|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
27-503 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 850.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 27 GSEPTNTKKKYNLPVDAEDKATVFKLFSFAKPHMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASV 106
Cdd:PLN00028 2 PASPDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 107 SGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLVN 186
Cdd:PLN00028 82 SGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTAN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 187 GTAAGWGNMGGGITQLLMPIVYEIIRRCGSTAFTAWRIAFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKF 266
Cdd:PLN00028 162 GIAAGWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTMPKDSF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 267 GKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAAKRFGM 346
Cdd:PLN00028 242 SKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFGM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 347 RGRLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLFSLGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQL 426
Cdd:PLN00028 322 RGRLWALWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQL 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15223124 427 VFFSTSRFTTEEGLTWMGVMIVACTLPVTLIHFPQWGSMFFPPSNDSVDatEHYYVGEYSKEEQQIGMHLKSKLFAD 503
Cdd:PLN00028 402 LFFTGSSYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAVE--EDYYASEWTEEEKEKGLHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
63-456 |
1.22e-140 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 410.49 E-value: 1.22e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 63 FHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPR-YGCAFLVMLSAPTVF 141
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 142 SMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIRRcgSTAFTA 221
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVF--DGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 222 WRIAFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEkagevakdkFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIA 301
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE---------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 302 EYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRGRLWTLWIIQTSGGLFCVWLGRANT--LVTAVVS 379
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGRRRLWWLFIVMTIGAALLSLSLPTSGtnLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15223124 380 MVLFSLGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQLVFFSTS--RFTTEEGLTWMGVMIVACTLPVTL 456
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSAlmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
61-420 |
3.91e-82 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 259.54 E-value: 3.91e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 61 RTFHLSWISFSTCFVSTFAAAPLIP-IIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAF-LVMLSAP 138
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALsLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 139 TVFSMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMP-IVYEIIRRCGST 217
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpIIGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 218 AFTAWRIAF-FVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKFGkilwyavtNYRTWIFVLLYGYSMGVELST 296
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFG--------NRHTWILALLYSVTFGSFLGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 297 DNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAAKRfgmrgRLWTLWIIQTSGGLFCVWLG--RANTLV 374
Cdd:TIGR00886 233 SSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGA-----RKLLMNFLGVAMGAFLVVLGlvSDGSLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15223124 375 TAVVSMVLFSLGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFG 420
Cdd:TIGR00886 308 AFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLG 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
57-428 |
3.55e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 173.91 E-value: 3.55e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 57 KPHMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 136
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 137 APTVFSMSFVSDAAGFITVRFMIGFCL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcg 215
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 216 staftAWRIAFFVPGWLHIIMGILVLTLGQDLPGGNRAAmekagevAKDKFGKILwYAVTNYRTWIFVLLYGYSMGVELS 295
Cdd:COG2223 157 -----GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA-------AKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 296 TDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGmrGRLWTLWIIQTSGGLFCVWLGRANTLVT 375
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RIG--GRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15223124 376 AVVSMVLFSLGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
57-457 |
1.77e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.79 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 57 KPHMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 136
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 137 APTVFSMSFVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVyeiirrcg 215
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 216 sTAFTAWRIAFFVPGWLHIIMGILVLTLgqdlpggnraamekagevakdkfgkILWYAVTNYRTWIFVLLYGYSmgvels 295
Cdd:COG2271 158 -LAAFGWRAAFLILGLPGLLLALLRFWL-------------------------LALAYFLVYFALYGFLTWLPT------ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 296 tdnviaeYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGmRGRLWTLWIIQTSGGLFCVWLGRANTLVT 375
Cdd:COG2271 206 -------YLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD----RLG-RRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 376 AVVSMVLFSLGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLVF-FSTSRFTTEEGLTWMGVMIVACTLP 453
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALL 353
|
....
gi 15223124 454 VTLI 457
Cdd:COG2271 354 ALLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
65-423 |
9.83e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.39 E-value: 9.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 65 LSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 144
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 145 FVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIRrcgstaftaWR 223
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---------WR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 224 IAFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKFGKILwyavtnYRTWIFVLLYGYSMGVELSTDNVIAEY 303
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL------RDPVLWLLLALLLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 304 FFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRGRLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLF 383
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15223124 384 SLGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGL 423
Cdd:pfam07690 302 GFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
67-423 |
4.42e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 82.71 E-value: 4.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 67 WISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFV 146
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 147 SDAAGFITVRFMIGFCLATFVS-CQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgstaftAWRIA 225
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPaALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 226 FFVPGWLHIIMGILVLTLgqdlpggnraaMEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFF 305
Cdd:COG2814 167 FLVNAVLALLALLLLLRL-----------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 306 DRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRgrlWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLFSL 385
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRR---RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 15223124 386 GAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGL 423
Cdd:COG2814 309 GFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
67-456 |
1.09e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 67 WISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGC-AFLVMLSAPTVFsMSF 145
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLlLGLLLFALGALL-FAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 146 VSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgstaFTAWRI 224
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-------GFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 225 AFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVakdKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYF 304
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK---SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 305 FDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAakrfgmRGRLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLFS 384
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15223124 385 LGAQAACGATFAIVPF-VSRRALGIISGLTGAGGNFGSGLTQLVF-FSTSRFTTEEGLTWMGVMIVACTLPVTL 456
Cdd:cd06174 305 FGLGGLLPLSFALIAElFPPEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
67-428 |
9.61e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 63.55 E-value: 9.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 67 WISFSTCFV--STFAAAplIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 144
Cdd:TIGR00881 1 FIGYAAYYLvrKNFALA--MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 145 FVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGItqlLMPIVYEIIRRCGStaftaWR 223
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGL---LPPLVLFGIAELYS-----WH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 224 IAFFVPGWLHIIMGILVLTLGQDLP-------------GGNRAAMEKAGEVAKDKFGKiLWYAVTNYRTWIFVLLYGYSM 290
Cdd:TIGR00881 151 WVFIVPGIIAIIVSLICFLLLRDSPqscglppaeempnEEPDGDAEKKEEELTKKQIF-LQYVLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 291 GVELSTDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASD--IAAKRFGMrGRLWTLWIIQTSGGLFCVwlG 368
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPL-AVFFMALIIVSLLVYWLN--P 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15223124 369 RANTLVTAVVSMVL--FSLGAQAACGAtfAIVPFVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:TIGR00881 307 AANPLMDLICLFALgfLVYGPQMLIGV--IASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
66-428 |
1.41e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.03 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 66 SWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSF 145
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 146 VSDAAGFITVRFMIGFCLATFV-SCQYWMSTMFNSQIIGLVNG---TAAgwgNMGGGITQLLMPIVyeiirrcgstAFTA 221
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGirqTGV---PLGGALAAALLPPL----------ALHY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 222 -WRIAFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKfgkilwyAVTNYRTWIFVLLYGYSM-GVELSTDNV 299
Cdd:cd17475 148 gWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLK-------EVLRNRDVWLIAIAGALLvAPQFALLTF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 300 IAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaaKRFGMRGRLWTLWIIQTSGGLFCV--WLGRANTLVTAV 377
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGRRRPVLVITAAIAAAALLVlsLLSPGTPLWLLV 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15223124 378 VSMVLFSLGAQAACGATFA-IVPFVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:cd17475 298 LLLILLGLFAIGWNGLYLTlVAESAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
85-428 |
6.60e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 85 PIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYG-CAFLVMLSAPTVFsMSFVSDAAGFITVRFMIGFCL 163
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVlAVSMLLWSLFTAL-TGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 164 ATFVSC-----QYWMSTMFNSQIIGLVNgTAAGWGNMgggitqLLMPIVYEIIrrcgsTAFTaWRIAFFVPGWLHIIMGI 238
Cdd:cd17319 106 AGFFPGaikalAEWFPARERGRATGLFN-SGAPLGAA------IGPPLSGWLL-----LLFG-WRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 239 LVLTLGQDLpggnraamekagevakdkFGKILWYAVTNYRTWIFVLLygysmgvelstdnvIAEYFFDRFHLKLHTAGII 318
Cdd:cd17319 173 LWWFYLRQV------------------WGLALGYFGINYALYGLLTW--------------LPTYLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 319 AACFGMANFFARPAGGWASDiaaKRFGMRGRlwtlWIIQTSGGLFCVWLGRANTLVTAVVSMVLFSL---GAQAACGATF 395
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSD---RLLRGARR----LVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLagfGIGAASPVFW 293
|
330 340 350
....*....|....*....|....*....|....
