGKVSPLWLVLAYLLLTIGELCLSpVG-LSMITKLAPA 413
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30692706 507 GLKSFGSALCMMSMSMGNFVSSLLVTMvvkISTEDHMPgwiprnlnkghldrFYFLLAALTSIDLVVYIACAKWYK 582
Cdd:COG3104 414 RFAGQMMGLWFLATALGNLLAGLLAGL---YAVPGYTA--------------YFLLLGGIALVAGVVLLLLSPKLR 472
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
43-575 6.01e-34

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 134.53  E-value: 6.01e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  43 AGIVILLNQGLATLAFFGVGVNLVLFLT-RVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVI 121
Cdd:cd17348   3 ACAAVLLVELLERAAFYGITSNLVLFLNgSPFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 122 GlsslslssyMFLIrprgcgdevtPCGSHSMMeitmfYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegySKIAFFSY 201
Cdd:cd17348  83 G---------MLLF----------PATAAPAL-----YAGLLLVGLGVGSVKANITPFGADQVKDRGPE---ATRRFFNW 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 202 FYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPryryfkptgnplsrfcqvlvaatkkssveapl 281
Cdd:cd17348 136 FYWSINLGAILSLGGVAYIQQNVSFLIGYSIPAVCVGLAFLVFLCGQP-------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 282 rgreemydgdsegknasvntgrrivhtdefKFLDkaayitardlddkkqdsvnpwrlcpvtqveeVKCILRLMPIWLCTI 361
Cdd:cd17348 184 ------------------------------VFID-------------------------------VKALVKILPVFLALI 202
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 362 IYSVVFTQMASLFVEQG-----------AAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSKgit 430
Cdd:cd17348 203 PYWTVYFQMQTTYVLQSlhlkipnifisNIAGITNSSHTFPAAWLTMFDAVLILILIPLKDKLVDPFLKRRGLLPSS--- 279
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 431 eLHRMGIGLVIAVIAMIAAGIVECYRLKYADKSCTHCDG-------SSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQ 503
Cdd:cd17348 280 -LKRIAVGMFFVMCSAIAAGILESKRLEIVKHNTTIQQQignvtyyAADLPIWWQIPQYLLIGISEIFASIAGLEFAYSA 358
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30692706 504 TPDGLKSFGSALCMMSMSMGNFVSSLLVTMVvkiSTEDHmpGWIPR-----NLNKGHLDRFYFLLAALTSIDLVVYI 575
Cdd:cd17348 359 APKSMQSAIMGLFFFFSGVGSFVGSGLLALV---SIKEI--GWMSShkdfgNINGCRLNYYFFLLAGIQGVTLLLFL 430
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
92-527 8.32e-26

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 110.64  E-value: 8.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  92 YIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlsslslssYMFLIrprgCGDevTPCGSHSMMEITMFYFSIYLIALGYGG 171
Cdd:cd17350  60 YVTPVIGAYVADQFLGRYNTIVCGAVIYFVG--------ILILT----CTS--IPSVIDAGAGLGGFVVAIIIIGLGTGG 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 172 YQPNIATLGADQFDEEHP-----KEGYSKIA--------FFSYFYLALNLGSlFSNTILGYFE-DEGMWaLGFWASTGSA 237
Cdd:cd17350 126 IKSNVSPLIADQLPKIKPyvktlKNGERVIVdpvvtlsrIYMIFYWAINVGS-LSLLATTYLErTKGFW-YAYLLPLCVF 203
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 238 IIGLILFLVGTPRYryfkptgnplsrfcqvlvaatkkssveaplrgreemydgdsegknasvntgrrIVHTDEFkfldka 317
Cdd:cd17350 204 VIPLIILAFGKKFY-----------------------------------------------------KIRPDLF------ 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 318 ayitardlddkkqdsvnpwrlcpvtqVEEVKCILRLMPIWLCTIIYSVVFTQMASLFVEQGAAMNTSvsdfKIPPASMSS 397
Cdd:cd17350 225 --------------------------IDELKRALRACKVFLFYPIYWVCYGQMTSNFISQAGQMQLH----GVPNDLFQA 274
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 398 FDILSVALFIFLYRRVLEPVANRFKKNgSKGITelhRMGIGLVIAVIAMIAAGIVEcyRLKYADKSC----THCDGSSSL 473
Cdd:cd17350 275 FDSIALIIFIPILENIIYPLLRKYNIP-FKPIT---RITLGFMFASFSMIYAAVLQ--AKIYQAGPCyanpTGTCSPNDI 348
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 30692706 474 SIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGNFVS 527
Cdd:cd17350 349 HVWIQIPAYVLIAFSEIFASITGLEYAYTKAPPSMKSFITALFLLTNAFGAALS 402
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
47-526 4.81e-25

