NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|42562325|ref|NP_173961|]
View 

RNA helicase family protein [Arabidopsis thaliana]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
40-715 3.23e-173

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 516.94  E-value: 3.23e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKmIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:COG1643   9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVGETV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKkiqrtrsqpvsektefgnva 199
Cdd:COG1643  88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL-------------------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 200 sQVQTTTRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYT--VHPESDYVDA 277
Cdd:COG1643 148 -DLQPALRP-------------------DLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDA 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 278 TLVTIFQIHFEEkPGDILVFLTGQDEIESVERLVQERLQNIPEdkrkLLPLaiFSALPSEQQMKVFAPAPTGFRKVILAT 357
Cdd:COG1643 208 VADAVREALAEE-PGDILVFLPGEREIRRTAEALRGRLPPDTE----ILPL--YGRLSAAEQDRAFAPAPHGRRRIVLAT 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 358 NIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEI 437
Cdd:COG1643 281 NIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEI 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 438 KRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQF 517
Cdd:COG1643 361 LRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRL-TPLGRALARLPLDPRLARMLLAAAEL 439
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 518 NCLEEMLITVAVLSVEsifyDPRekREEARTsknhfasvegDHLTYLSVYRESDEFlekrkaagsgnnidkimkkwcKEN 597
Cdd:COG1643 440 GCLREAAILAALLSER----DPR--RGAAGS----------DLLARLNLWRRLREQ---------------------QRE 482
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 598 YVNSRSLKHARDIYRQIREHVeQIGFNVSSCGNDMLAfrRCLAASFFLKAAQRQLD-GTYRaLESGEVVHIHPTSVLFRa 676
Cdd:COG1643 483 FLSYLRLREWRDLARQLRRLL-GEGANEEPADYEAIG--LLLALAYPDRIARRRGEgGRYL-LARGRGAALFPGSPLAK- 557
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....
gi 42562325 677 KPECVIFnELMQTSkkyiKNLTI-----IDSLWLSELAPHHFQT 715
Cdd:COG1643 558 KEWLVAA-ELVGGA----AEARIrlaapIDPEWLEELAAHLIKR 596
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
40-715 3.23e-173

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 516.94  E-value: 3.23e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKmIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:COG1643   9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVGETV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKkiqrtrsqpvsektefgnva 199
Cdd:COG1643  88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL-------------------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 200 sQVQTTTRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYT--VHPESDYVDA 277
Cdd:COG1643 148 -DLQPALRP-------------------DLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDA 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 278 TLVTIFQIHFEEkPGDILVFLTGQDEIESVERLVQERLQNIPEdkrkLLPLaiFSALPSEQQMKVFAPAPTGFRKVILAT 357
Cdd:COG1643 208 VADAVREALAEE-PGDILVFLPGEREIRRTAEALRGRLPPDTE----ILPL--YGRLSAAEQDRAFAPAPHGRRRIVLAT 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 358 NIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEI 437
Cdd:COG1643 281 NIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEI 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 438 KRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQF 517
Cdd:COG1643 361 LRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRL-TPLGRALARLPLDPRLARMLLAAAEL 439
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 518 NCLEEMLITVAVLSVEsifyDPRekREEARTsknhfasvegDHLTYLSVYRESDEFlekrkaagsgnnidkimkkwcKEN 597
Cdd:COG1643 440 GCLREAAILAALLSER----DPR--RGAAGS----------DLLARLNLWRRLREQ---------------------QRE 482
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 598 YVNSRSLKHARDIYRQIREHVeQIGFNVSSCGNDMLAfrRCLAASFFLKAAQRQLD-GTYRaLESGEVVHIHPTSVLFRa 676
Cdd:COG1643 483 FLSYLRLREWRDLARQLRRLL-GEGANEEPADYEAIG--LLLALAYPDRIARRRGEgGRYL-LARGRGAALFPGSPLAK- 557
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....
gi 42562325 677 KPECVIFnELMQTSkkyiKNLTI-----IDSLWLSELAPHHFQT 715
Cdd:COG1643 558 KEWLVAA-ELVGGA----AEARIrlaapIDPEWLEELAAHLIKR 596
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
40-711 9.90e-142

