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Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
8-1021
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 775.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 8 SA L DNVVV KSPND R R L YR V I E L E NGL CA LL IH DP diypegsvpdqideddedgeeedsdgssedddddeddeedgegdee 87
Cdd:COG1025 29 QP L AETII KSPND P R Q YR A I T L D NGL KV LL VS DP ---------------------------------------------- 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 88 dedededevkgkgdh Q TK K A AAA MC V SM GSF L DP PEA QGLAHFLEHMLF M G STEF P DEN EY DSYL SKHGGS S NA Y T EM E H 167
Cdd:COG1025 63 --------------- Q AD K S AAA LA V PV GSF D DP DDQ QGLAHFLEHMLF L G TKKY P EPG EY QEFI SKHGGS H NA S T AT E R 127
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 168 T C Y H FEV KREF L QG AL K RF SQ FF V APL MKT E AME RE VL AV DS E FNQALQN D AC R LQ Q LQCY T SAKG HPF N RF AW GN KKS L 247
Cdd:COG1025 128 T N Y Y FEV ENDA L EE AL D RF AD FF A APL FDP E YVD RE RN AV NA E YTLKRSD D GR R IY Q VHKE T LNPA HPF S RF SV GN LET L 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 248 S G am EN G VD LR ECIVKL Y KE YY HGG LMKLV VIGGE SLD M LE SWVVEL FG DVK N GSKIR P T ------ LEAEGP I W kggkl Y 321
Cdd:COG1025 208 S D -- KP G SK LR DELLAF Y QR YY SAN LMKLV LYSNQ SLD E LE KLARQT FG AIP N RNLSV P P itvply TPEQLG I I ----- I 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 322 RLEAV K DVHI L D L TWTL P PLRSA Y VK KP ED Y LAH LLG H EG R GSL HSF LK AK G W A T SLSAG V G DD G I N RS slay V F GM S IH 401
Cdd:COG1025 281 HIVPL K PRRQ L R L EFPI P NNQAY Y RS KP LT Y ISY LLG N EG E GSL LDW LK KQ G L A E SLSAG G G IS G R N FG ---- D F SI S VS 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 402 LTD S GL EKIYD II GYIYQ Y LK L L R DVSP QEW I F K E LQDIGNMD FRF A E EQPAD DY AAE LS E NML A YPVE H V IYG DY VYQT 481
Cdd:COG1025 357 LTD K GL AHRDE II AAVFA Y IE L I R QQGI QEW Y F D E QAQLLELA FRF Q E KTRPM DY VSW LS D NML R YPVE D V LDA DY LMDG 436
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 482 W DP KL I EDLMGFF TP Q N M RI DVV S KSIKSE ef QQEP W FGSS Y IEEDVPLSLMES W SNP S e VDNS L H LP SK N QF IP C DFS I 561
Cdd:COG1025 437 F DP AA I RARLAQL TP E N A RI WLI S PDVPTD -- KTAY W YDTP Y SVDPITQEQLAK W QQA S - QNPA L S LP EL N PY IP D DFS L 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 562 RAIN sdvdp K SQSP P RCII DEP FMKF WY KL D ET F KV P R A NT Y FRINLKG A YA S VK N CL LT E L YIN LL K D E LNE II YQAS I 641
Cdd:COG1025 514 IKLD ----- K ESAK P ELLV DEP GLRL WY MP D QY F AE P K A DI Y LSLRNPQ A VD S AR N QV LT R L LDY LL N D A LNE LS YQAS V 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 642 A K L ET SL SMYGDK L E L KVY GF NE K I P A LL SKI L AIAK SF M P NL ERF KVI K ENME R GFR N TN - M KP LNH s TYLR L Q - LL CK 719
Cdd:COG1025 589 A G L SY SL YAHQGG L T L SAS GF TQ K Q P K LL EAL L DQLA SF E P TE ERF AQA K SQLL R QLD N AE k A KP YSQ - LFSP L S r LL QP 667
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 720 RIYDSD E K L SV L NDLS L D DL NS F IPE L RS Q IFI E A L CH GNLSE DE A VNISNIF K DS L TVEPLPSKC R hg E Q ITCFPMGAK 799
Cdd:COG1025 668 PYFERE E L L AA L ESIT L Q DL RA F REQ L LQ Q LHL E M L VV GNLSE EQ A KQLADSL K KQ L APNGTGEEP R -- R Q VVDLDKSGS 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 800 L VRDVNV knk SE T N S VVEL YYQ IEPEEAQ S trt K A VLD L FHE II EEPL FNQLRT K EQLGYVV EC G PRLTY R VH G FC F C VQ 879
Cdd:COG1025 746 L NLEKAC --- DH T D S ALLI YYQ SGYDSLA S --- M A LSS L LGQ II SPWF FNQLRT E EQLGYVV GA G YMPLG R QP G LG F Y VQ 819
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 880 S SKYG P VH LL G R V D N F I K DI E GL L EQ L DD E SYED Y RS G M I AR LLE K D PS L LS E TND LW SQ I VDKRYM FD FSH K EAEELRS 959
Cdd:COG1025 820 S PVAS P AY LL E R I D D F L K QF E ER L LA L SE E EFAQ Y KQ G L I NQ LLE P D QN L SE E AQR LW VD I GNGDFE FD TRE K LIAAVKK 899
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145335200 960 IQKK D V I SWYKTYFRE ss P KCR RL AVRVW G CDTN mke TQTDQ K AVQV I A D AV AF KS T SKFYP 1021
