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Conserved domains on  [gi|145335142|ref|NP_172040|]
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chromatin remodeling 31 [Arabidopsis thaliana]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13029103)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as human DNA excision repair protein ERCC-6-like and DNA repair and recombination protein RAD54-like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 823-1097 9.32e-92

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 296.51  E-value: 9.32e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNLAGTimlnelkdFENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPD-CKPVIIAPASLLLTW 901
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGT--------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNW 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  902 AEEFKKWNIS--IPFHNLSSLDFTGKENSaalgllmqknatarsnneiRMVKIYSWIKSKSILGISYNLYEKLAGVKDED 979
Cdd:cd18007    73 EDEFKKWLPPdlRPLLVLVSLSASKRADA-------------------RLRKINKWHKEGGVLLIGYELFRNLASNATTD 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  980 KKTKMvrevkpdkelDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18007   134 PRLKQ----------EFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARP 203

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 145335142 1060 KYLErlTSTLKKSGMTVTKRGKKNLGNEINNRGIEELK 1097
Cdd:cd18007   204 KYLG--TLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 1198-1329 1.42e-44

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 157.64  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1198 SVKTRFLMEFVELCEVIKEKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPkSKAKVFL 1277
Cdd:cd18793    10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-----GIKYLRLDGSTSSKERQKLVDRFNED-PDIRVFL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1278 ASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLV 1329
Cdd:cd18793    84 LSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 823-1097 9.32e-92

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 296.51  E-value: 9.32e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNLAGTimlnelkdFENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPD-CKPVIIAPASLLLTW 901
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGT--------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNW 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  902 AEEFKKWNIS--IPFHNLSSLDFTGKENSaalgllmqknatarsnneiRMVKIYSWIKSKSILGISYNLYEKLAGVKDED 979
Cdd:cd18007    73 EDEFKKWLPPdlRPLLVLVSLSASKRADA-------------------RLRKINKWHKEGGVLLIGYELFRNLASNATTD 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  980 KKTKMvrevkpdkelDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18007   134 PRLKQ----------EFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARP 203

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 145335142 1060 KYLErlTSTLKKSGMTVTKRGKKNLGNEINNRGIEELK 1097
Cdd:cd18007   204 KYLG--TLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 817-1335 3.57e-68

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 243.98  E-value: 3.57e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  817 PGVKSQMYPHQQEGFEFIWknlagtiMLNELKdfensdetGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPAS 896
Cdd:COG0553   236 AGLKATLRPYQLEGAAWLL-------FLRRLG--------LGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  897 LLLTWAEEFKKWNISIPFHnlsslDFTGKENSAalgllmqknatarsnneirmvKIYSWIKSKSILGISYNLyeklagvk 976
Cdd:COG0553   301 LVGNWQRELAKFAPGLRVL-----VLDGTRERA---------------------KGANPFEDADLVITSYGL-------- 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  977 dedkktkmVRevkpdkelDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGL 1056
Cdd:COG0553   347 --------LR--------RDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDF 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1057 ARPKYLERLTSTLKKSGMTVTKRGKKNLgneinnrgiEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRVL 1136
Cdd:COG0553   411 LNPGLLGSLKAFRERFARPIEKGDEEAL---------ERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALY 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1137 ESI---------EVTHNRKTKNVFETEHKLSLVSVHPSLVsrckISEKERLSIDeallaqlkkvrldpnqSVKTRFLMEF 1207
Cdd:COG0553   482 EAVleylrreleGAEGIRRRGLILAALTRLRQICSHPALL----LEEGAELSGR----------------SAKLEALLEL 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1208 VElcEVIK--EKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDpKSKAKVFLASTKACSE 1285
Cdd:COG0553   542 LE--ELLAegEKVLVFSQFTDTLDLLEERLEER-----GIEYAYLHGGTSAEERDELVDRFQE-GPEAPVFLISLKAGGE 613

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 145335142 1286 GISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLVAKGTPE 1335
Cdd:COG0553   614 GLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIE 663
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 1198-1329 1.42e-44