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 447.29  E-value: 9.90e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325     40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:TIGR01967   65 NLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnva 199
Cdd:TIGR01967  144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD------------ 211
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    200 sqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILY------TVHPESD 273
Cdd:TIGR01967  212 -----------------------------LKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrplveeQEDDDLD 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    274 YVDATLVTIFQIhFEEKPGDILVFLTGQDEI-ESVERLVQERLQNIpedkrKLLPLaiFSALPSEQQMKVFAPApTGfRK 352
Cdd:TIGR01967  263 QLEAILDAVDEL-FAEGPGDILIFLPGEREIrDAAEILRKRNLRHT-----EILPL--YARLSNKEQQRVFQPH-SG-RR 332
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    353 VILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDS 432
Cdd:TIGR01967  333 IVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEF 412
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    433 TKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLEN--PVGYQMSRLPLEPVYSKA 510
Cdd:TIGR01967  413 TDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEAEPQltPIGRQLAQLPVDPRLARM 492
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    511 LILANQFNCLEEMLITVAVLSVEsifyDPREKREE----ARTSKNHFASVEGDHLTYLSVYResdeFLEKRKAAGSGNNi 586
Cdd:TIGR01967  493 LLEAHRLGCLQEVLIIASALSIQ----DPRERPMEkqqaADQAHARFKDPRSDFLSRVNLWR----HIEEQRQALSANQ- 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    587 dkiMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFF----LKAAQRQLDGTyraleSG 662
Cdd:TIGR01967  564 ---FRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHEYDGA-----RG 635
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 42562325    663 EVVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPH 711
Cdd:TIGR01967  636 RKFHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
40-711 3.24e-128

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 411.38  E-value: 3.24e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:PRK11131   72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCV 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnva 199
Cdd:PRK11131  151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD------------ 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   200 sqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILY--TVHPESDYVDA 277
Cdd:PRK11131  219 -----------------------------LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpIVEEADDTERD 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   278 TLVTIFQIHFE---EKPGDILVFLTGQDEIesveRLVQERLQnipedKRKL-----LPLaiFSALPSEQQMKVFAPapTG 349
Cdd:PRK11131  270 QLQAIFDAVDElgrEGPGDILIFMSGEREI----RDTADALN-----KLNLrhteiLPL--YARLSNSEQNRVFQS--HS 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   350 FRKVILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKL 429
Cdd:PRK11131  337 GRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSR 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   430 EDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAI---IKALAELHSLGALADDGKLE-NPVGYQMSRLPLEP 505
Cdd:PRK11131  417 PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIqdgVRLLEELGAITTDEQASAYKlTPLGRQLAQLPVDP 496
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   506 VYSKALILANQFNCLEEMLITVAVLSVEsifyDPRE----KREEARTSKNHFASVEGDHLTYLSVYresdEFLEKRKAAG 581
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSIQ----DPRErpmdKQQASDEKHRRFADKESDFLAFVNLW----NYLQEQQKAL 568
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   582 SGNNidkiMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFFLKAAQRQLD-----GTY 656
Cdd:PRK11131  569 SSNQ----FRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEkqeytGAR 644
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325   657 RALesgevVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPH 711
Cdd:PRK11131  645 NAR-----FSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
41-255 3.98e-105

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 318.14  E-value: 3.98e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCReGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17978   1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFAR-GGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPvsektefgnvas 200
Cdd:cd17978  80 YSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQ------------ 147
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrKLSPLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17978 148 ------------------------KLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
480-564 1.95e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 97.34  E-value: 1.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    480 SLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFydPREKREEARTSKNHFASVEGD 559
Cdd:smart00847   1 ELGALDDDGRL-TPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77

                   ....*
gi 42562325    560 HLTYL 564
Cdd:smart00847  78 HLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
474-563 3.59e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 94.61  E-value: 3.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   474 ALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFYDP-------------- 539
Cdd:pfam04408   1 ALELLYYLGALDEDGEL-TPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarr 79
                          90       100
                  ....*....|....*....|....*
gi 42562325   540 -REKREEARTSKNHFASVEGDHLTY 563
Cdd:pfam04408  80 rRRAADEKARAKFARLDLEGDHLTL 104
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
40-715 3.23e-173

