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Conserved domains on  [gi|15223467|ref|NP_174046|]
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Paired amphipathic helix (PAH2) superfamily protein [Arabidopsis thaliana]

Protein Classification

PAH domain-containing protein( domain architecture ID 10496261)

PAH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 32-76 1.14e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 44.33  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467    32 EKYQEFVRIFIDYTANRFGFETLSASLQELLRDHANLCHGSNVLL 76
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 super family cl35027
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
92-180 2.49e-06

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5602:

Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.99  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467   92 FHINKVVGRSVPPAVAVPTMD--DATSYLNAVKEAFHDEPAKYMEITKLLTDLKARRINAASVIARMEELLKDHLNLLLG 169
Cdd:COG5602  107 SASNQNMERSPPPRIPYRPLDvsDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEG 186

                         90
                 ....*....|.
gi 15223467  170 FCVFLSPTRRF 180
Cdd:COG5602  187 FNTFLPSGYKI 197
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 194-238 3.19e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 42.79  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467   194 QVVDSVLQILRMHSEGNKSKDEASQEVRALIQGHEDLLMELSEIF 238
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
 
Name Accession Description Interval E-value
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 32-76 1.14e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 44.33  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467    32 EKYQEFVRIFIDYTANRFGFETLSASLQELLRDHANLCHGSNVLL 76
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
92-180 2.49e-06

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.99  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467   92 FHINKVVGRSVPPAVAVPTMD--DATSYLNAVKEAFHDEPAKYMEITKLLTDLKARRINAASVIARMEELLKDHLNLLLG 169
Cdd:COG5602  107 SASNQNMERSPPPRIPYRPLDvsDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEG 186

                         90
                 ....*....|.
gi 15223467  170 FCVFLSPTRRF 180
Cdd:COG5602  187 FNTFLPSGYKI 197
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 194-238 3.19e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 42.79  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467   194 QVVDSVLQILRMHSEGNKSKDEASQEVRALIQGHEDLLMELSEIF 238
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
 
Name Accession Description Interval E-value
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 32-76 1.14e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 44.33  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467    32 EKYQEFVRIFIDYTANRFGFETLSASLQELLRDHANLCHGSNVLL 76
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
92-180 2.49e-06

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.99  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467   92 FHINKVVGRSVPPAVAVPTMD--DATSYLNAVKEAFHDEPAKYMEITKLLTDLKARRINAASVIARMEELLKDHLNLLLG 169
Cdd:COG5602  107 SASNQNMERSPPPRIPYRPLDvsDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEG 186

                         90
                 ....*....|.
gi 15223467  170 FCVFLSPTRRF 180
Cdd:COG5602  187 FNTFLPSGYKI 197
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 194-238 3.19e-06

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 42.79  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15223467   194 QVVDSVLQILRMHSEGNKSKDEASQEVRALIQGHEDLLMELSEIF 238
Cdd:pfam02671   1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
8-240 1.54e-05

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 45.68  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467    8 PEFNFEDGMAYFDAVKVALQDtEPEKYQEFVRIFIDYTANRFGFETLSASLQELLRDHANLCHGSNVLLP----FRLQTA 83
Cdd:COG5602  124 RPLDVSDALSYLEKVKEQFSN-RPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFLPsgykIEGSLP 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467   84 IPPEASAEFHINKVVGRSVPPAVAVPT---MDDATSYLNAVKEAFHDEPAKYMEITKLLTDLKARRINAAsvIArmeell 160
Cdd:COG5602  203 QPNGSRLHVTTPQGPLSSPPVQSSYYVapcNHDQRTSHPTLPSDSQPEPSAPSHMPSDARGKHQVDFNQA--II------ 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223467  161 kdhlnlllgfcvflsptrrFITKLKARFLgDGSQVVDSVLQILRMHSEGNKSKDEASQEVRALIQGHEDLLMELSEIFSD 240
Cdd:COG5602  275 -------------------FVNKVKVRFQ-NNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLPD 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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