Cdd:COG1025 900 LTRA D L I DFFQQAVIA -- P QGL RL LSQSQ G TKHS --- KADEL K GWKT I T D IS AF QK T LPVKE 956
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
8-1021
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 775.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 8 SA L DNVVV KSPND R R L YR V I E L E NGL CA LL IH DP diypegsvpdqideddedgeeedsdgssedddddeddeedgegdee 87
Cdd:COG1025 29 QP L AETII KSPND P R Q YR A I T L D NGL KV LL VS DP ---------------------------------------------- 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 88 dedededevkgkgdh Q TK K A AAA MC V SM GSF L DP PEA QGLAHFLEHMLF M G STEF P DEN EY DSYL SKHGGS S NA Y T EM E H 167
Cdd:COG1025 63 --------------- Q AD K S AAA LA V PV GSF D DP DDQ QGLAHFLEHMLF L G TKKY P EPG EY QEFI SKHGGS H NA S T AT E R 127
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 168 T C Y H FEV KREF L QG AL K RF SQ FF V APL MKT E AME RE VL AV DS E FNQALQN D AC R LQ Q LQCY T SAKG HPF N RF AW GN KKS L 247
Cdd:COG1025 128 T N Y Y FEV ENDA L EE AL D RF AD FF A APL FDP E YVD RE RN AV NA E YTLKRSD D GR R IY Q VHKE T LNPA HPF S RF SV GN LET L 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 248 S G am EN G VD LR ECIVKL Y KE YY HGG LMKLV VIGGE SLD M LE SWVVEL FG DVK N GSKIR P T ------ LEAEGP I W kggkl Y 321
Cdd:COG1025 208 S D -- KP G SK LR DELLAF Y QR YY SAN LMKLV LYSNQ SLD E LE KLARQT FG AIP N RNLSV P P itvply TPEQLG I I ----- I 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 322 RLEAV K DVHI L D L TWTL P PLRSA Y VK KP ED Y LAH LLG H EG R GSL HSF LK AK G W A T SLSAG V G DD G I N RS slay V F GM S IH 401
Cdd:COG1025 281 HIVPL K PRRQ L R L EFPI P NNQAY Y RS KP LT Y ISY LLG N EG E GSL LDW LK KQ G L A E SLSAG G G IS G R N FG ---- D F SI S VS 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 402 LTD S GL EKIYD II GYIYQ Y LK L L R DVSP QEW I F K E LQDIGNMD FRF A E EQPAD DY AAE LS E NML A YPVE H V IYG DY VYQT 481
Cdd:COG1025 357 LTD K GL AHRDE II AAVFA Y IE L I R QQGI QEW Y F D E QAQLLELA FRF Q E KTRPM DY VSW LS D NML R YPVE D V LDA DY LMDG 436
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 482 W DP KL I EDLMGFF TP Q N M RI DVV S KSIKSE ef QQEP W FGSS Y IEEDVPLSLMES W SNP S e VDNS L H LP SK N QF IP C DFS I 561
Cdd:COG1025 437 F DP AA I RARLAQL TP E N A RI WLI S PDVPTD -- KTAY W YDTP Y SVDPITQEQLAK W QQA S - QNPA L S LP EL N PY IP D DFS L 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 562 RAIN sdvdp K SQSP P RCII DEP FMKF WY KL D ET F KV P R A NT Y FRINLKG A YA S VK N CL LT E L YIN LL K D E LNE II YQAS I 641
Cdd:COG1025 514 IKLD ----- K ESAK P ELLV DEP GLRL WY MP D QY F AE P K A DI Y LSLRNPQ A VD S AR N QV LT R L LDY LL N D A LNE LS YQAS V 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 642 A K L ET SL SMYGDK L E L KVY GF NE K I P A LL SKI L AIAK SF M P NL ERF KVI K ENME R GFR N TN - M KP LNH s TYLR L Q - LL CK 719
Cdd:COG1025 589 A G L SY SL YAHQGG L T L SAS GF TQ K Q P K LL EAL L DQLA SF E P TE ERF AQA K SQLL R QLD N AE k A KP YSQ - LFSP L S r LL QP 667
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 720 RIYDSD E K L SV L NDLS L D DL NS F IPE L RS Q IFI E A L CH GNLSE DE A VNISNIF K DS L TVEPLPSKC R hg E Q ITCFPMGAK 799
Cdd:COG1025 668 PYFERE E L L AA L ESIT L Q DL RA F REQ L LQ Q LHL E M L VV GNLSE EQ A KQLADSL K KQ L APNGTGEEP R -- R Q VVDLDKSGS 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 800 L VRDVNV knk SE T N S VVEL YYQ IEPEEAQ S trt K A VLD L FHE II EEPL FNQLRT K EQLGYVV EC G PRLTY R VH G FC F C VQ 879
Cdd:COG1025 746 L NLEKAC --- DH T D S ALLI YYQ SGYDSLA S --- M A LSS L LGQ II SPWF FNQLRT E EQLGYVV GA G YMPLG R QP G LG F Y VQ 819
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 880 S SKYG P VH LL G R V D N F I K DI E GL L EQ L DD E SYED Y RS G M I AR LLE K D PS L LS E TND LW SQ I VDKRYM FD FSH K EAEELRS 959
Cdd:COG1025 820 S PVAS P AY LL E R I D D F L K QF E ER L LA L SE E EFAQ Y KQ G L I NQ LLE P D QN L SE E AQR LW VD I GNGDFE FD TRE K LIAAVKK 899
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145335200 960 IQKK D V I SWYKTYFRE ss P KCR RL AVRVW G CDTN mke TQTDQ K AVQV I A D AV AF KS T SKFYP 1021