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 516.94  E-value: 3.23e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKmIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:COG1643   9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVGETV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKkiqrtrsqpvsektefgnva 199
Cdd:COG1643  88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLL-------------------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 200 sQVQTTTRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYT--VHPESDYVDA 277
Cdd:COG1643 148 -DLQPALRP-------------------DLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDA 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 278 TLVTIFQIHFEEkPGDILVFLTGQDEIESVERLVQERLQNIPEdkrkLLPLaiFSALPSEQQMKVFAPAPTGFRKVILAT 357
Cdd:COG1643 208 VADAVREALAEE-PGDILVFLPGEREIRRTAEALRGRLPPDTE----ILPL--YGRLSAAEQDRAFAPAPHGRRRIVLAT 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 358 NIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEI 437
Cdd:COG1643 281 NIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEI 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 438 KRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQF 517
Cdd:COG1643 361 LRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRL-TPLGRALARLPLDPRLARMLLAAAEL 439
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 518 NCLEEMLITVAVLSVEsifyDPRekREEARTsknhfasvegDHLTYLSVYRESDEFlekrkaagsgnnidkimkkwcKEN 597
Cdd:COG1643 440 GCLREAAILAALLSER----DPR--RGAAGS----------DLLARLNLWRRLREQ---------------------QRE 482
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 598 YVNSRSLKHARDIYRQIREHVeQIGFNVSSCGNDMLAfrRCLAASFFLKAAQRQLD-GTYRaLESGEVVHIHPTSVLFRa 676
Cdd:COG1643 483 FLSYLRLREWRDLARQLRRLL-GEGANEEPADYEAIG--LLLALAYPDRIARRRGEgGRYL-LARGRGAALFPGSPLAK- 557
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....
gi 42562325 677 KPECVIFnELMQTSkkyiKNLTI-----IDSLWLSELAPHHFQT 715
Cdd:COG1643 558 KEWLVAA-ELVGGA----AEARIrlaapIDPEWLEELAAHLIKR 596
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
40-711 9.90e-142

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 447.29  E-value: 9.90e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325     40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:TIGR01967   65 NLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnva 199
Cdd:TIGR01967  144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD------------ 211
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    200 sqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILY------TVHPESD 273
Cdd:TIGR01967  212 -----------------------------LKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrplveeQEDDDLD 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    274 YVDATLVTIFQIhFEEKPGDILVFLTGQDEI-ESVERLVQERLQNIpedkrKLLPLaiFSALPSEQQMKVFAPApTGfRK 352
Cdd:TIGR01967  263 QLEAILDAVDEL-FAEGPGDILIFLPGEREIrDAAEILRKRNLRHT-----EILPL--YARLSNKEQQRVFQPH-SG-RR 332
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    353 VILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDS 432
Cdd:TIGR01967  333 IVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEF 412
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    433 TKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLEN--PVGYQMSRLPLEPVYSKA 510
Cdd:TIGR01967  413 TDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEAEPQltPIGRQLAQLPVDPRLARM 492
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    511 LILANQFNCLEEMLITVAVLSVEsifyDPREKREE----ARTSKNHFASVEGDHLTYLSVYResdeFLEKRKAAGSGNNi 586
Cdd:TIGR01967  493 LLEAHRLGCLQEVLIIASALSIQ----DPRERPMEkqqaADQAHARFKDPRSDFLSRVNLWR----HIEEQRQALSANQ- 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    587 dkiMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFF----LKAAQRQLDGTyraleSG 662
Cdd:TIGR01967  564 ---FRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHEYDGA-----RG 635
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 42562325    663 EVVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPH 711
Cdd:TIGR01967  636 RKFHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
40-711 3.24e-128

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 411.38  E-value: 3.24e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:PRK11131   72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCV 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnva 199
Cdd:PRK11131  151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD------------ 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   200 sqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILY--TVHPESDYVDA 277
Cdd:PRK11131  219 -----------------------------LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpIVEEADDTERD 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   278 TLVTIFQIHFE---EKPGDILVFLTGQDEIesveRLVQERLQnipedKRKL-----LPLaiFSALPSEQQMKVFAPapTG 349
Cdd:PRK11131  270 QLQAIFDAVDElgrEGPGDILIFMSGEREI----RDTADALN-----KLNLrhteiLPL--YARLSNSEQNRVFQS--HS 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   350 FRKVILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKL 429
Cdd:PRK11131  337 GRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSR 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   430 EDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAI---IKALAELHSLGALADDGKLE-NPVGYQMSRLPLEP 505
Cdd:PRK11131  417 PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIqdgVRLLEELGAITTDEQASAYKlTPLGRQLAQLPVDP 496
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   506 VYSKALILANQFNCLEEMLITVAVLSVEsifyDPRE----KREEARTSKNHFASVEGDHLTYLSVYresdEFLEKRKAAG 581
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSIQ----DPRErpmdKQQASDEKHRRFADKESDFLAFVNLW----NYLQEQQKAL 568
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   582 SGNNidkiMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFFLKAAQRQLD-----GTY 656
Cdd:PRK11131  569 SSNQ----FRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEkqeytGAR 644
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325   657 RALesgevVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPH 711
Cdd:PRK11131  645 NAR-----FSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
41-255 3.98e-105