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 157.64  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1198 SVKTRFLMEFVELCEVIKEKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPkSKAKVFL 1277
Cdd:cd18793    10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-----GIKYLRLDGSTSSKERQKLVDRFNED-PDIRVFL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1278 ASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLV 1329
Cdd:cd18793    84 LSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 1200-1318 1.25e-23

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 96.90  E-value: 1.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  1200 KTRFLMEfvELCEVIKEKVLVFSQYIDplKLIMKHLVSRFKWNpgeeVLYMHGKLEQKQRQTLINEFNDPKSKakvFLAS 1279
Cdd:pfam00271    2 KLEALLE--LLKKERGGKVLIFSQTKK--TLEAELLLEKEGIK----VARLHGDLSQEEREEILEDFRKGKID---VLVA 70

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 145335142  1280 TKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIG 1318
Cdd:pfam00271   71 TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
1244-1318 1.97e-18

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 81.10  E-value: 1.97e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145335142   1244 GEEVLYMHGKLEQKQRQTLINEFNDPKSKakvFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIG 1318
Cdd:smart00490   11 GIKVARLHGGLSQEEREEILDKFNNGKIK---VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 1008-1335 6.26e-18

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 90.24  E-value: 6.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1008 LVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYL---ERLTSTLKKSGmtvtkrgkKNL 1084
Cdd:PLN03142  295 IIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFssaETFDEWFQISG--------END 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1085 GNEInnrgIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQ----RRVLES-IEVTHN-RKTKNVFETEHKLS 1158
Cdd:PLN03142  367 QQEV----VQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQkqyyKALLQKdLDVVNAgGERKRLLNIAMQLR 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1159 LVSVHPSLVSRCKISEKerLSIDEALLAQLKK-VRLDpnqsvktrflmefvELCEVIKEK---VLVFSQYIDPLKLIMKH 1234
Cdd:PLN03142  443 KCCNHPYLFQGAEPGPP--YTTGEHLVENSGKmVLLD--------------KLLPKLKERdsrVLIFSQMTRLLDILEDY 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1235 LVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPKSKAKVFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRA 1314
Cdd:PLN03142  507 LMYR-----GYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRA 581

                         330       340
                  ....*....|....*....|.
gi 145335142 1315 YRIGQKRIVYTYHLVAKGTPE 1335
Cdd:PLN03142  582 HRIGQKKEVQVFRFCTEYTIE 602
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 826-1135 4.56e-17

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 83.50  E-value: 4.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   826 HQQEGFEFIWKNLAGTIMlnelkdfensdetgGCIMSHAPGTGKTrLTIIFLQAYLQcfpDCKP------VIIAPASLLL 899
Cdd:pfam00176    1 YQIEGVNWMLSLENNLGR--------------GGILADEMGLGKT-LQTISLLLYLK---HVDKnwggptLIVVPLSLLH 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   900 TWAEEFKKWNisipfhNLSSLDftgkensaALGLLMQKNATARSNNEIRMVKIYSwiksksILGISYNlyeklagvkded 979
Cdd:pfam00176   63 NWMNEFERWV------SPPALR--------VVVLHGNKRPQERWKNDPNFLADFD------VVITTYE------------ 110

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   980 kktkMVREVKpdkelddiREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:pfam00176  111 ----TLRKHK--------ELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRP 178

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  1060 KYLerltstlkksgmTVTKRGKKNLGNEINNR----GIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRV 1135
Cdd:pfam00176  179 GPF------------GSLSTFRNWFDRPIERGggkkGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKL 246
DEXDc smart00487
DEAD-like helicases superfamily;
822-1050 2.22e-11

