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Conserved domains on  [gi|30688695|ref|NP_173815|]
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Acyl-CoA N-acyltransferases (NAT) superfamily protein [Arabidopsis thaliana]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18102377)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 214-295 1.08e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.19  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVllmlQRRKHLMRK 293
Cdd:COG0456  15 EIEDLAVDPEYRGRGIGRALLEAALERARERGARR-LRLEVREDNEAAIALYEKLGFEEVGERPNYY----GDDALVMEK 89


                ..
gi 30688695 294 KL 295
Cdd:COG0456  90 EL 91
yhbS super family cl43796
Predicted N-acetyltransferase YhbS [General function prediction only];
111-295 1.93e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


The actual alignment was detected with superfamily member COG3153:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 40.84  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 111 VRVMRHEEMDSTVHLLAESFGESMllpsgyqsvlrfliKQYLIER-REVLPHAVTLVGFfrkkvdefsDDGEeeavMAGT 189
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAFGPGR--------------EAELVDRlREDPAAGLSLVAE---------DDGE----IVGH 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 190 VevclekrgaNASPPSPTPPKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRmVDEAPFnmYKKAG 269
Cdd:COG3153  54 V---------ALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARA-VVLLGD-PSLLPF--YERFG 120

                       170       180
                ....*....|....*....|....*.
gi 30688695 270 YEVVKTDTvlvlLMLQRRKHLMRKKL 295
Cdd:COG3153 121 FRPAGELG----LTLGPDEVFLAKEL 142
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 214-295 1.08e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.19  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVllmlQRRKHLMRK 293
Cdd:COG0456  15 EIEDLAVDPEYRGRGIGRALLEAALERARERGARR-LRLEVREDNEAAIALYEKLGFEEVGERPNYY----GDDALVMEK 89


                ..
gi 30688695 294 KL 295
Cdd:COG0456  90 EL 91
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
111-295 1.93e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 40.84  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 111 VRVMRHEEMDSTVHLLAESFGESMllpsgyqsvlrfliKQYLIER-REVLPHAVTLVGFfrkkvdefsDDGEeeavMAGT 189
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAFGPGR--------------EAELVDRlREDPAAGLSLVAE---------DDGE----IVGH 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 190 VevclekrgaNASPPSPTPPKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRmVDEAPFnmYKKAG 269
Cdd:COG3153  54 V---------ALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARA-VVLLGD-PSLLPF--YERFG 120

                       170       180
                ....*....|....*....|....*.
gi 30688695 270 YEVVKTDTvlvlLMLQRRKHLMRKKL 295
Cdd:COG3153 121 FRPAGELG----LTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 214-270 4.63e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.42  E-value: 4.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30688695   214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRMVDEAPFNMYKKAGY 270
Cdd:pfam00583  61 EIEGLAVAPEYRGKGIGTALLQALLEWARERGCER-IFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 208-239 5.55e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.94  E-value: 5.55e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 30688695 208 PPKESPYICNMTVKEDLRRRGIGWHLLKASEE 239
Cdd:cd04301  21 SGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 214-295 1.08e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.19  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVllmlQRRKHLMRK 293
Cdd:COG0456  15 EIEDLAVDPEYRGRGIGRALLEAALERARERGARR-LRLEVREDNEAAIALYEKLGFEEVGERPNYY----GDDALVMEK 89


                ..
gi 30688695 294 KL 295
Cdd:COG0456  90 EL 91
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 209-295 2.98e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 45.75  E-value: 2.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 209 PKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRmvDEAPfNMYKKAGYEVVKTDTVLVLLMLQRRK 288
Cdd:COG1246  49 DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKR-LFLLTT--SAAI-HFYEKLGFEEIDKEDLPYAKVWQRDS 124


                ....*..
gi 30688695 289 HLMRKKL 295
Cdd:COG1246 125 VVMEKDL 131
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
111-295 1.93e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 40.84  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 111 VRVMRHEEMDSTVHLLAESFGESMllpsgyqsvlrfliKQYLIER-REVLPHAVTLVGFfrkkvdefsDDGEeeavMAGT 189
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAFGPGR--------------EAELVDRlREDPAAGLSLVAE---------DDGE----IVGH 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688695 190 VevclekrgaNASPPSPTPPKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRmVDEAPFnmYKKAG 269
Cdd:COG3153  54 V---------ALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARA-VVLLGD-PSLLPF--YERFG 120

                       170       180
                ....*....|....*....|....*.
gi 30688695 270 YEVVKTDTvlvlLMLQRRKHLMRKKL 295
Cdd:COG3153 121 FRPAGELG----LTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 214-270 4.63e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.42  E-value: 4.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30688695   214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPSKdVYLHCRMVDEAPFNMYKKAGY 270
Cdd:pfam00583  61 EIEGLAVAPEYRGKGIGTALLQALLEWARERGCER-IFLEVAADNLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 214-272 9.11e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 37.82  E-value: 9.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30688695   214 YICNMTVKEDLRRRGIGWHLLKASEELISQispsKDVYLHCRMVDEAPFNMYKKAGYEV 272
Cdd:pfam13508  30 AELRLAVHPEYRGQGIGRALLEAAEAAAKE----GGIKLLELETTNRAAAFYEKLGFEE 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 208-239 5.55e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.94  E-value: 5.55e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 30688695 208 PPKESPYICNMTVKEDLRRRGIGWHLLKASEE 239
Cdd:cd04301  21 SGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
214-281 7.08e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 35.27  E-value: 7.08e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30688695 214 YICNMTVKEDLRRRGIGWHLLKASEELISQISPsKDVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVL 281
Cdd:COG3393  17 EISGVYTHPEYRGRGLASALVAALAREALARGA-RTPFLYVDADNPAARRLYERLGFRPVGEYATVLF 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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