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 318.14  E-value: 3.98e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCReGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17978   1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFAR-GGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPvsektefgnvas 200
Cdd:cd17978  80 YSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQ------------ 147
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrKLSPLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17978 148 ------------------------KLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
41-505 4.64e-91

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 302.07  E-value: 4.64e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFcrEGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPG--IGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALlkkiqrtrsqpvsektefgnvAS 200
Cdd:TIGR01970  79 YRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLAL---------------------AL 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   201 QVQTTTRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILY-TVHPESDYVDATL 279
Cdd:TIGR01970 138 DVQSSLRE-------------------DLKILAMSATLDGERLSSLLPDAPVVESEGRSFPVEIRYlPLRGDQRLEDAVS 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   280 VTIFQIhFEEKPGDILVFLTGQDEIESVERLVQERLQNipedKRKLLPLaiFSALPSEQQMKVFAPAPTGFRKVILATNI 359
Cdd:TIGR01970 199 RAVEHA-LASETGSILVFLPGQAEIRRVQEQLAERLDS----DVLICPL--YGELSLAAQDRAIKPDPQGRRKVVLATNI 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   360 AETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEIKR 439
Cdd:TIGR01970 272 AETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQ 351
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42562325   440 CNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLeNPVGYQMSRLPLEP 505
Cdd:TIGR01970 352 ADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRL-TAHGKAMAALGCHP 416
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
40-530 2.43e-84

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 283.74  E-value: 2.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   40 SLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLP-QFLYNAGFcrEGKMIgITQPRRIAAVTVAKRVAEECEVQLGQK 118
Cdd:PRK11664   3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGI--NGKII-MLEPRRLAARNVAQRLAEQLGEKPGET 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  119 VGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLkkiqrtrsqpvsektefgnv 198
Cdd:PRK11664  80 VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALL-------------------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  199 aSQVQTTTRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYTVHPESDY-VDA 277
Cdd:PRK11664 140 -LDVQQGLRD-------------------DLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRfDEA 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  278 TLVTIFQIhFEEKPGDILVFLTGQDEIesveRLVQERLQNIPEDKRKLLPLaiFSALPSEQQMKVFAPAPTGFRKVILAT 357
Cdd:PRK11664 200 VARATAEL-LRQESGSLLLFLPGVGEI----QRVQEQLASRVASDVLLCPL--YGALSLAEQQKAILPAPAGRRKVVLAT 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  358 NIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEI 437
Cdd:PRK11664 273 NIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEI 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  438 KRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQF 517
Cdd:PRK11664 353 LHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRL-TARGRKMAALGNDPRLAAMLVAAKED 431
                        490
                 ....*....|...
gi 42562325  518 NclEEMLITVAVL 530
Cdd:PRK11664 432 D--EAALATAAKL 442
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
57-255 1.66e-76

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 242.75  E-value: 1.66e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  57 NDILIIVGETGSGKTTQLPQFLYNAGFCREGK-MIGITQPRRIAAVTVAKRVAEECEVQLGQKVGYSIRFDDTTSGSTRL 135
Cdd:cd17917   1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKgRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 136 KYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRsqpvsektefgnvasqvqtttrdangpqqn 215
Cdd:cd17917  81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKR------------------------------ 130
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 42562325 216 gvlkgyqgrklSPLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17917 131 -----------PDLKVILMSATLDAEKFSSYFGGAPVIHI 159
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
260-421 2.98e-76

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 242.44  E-value: 2.98e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 260 FPVDILYT-----------VHPESDYVDATLVTIFQIHFEEKPGDILVFLTGQDEIESVERLVQERLQNipEDKRKLLPL 328
Cdd:cd18791   1 FPVEVYYLedilellgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLS--PDLGKLLVL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 329 AIFSALPSEQQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGR 408
Cdd:cd18791  79 PLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGR 158
                       170
                ....*....|...
gi 42562325 409 AGREGPGKSFRLY 421
Cdd:cd18791 159 AGRTRPGKCYRLY 171
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
36-247 1.08e-69