Cdd:COG1025 900 LTRA D L I DFFQQAVIA -- P QGL RL LSQSQ G TKHS --- KADEL K GWKT I T D IS AF QK T LPVKE 956
PRK15101
PRK15101 protease3; Provisional
16-970
6.25e-113
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 372.00
E-value: 6.25e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 16 KS PN D R R L Y RV I E L E NG LCA LL IH DP diypegsvpdqideddedgeeedsdgssedddddeddeedgegdeedededede 95
Cdd:PRK15101 36 KS EK D P R Q Y QA I R L D NG MTV LL VS DP ------------------------------------------------------ 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 96 vkgkgdh Q TK K AA AA MCVSM GS FL DP PEA QGLAH F LEHM LF MGS TEF P DENEYDSY L S KHGGS S NA Y T EMEH T CYHF EV K 175
Cdd:PRK15101 62 ------- Q AV K SL AA LALPV GS LE DP DAQ QGLAH Y LEHM VL MGS KKY P QPDSLAEF L K KHGGS H NA S T ASYR T AFYL EV E 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 176 REF L QG A LK R FSQFFVA PL MKTEAME RE VL AV DS E FNQ A LQN D AC R LQ Q LQCY T SAKG HP FN RF AW GN KKS LS G am EN G V 255
Cdd:PRK15101 135 NDA L PP A VD R LADAIAE PL LDPKNAD RE RN AV NA E LTM A RSR D GM R MA Q VSAE T INPA HP GS RF SG GN LET LS D -- KP G S 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 256 D L RECI V KL Y KE YY HGG LMK L V VIGGES L DM L ESWVVEL FG D V K N GSKIR P TL ------ E A EGP I W ------ KGG K LY R L 323
Cdd:PRK15101 213 K L QDAL V DF Y QR YY SAN LMK A V IYSNQP L PE L AKLAADT FG R V P N KNASV P EI tvpvvt D A QKG I I ihyvpa QPR K VL R V 292
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 324 E avkdvhi LDLTWTLPPL RS ayvk K PED Y LAH L L G HEGR G S L HSF L KAK G W A TSL SAG v G D DGIN R S S la Y VF GM S IH LT 403
Cdd:PRK15101 293 E ------- FRIDNNSAKF RS ---- K TDE Y ISY L I G NRSP G T L SDW L QKQ G L A EGI SAG - A D PMVD R N S -- G VF AI S VS LT 358
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 404 D S GL EKIYDIIGY I YQ YL K LLR DVSPQEWI F K EL QDIGNM DFR FAEEQPAD DY AAE L SEN ML AY PVEH VIYGD Y VYQTW D 483
Cdd:PRK15101 359 D K GL AQRDQVVAA I FS YL N LLR EKGIDKSY F D EL AHVLDL DFR YPSITRDM DY IEW L ADT ML RV PVEH TLDAP Y IADRY D 438
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 484 PK L I EDLMGFF TPQN M RI DVV S KSIKSE ef QQEPWFGSS Y IEEDVPLSLMES W SNPSE v DNS L H LP SK N QF IP C DFS I ra 563
Cdd:PRK15101 439 PK A I KARLAEM TPQN A RI WYI S PQEPHN -- KTAYFVDAP Y QVDKISEQTFAD W QQKAQ - NIA L S LP EL N PY IP D DFS L -- 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 564 I NS D vdp K SQSP P RC I I DEP ----- F M KFW Y KL DE tfkv P R A NTYFRINLKG A YA S VK N CL L TE L -- Y INL L kd E L NEII 636
Cdd:PRK15101 514 I KA D --- K AYKH P EL I V DEP glrvv Y M PSQ Y FA DE ---- P K A DISLVLRNPK A MD S AR N QV L FA L nd Y LAG L -- A L DQLS 584
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 637 Y QAS IAKLET S LS m YGDK L ELKVY G FNEKI P A LL SKI L AIAK SF M P NL E RFKVI K ---- E NMER ----- GFRNTN M -- KP 705
Cdd:PRK15101 585 N QAS VGGISF S TN - ANNG L MVNAN G YTQRL P Q LL QAL L EGYF SF T P TE E QLAQA K swyr E QLDS aekgk AYEQAI M pa QM 663
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 706 L NHST Y lrlqllckri YDS DE KLSV L NDLS L D D LNSFIPE L R S QIFI E A L CH GNL S E DEAVNISNIFKDS L tveplps KC 785
Cdd:PRK15101 664 L SQVP Y ---------- FER DE RRKL L PSIT L K D VLAYRDA L L S GATP E F L VV GNL T E EQVTTLARDVQKQ L ------- GA 726
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 786 R h G EQIT cfp M G AKL V R D ---- VN VKN -- K S ETNSVVEL Y YQIEPE E A QS TRTKAV L D lfh E II EEPLF NQLRT K EQLGY 859
Cdd:PRK15101 727 D - G TEWW --- R G KDV V V D kkqs VN FEK ag S S TDSALAAV Y VPTGYD E Y QS SAYSSL L G --- Q II QPWFY NQLRT E EQLGY 799
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 860 V V ECG P RLTY R VH G FC F CV QS SKYG P VH L LG R VDN F IKDI E GL L EQLDD E SYED Y RSGM I AR LL EK d P SL L S E TNDLW S Q 939
Cdd:PRK15101 800 A V FAF P MSVG R QW G MG F LL QS NDKQ P AY L WQ R YQA F FPQA E AK L RAMKP E EFAQ Y QQAL I NQ LL QA - P QT L G E EASRL S K 878
970 980 990
....*....|....*....|....*....|..