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 64.82  E-value: 2.22e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142    822 QMYPHQQEGFEFIWKNLagtimlnelkdfensdetGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAP-ASLLLT 900
Cdd:smart00487    8 PLRPYQKEAIEALLSGL------------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQ 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142    901 WAEEFKKWNisiPFHNLSSLDFTGKENSAalgllMQKNATARSNNEIrmvkiyswiksksILGIsynlYEKLagvkdedk 980
Cdd:smart00487   70 WAEELKKLG---PSLGLKVVGLYGGDSKR-----EQLRKLESGKTDI-------------LVTT----PGRL-------- 116

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145335142    981 ktkmvrevkpdkeLDDIRE--ILMGRPGLLVLDEAH-TPRNQRSCIWKTLSKV--ETQKRILLSGTPFQN--NFLEL 1050
Cdd:smart00487  117 -------------LDLLENdkLSLSNVDLVILDEAHrLLDGGFGDQLEKLLKLlpKNVQLLLLSATPPEEieNLLEL 180
 
Name Accession Description Interval E-value
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 823-1097 9.32e-92

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 296.51  E-value: 9.32e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNLAGTimlnelkdFENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPD-CKPVIIAPASLLLTW 901
Cdd:cd18007     1 LKPHQVEGVRFLWSNLVGT--------DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrSRPLVLCPASTLYNW 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  902 AEEFKKWNIS--IPFHNLSSLDFTGKENSaalgllmqknatarsnneiRMVKIYSWIKSKSILGISYNLYEKLAGVKDED 979
Cdd:cd18007    73 EDEFKKWLPPdlRPLLVLVSLSASKRADA-------------------RLRKINKWHKEGGVLLIGYELFRNLASNATTD 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  980 KKTKMvrevkpdkelDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18007   134 PRLKQ----------EFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARP 203

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 145335142 1060 KYLErlTSTLKKSGMTVTKRGKKNLGNEINNRGIEELK 1097
Cdd:cd18007   204 KYLG--TLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 817-1335 3.57e-68

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 243.98  E-value: 3.57e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  817 PGVKSQMYPHQQEGFEFIWknlagtiMLNELKdfensdetGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPAS 896
Cdd:COG0553   236 AGLKATLRPYQLEGAAWLL-------FLRRLG--------LGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  897 LLLTWAEEFKKWNISIPFHnlsslDFTGKENSAalgllmqknatarsnneirmvKIYSWIKSKSILGISYNLyeklagvk 976
Cdd:COG0553   301 LVGNWQRELAKFAPGLRVL-----VLDGTRERA---------------------KGANPFEDADLVITSYGL-------- 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  977 dedkktkmVRevkpdkelDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGL 1056
Cdd:COG0553   347 --------LR--------RDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDF 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1057 ARPKYLERLTSTLKKSGMTVTKRGKKNLgneinnrgiEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRVL 1136
Cdd:COG0553   411 LNPGLLGSLKAFRERFARPIEKGDEEAL---------ERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALY 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1137 ESI---------EVTHNRKTKNVFETEHKLSLVSVHPSLVsrckISEKERLSIDeallaqlkkvrldpnqSVKTRFLMEF 1207
Cdd:COG0553   482 EAVleylrreleGAEGIRRRGLILAALTRLRQICSHPALL----LEEGAELSGR----------------SAKLEALLEL 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1208 VElcEVIK--EKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDpKSKAKVFLASTKACSE 1285
Cdd:COG0553   542 LE--ELLAegEKVLVFSQFTDTLDLLEERLEER-----GIEYAYLHGGTSAEERDELVDRFQE-GPEAPVFLISLKAGGE 613

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 145335142 1286 GISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLVAKGTPE 1335
Cdd:COG0553   614 GLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIE 663
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 1198-1329 1.42e-44

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 157.64  E-value: 1.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1198 SVKTRFLMEFVELCEVIKEKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPkSKAKVFL 1277
Cdd:cd18793    10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-----GIKYLRLDGSTSSKERQKLVDRFNED-PDIRVFL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1278 ASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLV 1329
Cdd:cd18793    84 LSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 823-1064 1.13e-29

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 116.90  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWknlagtimlnelkdfENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPV-IIAPASLLLTW 901
Cdd:cd17919     1 LRPYQLEGLNFLL---------------ELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVlVVCPLSVLENW 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  902 AEEFKKWnisipFHNLSSLDFTGkensaalgllmqknatarSNNEIRMVKIYSWIKSKSILGISYNLYEKlagvkdedkk 981
Cdd:cd17919    66 EREFEKW-----TPDLRVVVYHG------------------SQRERAQIRAKEKLDKFDVVLTTYETLRR---------- 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  982 tkmvrevkpdkeldDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKY 1061
Cdd:cd17919   113 --------------DKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPF 178


                  ...
gi 145335142 1062 LER 1064
Cdd:cd17919   179 LLR 181
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 823-1059 3.65e-29

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 117.39  E-value: 3.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNLAGtimlnelkdfENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKP-----VIIAPASL 897
Cdd:cd18004     1 LRPHQREGVQFLYDCLTG----------RRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  898 LLTWAEEFKKWnisipfhnlssldftgkensaaLGLLMQKNATARSNNEIRMVKI--YSWIKSKSILGISYNLYEKLAGV 975
Cdd:cd18004    71 VGNWKAEFDKW----------------------LGLRRIKVVTADGNAKDVKASLdfFSSASTYPVLIISYETLRRHAEK 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  976 KDEDKktkmvrevkpdkelddireilmgRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLG 1055
Cdd:cd18004   129 LSKKI-----------------------SIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVD 185


                  ....
gi 145335142 1056 LARP 1059
Cdd:cd18004   186 FVNP 189
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 825-1062 2.89e-25

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 106.13  E-value: 2.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLAGTimLNELKDFENSdetgGCIMSHAPGTGKTRLTIIFLQAYLQC--FPDCKPV-IIAPASLLLTW 901
Cdd:cd18068     3 PHQVDGVQFMWDCCCES--LKKTKKSPGS----GCILAHCMGLGKTLQVVTFLHTVLLCekLENFSRVlVVCPLNTVLNW 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  902 AEEFKKWnisipfhnlssLDFTGKENSAALGLLmqknATARSNNEiRMVKIYSWIKSKSILGISYNLYEKLAGVKDEDKK 981
Cdd:cd18068    77 LNEFEKW-----------QEGLKDEEKIEVNEL----ATYKRPQE-RSYKLQRWQEEGGVMIIGYDMYRILAQERNVKSR 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  982 TKMvrevkpdKEldDIREILMGR-PGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPK 1060
Cdd:cd18068   141 EKL-------KE--IFNKALVDPgPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPN 211


                  ..
gi 145335142 1061 YL 1062
Cdd:cd18068   212 LL 213
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 1200-1318 1.25e-23

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 96.90  E-value: 1.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  1200 KTRFLMEfvELCEVIKEKVLVFSQYIDplKLIMKHLVSRFKWNpgeeVLYMHGKLEQKQRQTLINEFNDPKSKakvFLAS 1279
Cdd:pfam00271    2 KLEALLE--LLKKERGGKVLIFSQTKK--TLEAELLLEKEGIK----VARLHGDLSQEEREEILEDFRKGKID---VLVA 70

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 145335142  1280 TKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIG 1318
Cdd:pfam00271   71 TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 825-1062 2.58e-21

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 94.11  E-value: 2.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLagtimLNELKDFENSDETGgCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPASLLLTWAEE 904
Cdd:cd18069     3 PHQIGGIRFLYDNI-----IESLERYKGSSGFG-CILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  905 FKKWnisipfhnLSSLDFTGKENSAALGLLM----QKNATARSNneirmvKIYSWIKSKSILGISYNLYEKLAGvkdedk 980
Cdd:cd18069    77 FNKW--------LPPPEALPNVRPRPFKVFIlndeHKTTAARAK------VIEDWVKDGGVLLMGYEMFRLRPG------ 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  981 ktkmvrevkpdkelddireilmgrPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPK 1060
Cdd:cd18069   137 ------------------------PDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPD 192


                  ..
gi 145335142 1061 YL 1062
Cdd:cd18069   193 FL 194
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 825-1062 4.35e-21

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 94.07  E-value: 4.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLAGTIMLNelkdfensdeTGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKP-----VIIAPASLLL 899
Cdd:cd18067     3 PHQREGVKFLYRCVTGRRIRG----------SHGCIMADEMGLGKTLQCITLMWTLLRQSPQCKPeidkaIVVSPSSLVK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  900 TWAEEFKKWnisipFH-NLSSLDFTGKENSAALGLLMQkNATARSNNEIRMVKIYSwiksksilgisynlYEKLAGVKDE 978
Cdd:cd18067    73 NWANELGKW-----LGgRLQPLAIDGGSKKEIDRKLVQ-WASQQGRRVSTPVLIIS--------------YETFRLHVEV 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  979 DKKTKMvrevkpdkelddireilmgrpGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLAR 1058
Cdd:cd18067   133 LQKGEV---------------------GLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVN 191


                  ....
gi 145335142 1059 PKYL 1062
Cdd:cd18067   192 PGIL 195
HELICc smart00490
helicase superfamily c-terminal domain;
1244-1318 1.97e-18

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 81.10  E-value: 1.97e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145335142   1244 GEEVLYMHGKLEQKQRQTLINEFNDPKSKakvFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIG 1318
Cdd:smart00490   11 GIKVARLHGGLSQEEREEILDKFNNGKIK---VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 1008-1335 6.26e-18

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 90.24  E-value: 6.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1008 LVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYL---ERLTSTLKKSGmtvtkrgkKNL 1084
Cdd:PLN03142  295 IIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFssaETFDEWFQISG--------END 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1085 GNEInnrgIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQ----RRVLES-IEVTHN-RKTKNVFETEHKLS 1158
Cdd:PLN03142  367 QQEV----VQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQkqyyKALLQKdLDVVNAgGERKRLLNIAMQLR 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1159 LVSVHPSLVSRCKISEKerLSIDEALLAQLKK-VRLDpnqsvktrflmefvELCEVIKEK---VLVFSQYIDPLKLIMKH 1234
Cdd:PLN03142  443 KCCNHPYLFQGAEPGPP--YTTGEHLVENSGKmVLLD--------------KLLPKLKERdsrVLIFSQMTRLLDILEDY 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1235 LVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPKSKAKVFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRA 1314
Cdd:PLN03142  507 LMYR-----GYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRA 581

                         330       340
                  ....*....|....*....|.
gi 145335142 1315 YRIGQKRIVYTYHLVAKGTPE 1335
Cdd:PLN03142  582 HRIGQKKEVQVFRFCTEYTIE 602
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 826-1135 4.56e-17

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 83.50  E-value: 4.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   826 HQQEGFEFIWKNLAGTIMlnelkdfensdetgGCIMSHAPGTGKTrLTIIFLQAYLQcfpDCKP------VIIAPASLLL 899
Cdd:pfam00176    1 YQIEGVNWMLSLENNLGR--------------GGILADEMGLGKT-LQTISLLLYLK---HVDKnwggptLIVVPLSLLH 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   900 TWAEEFKKWNisipfhNLSSLDftgkensaALGLLMQKNATARSNNEIRMVKIYSwiksksILGISYNlyeklagvkded 979
Cdd:pfam00176   63 NWMNEFERWV------SPPALR--------VVVLHGNKRPQERWKNDPNFLADFD------VVITTYE------------ 110

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   980 kktkMVREVKpdkelddiREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:pfam00176  111 ----TLRKHK--------ELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRP 178

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  1060 KYLerltstlkksgmTVTKRGKKNLGNEINNR----GIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRV 1135
Cdd:pfam00176  179 GPF------------GSLSTFRNWFDRPIERGggkkGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKL 246
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 825-1082 2.19e-13