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 225.44  E-value: 1.08e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  36 EHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKmIGITQPRRIAAVTVAKRVAEECEVQL 115
Cdd:cd17971   1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGK-IGCTQPRRVAAMSVAKRVAEEFGCCL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 116 GQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektef 195
Cdd:cd17971  80 GQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD-------- 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 42562325 196 gnvasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYF 247
Cdd:cd17971 152 ---------------------------------LKLIVTSATLDAVKFSQYF 170
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
32-255 2.97e-68

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 221.91  E-value: 2.97e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  32 QKIAEHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCR-EGKMIGITQPRRIAAVTVAKRVAEE 110
Cdd:cd17973   4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHqPKKLVACTQPRRVAAMSVAQRVAEE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 111 CEVQLGQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvs 190
Cdd:cd17973  84 MDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD--- 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 191 ektefgnvasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17973 161 --------------------------------------LKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
41-250 6.15e-67

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 218.14  E-value: 6.15e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17974   1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnvas 200
Cdd:cd17974  81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD------------- 147
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGA 250
Cdd:cd17974 148 ----------------------------LKLLISSATMDAEKFSAFFDDA 169
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
41-255 1.77e-66

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 216.94  E-value: 1.77e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17983   1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnvas 200
Cdd:cd17983  80 YAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD------------- 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17983 147 ----------------------------LKLIVTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
41-245 1.48e-65

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 214.91  E-value: 1.48e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGF----CREGKMIGITQPRRIAAVTVAKRVAEECEVqLG 116
Cdd:cd17982   1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFgspeSDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 117 QKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPVSEKTefg 196
Cdd:cd17982  80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYLQDQ--- 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 42562325 197 nvasqvqtttrdangpqqngvlkgyqgrKLSPLKLIIMSASLDARVFSE 245
Cdd:cd17982 157 ----------------------------TVKPLKLVIMSATLRVEDFTE 177
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
41-255 3.09e-63

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 208.56  E-value: 3.09e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17984   1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG-MIGVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIqrtrsqpvsektefgnvas 200
Cdd:cd17984  80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKL------------------- 140
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngVLKGYQGRKlSPLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17984 141 ----------------FQEKSPNRK-EHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
41-247 5.30e-63

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 208.09  E-value: 5.30e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17980   1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDD-TTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnva 199
Cdd:cd17980  81 YCIRFDDcTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD------------ 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 42562325 200 sqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYF 247
Cdd:cd17980 149 -----------------------------LRLIVASATLDAEKFRDFF 167
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
41-255 1.64e-49

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 171.10  E-value: 1.64e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGkMIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17989   1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnvas 200
Cdd:cd17989  80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD------------- 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17989 147 ----------------------------LKVIITSATIDAERFSRHFNNAPIIEV 173
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
41-255 7.93e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 169.16  E-value: 7.93e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCRegkmIGITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17979   1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFESLNQYGSKVA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgnvas 200
Cdd:cd17979  77 YQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD------------- 143
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325 201 qvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17979 144 ----------------------------LKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
41-255 1.06e-37

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 138.43  E-value: 1.06e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKM---IGITQPRRIAAVTVAKRVAEECEVQLGQ 117
Cdd:cd17985   1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPvanIICTQPRRISAISVAERVAQERAERVGQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 118 KVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektefgn 197
Cdd:cd17985  81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD---------- 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42562325 198 vasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17985 151 -------------------------------LKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
41-247 1.36e-37

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 138.51  E-value: 1.36e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKM----IGITQPRRIAAVTVAKRVAEE--CEVQ 114
Cdd:cd17975   1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAqkcnIVCTQPRRISAMSLATRVCEElgCESG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 115 LGQK---VGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvse 191
Cdd:cd17975  81 PGGKnslCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD---- 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42562325 192 ktefgnvasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYF 247
Cdd:cd17975 157 -------------------------------------LHLILMSATVDCEKFSSYF 175
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
41-255 6.27e-37

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 136.51  E-value: 6.27e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYN-------AGFCRegkmIGITQPRRIAAVTVAKRVA-EECE 112
Cdd:cd17981   1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDdaiergkGSSCR----IVCTQPRRISAISVAERVAaERAE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 113 -VQLGQKVGYSIRFDDT---TSGStrLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQp 188
Cdd:cd17981  77 sCGLGNSTGYQIRLESRkprKQGS--ILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD- 153
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562325 189 vsektefgnvasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17981 154 ----------------------------------------LKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
41-253 2.72e-36