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 107.60  E-value: 4.81e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  47 ILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlssl 126
Cdd:cd17411   7 IVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYVVG---- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 127 slssymFLIRPRGcgdeVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEgysKIAFFSYFYLAL 206
Cdd:cd17411  83 ------HVIKSVG----AIPTVGDQQVHVVLSMIGLFLIALGTGGIKPCVAAFGGDQFEEEHARE---RSKFFSIFYLSI 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 207 NLGSLFSNTILGYFE------DEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkssveap 280
Cdd:cd17411 150 NAGSLISTFVTPILRgdvqcfGGDCYALAFGVPAALMVVALVVFIAGSGMYK---------------------------- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 281 lrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPIWLCT 360
Cdd:cd17411 202 -----------------------------------------------------------------EVKMVTRVLFLYIPL 216
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 361 IIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgskgITELHRMGIGLV 440
Cdd:cd17411 217 PMFWALFDQQGSRWTLQATRMNDFGGGFVLQPDQMQTLNPLLILVFIPIFDLGIYPLVSKCKIN----FTSLRKMATGMI 292
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 441 IAVIAMIAAGIVECYrlkyadkscthcdgssslsIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSM 520
Cdd:cd17411 293 LAALAFAVAAAVEIK-------------------IAWQLPQYVLLSAGEVMFSITGLEFSYSQAPASMKSVLQAGWLLTV 353

                ....*.
gi 30692706 521 SMGNFV 526
Cdd:cd17411 354 AFGNVI 359
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
58-453 6.64e-25

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 109.46  E-value: 6.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706    58 FFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSLSLSSYMFLirp 137
Cdd:TIGR00926   3 YYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSS--- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   138 rgcgdevtpcgSHSMMEITMFyFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSkiaFFSYFYLALNLGSLFSNTI- 216
Cdd:TIGR00926  80 -----------GHPLHDLLDL-LGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSR---FFSFFYFAINAGSLISTIIt 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   217 ------LGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSsveaplrgreemydg 290
Cdd:TIGR00926 145 pilrgdVGCFGCQDCYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKR--------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   291 dseGKNASvntGRRIVHtdefkFLDKAAYITARDLddkkqdsvnpwrlcpvtqVEEVKCILRLMPIWLCTIIYSVVFTQM 370
Cdd:TIGR00926 210 ---FSTRS---EHWPLH-----WLDYAKDKHDIRM------------------IRSTKRLLRVLVLFIPLPMFWALFDQQ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   371 ASLFVEQGAAMNTSVSDFKIPPASMSSFDILsvaLFIFLYRRVLEPVANRFKKNGSKgITELHRMGIGLVIAVIAMIAAG 450
Cdd:TIGR00926 261 GSRWTLQATRMDGDVGGFEIQPDQMQVVNPL---LILIFVPIFDYIVYPAIAKCGTR-FTSLRKMAVGGLLAALSFFVAA 336

                  ...
gi 30692706   451 IVE 453
Cdd:TIGR00926 337 LVQ 339
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
47-581 1.03e-24

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 106.85  E-value: 1.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  47 ILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSL 126
Cdd:cd17412   7 IVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTIGQAVM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 127 SLSSYMFLIRPR--GCGDEVTpcgshsmMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEgysKIAFFSYFYL 204
Cdd:cd17412  87 AVSAIHDLTDANrdGTPDNLT-------LHVALSMIGLLLIALGTGGIKPCVAAFGGDQFEEHQEKQ---RSRFFSIFYL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 205 ALNLGSLFSNTIL--------GYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRyfkptgnplsrfcqvlvaatkkss 276
Cdd:cd17412 157 SINAGSLLSTIITpilrsqecGIHSKQKCYPLAFGVPAALMVVALIVFILGSKMYK------------------------ 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 277 veaplrgreemydgdsegknasvntgrrivhtdefkfldkaayitardlddkkqdsvnpwrlcpvtqveEVKCILRLMPI 356
Cdd:cd17412 213 ---------------------------------------------------------------------QIKMVLKVLFL 223
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 357 WLCTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNgskgITELHRMG 436
Cdd:cd17412 224 YIPLPMFWALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQTVNPILIIIMVPIFDAVIYPLIKKCKIN----FTPLRKMT 299
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 437 IGLVIAVIAMIAAGIVEcyrlkyadkscthcdgsssLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALC 516
Cdd:cd17412 300 VGMFLAALAFVAAALLQ-------------------IQMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGW 360
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30692706 517 MMSMSMGNFVsSLLVTMVVKISTEdhmpgWIPrnlnkghldrfYFLLAALTSIDLVVYIACAKWY 581
Cdd:cd17412 361 LLTVAVGNII-VLIVAEAGSISEQ-----WAE-----------YVLFAALLVAVCIIFAIMAYFY 408
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
57-251 2.50e-21

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 96.49  E-value: 2.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  57 AFFGVGVNLVLFLTRVLQQ--NNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSlslssyMFL 134
Cdd:cd17346  17 SYYGMRAILILYLTAQLGDgfSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGILMALGYLL------LAL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 135 irprgcgdevtpcgshSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegysKIAFFSYFYLALNLGSLFSN 214
Cdd:cd17346  91 ----------------SPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPR----RDSGFSIFYMGINLGAFLAP 150
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 30692706 215 TILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRY 251
Cdd:cd17346 151 LLCGTLGDNYGYHYGFGLAAVGMLLGLLIFLLGRKKL 187
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
44-567 3.11e-18

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907 [Multi-domain]  Cd Length: 437  Bit Score: 87.50  E-value: 3.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  44 GIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGL 123
Cdd:cd17349   4 VICLLLVELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHFLGT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 124 SSLSLSSYMFLIRPRGCGDEVTPCGSHSmmEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSkiaFFSYFY 203
Cdd:cd17349  84 ALLPVVAFPFEDFYIDTHHIIHTLAKRE--QTLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKLMS---FFNWFY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 204 LALNLGSLFSNTILGYFEDEGMWALGFwastgsaiigLILFLvgtpryryfkptgnplsrfcQVLVAATKkssveaplrg 283
Cdd:cd17349 159 WLVNLNSAVVFVGISYIQQSVAKNLGF----------LIPFM--------------------SVLMALIT---------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 284 reemydgdsegknasvntgrriVHTDEFKFLDkaayitardlddkkqdsvnpwrlcpvtqveeVKCILRLMPIWLCTIIY 363
Cdd:cd17349 199 ----------------------LHMVRNDLIN-------------------------------TKNLVRLFPLFAFQILY 225
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 364 SVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIflyrRVLEPVANRFKKNGSKGITELHRMGIGLVIAV 443
Cdd:cd17349 226 RTCIMQIPSGYYLQTMNSNLNLGGFLLPIAAMNVISIIPLLILA----PFLEYFSSCLFSSKRYGPFLSACIIAGHLCAA 301
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 444 IAMIAAGIVECYRLKYADKSCTHCDGS---SSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSM 520
Cdd:cd17349 302 LSVMVAGFSEIHRKRFPLVEQTLSGKVllvSSMPCFQLAPQYVLLGVAEALVTPACSLITFRLVPSSIRGISMHFLTLFN 381
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 30692706 521 SMGNFVSSLLVTMVVKISTEDhmpgWIPRNLNKGHLDRFYFLLAALT 567
Cdd:cd17349 382 GAGCFMGALLIQLVYLISEGN----WFPNTLNKGNLERFFFFLASLM 424
PRK15462 PRK15462
dipeptide permease;
56-257 3.30e-15

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 78.45  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   56 LAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlsslslssYMFLi 135
Cdd:PRK15462  23 FSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIG--------HVVL- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  136 rprgCGDEVTPcgshsmmeiTMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKegysKIAFFSYFYLALNLGSLFSNT 215
Cdd:PRK15462  94 ----GASEIHP---------SFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPR----RDGGFSLMYAAGNVGSIIAPI 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 30692706  216 ILGYFEDEGMWALGFWASTGSAIIGLILFLVGTpryRYFKPT 257
Cdd:PRK15462 157 ACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGN---RHFTHT 195
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
57-262 2.21e-10

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 63.32  E-value: 2.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706    57 AFFGVGVNLVLFL--TRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSLSLSSYMFL 134
Cdd:TIGR00924  25 SYYGMQGILAVYLvqQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLGGIVLMLGHFMLAMSIYPDL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   135 irprgcgdevtpcgshsmmeitmFYFSIYLIALGYGGYQPNIATLGADQFDE-EHPKegysKIAFFSYFYLALNLGSLFS 213
Cdd:TIGR00924 105 -----------------------IFYGLGTIAVGSGLFKANPSSMVGKLYERgDMPR----RDGGFTLFYMSINIGSFIS 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 30692706   214 NTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNPLS 262
Cdd:TIGR00924 158 PLLAGVIAENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLS 206
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-249 1.09e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.44  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  45 IVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDsYWGRYKTCAIFQVIFVIGLS 124
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK-RFGKKKAFIIGLLLAALGLL 309
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 125 SlslssyMFLIRPrgcgdevtpcgshsmMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIA-FFSYFY 203
Cdd:COG2211 310 L------LFFLGP---------------GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGlYFGIFT 368
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 30692706 204 LALNLGSLFSNTILGYFedegMWALGFWAS---TGSAIIGLILFLVGTP 249
Cdd:COG2211 369 FAIKLGQALAGALAGLL----LALFGYVAGaaqSPSALTGIRLLFFLLP 413
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
41-252 4.24e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 4.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLnqglATLAFFGVGVNLVLFLTRVLQQNNADAANnvskWTGTVYIFSLVGAF----LSDsYWGRYK--TCAI 114
Cdd:COG2271 183 WLLALAYFL----VYFALYGFLTWLPTYLVEVRGLSLAQAGL----LLSLPFLAGIVGSLlggwLSD-RLGRRRklVLAI 253
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 115 FQVIFVIGlsslslssyMFLIrprgcgdevtpcgsHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFdeehPKEGYS 194
Cdd:COG2271 254 GLLLAALA---------LLLL--------------ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARG 306
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 30692706 195 KIafFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYR 252
Cdd:COG2271 307 TA--SGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_1 pfam07690
Major Facilitator Superfamily;
47-250 4.56e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 4.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706    47 ILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDsYWGRYKTCAIFQVIFVIGLssl 126
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGRRRVLLIGLLLFALGL--- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   127 slssYMFLIRPRgcgdevtpcgshsmmeITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHpkegysKIAFFSYFYLAL 206
Cdd:pfam07690  77 ----LLLLFASS----------------LWLLLVLRVLQGLGAGALFPAALALIADWFPPEE------RGRALGLVSAGF 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 30692706   207 NLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPR 250
Cdd:pfam07690 131 GLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
35-250 9.59e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.05  E-value: 9.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  35 RSNSGQWVAGIVILLNQGLATLAFFGVGVnLVLFLTRVLQQNNADAAnnvskWTGTVY-----IFSLVGAFLSDSYwGRY 109
Cdd:COG2814   3 ATPRRRWLALLALALGAFLSGLGIGIVLP-ALPLIAADLGASPAQAG-----LVVTAYllgaaLGAPLAGRLADRF-GRR 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 110 KTCAIFQVIFVIGlsslslssyMFLirprgcgdevtpCG-SHSmmeITMFYFSIYLIALGYGGYQPNIATLGADQFDEEH 188
Cdd:COG2814  76 RVLLLGLLLFALG---------SLL------------CAlAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPER 131
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30692706 189 pkegysKIAFFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPR 250
Cdd:COG2814 132 ------RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE 187
tppB PRK09584
dipeptide/tripeptide permease DtpA;
58-245 6.58e-05

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 45.91  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706   58 FFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGlsslslssYMFLirp 137
Cdd:PRK09584  37 YYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIG--------YALV--- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  138 rgcgdevtpcgSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPK-EGYskiafFSYFYLALNLGSLFSNTI 216
Cdd:PRK09584 106 -----------AWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRlDGA-----FTMYYMSINIGSFFSMLA 169
                        170       180
                 ....*....|....*....|....*....
gi 30692706  217 LGYFEDEGMWALGFWASTGSAIIGLILFL 245
Cdd:PRK09584 170 TPWLAAKYGWSVAFALSVVGMLITVVNFA 198
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
47-547 1.27e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.72  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  47 ILLNQGLATLAFFGVGVNLVLFLtRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDsYWGRYKTCAIFQVIFVIGlssl 126
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLAD-RFGRRPVLLLGLLLFALG---- 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 127 slssyMFLIrprgcgdevtpCGSHSmmeITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHpkegysKIAFFSYFYLAL 206
Cdd:cd06174  75 -----ALLF-----------AFAPS---FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE------RGRALGLLQAFG 129
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 207 NLGSLFSNTILGYF--EDEGMWALGFWASTGSAIIGLILFLVGTPryryfkptgnplsrfcqvlvaatkkssveaplrgr 284
Cdd:cd06174 130 SVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVP----------------------------------- 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 285 eemydgdsegknasvntgrrivhtdefkfldkaayitardlDDKKQDSVNPWRLCPVTQVEEVKCILRLMPIWLCTIIYS 364
Cdd:cd06174 175 -----------------------------------------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 365 VVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLepvanrfkkngSKGITELHRMGIGLVIAVI 444
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLS-----------DRLIGRKPLLLIGLLLMAL 282
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 445 AMIAAGIvecyrlkyadkscthcdgSSSLSIFWQApqYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGN 524
Cdd:cd06174 283 GLALLLL------------------APSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342
                       490       500
                ....*....|....*....|...
gi 30692706 525 FVSSLLVTMVVKISTEDHMPGWI 547
Cdd:cd06174 343 AIGPLLAGFLLAATFGLTGAFLV 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
52-245 1.46e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  52 GLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYI----FSLVGAFLSDSYWGRYKTCAIFQVIFVIGlssls 127
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLagalGSLLLGLLSDRLIGRKPLLLIGLLLMALG----- 283
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 128 lSSYMFLIRPRgcgdevtpcgshsmmeiTMFYFSIYLIALGYGGYQPNIATLGADQFDEEHpkegysKIAFFSYFYLALN 207
Cdd:cd06174 284 -LALLLLAPSL-----------------LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI------RGTAFGLLNTFGF 339
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 30692706 208 LGSLFSNTILGYFEDE-GMWALGFWASTGSAIIGLILFL 245
Cdd:cd06174 340 LGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
18-243 3.72e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.37  E-value: 3.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  18 EEETRDGTVDYYGRPSIRSNSGqWVAGIVILLNqglatlAFFGVGV--NLVLFLTRVLQQNNADAANNVSkwtgtVY-IF 94
Cdd:cd17353 194 ANNAENSPRDYTPREMLRTPTF-WLLWLMFFLN------ATAGLMLigQAKPIGQEFAGLDAGIAALAVS-----ILsIF 261
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  95 SLVG----AFLSDsYWGRYKTcaiFQVIFVIGLSSlslssyMFLIrprgcgdevtpcgSHSMMEITMFYFSIYLIALGYG 170
Cdd:cd17353 262 NGGGrpfwGWLSD-KIGRKNT---LSIAFLIQGVA------MFLL-------------PFIGSVAVLFVLGVALIGFCYG 318
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30692706 171 GYQPNIATLGADQFDEEHpkegYSKIafFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLIL 243
Cdd:cd17353 319 GGFALFPALTADFFGTKN----AGTN--YGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
41-252 4.45e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.95  E-value: 4.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706  41 WVAGIVILLNQGlatlAFFGVGVNLVLFLTRVLQQNNADAANnvskWTGTVYIFSLV----GAFLSDsYWGRYKTCAIFQ 116
Cdd:COG2223 208 WLLSLLYFGTFG----SFIGFSSWLPPYLVDQFGLSAATAGL----LAALFALLGALgrplGGWLSD-RIGGRRVLLIVF 278
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30692706 117 VIFVIGlsslslssyMFLIrprgcgdevtpcgSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHpkegYSKI 196
Cdd:COG2223 279 ALMALG---------LLLL-------------ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN----AGAV 332
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30692706 197 AffSYFYLALNLGSLFSNTILGYFEDE-GMWALGFWASTGSAIIGLILFLVGTPRYR 252
Cdd:COG2223 333 Y--GLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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