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 71.64  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLagtimlnelkdfensDETGGCIMSHAPGTGKTRLTIIFLQAYLQ------------CFPDCKP--- 889
Cdd:cd18005     3 DYQREGVEFMYDLY---------------KNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrennrPRFKKKPpas 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  890 ------VIIAPASLLLTWAEEFKKW---NISIpFHnlSSLDFTGKENSAALGLLmqknatarsnnEIRMVKiyswiksks 960
Cdd:cd18005    68 sakkpvLIVAPLSVLYNWKDELDTWghfEVGV-YH--GSRKDDELEGRLKAGRL-----------EVVVTT--------- 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  961 ilgisynlYEKLAGVKDEdkktkmvrevkpdkeLDDIREILmgrpglLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSG 1040
Cdd:cd18005   125 --------YDTLRRCIDS---------------LNSINWSA------VIADEAHRIKNPKSKLTQAMKELKCKVRIGLTG 175

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 145335142 1041 TPFQNNFLELCNVLGLARPKYLERLtSTLKKSGMTVTKRGKK 1082
Cdd:cd18005   176 TLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSEPIKRGQR 216
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 866-1050 4.97e-13

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 70.07  E-value: 4.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  866 GTGKTRLTIIFLqAYLQC-FPDCKP-VIIAPASLLLTWAEEFKKWnisIPfhNLSSLDFTGkensaalgllmqknatarS 943
Cdd:cd18003    29 GLGKTIQTIALL-AHLACeKGNWGPhLIVVPTSVMLNWEMEFKRW---CP--GFKILTYYG------------------S 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  944 NNEiRMVKIYSWIKSKS--ILGISYNLYeklagVKDEdkktKMVREVKPdkelddireilmgrpGLLVLDEAHTPRNQRS 1021
Cdd:cd18003    85 AKE-RKLKRQGWMKPNSfhVCITSYQLV-----VQDH----QVFKRKKW---------------KYLILDEAHNIKNFKS 139

                         170       180
                  ....*....|....*....|....*....
gi 145335142 1022 CIWKTLSKVETQKRILLSGTPFQNNFLEL 1050
Cdd:cd18003   140 QRWQTLLNFNTQRRLLLTGTPLQNSLMEL 168
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 823-1062 3.75e-12

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 67.78  E-value: 3.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWK---NLAGTIMLNELkdfensdetggcimshapGTGKTrLTIIflqAYLQCFPDCKPV----IIAPA 895
Cdd:cd18001     1 LYPHQREGVAWLWSlhdGGKGGILADDM------------------GLGKT-VQIC---AFLSGMFDSGLIksvlVVMPT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  896 SLLLTWAEEFKKWNISIP---FHNLSSldftgkensaalgllmqknaTARSNNEIRMvkiyswIKSKSILGISY----NL 968
Cdd:cd18001    59 SLIPHWVKEFAKWTPGLRvkvFHGTSK--------------------KERERNLERI------QRGGGVLLTTYgmvlSN 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  969 YEKLAGVKDEDKKTKMVrevkpdkelddireilmgrpgllVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFL 1048
Cdd:cd18001   113 TEQLSADDHDEFKWDYV-----------------------ILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLK 169

                         250
                  ....*....|....
gi 145335142 1049 ELCNVLGLARPKYL 1062
Cdd:cd18001   170 ELWALFDFACNGSL 183
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 825-1067 3.82e-12

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 67.56  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLAGTIMlnelkdfensDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPD-CKPV-----IIAPASLL 898
Cdd:cd18066     3 PHQREGIEFLYECVMGMRV----------NERFGAILADEMGLGKTLQCISLIWTLLRQGPYgGKPVikralIVTPGSLV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  899 LTWAEEFKKWnisipfhnlssldftgkensaaLGLLMQKNATARSNNEIRmvkiySWIKSK--SILGISYNLyeklagvk 976
Cdd:cd18066    73 KNWKKEFQKW----------------------LGSERIKVFTVDQDHKVE-----EFIASPlySVLIISYEM-------- 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  977 dedkktkMVRevkpdkELDDIREILMgrpGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGL 1056
Cdd:cd18066   118 -------LLR------SLDQISKLNF---DLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF 181