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 134.38  E-value: 2.72e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIgITQPRRIAAVTVAKRVAEECEVQLGQKVG 120
Cdd:cd17990   1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKII-VLEPRRVAARAAARRLATLLGEAPGETVG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 121 YSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRsqpvsektefgnvas 200
Cdd:cd17990  80 YRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLL--------------- 144
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 42562325 201 qvqtttRDangpqqngvlkgyqgrklsPLKLIIMSASLDARVFSEYFGGAKAV 253
Cdd:cd17990 145 ------RD-------------------DLRLLAMSATLDGDGLAALLPEAPVV 172
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
41-255 4.51e-36

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 133.80  E-value: 4.51e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLY-----NAGFCRegkmIGITQPRRIAAVTVAKRVAEECEVQL 115
Cdd:cd17987   1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLddcyaNGIPCR----IFCTQPRRLAAIAVAERVAAERGEKI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 116 GQKVGYSIRFDDTTSGSTRLKYMTDGLLLReALLDPH--LSRYSVIIVDEAHDRSVHTDVLLALLKKIQrtrsqpvsekt 193
Cdd:cd17987  77 GQTVGYQIRLESRVSPKTLLTFCTNGVLLR-TLMAGDsaLSTVTHVIVDEVHERDRFSDFLLTKLRDIL----------- 144
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562325 194 efgnvasqvqtttrdangpqqngvlkgyqgRKLSPLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17987 145 ------------------------------QKHPNLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
41-248 6.77e-36

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 133.40  E-value: 6.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKM-IGITQPRRIAAVTVAKRVAEECEVQLGQKV 119
Cdd:cd17988   1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCnIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 120 GYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPVsektefgnva 199
Cdd:cd17988  81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRHV---------- 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 42562325 200 sqvqtttrdangpqqngvlkgyqgrklsplKLIIMSASLDARVFSEYFG 248
Cdd:cd17988 151 ------------------------------KIILMSATISCKEFADYFT 169
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
41-255 1.19e-33

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 127.22  E-value: 1.19e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCR-EGKM--IGITQPRRIAAVTVAKRVAEECEVQLGQ 117
Cdd:cd17976   1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRgRGARcnVVITQPRRISAVSVAQRVAHELGPNLRR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 118 KVGYSIRFDDT--TSGSTRLkYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQpvsektef 195
Cdd:cd17976  81 NVGYQVRLESRppPRGGALL-FCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE-------- 151
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 196 gnvasqvqtttrdangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17976 152 ---------------------------------LRVVLMSATGDNQRLSRYFGGCPVVRV 178
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
32-255 1.53e-33

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 128.80  E-value: 1.53e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  32 QKIAEHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLY-------NAGFCRegkmIGITQPRRIAAVTVA 104
Cdd:cd17972  50 QQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILddfiqndRAAECN----IVVTQPRRISAVSVA 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 105 KRVAEECEVQLGQKVGYSIRFDDTTS---GStrLKYMTDGLLLREalLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKki 181
Cdd:cd17972 126 ERVAFERGEEVGKSCGYSVRFESVLPrphAS--ILFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLR-- 199
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42562325 182 qrtrsqpvsektefgnvasQVQTTTRDangpqqngvlkgyqgrklspLKLIIMSASLDARVFSEYFGGAKAVHV 255
Cdd:cd17972 200 -------------------DVVQAYPD--------------------LRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
41-187 2.65e-32

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 123.40  E-value: 2.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLynAGFCREGK----MIGITQPRRIAAVTVAKRVAEECEVQLG 116
Cdd:cd17977   1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWC--AEYCLSAHyqhgVVVCTQVHKQTAVWLALRVADEMDVNIG 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42562325 117 QKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQ 187
Cdd:cd17977  79 HEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE 149
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
41-185 9.45e-29

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 113.07  E-value: 9.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  41 LPIASVEKRLVEEVQ-KNDILIIVGETGSGKTTQLPQ----FLYNAGFCRegKMIGITQPRRIAAVTVAKRVAEECEVQL 115
Cdd:cd17986   1 LPIWAAKFTFLEQLEsPSGIVLVSGEPGSGKSTQVPQwcaeFALSRGFQK--GQVTVTQPHPLAARSLALRVADEMDLNL 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 116 GQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTR 185
Cdd:cd17986  79 GHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQR 148
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
480-564 1.95e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 97.34  E-value: 1.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    480 SLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFydPREKREEARTSKNHFASVEGD 559
Cdd:smart00847   1 ELGALDDDGRL-TPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77

