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Conserved domains on  [gi|15217872|ref|NP_174143|]
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purine permease 3 [Arabidopsis thaliana]

Protein Classification

purine permease( domain architecture ID 12180965)

purine permease is a proton-coupled transporter that mediates the uptake of nucleosides, nucleotides, and their derivatives, such as adenine and cytosine, as well as purine derivatives (hypoxanthine), phytohormones (zeatin and kinetin), and alkaloids (caffeine and nicotine)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 5-327 1.08e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


:

Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 409.36  E-value: 1.08e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872     5 LVIINCIILAIGNCGGPLIMRLYFNNGGKRIWFSTFLETAGFPVIFIPLLFSYITRRRSNnvgDSTSFFLIKPRLLIAAV 84
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSFLSKKRNQ---ETTSFSSSFKRLVIIYI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872    85 IVGILSGFDNYLYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAVLGMHTETDKPVHETH 164
Cdd:pfam16913  79 VLGLLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   165 KQYITGFLITVAAAVMYAFILPLVELAYQKAKQTMSYTLVLEFQLILCLLASIVSVIGMFIAGDFKALPKEAREFKLGEA 244
Cdd:pfam16913 159 KKYVIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   245 LFYVVAVFSAIIWQGFFLGAIGLIFSTSSLVSGIMISVLLPITEVLAVIFYHEKFQAEKGLSLALSLWGFVSYFYGEIKS 324
Cdd:pfam16913 239 LYVLTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKD 318


                  ...
gi 15217872   325 GED 327
Cdd:pfam16913 319 KKK 321
 
Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 5-327 1.08e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 409.36  E-value: 1.08e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872     5 LVIINCIILAIGNCGGPLIMRLYFNNGGKRIWFSTFLETAGFPVIFIPLLFSYITRRRSNnvgDSTSFFLIKPRLLIAAV 84
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSFLSKKRNQ---ETTSFSSSFKRLVIIYI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872    85 IVGILSGFDNYLYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAVLGMHTETDKPVHETH 164
Cdd:pfam16913  79 VLGLLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   165 KQYITGFLITVAAAVMYAFILPLVELAYQKAKQTMSYTLVLEFQLILCLLASIVSVIGMFIAGDFKALPKEAREFKLGEA 244
Cdd:pfam16913 159 KKYVIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   245 LFYVVAVFSAIIWQGFFLGAIGLIFSTSSLVSGIMISVLLPITEVLAVIFYHEKFQAEKGLSLALSLWGFVSYFYGEIKS 324
Cdd:pfam16913 239 LYVLTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKD 318


                  ...
gi 15217872   325 GED 327
Cdd:pfam16913 319 KKK 321
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 71-299 4.02e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 51.00  E-value: 4.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872  71 SFFLIKPRLLIAAVIVGILSGF-DNYLYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAV 149
Cdd:COG0697  56 RLPPLSRRDWLLLLLRGLLGLAlAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872 150 LGmhtetdKPVHETHKQYITGFLITVAAAVMYAFILplveLAYQKAKQTMSytlVLEFQLILCLLASIVSVIGMFIAGDF 229
Cdd:COG0697 136 IV------GPGGGGGGGSLLGDLLALLAALSWALYT----VLTRRLSRRLD---PLTLTFWQMLVGALLLLPLALLTGLP 202

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217872 230 KALPkearefklgealfyvVAVFSAIIWQGFFLGAIGLIFSTSSL------VSGIMISVLLPITEVLAVIFYHEKF 299
Cdd:COG0697 203 LPLS---------------AAAWLALLYLGLFGTALAYLLWFRALrrlgasRAAPLTYLEPVFAVLLGWLLLGEPL 263
 
Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 5-327 1.08e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 409.36  E-value: 1.08e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872     5 LVIINCIILAIGNCGGPLIMRLYFNNGGKRIWFSTFLETAGFPVIFIPLLFSYITRRRSNnvgDSTSFFLIKPRLLIAAV 84
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSFLSKKRNQ---ETTSFSSSFKRLVIIYI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872    85 IVGILSGFDNYLYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAVLGMHTETDKPVHETH 164
Cdd:pfam16913  79 VLGLLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   165 KQYITGFLITVAAAVMYAFILPLVELAYQKAKQTMSYTLVLEFQLILCLLASIVSVIGMFIAGDFKALPKEAREFKLGEA 244
Cdd:pfam16913 159 KKYVIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   245 LFYVVAVFSAIIWQGFFLGAIGLIFSTSSLVSGIMISVLLPITEVLAVIFYHEKFQAEKGLSLALSLWGFVSYFYGEIKS 324
Cdd:pfam16913 239 LYVLTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKD 318


                  ...
gi 15217872   325 GED 327
Cdd:pfam16913 319 KKK 321
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 71-299 4.02e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 51.00  E-value: 4.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872  71 SFFLIKPRLLIAAVIVGILSGF-DNYLYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAV 149
Cdd:COG0697  56 RLPPLSRRDWLLLLLRGLLGLAlAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872 150 LGmhtetdKPVHETHKQYITGFLITVAAAVMYAFILplveLAYQKAKQTMSytlVLEFQLILCLLASIVSVIGMFIAGDF 229
Cdd:COG0697 136 IV------GPGGGGGGGSLLGDLLALLAALSWALYT----VLTRRLSRRLD---PLTLTFWQMLVGALLLLPLALLTGLP 202

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217872 230 KALPkearefklgealfyvVAVFSAIIWQGFFLGAIGLIFSTSSL------VSGIMISVLLPITEVLAVIFYHEKF 299
Cdd:COG0697 203 LPLS---------------AAAWLALLYLGLFGTALAYLLWFRALrrlgasRAAPLTYLEPVFAVLLGWLLLGEPL 263
UPF0182 pfam03699
Uncharacterized protein family (UPF0182); This family contains uncharacterized integral ...
 181-323 2.31e-03

Uncharacterized protein family (UPF0182); This family contains uncharacterized integral membrane proteins.


Pssm-ID: 427447  Cd Length: 752  Bit Score: 39.77  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872   181 YAFILPLvelayqkakqtmsYTLVLEFQLILCLLASIVSVIGMFIAGDFKALPKEAREFKLGEALFYV-VAVFSAIIWQG 259
Cdd:pfam03699 131 YVFSLPF-------------LELLLGWLLGLVILALIATLLTYYLYGGIRLDGRGPGLSRAARRHLSVlLGLFFLLKAVG 197

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15217872   260 FFLGAIGLIFSTSSLVSGIM---ISVLLPITEVLAVIfyhekfqaekglSLALSLWGFVSYFYGEIK 323
Cdd:pfam03699 198 YWLDRYELLYSRRGVVYGAGytdVNAVLPAYTILAVI------------ALLVAVLFFVNIFRRKWR 252
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 73-152 8.08e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 36.02  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217872    73 FLIKPRLLIAAVIVGILSGFDNY-LYAYGIAYLPVSTAALIIASQLAFIAIFSFFMVKHKFTPFTINAVVLLTVGAAVLG 151
Cdd:pfam00892  56 LVIPLKSWLALLYLGVLGTFLGFlLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLIL 135


                  .
gi 15217872   152 M 152
Cdd:pfam00892 136 L 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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