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Conserved domains on  [gi|30680757|ref|NP_172342|]
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MALE GAMETOPHYTE DEFECTIVE 2 [Arabidopsis thaliana]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 181-342 5.40e-47

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


:

Pssm-ID: 467690  Cd Length: 193  Bit Score: 157.91  E-value: 5.40e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 181 CAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVVRGAARNMIKILNGS--------------- 245
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGchplpleeevvlils 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 246 -----------------DNEVLIIKSVTHRDFNEMIKRIPNPVYLFqgiVLRRGAKGTGMKSIELALSMCDIVDIYGFTV 308
Cdd:cd19952  80 raaaadfkrlkrrkkrhDNAVLLLTDPAPDLLSYVRKRLEKLGLKS---FFGGNAPSSGLLAVLLALQLCDSVDLYGFGV 156

                       170       180       190
                ....*....|....*....|....*....|....
gi 30680757 309 DPgytewtryfstprkGHNPLQGRAYYQLLECLG 342
Cdd:cd19952 157 DS--------------GHAPKVPYHYYDLVEAEE 176
 
Name Accession Description Interval E-value
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 181-342 5.40e-47

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 157.91  E-value: 5.40e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 181 CAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVVRGAARNMIKILNGS--------------- 245
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGchplpleeevvlils 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 246 -----------------DNEVLIIKSVTHRDFNEMIKRIPNPVYLFqgiVLRRGAKGTGMKSIELALSMCDIVDIYGFTV 308
Cdd:cd19952  80 raaaadfkrlkrrkkrhDNAVLLLTDPAPDLLSYVRKRLEKLGLKS---FFGGNAPSSGLLAVLLALQLCDSVDLYGFGV 156

                       170       180       190
                ....*....|....*....|....*....|....
gi 30680757 309 DPgytewtryfstprkGHNPLQGRAYYQLLECLG 342
Cdd:cd19952 157 DS--------------GHAPKVPYHYYDLVEAEE 176
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 160-306 6.96e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 98.45  E-value: 6.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757   160 EEHLNvILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLV--------- 230
Cdd:pfam00777  26 EELLE-LLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-KGYEKDVGSKTTLRTMnpesaidsk 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757   231 --------VRGAARNMIKILNGSDNEVLIIKSVTH------RDFNEMIK-----------RIPNPV---YLFQGIVLRRG 282
Cdd:pfam00777 104 ygnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKgnvsrsLRVLYTLKevkipvdpdkvLFLHPDflrYVANFWLRSHG 183

                         170       180
                  ....*....|....*....|....*...
gi 30680757   283 AKG----TGMKSIELALSMCDIVDIYGF 306
Cdd:pfam00777 184 LKGrrpsTGLLMLSLALHLCDEVSLYGF 211
 
Name Accession Description Interval E-value
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 181-342 5.40e-47

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 157.91  E-value: 5.40e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 181 CAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVVRGAARNMIKILNGS--------------- 245
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGchplpleeevvlils 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 246 -----------------DNEVLIIKSVTHRDFNEMIKRIPNPVYLFqgiVLRRGAKGTGMKSIELALSMCDIVDIYGFTV 308
Cdd:cd19952  80 raaaadfkrlkrrkkrhDNAVLLLTDPAPDLLSYVRKRLEKLGLKS---FFGGNAPSSGLLAVLLALQLCDSVDLYGFGV 156

                       170       180       190
                ....*....|....*....|....*....|....
gi 30680757 309 DPgytewtryfstprkGHNPLQGRAYYQLLECLG 342
Cdd:cd19952 157 DS--------------GHAPKVPYHYYDLVEAEE 176
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 160-306 6.96e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 98.45  E-value: 6.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757   160 EEHLNvILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLV--------- 230
Cdd:pfam00777  26 EELLE-LLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-KGYEKDVGSKTTLRTMnpesaidsk 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757   231 --------VRGAARNMIKILNGSDNEVLIIKSVTH------RDFNEMIK-----------RIPNPV---YLFQGIVLRRG 282
Cdd:pfam00777 104 ygnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKgnvsrsLRVLYTLKevkipvdpdkvLFLHPDflrYVANFWLRSHG 183