                   ....*
gi 42562325    560 HLTYL 564
Cdd:smart00847  78 HLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
474-563 3.59e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 94.61  E-value: 3.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   474 ALAELHSLGALADDGKLeNPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFYDP-------------- 539
Cdd:pfam04408   1 ALELLYYLGALDEDGEL-TPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarr 79
                          90       100
                  ....*....|....*....|....*
gi 42562325   540 -REKREEARTSKNHFASVEGDHLTY 563
Cdd:pfam04408  80 rRRAADEKARAKFARLDLEGDHLTL 104
DEXDc smart00487
DEAD-like helicases superfamily;
60-185 2.08e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 89.86  E-value: 2.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325     60 LIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVGY------SIRFDDTTSGST 133
Cdd:smart00487  27 VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQLRKLESGKT 106
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 42562325    134 RLKYMTDGLLLREALLDP-HLSRYSVIIVDEAHDRS--VHTDVLLALLKKIQRTR 185
Cdd:smart00487 107 DILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV 161
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
636-711 4.99e-20

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 84.61  E-value: 4.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   636 RRCLAASFFLKAAQRQLDG-TYRALESGEVVHIHPTSVLFRA---KPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPH 711
Cdd:pfam07717   2 RAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEktfPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAPH 81
HELICc smart00490
helicase superfamily c-terminal domain;
322-413 1.23e-12

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 63.77  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    322 KRKLLPLAIFSALPSEQQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIDpgfvkarsYDPskgmesldvvPASKAQ 401
Cdd:smart00490   9 ELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVII--------YDL----------PWSPAS 70
                           90
                   ....*....|..
gi 42562325    402 TLQRSGRAGREG 413
Cdd:smart00490  71 YIQRIGRAGRAG 82
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
281-413 2.18e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 63.77  E-value: 2.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   281 TIFQIHFEEKPGDILVFLtgqdeiESVERLVQERLQNipedKRKLLPLAIFSALPSEQQMKVFAPAPTGFRKVILATNIA 360
Cdd:pfam00271   5 ALLELLKKERGGKVLIFS------QTKKTLEAELLLE----KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVA 74
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 42562325   361 ETSITIPGIRYVIDpgfvkarsYDPSKGMESLdvvpaskaqtLQRSGRAGREG 413
Cdd:pfam00271  75 ERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGRAG 109
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
19-455 3.31e-08

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 56.91  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   19 NPKSPTVSPFsmrqkiaehrRSLPIaSVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFL--YN---AGFCREGKMIGIT 93
Cdd:PHA02653 152 NPEPFSKIPL----------ASLQP-DVQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLlwFNylfGGFDNLDKIDPNF 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325   94 QPRRIaaVTVAKRVAEeceVQLGQKVgY--SIRFDDTTSGSTRLKY--MTD----------GLLLR-EALLDPHLSRYSV 158
Cdd:PHA02653 221 IERPI--VLSLPRVAL---VRLHSIT-LlkSLGFDEIDGSPISLKYgsIPDelintnpkpyGLVFStHKLTLNKLFDYGT 294
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  159 IIVDEAHDRSVHTDVLLALL-KKIQRTRSqpvsektefgnvasqvqtttrdangpqqngvlkgyqgrklsplkLIIMSAS 237
Cdd:PHA02653 295 VIIDEVHEHDQIGDIIIAVArKHIDKIRS--------------------------------------------LFLMTAT 330
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  238 L--DARVFSEYFGGAKAVHVQGRQ-FPVDILYtVHPESD------YVDATLVTIFQIHFEEKPGD---ILVFLTGQDEIE 305
Cdd:PHA02653 331 LedDRDRIKEFFPNPAFVHIPGGTlFPISEVY-VKNKYNpknkraYIEEEKKNIVTALKKYTPPKgssGIVFVASVSQCE 409
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  306 SVERLVQERLQNipedkrkLLPLAIFSALPSEQQM--KVFA-PAPTgfrkVILATNIAETSITIPGIRYVIDPG--FVKA 380
Cdd:PHA02653 410 EYKKYLEKRLPI-------YDFYIIHGKVPNIDEIleKVYSsKNPS----IIISTPYLESSVTIRNATHVYDTGrvYVPE 478
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42562325  381 rsydPSKGMESLdvvpASKAQTLQRSGRAGREGPGKSFRLYPEREFekledstKPeIKRCN---LSNIILQLKALGID 455
Cdd:PHA02653 479 ----PFGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYFYDLDLL-------KP-IKRIDsefLHNYILYAKYFNLT 540
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
60-183 1.09e-07