gi 15223124 396 AIVP-FVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:cd17319 294 SLPAdLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
57-416 |
9.41e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 9.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 57 KPHMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 136
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 137 APTVFSMSFVSDAAGFITVRFMIGFCLATF-VSCQYWMSTMFN---SQIIGLVNGtaagwGNMGGGItqlLMPIVYEIIR 212
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPetaASRLNLLHA-----FFSLGAL---LGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 213 RCGSTAftAWRIAFFVPGWLHIIMGILVLTlgQDLPGGNRAAMEKAGEVAKDKFgkilwyAVTNYRTWIFVLLYGYSMGV 292
Cdd:COG0738 156 LLGLSL--SWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAIFLYVGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 293 ELSTDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARpaggWASDIAAKRFgmrGRLWTLWIIQTSGGLFCVWLGRANT 372
Cdd:COG0738 226 EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR----FLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15223124 373 LVTAVVSMVLFSLGAQAACGATFAIVP-FVSRRALGIISGLTGAG 416
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALdGLGKRTAAAVSAVLIMG 343
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
59-457 |
1.97e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 59.21 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 59 HMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAP 138
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 139 TVFSMSFVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIvyeIIRRCGst 217
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAAS---LASYYG-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 218 aftaWRIAFFVPGWLHIIMGILVLtlgqdlpggnraamekagevakdkfgkiLWYAVTNYRTWIFVLLYGYSMGVELSTD 297
Cdd:cd17312 156 ----WRAAFLVPGIVGLVVAIILF----------------------------FFLRDSPPYVWVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 298 NVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAAKrfGMRGRLWTLWIIQTSGGLFCVWLGRANTLVTAV 377
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 378 V-SMVLFSLGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQLVFFSTSrftteEGLTWMGV---MIVACTLP 453
Cdd:cd17312 282 LlFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYII-----DHYGWSTVfyfLISAALLS 356
|
....
gi 15223124 454 VTLI 457
Cdd:cd17312 357 VLLL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
69-449 |
7.92e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 69 SFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYG--------CAFLVMLSAPTV 140
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGrrrpwiliGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 141 FSMSFVSDAAGFITvrFMIGFCLATFVScqywmsTMFNSQIIGLVN---------GTAAGWGNMGGGITQLLMPIV-YEI 210
Cdd:COG2211 99 FTAPDLSPTGKLIY--ALVTYLLLGLAY------TLVNIPYSALGAeltpdyeerTRLSSWRFAFAGLGGLLASVLpPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 211 IRRCGSTAFTAWRIAFFVPGWLHIIMGILVLTLGQDLPggnraamekAGEVAKDKFGKILWYAVTNyRTWIFVLLYGYSM 290
Cdd:COG2211 171 VAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP---------VPEEEKVSLKESLKALLKN-RPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 291 GVELSTDNVIAEYFF-DRFHLKLHTAGIIAACFGMANFFARPAGGWAsdiaAKRFGMRgRLWTLWIIQTSGGLFCVWLGR 369
Cdd:COG2211 241 FLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRL----AKRFGKK-KAFIIGLLLAALGLLLLFFLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 370 ANTLVTAVVSMVLFSLGAQAACGATFAIVPFVS--------RRALGIISGLTGAGGNFGSGLTQLVF--------FSTSR 433
Cdd:COG2211 316 PGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAglllalfgYVAGA 395
|
410
....*....|....*.
gi 15223124 434 FTTEEGLTWMGVMIVA 449
Cdd:COG2211 396 AQSPSALTGIRLLFFL 411
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-423 |
1.53e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 74 FVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFI 153
Cdd:cd17324 12 GTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 154 TVRFMIGFCLATFVSCQY-WMSTMFNSQIIGLVNGTAAGwGNMGGGIT-QLLMPIVyeiirrcgsTAFTAWRIAFFVPGW 231
Cdd:cd17324 92 LARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLVLgRPLGGLL---------GQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 232 LHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSmgvelstdnVIAEYFFDRFHLK 311
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT---------YLAPFLTDVPGFS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 312 LHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRGRLWTLWIIQTSGGLFCVWlgrANTLVTAVVSMVLFSLGAQAAC 391
Cdd:cd17324 233 SSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGFFAAH 305
|
330 340 350
....*....|....*....|....*....|..
gi 15223124 392 GATFAIVPFVSRRALGIISGLTGAGGNFGSGL 423
Cdd:cd17324 306 SALQTRVLRLAPEARGLASSLYLAAYNLGGAL 337
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
99-248 |
3.90e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 52.40 E-value: 3.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 99 GNAGVASVSGSI---FSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGF------------CL 163
Cdd:PRK11273 63 GDLGFALSGISIaygFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFlcgwfqgmgwppCG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 164 ATFVscqYWMSTMFNSQIIGLVNGTAagwgNMGGGITQLLMPIvyeiirrcGSTAFTAWRIAFFVPGWLHIIMGILVLTL 243
Cdd:PRK11273 143 RTMV---HWWSQKERGGIVSVWNCAH----NVGGGLPPLLFLL--------GMAWFNDWHAALYMPAFAAILVALFAFAM 207
|
....*
gi 15223124 244 GQDLP 248
Cdd:PRK11273 208 MRDTP 212
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-423 |
8.39e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 8.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 67 WISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYgcaFLVM---LSAPTVFSM 143
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR---LLLLgllLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 144 SFVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEiirrcgstaFTAW 222
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD---------ALGY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 223 RIAFFVPGWLHIIMGILVLTLgqdLPGGNRAAmeKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAE 302
Cdd:cd17325 150 RAPFLVCAALALLALVLALLL---LPEPRPPP--NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 303 YFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFgmrGRLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVL 382
Cdd:cd17325 225 YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RI---GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15223124 383 FSLGAQAACGATFAIV-PFVSRRALGIISGLTGAGGNFGSGL 423
Cdd:cd17325 298 LGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
61-244 |
5.65e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 61 RTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVM--LSAP 138
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGllLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 139 TVFSMSFVSDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQIIGlvngTAAGWGNMGGGITQLLMPIVYEIIrrcgsT 217
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPKKARG----TASGLVNTFGFLGGALGPLLVGYL-----L 331
|
170 180
....*....|....*....|....*..
gi 15223124 218 AFTAWRIAFFVPGWLHIIMGILVLTLG 244
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
73-428 |
1.15e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 73 CFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGF 152
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 153 ITVRFMIGFCLATFVSCqywMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVyeiirrcGSTAFTAWriAFFVPGWL 232
Cdd:cd17489 88 LVLRLIHGIGWGAFTTA---AATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-------GLFLYQHL--GFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 233 HIIMGILVLTLGQDLPGGNRAAmEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSmgvelSTDNVIAEYFFDRFHlkl 312
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVA-AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG-----AISTFLPLYAAERGI--- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 313 HTAGIIAACFGMANFFARPAGGWASDIaakrfgmRGRLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLFSLG---AQA 389
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDR-------KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfglLFP 299
|
330 340 350
....*....|....*....|....*....|....*....
gi 15223124 390 ACGAtfAIVPFVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:cd17489 300 ALQA--LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
76-248 |
1.30e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.62 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 76 STFAAAplIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITV 155
Cdd:cd17345 20 NNFSLA--QPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 156 RFMIGFCLATFVS-----CQYWMSTMFNSQIIGlvnGTAAGWG---NMGGGITQLLMPIvyeiirrcGSTAFTA--WRIA 225
Cdd:cd17345 98 MFILLFLNGWFQGmgwppSGRTMVHWFSKKERG---TWTSIWNishNVGGGLVGPLAGL--------GLAIFGDgwWRGA 166
|
170 180
....*....|....*....|...
gi 15223124 226 FFVPGWLHIIMGILVLTLGQDLP 248
Cdd:cd17345 167 FIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
74-452 |
3.12e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 74 FVSTFAAAPLIPIIRENLNLTkhDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAF-LVMLSAPTVFSMsFVSDAAGF 152
Cdd:cd17316 16 FLIGFVAPVLAAEFSLGLSLL--QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILtLLLFGLATLLIG-LLPTPILL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 153 ITVRFMIGFCL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgsTAFTAWRIAFFVPGW 231
Cdd:cd17316 93 LVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGDWGWRILFLIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 232 LHIIMGILVltlgqdlpggnraamekagevakdkfgKILWYAVTnyrTWIFVLLYGYSMGVELSTdnviaeYFFDRFHLK 311
Cdd:cd17316 168 PALLALLLR---------------------------RRTLLLIL---LWFFISFGYYGLTTFLPT------YLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 312 LHTAGIIAACFGMANFFARPAGGWASDIAAKRFGMrgrLWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLF-SLGAQAA 390
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL---VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFfVGGVWGA 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15223124 391 CGATFAIVPFVSRRALGiiSGLTGAGGNFGSGLTQLVFFS--TSRFTTEEGLTWMGVMIVACTL 452
Cdd:cd17316 289 LYAYLAELFPTEVRATG--VGLSYNLGRLGGGGAPPLIALllASTGGTGVPALILALLAIVALI 350
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
87-292 |
3.37e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.09 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 87 IRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGFCLA-T 165
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESgV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 166 FVSCQYWMSTMFNSQIIGLVNG---TAAGWGNMGGGItqllmpIVYEIIRRCGSTAFTAWRIAFFVPGWLHIIMGILVLT 242
Cdd:cd17327 112 FPGFILYLGMWYKREEQAKRIAffyAAAGLGSIFGGL------LAYGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFF 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15223124 243 LGQDLPGGNR--------------AAMEKAGEVAKDKFgKILWYAVTNYRTWIFVLLYGYSMGV 292
Cdd:cd17327 186 WLPDNPSKAWflteeekelaverlRANQTGKGDQKFKW-KQIKEAFKDPRTWLLFLFFFCSQIT 248
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
273-470 |
2.42e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 273 AVTNYRTWIFVLL---YGYSMGVELSTdNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRgr 349
Cdd:COG2271 3 APSRYRWRILALLflaYFLNYLDRSNL-SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFGRR-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 350 lWTLWIIQTSGGLFCVWLGRANTLVTAVVSMVLFSLGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLT---- 424
Cdd:COG2271 76 -RVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAeWFPPKERGRALGIFNAGGPLGGALAppll 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15223124 425 ---------QLVFFSTSRFtteeGLTWMGVMIVACTLPVTLIHFPQWGSMFFPPS 470
Cdd:COG2271 155 gwllaafgwRAAFLILGLP----GLLLALLRFWLLALAYFLVYFALYGFLTWLPT 205
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
67-428 |
3.22e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.08 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 67 WISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFV 146
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 147 SDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQiiglvNGTAAGWGNMGGGITQLLMPIVYEIIrrcgSTAFTAWRIA 225
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANtFVGALFEES-----SATRLNVLHGFFGLGALIGPLIATSL----LTSELSWSWA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 226 FFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKFGKILwyavtNYRTWIFVLLYGYSMGVELSTDNVIAEYFF 305
Cdd:cd17333 153 YLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLR-----NPSIILGALALFLYVGAETAFSSWVPSYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 306 DRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakrfgmRGRLWTLWIIQTSGG-LFCVWLGRANTLVTAVVSMVL-- 382
Cdd:cd17333 228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR--------RIKPHTLLVLSGSGAlLGLLILLLAPTLVVGLVATALlg 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15223124 383 FSLGAQAACGATFAI--VPFVSRRALGIISGLTGAGGNFGSGLTQLVF 428
Cdd:cd17333 300 LFMAALFPTILSLGIsnLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
222-406 |
1.93e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.68 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 222 WRIAFFVPGWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDkFGKILWYAVTNyRTWIFVLLyGYSmGVELSTDNV-- 299
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATS-FLADLKALAKN-PSFILSTL-GFT-AVSFVTGALaf 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 300 -IAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAAKRFGMRGRLWTLWIIQTS--GGLFCVWLGRANTLVTA 376
Cdd:cd17328 229 wAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGllAAAPFLFLALVLALSNL 308
|
170 180 190
....*....|....*....|....*....|....*.
gi 15223124 377 VVSMVLFSLGAQAAC---GATFAIVPFV---SRRAL 406
Cdd:cd17328 309 LLAWVLLFLGEFLLSlnwAPVFAILLYVvipTRRST 344
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
32-415 |
2.73e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 40.42 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 32 NTKKKYNLPVDAEDKAtvfklfsFAKPHMRTFHLSWISFSTCFV--STFAAAPliPIIRENLNLTKHDIGNAGVASVSGS 109
Cdd:PRK09556 7 VRKPTLDLPLEVQRKM-------WFKPFMQSYLVVFIGYLTMYLirKNFKAAQ--NDMISTYGLSTTELGMIGLGFSITY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 110 IFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFvSDAAGFITVRFMI------GFCLATFVSCQY-----WMSTMFN 178
Cdd:PRK09556 78 GVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGA-SLGSGSVSLGLMIalwalsGFFQSTGGPCSYstitrWTPRRKR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 179 SQIIGLVNgTAAGWGNMGGGITQLLmpivyeiirrcGSTAFTAWRIA--FFVPGWLHIIMGILVLTLGQDLP---GGNRA 253
Cdd:PRK09556 157 GRFLGFWN-ISHNLGGAGAGGVALW-----------GANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPeelGWGKA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 254 ------AMEKAGEVAKD----KFGKILWYAVTNYRTWIF----VLLYGYSMGVelstDNVIAEYFFDRFHLKLHTAGIIA 319
Cdd:PRK09556 225 eeifgePISEEDKETEStdmtKWQIFVEYVLKNPVIWLLcfanIFLYIVRIGI----DNWSPVYAFQELGFSKEDAINTF 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 320 ACFGMANFFARPAGGWASDIAAKRFGMRGRLWTLWIIqtsgglFCVWLGRANTLVTAVVSmVLFSLGA-----QAACGAt 394
Cdd:PRK09556 301 TLFEIGALVGSLLWGWLSDLANGRRALVACIALALII------FTLGVYQHATSEYMYLA-SLFALGFlvfgpQLLIGV- 372
|
410 420
....*....|....*....|.
gi 15223124 395 fAIVPFVSRRALGIISGLTGA 415
Cdd:PRK09556 373 -AAVGFVPKKAIGVANGIKGT 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
283-460 |
3.60e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 283 VLLYGYSMGVELSTDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFGMRgrlWTLWIIQTSGGL 362
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRR---PVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 363 FCVWLGRANTLVTAVVSMVLFSLGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLVFFSTSRFTTEEGLT 441
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAdLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA 153
|
170
....*....|....*....
gi 15223124 442 WMGVMIVACTLPVTLIHFP 460
Cdd:cd06174 154 VFLIAAALALLAAILLLLV 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
81-417 |
4.31e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.46 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 81 APLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIG 160
Cdd:cd17478 16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 161 FClatfvscqywmSTMFN---SQIIGLVNGTAAGW--------GNMGGGITQLLMPIVYEIIRRCGSTAFTAWriaffvP 229
Cdd:cd17478 96 IG-----------SAAFHpegARLASQAAGGRRGLamsifsvgGNLGFALGPLIAAALVALFGGLGLLILLII------P 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 230 GwlhIIMGILVLTLGQDLP--GGNRAAMEKAGEVAKDKFGKILWYAVTNY-RTWIFVllygysmgvelSTDNVIAEYFFD 306
Cdd:cd17478 159 G---LAVALLLLRLRPLKKpeAKKAAAKSSARSTLKGVWRALLLLLIIVFlRSWVLS-----------SLTTFLPFYLVQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 307 RFhLKLHTAGIIAACFGMANFFARPAGGWASDiaakRFgmrGRLWTLWIIqTSGGLFCVWLGRANTLVTAVVSMVLFSLG 386
Cdd:cd17478 225 RG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSD----RF---GRRRVIIAS-LLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
330 340 350
....*....|....*....|....*....|....*.
gi 15223124 387 AQAACGATFAIVPFVSRRALGIISGLT-----GAGG 417
Cdd:cd17478 296 LFASFPVTVVLAQELLPGNVGLASGLMmglsfGLGG 331
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
65-205 |
8.91e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 65 LSWISFSTCFVSTFAAAPLIpiIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPR--YGCAFLVMLSAPTVFS 142
Cdd:cd17316 184 LLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktLVIGLILSGILALPLF 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15223124 143 MSFVSDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMP 205
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIA 325
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
56-354 |
9.19e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 56 AKPHMRTFHLSWISFSTCFVSTFAAAPLIPIIRENLNLTKHDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYgcAFLVML 135
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR--VLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 136 SAPTVFS--MSFVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLvngtAAGWGNMGGGITQLLMPIVYEIIr 212
Cdd:COG0477 87 LLFGLASllCGLAPSPELLIAARALQGIGAGGlMPGALALIAELFPARERGR----ALGLWGAAIGLGLALGPLLGGLL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 213 rcgsTAFTAWRIAFfvpgWLHIIMGILVLTLGQDLPGGNRAAMEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGV 292
Cdd:COG0477 162 ----VAALGWRWIF----LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15223124 293 ELSTDNVIAEYFFDRFHLKLHTAGIIAACFGMANFFARPAGGWASDIAAKRFGMRGRLWTLW 354
Cdd:COG0477 234 LAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
218-452 |
9.39e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.33 E-value: 9.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 218 AFTAWRIAFFVPGWLHIIMGILVLT-LGQDLPGGNRAAMEKAgevakdkFGKILWYAVTNYRTWIFVLLYGYSMGVELST 296
Cdd:cd17320 148 LFFGWRAIFVFLALLGLLLLLLVLLfLPETLPEEKRKPLLSS-------LLRAYKRVLKNRRFLGYALALGLSFAGLFAY 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223124 297 DNVIAEYFFDRFHLklhTAGIIAACFGMaNFFARPAGGWASDIAAKRFGMRGRLWTLWIIQTSGGLFCV--WLGRANTLV 374
Cdd:cd17320 221 LAAAPFIYIEQLGL---SPAQFGLLFAL-NAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLlaALLGGLSLW 296
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15223124 375 TAVVSMVLFSLGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQLVffstSRFTTEEGLTWMGVMIVACTL 452
Cdd:cd17320 297 PLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGAL----VGLLPNGTALPMGLLILVLGL 370
|
|
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