gi 145335200 940 IV D KRY M - FD FSH K EAEELRSIQKKDVISWYK 970
Cdd:PRK15101 879 DF D RGN M r FD SRD K IIAQIKLLTPQKLADFFH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
445-730
4.44e-106
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 332.23
E-value: 4.44e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 445 FRF A E EQ P AD DY AAE L SE NM LA YP V E HVIY GDY VYQTW DP K LI ED L MGFF TP Q N M RI DV VSK SIKS E EF Q Q EPW F G SS Y I 524
Cdd:pfam16187 1 FRF Q E KS P PS DY VSS L AS NM QP YP P E DILS GDY LLREY DP E LI QE L LDYL TP E N A RI TL VSK EFEG E TD Q K EPW Y G TE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 525 E E DV P LS L MES W S N PS E VDNS LHLP SK N Q FIP C DF SIR ain SDVDPKSQSP P RC I I D E P FMKF WYK L D E TF K VP R AN T Y F 604
Cdd:pfam16187 81 V E PI P EE L LKK W K N AP E PNPE LHLP EP N P FIP T DF DLK --- KKEVKEPAKY P VL I R D T P LSRL WYK K D D TF W VP K AN I Y L 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 605 RINLKG AY A S VK N CL LT E LY IN LLKD E LNE II Y Q A SI A K L ET SLS MYGDK L E L K V Y G F N E K I P A LL S KIL AIAKS F MPNL 684
Cdd:pfam16187 158 SLRSPL AY S S PR N AV LT R LY VE LLKD S LNE YA Y D A EL A G L SY SLS ATERG L T L S V S G Y N D K L P V LL E KIL EKLRD F EIDP 237
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 145335200 685 E RF KV IKE NME R GFR N - TNMK P LNHSTYLR L Q LL CK R IYDSD EKL SV 730
Cdd:pfam16187 238 D RF EI IKE QLL R SYK N f ALEQ P YQQAFDYL L Y LL EE R SWTPE EKL EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
101-897
2.71e-38
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 153.49
E-value: 2.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 101 DHQT K K AAA AMC V SM GS FLD P PEAQ GLAHFLEH M LF M G STE F PDENEYDSYLSKH GG SS NA Y T EMEH T CYH FE VKREF L Q 180
Cdd:TIGR02110 16 QPDA K R AAA LLR V AA GS HDE P SAWP GLAHFLEH L LF L G GER F QGDDRLMPWVQRQ GG QV NA T T LERT T AFF FE LPAAA L A 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 181 GA L K R FSQFFVA PL MKT E AME RE VLAVDS E F n Q A L QNDA CR L QQLQCYTSAKG - HP FN RF AW G NKK SL SG ame NGVDLRE 259
Cdd:TIGR02110 96 AG L A R LCDMLAR PL LTA E DQQ RE REVLEA E Y - I A W QNDA DT L REAALLDALQA g HP LR RF HA G SRD SL AL --- PNTAFQQ 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 260 CIVKLYKEY Y HG G L M K L VVI G GE SLD M LE SWVVELFGDVKN G SKIRPT le AEG P IWKGGK L yr LE A VKDVHI L D L TWT L P 339
Cdd:TIGR02110 172 ALRDFHRRH Y QA G N M Q L WLQ G PQ SLD E LE QLAARFGASLAA G GECAQA -- PPA P LLRFDR L -- TL A GGSEPR L W L LFA L A 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 340 P L RSA y VKKPEDY L AHL L GH E GR G S L HSF L KAK G W A T S LS A GV -- G D D G in RSS LA YV F gmsi HLTDSGLEKIYD I IGYI 417
Cdd:TIGR02110 248 G L PAT - ARDNVTL L CEF L QD E AP G G L LAQ L RER G L A E S VA A TW ly Q D A G -- QAL LA LE F ---- SARCISAAAAQQ I EQLL 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 418 Y Q Y L KL L RDVSP ---- QEWIFKELQDIG -------- NMDF R FAEEQPADDYAAE L SENML A YPVEHVIYGDYVY Q T ---- 481
Cdd:TIGR02110 321 T Q W L GA L AEQTW aeql EHYAQLAQRRFQ tlalspla QLRG R ALGFALGCALPDA L TDFLA A LQDCPRTRLLTQQ Q I pgap 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 482 ------------ WDPKLIEDLMGFF T PQNM R IDVVSKSIKSEEFQQE P wfgssyi EEDVPLS L MES W SN PS EVDNS L H L P 549
Cdd:TIGR02110 401 fahsglhapvar LARAVVQARSVSL T LAAS R CSAPKSPTRCAFLAAL P ------- SDKTERA L ALR W GF PS HPPEE L A L A 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 550 SKN Q FI P cdfsirainsdvdpksqspprciidepfmkfwykldetfkvprantyfrinlkgayasvknclltelyinllk 629
Cdd:TIGR02110 474 LQR Q LR P ------------------------------------------------------------------------- 480
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 630 delne IIYQ A SI A KLET S LSMY G DKLE L KVY G FNEKIP A LL S KI LA iaksfmpnlerfkvikenme RGFRNTN M KPLNHS 709
Cdd:TIGR02110 481 ----- LLAD A RH A GVNG S WQAT G ASWQ L LLN G PRSPMR A VF S VA LA -------------------- LLALAAP M LAQPAA 535
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 710 TYLRLQLLCK R iydsdekl SV L ND L S lddl NSFIPE L RS Q I -- FIE A LCHGN -- L SEDE A VNI S NIFK D SLTVE PLP SKC 785
Cdd:TIGR02110 536 NRASAPSIPI R -------- QL L AA L P ---- ERLLKS L PA Q Q dd WLA A RWGAA tq L AQRV A LQL S PGTA D LARPT PLP ARL 603
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 786 RH G EQITCFPM G aklvrdvnvknkset NSVVE L YY qie P EEAQSTRTK A VLD L FHEII E E P L F NQ LR TKE QLGYVV E C GP 865
Cdd:TIGR02110 604 GR G WVPLACDG G --------------- EQALL L FC --- P LPTADVASE A AWR L LAQLL E P P F F QR LR VEL QLGYVV F C RY 665
810 820 830
....*....|....*....|....*....|..
gi 145335200 866 R LTYRVH G FC F CV QS SKYGPVH LL GRVDN F IK 897
Cdd:TIGR02110 666 R RVADRD G LL F AL QS PDASARE LL QHIKR F LR 697
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
8-1021
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 775.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 8 SA L DNVVV KSPND R R L YR V I E L E NGL CA LL IH DP diypegsvpdqideddedgeeedsdgssedddddeddeedgegdee 87
Cdd:COG1025 29 QP L AETII KSPND P R Q YR A I T L D NGL KV LL VS DP ---------------------------------------------- 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 88 dedededevkgkgdh Q TK K A AAA MC V SM GSF L DP PEA QGLAHFLEHMLF M G STEF P DEN EY DSYL SKHGGS S NA Y T EM E H 167
Cdd:COG1025 63 --------------- Q AD K S AAA LA V PV GSF D DP DDQ QGLAHFLEHMLF L G TKKY P EPG EY QEFI SKHGGS H NA S T AT E R 127
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 168 T C Y H FEV KREF L QG AL K RF SQ FF V APL MKT E AME RE VL AV DS E FNQALQN D AC R LQ Q LQCY T SAKG HPF N RF AW GN KKS L 247
Cdd:COG1025 128 T N Y Y FEV ENDA L EE AL D RF AD FF A APL FDP E YVD RE RN AV NA E YTLKRSD D GR R IY Q VHKE T LNPA HPF S RF SV GN LET L 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 248 S G am EN G VD LR ECIVKL Y KE YY HGG LMKLV VIGGE SLD M LE SWVVEL FG DVK N GSKIR P T ------ LEAEGP I W kggkl Y 321
Cdd:COG1025 208 S D -- KP G SK LR DELLAF Y QR YY SAN LMKLV LYSNQ SLD E LE KLARQT FG AIP N RNLSV P P itvply TPEQLG I I ----- I 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 322 RLEAV K DVHI L D L TWTL P PLRSA Y VK KP ED Y LAH LLG H EG R GSL HSF LK AK G W A T SLSAG V G DD G I N RS slay V F GM S IH 401
Cdd:COG1025 281 HIVPL K PRRQ L R L EFPI P NNQAY Y RS KP LT Y ISY LLG N EG E GSL LDW LK KQ G L A E SLSAG G G IS G R N FG ---- D F SI S VS 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 402 LTD S GL EKIYD II GYIYQ Y LK L L R DVSP QEW I F K E LQDIGNMD FRF A E EQPAD DY AAE LS E NML A YPVE H V IYG DY VYQT 481
Cdd:COG1025 357 LTD K GL AHRDE II AAVFA Y IE L I R QQGI QEW Y F D E QAQLLELA FRF Q E KTRPM DY VSW LS D NML R YPVE D V LDA DY LMDG 436
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 482 W DP KL I EDLMGFF TP Q N M RI DVV S KSIKSE ef QQEP W FGSS Y IEEDVPLSLMES W SNP S e VDNS L H LP SK N QF IP C DFS I 561
Cdd:COG1025 437 F DP AA I RARLAQL TP E N A RI WLI S PDVPTD -- KTAY W YDTP Y SVDPITQEQLAK W QQA S - QNPA L S LP EL N PY IP D DFS L 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 562 RAIN sdvdp K SQSP P RCII DEP FMKF WY KL D ET F KV P R A NT Y FRINLKG A YA S VK N CL LT E L YIN LL K D E LNE II YQAS I 641
Cdd:COG1025 514 IKLD ----- K ESAK P ELLV DEP GLRL WY MP D QY F AE P K A DI Y LSLRNPQ A VD S AR N QV LT R L LDY LL N D A LNE LS YQAS V 588
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 642 A K L ET SL SMYGDK L E L KVY GF NE K I P A LL SKI L AIAK SF M P NL ERF KVI K ENME R GFR N TN - M KP LNH s TYLR L Q - LL CK 719
Cdd:COG1025 589 A G L SY SL YAHQGG L T L SAS GF TQ K Q P K LL EAL L DQLA SF E P TE ERF AQA K SQLL R QLD N AE k A KP YSQ - LFSP L S r LL QP 667
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 720 RIYDSD E K L SV L NDLS L D DL NS F IPE L RS Q IFI E A L CH GNLSE DE A VNISNIF K DS L TVEPLPSKC R hg E Q ITCFPMGAK 799
Cdd:COG1025 668 PYFERE E L L AA L ESIT L Q DL RA F REQ L LQ Q LHL E M L VV GNLSE EQ A KQLADSL K KQ L APNGTGEEP R -- R Q VVDLDKSGS 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 800 L VRDVNV knk SE T N S VVEL YYQ IEPEEAQ S trt K A VLD L FHE II EEPL FNQLRT K EQLGYVV EC G PRLTY R VH G FC F C VQ 879
Cdd:COG1025 746 L NLEKAC --- DH T D S ALLI YYQ SGYDSLA S --- M A LSS L LGQ II SPWF FNQLRT E EQLGYVV GA G YMPLG R QP G LG F Y VQ 819
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 880 S SKYG P VH LL G R V D N F I K DI E GL L EQ L DD E SYED Y RS G M I AR LLE K D PS L LS E TND LW SQ I VDKRYM FD FSH K EAEELRS 959
Cdd:COG1025 820 S PVAS P AY LL E R I D D F L K QF E ER L LA L SE E EFAQ Y KQ G L I NQ LLE P D QN L SE E AQR LW VD I GNGDFE FD TRE K LIAAVKK 899
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145335200 960 IQKK D V I SWYKTYFRE ss P KCR RL AVRVW G CDTN mke TQTDQ K AVQV I A D AV AF KS T SKFYP 1021
Cdd:COG1025 900 LTRA D L I DFFQQAVIA -- P QGL RL LSQSQ G TKHS --- KADEL K GWKT I T D IS AF QK T LPVKE 956
PRK15101
PRK15101 protease3; Provisional
16-970
6.25e-113
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 372.00
E-value: 6.25e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 16 KS PN D R R L Y RV I E L E NG LCA LL IH DP diypegsvpdqideddedgeeedsdgssedddddeddeedgegdeedededede 95
Cdd:PRK15101 36 KS EK D P R Q Y QA I R L D NG MTV LL VS DP ------------------------------------------------------ 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 96 vkgkgdh Q TK K AA AA MCVSM GS FL DP PEA QGLAH F LEHM LF MGS TEF P DENEYDSY L S KHGGS S NA Y T EMEH T CYHF EV K 175
Cdd:PRK15101 62 ------- Q AV K SL AA LALPV GS LE DP DAQ QGLAH Y LEHM VL MGS KKY P QPDSLAEF L K KHGGS H NA S T ASYR T AFYL EV E 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 176 REF L QG A LK R FSQFFVA PL MKTEAME RE VL AV DS E FNQ A LQN D AC R LQ Q LQCY T SAKG HP FN RF AW GN KKS LS G am EN G V 255
Cdd:PRK15101 135 NDA L PP A VD R LADAIAE PL LDPKNAD RE RN AV NA E LTM A RSR D GM R MA Q VSAE T INPA HP GS RF SG GN LET LS D -- KP G S 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 256 D L RECI V KL Y KE YY HGG LMK L V VIGGES L DM L ESWVVEL FG D V K N GSKIR P TL ------ E A EGP I W ------ KGG K LY R L 323
Cdd:PRK15101 213 K L QDAL V DF Y QR YY SAN LMK A V IYSNQP L PE L AKLAADT FG R V P N KNASV P EI tvpvvt D A QKG I I ihyvpa QPR K VL R V 292
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 324 E avkdvhi LDLTWTLPPL RS ayvk K PED Y LAH L L G HEGR G S L HSF L KAK G W A TSL SAG v G D DGIN R S S la Y VF GM S IH LT 403
Cdd:PRK15101 293 E ------- FRIDNNSAKF RS ---- K TDE Y ISY L I G NRSP G T L SDW L QKQ G L A EGI SAG - A D PMVD R N S -- G VF AI S VS LT 358
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 404 D S GL EKIYDIIGY I YQ YL K LLR DVSPQEWI F K EL QDIGNM DFR FAEEQPAD DY AAE L SEN ML AY PVEH VIYGD Y VYQTW D 483
Cdd:PRK15101 359 D K GL AQRDQVVAA I FS YL N LLR EKGIDKSY F D EL AHVLDL DFR YPSITRDM DY IEW L ADT ML RV PVEH TLDAP Y IADRY D 438
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 484 PK L I EDLMGFF TPQN M RI DVV S KSIKSE ef QQEPWFGSS Y IEEDVPLSLMES W SNPSE v DNS L H LP SK N QF IP C DFS I ra 563
Cdd:PRK15101 439 PK A I KARLAEM TPQN A RI WYI S PQEPHN -- KTAYFVDAP Y QVDKISEQTFAD W QQKAQ - NIA L S LP EL N PY IP D DFS L -- 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 564 I NS D vdp K SQSP P RC I I DEP ----- F M KFW Y KL DE tfkv P R A NTYFRINLKG A YA S VK N CL L TE L -- Y INL L kd E L NEII 636
Cdd:PRK15101 514 I KA D --- K AYKH P EL I V DEP glrvv Y M PSQ Y FA DE ---- P K A DISLVLRNPK A MD S AR N QV L FA L nd Y LAG L -- A L DQLS 584
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 637 Y QAS IAKLET S LS m YGDK L ELKVY G FNEKI P A LL SKI L AIAK SF M P NL E RFKVI K ---- E NMER ----- GFRNTN M -- KP 705
Cdd:PRK15101 585 N QAS VGGISF S TN - ANNG L MVNAN G YTQRL P Q LL QAL L EGYF SF T P TE E QLAQA K swyr E QLDS aekgk AYEQAI M pa QM 663
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 706 L NHST Y lrlqllckri YDS DE KLSV L NDLS L D D LNSFIPE L R S QIFI E A L CH GNL S E DEAVNISNIFKDS L tveplps KC 785
Cdd:PRK15101 664 L SQVP Y ---------- FER DE RRKL L PSIT L K D VLAYRDA L L S GATP E F L VV GNL T E EQVTTLARDVQKQ L ------- GA 726
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 786 R h G EQIT cfp M G AKL V R D ---- VN VKN -- K S ETNSVVEL Y YQIEPE E A QS TRTKAV L D lfh E II EEPLF NQLRT K EQLGY 859
Cdd:PRK15101 727 D - G TEWW --- R G KDV V V D kkqs VN FEK ag S S TDSALAAV Y VPTGYD E Y QS SAYSSL L G --- Q II QPWFY NQLRT E EQLGY 799
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 860 V V ECG P RLTY R VH G FC F CV QS SKYG P VH L LG R VDN F IKDI E GL L EQLDD E SYED Y RSGM I AR LL EK d P SL L S E TNDLW S Q 939
Cdd:PRK15101 800 A V FAF P MSVG R QW G MG F LL QS NDKQ P AY L WQ R YQA F FPQA E AK L RAMKP E EFAQ Y QQAL I NQ LL QA - P QT L G E EASRL S K 878
970 980 990
....*....|....*....|....*....|..
gi 145335200 940 IV D KRY M - FD FSH K EAEELRSIQKKDVISWYK 970
Cdd:PRK15101 879 DF D RGN M r FD SRD K IIAQIKLLTPQKLADFFH 910
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
445-730
4.44e-106
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 332.23
E-value: 4.44e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 445 FRF A E EQ P AD DY AAE L SE NM LA YP V E HVIY GDY VYQTW DP K LI ED L MGFF TP Q N M RI DV VSK SIKS E EF Q Q EPW F G SS Y I 524
Cdd:pfam16187 1 FRF Q E KS P PS DY VSS L AS NM QP YP P E DILS GDY LLREY DP E LI QE L LDYL TP E N A RI TL VSK EFEG E TD Q K EPW Y G TE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 525 E E DV P LS L MES W S N PS E VDNS LHLP SK N Q FIP C DF SIR ain SDVDPKSQSP P RC I I D E P FMKF WYK L D E TF K VP R AN T Y F 604
Cdd:pfam16187 81 V E PI P EE L LKK W K N AP E PNPE LHLP EP N P FIP T DF DLK --- KKEVKEPAKY P VL I R D T P LSRL WYK K D D TF W VP K AN I Y L 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 605 RINLKG AY A S VK N CL LT E LY IN LLKD E LNE II Y Q A SI A K L ET SLS MYGDK L E L K V Y G F N E K I P A LL S KIL AIAKS F MPNL 684
Cdd:pfam16187 158 SLRSPL AY S S PR N AV LT R LY VE LLKD S LNE YA Y D A EL A G L SY SLS ATERG L T L S V S G Y N D K L P V LL E KIL EKLRD F EIDP 237
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 145335200 685 E RF KV IKE NME R GFR N - TNMK P LNHSTYLR L Q LL CK R IYDSD EKL SV 730
Cdd:pfam16187 238 D RF EI IKE QLL R SYK N f ALEQ P YQQAFDYL L Y LL EE R SWTPE EKL EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
101-897
2.71e-38
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 153.49
E-value: 2.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 101 DHQT K K AAA AMC V SM GS FLD P PEAQ GLAHFLEH M LF M G STE F PDENEYDSYLSKH GG SS NA Y T EMEH T CYH FE VKREF L Q 180
Cdd:TIGR02110 16 QPDA K R AAA LLR V AA GS HDE P SAWP GLAHFLEH L LF L G GER F QGDDRLMPWVQRQ GG QV NA T T LERT T AFF FE LPAAA L A 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 181 GA L K R FSQFFVA PL MKT E AME RE VLAVDS E F n Q A L QNDA CR L QQLQCYTSAKG - HP FN RF AW G NKK SL SG ame NGVDLRE 259
Cdd:TIGR02110 96 AG L A R LCDMLAR PL LTA E DQQ RE REVLEA E Y - I A W QNDA DT L REAALLDALQA g HP LR RF HA G SRD SL AL --- PNTAFQQ 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 260 CIVKLYKEY Y HG G L M K L VVI G GE SLD M LE SWVVELFGDVKN G SKIRPT le AEG P IWKGGK L yr LE A VKDVHI L D L TWT L P 339
Cdd:TIGR02110 172 ALRDFHRRH Y QA G N M Q L WLQ G PQ SLD E LE QLAARFGASLAA G GECAQA -- PPA P LLRFDR L -- TL A GGSEPR L W L LFA L A 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 340 P L RSA y VKKPEDY L AHL L GH E GR G S L HSF L KAK G W A T S LS A GV -- G D D G in RSS LA YV F gmsi HLTDSGLEKIYD I IGYI 417
Cdd:TIGR02110 248 G L PAT - ARDNVTL L CEF L QD E AP G G L LAQ L RER G L A E S VA A TW ly Q D A G -- QAL LA LE F ---- SARCISAAAAQQ I EQLL 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 418 Y Q Y L KL L RDVSP ---- QEWIFKELQDIG -------- NMDF R FAEEQPADDYAAE L SENML A YPVEHVIYGDYVY Q T ---- 481
Cdd:TIGR02110 321 T Q W L GA L AEQTW aeql EHYAQLAQRRFQ tlalspla QLRG R ALGFALGCALPDA L TDFLA A LQDCPRTRLLTQQ Q I pgap 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 482 ------------ WDPKLIEDLMGFF T PQNM R IDVVSKSIKSEEFQQE P wfgssyi EEDVPLS L MES W SN PS EVDNS L H L P 549
Cdd:TIGR02110 401 fahsglhapvar LARAVVQARSVSL T LAAS R CSAPKSPTRCAFLAAL P ------- SDKTERA L ALR W GF PS HPPEE L A L A 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 550 SKN Q FI P cdfsirainsdvdpksqspprciidepfmkfwykldetfkvprantyfrinlkgayasvknclltelyinllk 629
Cdd:TIGR02110 474 LQR Q LR P ------------------------------------------------------------------------- 480
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 630 delne IIYQ A SI A KLET S LSMY G DKLE L KVY G FNEKIP A LL S KI LA iaksfmpnlerfkvikenme RGFRNTN M KPLNHS 709
Cdd:TIGR02110 481 ----- LLAD A RH A GVNG S WQAT G ASWQ L LLN G PRSPMR A VF S VA LA -------------------- LLALAAP M LAQPAA 535
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 710 TYLRLQLLCK R iydsdekl SV L ND L S lddl NSFIPE L RS Q I -- FIE A LCHGN -- L SEDE A VNI S NIFK D SLTVE PLP SKC 785
Cdd:TIGR02110 536 NRASAPSIPI R -------- QL L AA L P ---- ERLLKS L PA Q Q dd WLA A RWGAA tq L AQRV A LQL S PGTA D LARPT PLP ARL 603
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 786 RH G EQITCFPM G aklvrdvnvknkset NSVVE L YY qie P EEAQSTRTK A VLD L FHEII E E P L F NQ LR TKE QLGYVV E C GP 865
Cdd:TIGR02110 604 GR G WVPLACDG G --------------- EQALL L FC --- P LPTADVASE A AWR L LAQLL E P P F F QR LR VEL QLGYVV F C RY 665
810 820 830
....*....|....*....|....*....|..
gi 145335200 866 R LTYRVH G FC F CV QS SKYGPVH LL GRVDN F IK 897
Cdd:TIGR02110 666 R RVADRD G LL F AL QS PDASARE LL QHIKR F LR 697
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
101-414
1.31e-33
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 135.05
E-value: 1.31e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 101 D HQTKKAAAAMC V SM GS FLD PP EAQ GLAHFLEHMLF M G STEFP d EN E YDSY L SKH GGS S NA Y T EMEH T C Y HFE V KR E F L Q 180
Cdd:COG0612 31 D PEAPVVSVRLW V RV GS RDE PP GKT GLAHFLEHMLF K G TKKRS - AG E IAEE L EAL GGS L NA F T SFDY T V Y YLS V LS E D L E 109
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 181 G AL KRFSQFFVA P LMKT E AM ERE VLA V DS E FNQALQNDACRLQQLQCYTSAKG HP FN R FAW G NKK S LSGA - M E ngv DLR E 259
Cdd:COG0612 110 L AL ELLADRLLN P TFDE E EL ERE RGV V LE E IRRYEDDPDGLAFEALLAALYGD HP YG R PII G TEE S IEAI t R E --- DLR A 186
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 260 C ivkl YK E YY HGGLMK LVV I G GESLDMLESW V VEL FGD VKN G SKIRPTLE AE g P IWK G GKLYRLEA v K D V --- HIL d L TW 336
Cdd:COG0612 187 F ---- YK R YY RPNNAV LVV V G DVDPEEVLAL V EKY FGD LPA G PAPPRPDP AE - P PQT G PRRVVVDD - P D A eqa HIL - L GY 259
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 337 TL P PLRS ayvkk P ED Y ---- L AHL LG H e G RG S - L HSF L - KA KG W A T S LSAGVGD dginr SSL A YV F GMSIHLTDSG LE KI 410
Cdd:COG0612 260 PG P ARDD ----- P DY Y aldv L NEI LG G - G FS S r L FQE L r EK KG L A Y S VGSSFSP ----- YRD A GL F TIYAGTAPDK LE EA 328
....
gi 145335200 411 YDI I 414
Cdd:COG0612 329 LAA I 332
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
101-212
2.78e-32
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 122.80
E-value: 2.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 101 D HQTKKAAAAMCVSM GS FLD P PEAQ GLAHFLEHM L F M G STEF P D e NE YDSY L S K H GGS S NA Y T EM E H T C Y HF EV KREF L Q 180
Cdd:pfam00675 7 D PPADTSTVGLWIDA GS RYE P DNNN GLAHFLEHM A F K G TKKY P S - NE LEEE L E K L GGS L NA F T SR E N T V Y YA EV LNDD L P 85
90 100 110
....*....|....*....|....*....|..
gi 145335200 181 G A LK R FSQ FF VA PL MKTEAM ERE V L A V DS E FN 212
Cdd:pfam00675 86 K A VD R LAD FF RN PL FTESEI ERE R L V V LY E VE 117
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
256-440
6.58e-20
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 88.22
E-value: 6.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 256 DLR EC ivkl YK EY Y HGGL M K LV VI G GESLDM L ESWVVEL FGD VKNGS K IR P TLEAEG P IWKG G KLYRLEAV - KDVHI L D L 334
Cdd:pfam05193 6 DLR DF ---- YK KH Y SPDN M V LV IV G DVDHEE L LDLAEKY FGD LPASP K GK P RPPPLE P AKLK G REVVVPKK d EPQAH L A L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 335 TWTL PPL RSAYVKKPE D Y L AH LLG HEGRGS L HSF L KA K - G W A T S L S AGV gddgi NRS S LAYV FG MSIHLTD sgl E KIYDI 413
Cdd:pfam05193 82 AFPG PPL NNDEDSLAL D V L NE LLG GGMSSR L FQE L RE K e G L A Y S V S SFN ----- DSY S DSGL FG IYATVDP --- E NVDEV 153
170 180
....*....|....*....|....*..
gi 145335200 414 I GY I YQY L KL L RDVSPQ E WIFKELQDI 440
Cdd:pfam05193 154 I EL I LEE L EK L AQEGVT E EELERAKNQ 180
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
733-918
3.61e-14
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 71.66
E-value: 3.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 733 D L SLD DL NS F IPELR S QIFIEALCH G NLSED E AVN - ISNI F K D SLTVEPLPSKCRHG E QIT cfpmga KLV R D V N V KN K S E 811
Cdd:pfam05193 1 S L TRE DL RD F YKKHY S PDNMVLVIV G DVDHE E LLD l AEKY F G D LPASPKGKPRPPPL E PAK ------ LKG R E V V V PK K D E 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335200 812 TNSVVE L YYQIE P ee AQSTRTKAV LD LFH E IIEE ---- P LF NQ LR T KE Q L G Y V V ECGPRLT -- YRVH G FCFC V QSSKYGP 885
Cdd:pfam05193 75 PQAHLA L AFPGP P -- LNNDEDSLA LD VLN E LLGG gmss R LF QE LR E KE G L A Y S V SSFNDSY sd SGLF G IYAT V DPENVDE 152
170 180 190
....*....|....*....|....*....|....
gi 145335200 886 V hllgr VDNFIKDI E G L LEQ - LDD E SY E DYRSGM 918
Cdd:pfam05193 153 V ----- IELILEEL E K L AQE g VTE E EL E RAKNQL 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