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 51.64  E-value: 1.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  60 LIIVGETGSGKTTQLPQFLYNAGFCREGKMIgITQPRRIAAVTVAKRVAEEceVQLGQKVGYSIRFDD------TTSGST 133
Cdd:cd00046   4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLREL--FGPGIRVAVLVGGSSaeerekNKLGDA 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 42562325 134 RLKYMTDGLLLR--EALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQR 183
Cdd:cd00046  81 DIIIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRK 132
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
60-165 5.13e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 44.16  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    60 LIIVGETGSGKTT--QLPqFLYNAGFCREGKMIGITQPRRIAA---VTVAKRVAEECEVQLGQKV-GYSIRFDDTTSGST 133
Cdd:pfam00270  17 VLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLLgGDSRKEQLEKLKGP 95
                          90       100       110
                  ....*....|....*....|....*....|..
gi 42562325   134 RLKYMTDGLLLREALLDPHLSRYSVIIVDEAH 165
Cdd:pfam00270  96 DILVGTPGRLLDLLQERKLLKNLKLLVLDEAH 127
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
352-421 1.42e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 40.77  E-value: 1.42e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562325 352 KVILATNIAETSITIPGIRYVIDPGFVKarsydpskgmesldvvpaSKAQTLQRSGRAGREG--PGKSFRLY 421
Cdd:cd18785  24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGkdEGEVILFV 77
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
66-165 1.22e-03

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 39.84  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325  66 TGSGKTTQ-LPQFLYNAGfcREGKMIGITQPRRIAAVTVAkrvaeecEVQLGQKVGYSI-RFDDTTSGSTRLKYMTDGLL 143
Cdd:cd17931  10 PGAGKTTRvLPQIIREAI--KKRLRTLVLAPTRVVAAEMY-------EALRGLPIRYRTgAVKEEHGGNEIVDYMCHGTF 80
                        90       100
                ....*....|....*....|...
gi 42562325 144 LrEALLDPHL-SRYSVIIVDEAH 165
Cdd:cd17931  81 T-CRLLSPKRvPNYNLIIMDEAH 102
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
267-420 1.73e-03

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 39.26  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 267 TVHPESDYVDATLVTIFQIHFEEKPGDILVFLTGQDeieSVERLVQERLQNIPEDKRKllplaIF---------SALPSE 337
Cdd:cd18801   6 KIHPKLEKLEEIVKEHFKKKQEGSDTRVIIFSEFRD---SAEEIVNFLSKIRPGIRAT-----RFigqasgkssKGMSQK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 338 QQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIdpgfvkarSYDPSKgmesldvvpaSKAQTLQRSGRAGREGPGKS 417
Cdd:cd18801  78 EQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLII--------CYDASP----------SPIRMIQRMGRTGRKRQGRV 139

                ...
gi 42562325 418 FRL 420
Cdd:cd18801 140 VVL 142
AAA_22 pfam13401
AAA domain;
59-190 3.63e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.09  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325    59 ILIIVGETGSGKTTQLPQFLYNAGFCREGKmIGITQPRRIAAVTVAKRVAEEcevqlgqkvgysirFDDTTSGSTRLKYM 138
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPEVRDSV-VFVDLPSGTSPKDLLRALLRA--------------LGLPLSGRLSKEEL 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 42562325   139 TDglLLREALLdpHLSRYSVIIVDEAHDRSvhtDVLLALLKKIQRTRSQPVS 190
Cdd:pfam13401  72 LA--ALQQLLL--ALAVAVVLIIDEAQHLS---LEALEELRDLLNLSSKLLQ 116
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
265-413 8.08e-03

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 37.10  E-value: 8.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562325 265 LYTVHPESDYVDATLVTIFQIHFEEKpgdILVFLtgqDEIESVERLVQE-RLQNIPedkrkllPLAIFSALPSEQQMKVF 343
Cdd:cd18787   4 LYVVVEEEEKKLLLLLLLLEKLKPGK---AIIFV---NTKKRVDRLAELlEELGIK-------VAALHGDLSQEERERAL 70
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562325 344 ApaptGFR----KVILATNIAETSITIPGIRYVIdpgfvkarSYDPskgmesldvvPASKAQTLQRSGR---AGREG 413
Cdd:cd18787  71 K----KFRsgkvRVLVATDVAARGLDIPGVDHVI--------NYDL----------PRDAEDYVHRIGRtgrAGRKG 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH