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Conserved domains on  [gi|15222433|ref|NP_172233|]
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SCARECROW-like 14 [Arabidopsis thaliana]

Protein Classification

GRAS family protein( domain architecture ID 10507540)

GRAS family protein such as Arabidopsis thaliana protein SCARECROW, a transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
393-764 1.07e-144

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


:

Pssm-ID: 397536  Cd Length: 374  Bit Score: 429.01  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   393 LRTLLVLCAQAVSVDDRRTANEMLRQIREHSSPLGNGSERLAHYFANSLEARLAGTGTQIYTALSSKKTS---AADMLKA 469
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSIYSALPPRPTSpsdSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   470 YQTYMSVCPFKKAAIIFANHSMMRFTANANTIHIIDFGISYGFQWPALIHRLSlSRPGGSPKLRITGIELPQrgFRPAEG 549
Cdd:pfam03514  81 YKLFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALA-SRPGGPPHLRITGIGDPQ--FSSAEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   550 VQETGHRLARYCQRHNVPFEYNA-IAQKWETIQVEDLKLRQGEYVVVNSLFRFRNLLDETVLVNSPRDAVLKLIRKINPN 628
Cdd:pfam03514 158 LEETGDRLAQFADSLGVPFEFNPlVAKRLEDLDLEMLDVRPGEALAVNCVFALHRLLDESVSLESPRDTFLRLVRSLNPK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   629 VFIPAILSGNYNAPFFVTRFREALFHYSAVFDMCDSKLAREDEMRLMYEKEFYGREIVNVVACEGTERVERPETYKQWQA 708
Cdd:pfam03514 238 VVTLVEQEANHNSAPFLNRFVEALHYYSALFDSLEATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKWRE 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15222433   709 RLIRAGFRQLPLEKELMQNLKLKIENGYDKNFDVDQNGNWLLQGWKGRIVYASSLW 764
Cdd:pfam03514 318 RMRRAGFRPVPLSEFAVKQAKLLLRLYYVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
393-764 1.07e-144

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 429.01  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   393 LRTLLVLCAQAVSVDDRRTANEMLRQIREHSSPLGNGSERLAHYFANSLEARLAGTGTQIYTALSSKKTS---AADMLKA 469
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSIYSALPPRPTSpsdSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   470 YQTYMSVCPFKKAAIIFANHSMMRFTANANTIHIIDFGISYGFQWPALIHRLSlSRPGGSPKLRITGIELPQrgFRPAEG 549
Cdd:pfam03514  81 YKLFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALA-SRPGGPPHLRITGIGDPQ--FSSAEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   550 VQETGHRLARYCQRHNVPFEYNA-IAQKWETIQVEDLKLRQGEYVVVNSLFRFRNLLDETVLVNSPRDAVLKLIRKINPN 628
Cdd:pfam03514 158 LEETGDRLAQFADSLGVPFEFNPlVAKRLEDLDLEMLDVRPGEALAVNCVFALHRLLDESVSLESPRDTFLRLVRSLNPK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   629 VFIPAILSGNYNAPFFVTRFREALFHYSAVFDMCDSKLAREDEMRLMYEKEFYGREIVNVVACEGTERVERPETYKQWQA 708
Cdd:pfam03514 238 VVTLVEQEANHNSAPFLNRFVEALHYYSALFDSLEATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKWRE 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15222433   709 RLIRAGFRQLPLEKELMQNLKLKIENGYDKNFDVDQNGNWLLQGWKGRIVYASSLW 764
Cdd:pfam03514 318 RMRRAGFRPVPLSEFAVKQAKLLLRLYYVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
393-764 1.07e-144

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 429.01  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   393 LRTLLVLCAQAVSVDDRRTANEMLRQIREHSSPLGNGSERLAHYFANSLEARLAGTGTQIYTALSSKKTS---AADMLKA 469
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSIYSALPPRPTSpsdSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   470 YQTYMSVCPFKKAAIIFANHSMMRFTANANTIHIIDFGISYGFQWPALIHRLSlSRPGGSPKLRITGIELPQrgFRPAEG 549
Cdd:pfam03514  81 YKLFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALA-SRPGGPPHLRITGIGDPQ--FSSAEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   550 VQETGHRLARYCQRHNVPFEYNA-IAQKWETIQVEDLKLRQGEYVVVNSLFRFRNLLDETVLVNSPRDAVLKLIRKINPN 628
Cdd:pfam03514 158 LEETGDRLAQFADSLGVPFEFNPlVAKRLEDLDLEMLDVRPGEALAVNCVFALHRLLDESVSLESPRDTFLRLVRSLNPK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15222433   629 VFIPAILSGNYNAPFFVTRFREALFHYSAVFDMCDSKLAREDEMRLMYEKEFYGREIVNVVACEGTERVERPETYKQWQA 708
Cdd:pfam03514 238 VVTLVEQEANHNSAPFLNRFVEALHYYSALFDSLEATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKWRE 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15222433   709 RLIRAGFRQLPLEKELMQNLKLKIENGYDKNFDVDQNGNWLLQGWKGRIVYASSLW 764
Cdd:pfam03514 318 RMRRAGFRPVPLSEFAVKQAKLLLRLYYVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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