                         170       180
                  ....*....|....*....|....*...
gi 30680757   283 AKG----TGMKSIELALSMCDIVDIYGF 306
Cdd:pfam00777 184 LKGrrpsTGLLMLSLALHLCDEVSLYGF 211
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 167-327 3.49e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 94.25  E-value: 3.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 167 LPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDF-------------RLVVRG 233
Cdd:cd23963  52 LPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLttlnpsilkrrynSLKKNR 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 234 AARNMIKILNGSDNEVLIIKSVTHRDFNEMIKRI---------------PNPVYL--FQGIVLRRGAKG---TGMKSIEL 293
Cdd:cd23963 131 DRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAaralkknglnltvvySNPEHFlaVQKFWKRRGLEKrpsTGLYLVSL 210

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 30680757 294 ALSMCDIVDIYGF---TVDPG-------YTEwTRYFSTPRKGHN 327
Cdd:cd23963 211 ALTFCDEIHLYGFwpfPTDPNgrpvpyhYYD-DLSPSTKNKVHN 253
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 166-337 4.73e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 85.54  E-value: 4.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 166 ILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDF------------------ 227
Cdd:cd23969  52 LLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGTKSNLttmnpsviphaygdlvna 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 228 ----RLVVRgaarnmIKILNGSdneVLIIKSVTHRDFNEMIkRIPNPVYLFQGIVLR------------RG----AK--- 284
Cdd:cd23969 131 tdkeKFVER------LRQLGDS---ILWIPAFVSKGGEEHV-QWTNEIILKHKLNVKtaypplrlnhaiRGywltTKfri 200

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680757 285 ---GTGMKSIELALSMCDIVDIYG---FTVDpGYTEWTRY-------FSTPRKGHN-PLQGRAYYQL 337
Cdd:cd23969 201 krpSTGLLMYTLATRFCDEIHLYGfypFSED-GNGRAVKYhyydnrkYLTTARPHKmPEEFRALRSL 266
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 85-327 3.43e-18

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 83.10  E-value: 3.43e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757  85 EGTNSTWYNAQFKvfealefkynvceavllweqyRNMTTVLTREYLDVRPDG---WLdyaamriaQLGADKCYNRTLCEE 161
Cdd:cd23966   7 EGGDSDWFDERFN---------------------PSIEPLLTRKNKELPPDVlkwWL--------SLQSSKNSDLREVLE 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 162 HLNVILPAKPPFHPRQFH---KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVVRGAARNm 238
Cdd:cd23966  58 KLFQVVPGENPYRTRDPNrcrRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKTTHHFMYPESAVD- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 239 ikiLNGSDNEVLI---------IKSVTHrdfNEMIKRIPNPV--------------------YLFQGIVLRRGA-KGTGM 288
Cdd:cd23966 136 ---LDPGVHLVLVpfkvldlqwLISALT---TGEITRTYTPVkrfikadkdkvlvinpafikYVHDNWTEHHGRyPSTGF 209

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 30680757 289 KSIELALSMCDIVDIYGFTVDpGYTEWTRYFSTPRKGHN 327
Cdd:cd23966 210 LALIFALHICDEVSVFGFGAD-SKGNWHHYWEKNRSAGA 247
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 174-306 5.20e-17

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 79.62  E-value: 5.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 174 HPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLV------------VRGAARNMIKI 241
Cdd:cd23968  41 NTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTTLRLInsqilskpefnfLTDPLYRNVTL 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 242 L---NGSDNEVL--IIKSVTHRDFNEMIKR---IPN-PVYLFQ--GI-----VLRRGAKG--------TGMKSIELALSM 297
Cdd:cd23968 120 LvwdPSSYNVNLekWYKKPDFDFFPNYIKYrrrHPEePFYLIDprFLwrlwdILQEYTPEkikpnppsSGFIGIVLMLHL 199


                ....*....
gi 30680757 298 CDIVDIYGF 306
Cdd:cd23968 200 CDWVDVYEY 208
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 160-306 1.97e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 75.37  E-value: 1.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 160 EEHLNVILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKyaKYVGVK-----------RDFR 228
Cdd:cd23971  46 NEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLNDS--KDVGSKtnlvtanpsilREKF 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 229 LVVRGAARNMIKILNGSDNEVLIIK--SVTH------------RDFNEMIKRI-PNPVYLF--------QGIVLRRGAkg 285
Cdd:cd23971 124 HNLKKRRRPFVERMKVYGNALLLLPafSYTSntepslralytlEDFGSPQKVLfFNPEYLRnlsrywksKGLKARRLS-- 201

                       170       180
                ....*....|....*....|.
gi 30680757 286 TGMKSIELALSMCDIVDIYGF 306
Cdd:cd23971 202 TGLMLVSAALELCENVHLYGF 222
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 156-306 7.63e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 73.84  E-value: 7.63e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 156 RTL-CEEHLNVILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEkYAKYVGVKRDF-----RL 229
Cdd:cd23988  41 RTLnISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGTKSDFitmnpSV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 230 VVR--GAARN------MIKILNGSDNEVLIIKSVT------HRDF-NEMI-------------KRIPNPV---YLFQGIV 278
Cdd:cd23988 120 VQRafGGFRNesdrekFVHRLSMLNDSVLWIPAFMvkggekHVEWvNALIlknklkvrtaypsLRLIHAVrgyWLTNKVN 199

                       170       180
                ....*....|....*....|....*...
gi 30680757 279 LRRGAkgTGMKSIELALSMCDIVDIYGF 306
Cdd:cd23988 200 IKRPS--TGLLMYTLATRFCDEIHLYGF 225
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 161-306 2.53e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 72.43  E-value: 2.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 161 EHLNVILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDF------------- 227
Cdd:cd23970  51 PNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLttfnpsilekyyn 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 228 RLVVRGAARNMIKILNGSDNEVLII-------KSVTHR---DFNEMIKRIPNPVYLFQGIVLRR-----GAKG------- 285
Cdd:cd23970 130 NLLTIQDRNNFFLSLKKLDGAILWIpafffhtSATVTRtlvDFFVEHRGQLKVQLAWPGNIMQHvnrywKTKHlspkrls 209

                       170       180
                ....*....|....*....|.
gi 30680757 286 TGMKSIELALSMCDIVDIYGF 306
Cdd:cd23970 210 TGILMYTLASAICEEIHLYGF 230
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 161-227 4.19e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 71.51  E-value: 4.19e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680757 161 EHLNVILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEkYAKYVGVKRDF 227
Cdd:cd23987  47 QNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGTKTDL 112
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 180-310 5.48e-14

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 70.01  E-value: 5.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVV-RGAARNmiKILNGSDNEVLII--KSVt 256
Cdd:cd23967   4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKTTFRMFYpESAFRD--PEEYDSDWLLVLVpfKSM- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 257 hrDFN---EMIK-------------------------RIPNPVYL----FQGIVLRRGAKG------TGMKSIELALSMC 298
Cdd:cd23967  80 --DLLwlqAVIKgkkpngkggfwkkiatsvpkppkkiRILNPYILqeaaFDLIGLPMNGKQgknvptTGIIAIVMALHYC 157

                       170
                ....*....|..
gi 30680757 299 DIVDIYGFTVDP 310
Cdd:cd23967 158 DEVDIAGFGYDP 169
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 166-226 7.24e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 70.64  E-value: 7.24e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30680757 166 ILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKYAKYVGVKRD 226
Cdd:cd23990  52 MFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEKYVRDVGVKTD 112
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 180-309 1.24e-13

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 70.30  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPvNEKYAKYVGVKRDFRLV----VRGAARN--MIKILNGSDNEVLIIK 253
Cdd:cd23980  83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVypesFRELAQNvsMILVPFKTLDLEWVIS 161

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680757 254 SVTHRDFNEMIKRIPNPV----------------YLFQGIVLRRGA-KGTGMKSIELALSMCDIVDIYGFTVD 309
Cdd:cd23980 162 ATTTGTISHTYVPVPRKIkvkkekiliyhpafikYVFDRWLQGHGRyPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 179-312 1.30e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 66.50  E-value: 1.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 179 HKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLV-----------------VRGAARNMI-- 239
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIRVVshsslprllrnailllaGTRAPTVVVfw 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 240 ----KILNGSDNEVLIIKSVTHR----DF----NEMIKRIpnpVYLFQ---GIVlRRGAK---GTGMKSIELALSMCDIV 301
Cdd:cd23965  81 gpetKMNKDGAGKYNLLRSLSKKypdvEFysltPEKMDYA---DELFEketGKS-RIKSGtwlSTGWFTMLLALDVCDEI 156

                       170
                ....*....|.
gi 30680757 302 DIYGFtVDPGY 312
Cdd:cd23965 157 KVYGM-VPENY 166
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 180-321 1.73e-12

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 65.46  E-value: 1.73e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEkYAKYVGVKRDFRLVVRGAARNMIKILNGSDnEVLIIKSVTHRD 259
Cdd:cd23982   4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIRLFYPESAQFDPGIENDPD-TLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 260 FNEMIK---------------------------RIPNPVYL------FQGIVLRRGAK---GTGMKSIELALSMCDIVDI 303
Cdd:cd23982  82 FYWLYEilsnekrvrkgfwkqppriwdanpkqiRILNPYYTyvaatkLLQVPGQRKKKqkpTTGLLAITLALHLCDEVHI 161

                       170       180
                ....*....|....*....|....
gi 30680757 304 YGFtvdpGY------TEWTRYFST 321
Cdd:cd23982 162 AGF----GYpdngnsNQPIHYYNQ 181
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 166-306 1.42e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 64.00  E-value: 1.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 166 ILPAKPPFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKYAKYVGVKRDF------------------ 227
Cdd:cd23991  52 MFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLvtanpsiisikyaklner 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 228 ------RLVVRGAARNMIKILNGSDNEVLIIK-SVTHRDFNEMIKRIP-NPVYLfQGIVLRRGAKG-------TGMKSIE 292
Cdd:cd23991 132 rkpfleTVSVYGDAFLLLPAFSYRSNTALSFKvYYTLEDFKAKQKVIFfHPIYL-KHLAQFWRSKGvqvyrlsTGLMITS 210

                       170
                ....*....|....
gi 30680757 293 LALSMCDIVDIYGF 306
Cdd:cd23991 211 AALELCEEVKLYGF 224
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 166-230 3.08e-11

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 62.93  E-value: 3.08e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680757 166 ILPAKP--PFHPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPvNEKYAKYVGVKRDFRLV 230
Cdd:cd23986  35 YVPKIPlsKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRII 100
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 158-306 5.18e-11

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 62.42  E-value: 5.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 158 LCE--EHLNV--ILPAKPPFH--------PR--------QFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKY 217
Cdd:cd23985   5 LCElkDKVNVsmLEGTDFPFNtsewegylPKkslreevgPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT-AGF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 218 AKYVGVKRDFRL-----VVRGAARNMIKILNgsdNE-VLII--KSVTHRDFNEMIK-------------RIPNPVYLF-- 274
Cdd:cd23985  84 QQDVGTKTTIRLinsqlVTTEKHKFLKDSLY---NEgILIVwdPAPYHSDIPEWYKnpdynffenyktyRRLNPNQPFyi 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 30680757 275 -------------QGIV---LRRGAKGTGMKSIELALSMCDIVDIYGF 306
Cdd:cd23985 161 lhpqmqwelwdiiQENSpeeIQPNPPSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 154-326 3.69e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 59.96  E-value: 3.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 154 YNRTLCEEHLNVILPAKPP--FHPRQFHK----CAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKYaKYVGVKRDF 227
Cdd:cd23964  52 LNREVVERLLRNLNLTSSRymFVLRGGRPrcirCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFE-KDVGTKTSF 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 228 RLVVRGAARNMIK--ILNGSDNEVLIIKSVThRDFNEMIKRIPN-PVYLFQGIVLRRG------AKGTGMKSIE------ 292
Cdd:cd23964 131 YTFFPESLHNSLLkhVPQDKDTKYLFIPFKI-RDYDYLDAVLSGkPVPDGCDKGKRPPplfgpkLNATNVRLLHpdfiry 209

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30680757 293 ----------------------LALSMCDIVDIYGFTVDPGYTEwtRYFSTPRKGH 326
Cdd:cd23964 210 lfnrwlnsstsyrpttgalmllTALHTCDQVSVYGFGYDPRFSL--HYYDKTFVKF 263
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 120-324 5.42e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.50  E-value: 5.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 120 NMTTVLTREYLDVRPD---GWLdyaaMRIAQLgadKCYNRTLCEEHLNVILPAKPPFH---PRQFHKCAVVGNSGDLLKT 193
Cdd:cd23979  23 DISPVWTKENMELPPDvqyWWM----MLQPQF---KPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 194 EFGEEIDSHDAVFRDNEAPvNEKYAKYVGVKRDFRLVVRGAARNM----------IKILngsdnEVLIIKSV-------- 255
Cdd:cd23979  96 GYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTTHHFMYPESAKNLpanvsfvlvpFKTL-----DLLWITSAlstgqirf 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 256 THRDFNEMIK------RIPNPVYlFQGIVLRRGAK-----GTGMKSIELALSMCDIVDIYGFTVDP-----GYTEWTRYF 319
Cdd:cd23979 170 TYAPVKQFLRvdkdkvQIYNPAF-FKYIHDRWTEHhgrypSTGMLVLFFALHVCDEVNVYGFGADSrgnwhHYWENNRYA 248


                ....*
gi 30680757 320 STPRK 324
Cdd:cd23979 249 GEFRK 253
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 166-311 6.65e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 55.99  E-value: 6.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 166 ILPAKPPFhPRQFHKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNEKYAKYVG------------VKRDFR--LVV 231
Cdd:cd23989  52 LFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSREYTDDVGtktqlvtanpsiIDKRFQnlLWS 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 232 RGAARNMIKILN-------------GSDNEVLIIKSVTHRDFNEMIkRIPNPVYL-----F---QGIVLRRGAkgTGMKS 290
Cdd:cd23989 131 RKSFVESMKVYGrsyiympafsmktGTDPSLRVYYTLADVGANQTV-LFANPNFLrnvgkFwksKGVHAKRLS--TGLFL 207

                       170       180
                ....*....|....*....|....
gi 30680757 291 IELALSMCDIVDIYG---FTVDPG 311
Cdd:cd23989 208 VSAALGLCEEVTIYGfwpFSVDLD 231
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 180-309 1.63e-08

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 53.98  E-value: 1.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNeKYAKYVGVKRDFRLVV--------RGAARNMIKIL---NGSD-- 246
Cdd:cd23984   4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYpesifsdpSHYDPNTTVVLipfKPHDlr 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 247 --NEVLIIKSVTHRDF-----NEMIKRiPNPVYLFQGIVLRRGA------------------KGTGMKSIELALSMCDIV 301
Cdd:cd23984  83 wlLDLLMGKKVSAKGFwkkpaLNLIYK-PNQIRILNPFILRIAAyellhfpkrfpkekkpkhPTTGIIAITLALHICNEV 161


                ....*...
gi 30680757 302 DIYGFTVD 309
Cdd:cd23984 162 HIAGFKYD 169
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 179-312 2.38e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 54.09  E-value: 2.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 179 HKCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNeKYAKYVGVKRDFRLVVRGAARNMIK----ILNGSDNEVLII-- 252
Cdd:cd23978   2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLRVVAHSSVYRVLRrpqeFLNRTPETTLIFwg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 253 ---------KSVTHRDFNEMIKRIPN-PVY------------LFQGIVLRRGAKG-----TGMKSIELALSMCDIVDIYG 305
Cdd:cd23978  81 ppnkmqkdgKSNLFRIIQRASMTFPNmSAFvvsprrmrqfddLFRGETGRDRKKShswlsTGWFTMVIAVELCDNVHVYG 160


                ....*..
gi 30680757 306 FtVDPGY 312
Cdd:cd23978 161 M-VPPNY 166
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 175-329 3.03e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 50.64  E-value: 3.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 175 PRQFH--KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPvNEKYAKYVGVKRDFRLVVRGAA----RNMIKILNGSDNE 248
Cdd:cd23976  10 PLKMHckSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLRVIAHSSIqrilRNRNELLNVSQGT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 249 VLII-----------KSVTHRDFNEMIKRIPN-PVYL--------FQGIVLRRGAK---------GTGMKSIELALSMCD 299
Cdd:cd23976  89 VFIFwgpsnymrrdgKGLVYNNLQLMNQILPKlKVYTitrhkmlqFDELFKRETGKdrkisntwlSTGWFTMIIALELCD 168

                       170       180       190
                ....*....|....*....|....*....|
gi 30680757 300 IVDIYGFtVDPGYTEWTRYFSTPRKGHNPL 329
Cdd:cd23976 169 RINVYGM-VPPDFCRDPNHPSVPYHYYEPS 197
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 180-227 4.56e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 50.91  E-value: 4.56e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNeKYAKYVGVKRDF 227
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIK-GYEEDVGTRTSF 131
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 180-309 7.02e-07

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 49.15  E-value: 7.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVVRGAArnMIKILNGSDNEVLIIKSVTHRD 259
Cdd:cd23981   4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGA--IQKPEQYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 260 F--------NEMIK--------------------RIPNPVYL------FQGIVLRRGAKGT------GMKSIELALSMCD 299
Cdd:cd23981  81 FkwlkyivyKEKVSasdgfwksvatrvprepheiRILNPYFIqeaafsFIGLPFNNGLMGRgniptlGSVAITMALHNCD 160

                       170
                ....*....|
gi 30680757 300 IVDIYGFTVD 309
Cdd:cd23981 161 EVAVAGFGYD 170
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 180-227 2.29e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 48.60  E-value: 2.29e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVNeKYAKYVGVKRDF 227
Cdd:cd23974  86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITK-GFEKDVGRRTSF 132
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 180-312 6.77e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 46.78  E-value: 6.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPV--------------------------NEKYakYVGVKRDFRLVVRG 233
Cdd:cd23977   3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTagyeadvgnrsslrvvshtsvplllrNQGY--FFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 234 AARNMIKILNGsdnevliiksVTHRDFNEMIKRIPN-PVY------------LFQGIVLRRGAK-----GTGMKSIELAL 295
Cdd:cd23977  81 PERNMDRDGGG----------KTYRALLTLAKMYPHlQVYtlteekmaycdgVFQNETGKNRMKsgsflSTGWFTMILAL 150

                       170
                ....*....|....*..
gi 30680757 296 SMCDIVDIYGFtVDPGY 312
Cdd:cd23977 151 ELCEEILVYGM-VSDSY 166
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 180-309 7.58e-06

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 46.27  E-value: 7.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 180 KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPVnEKYAKYVGVKRDFRLVV-RGAARNMIKILNGSDNEVLIIKSVthr 258
Cdd:cd23983   4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYpEGAPKSEQEYDPTSLFVAVLFKSV--- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680757 259 DFN---------------------EMIKRIP---------NPVYLFQ-GIVL-------------RRGAKGTGMKSIELA 294
Cdd:cd23983  80 DFAwlkamvkkeplsfwsrlffwkEVADSIPlkpsqfrilNPLIIKEtALDIlqypepqsrlwgwDKNVPTLGVTAVVLA 159

                       170
                ....*....|....*
gi 30680757 295 LSMCDIVDIYGFTVD 309
Cdd:cd23983 160 THLCDEVSLAGFGYD 174
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 173-227 1.58e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 45.97  E-value: 1.58e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30680757 173 FHPRQFH----KCAVVGNSGDLLKTEFGEEIDSHDAVFRDNEApVNEKYAKYVGVKRDF 227
Cdd:cd23972  73 FFPRDTPgkciRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGA-VIKGFEEDVGTKTSF 130
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 181-230 1.68e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.23  E-value: 1.68e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 30680757 181 CAVVGNSGDLLKTEFGEEIDSHDAVFRDNEAPvNEKYAKYVGVKRDFRLV 230
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVV 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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