                         250
                  ....*....|.
gi 145335142 1057 ARPKYLERLTS 1067
Cdd:cd18066   182 VNPGILGSLST 192
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 859-1060 4.44e-12

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 66.25  E-value: 4.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  859 CIMSHAPGTGKTRLTIIFLqAYLQCFPDCKP-VIIAPASLLLTWAEEFKKWnisIPfhNLSSLDFTGKEnsaalgllmQK 937
Cdd:cd17998    22 GILADEMGLGKTIQVIAFL-AYLKEIGIPGPhLVVVPSSTLDNWLREFKRW---CP--SLKVEPYYGSQ---------EE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  938 NATARSNNEIRMVKIyswikskSILGISYNLyeklAGVKDEDKKtkMVREVKPDkelddireilmgrpgLLVLDEAHTPR 1017
Cdd:cd17998    87 RKHLRYDILKGLEDF-------DVIVTTYNL----ATSNPDDRS--FFKRLKLN---------------YVVYDEGHMLK 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 145335142 1018 NQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPK 1060
Cdd:cd17998   139 NMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 823-1064 4.89e-12

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 66.19  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWK---NLAGTIMLNELkdfensdetggcimshapGTGKTRLTIIFLQAyLQCFPDC-KPVII-APASL 897
Cdd:cd18000     1 LFKYQQTGVQWLWElhcQRVGGILGDEM------------------GLGKTIQIIAFLAA-LHHSKLGlGPSLIvCPATV 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  898 LLTWAEEFKKW----NISIpFHNLSSldFTGKENSAALGLlmqknataRSNNEIRMVKiyswiKSKSILGISYNLYEKLA 973
Cdd:cd18000    62 LKQWVKEFHRWwppfRVVV-LHSSGS--GTGSEEKLGSIE--------RKSQLIRKVV-----GDGGILITTYEGFRKHK 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  974 gvkdedkktkmvrevkpdkelDDIREILMGrpgLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNV 1053
Cdd:cd18000   126 ---------------------DLLLNHNWQ---YVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSL 181

                         250
                  ....*....|.
gi 145335142 1054 LGLARPKYLER 1064
Cdd:cd18000   182 FDFVFPPYLLR 192
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 823-1071 1.43e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 65.86  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGF---EFIWKNLAGTIMLNELkdfensdetggcimshapGTGKTRLTIIFLQAYLQCFPDCKPVII-APASLL 898
Cdd:cd18056     1 LHPYQLEGLnwlRFSWAQGTDTILADEM------------------GLGKTVQTAVFLYSLYKEGHSKGPFLVsAPLSTI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  899 LTWAEEFKKWNisipfHNLSSLDFTGKENSAALgllMQKNATARSNNEIRMVKIYSWIKsksilgisynlyeKLAGVKDE 978
Cdd:cd18056    63 INWEREFEMWA-----PDMYVVTYVGDKDSRAI---IRENEFSFEDNAIRGGKKASRMK-------------KEASVKFH 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  979 DKKTKMvrevkpdkELDDIREILMGRP--GLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGL 1056
Cdd:cd18056   122 VLLTSY--------ELITIDMAILGSIdwACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNF 193

                         250
                  ....*....|....*
gi 145335142 1057 ARPKYLERLTSTLKK 1071
Cdd:cd18056   194 LTPERFHNLEGFLEE 208
DEXDc smart00487
DEAD-like helicases superfamily;
822-1050 2.22e-11

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 64.82  E-value: 2.22e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142    822 QMYPHQQEGFEFIWKNLagtimlnelkdfensdetGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAP-ASLLLT 900
Cdd:smart00487    8 PLRPYQKEAIEALLSGL------------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQ 69

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142    901 WAEEFKKWNisiPFHNLSSLDFTGKENSAalgllMQKNATARSNNEIrmvkiyswiksksILGIsynlYEKLagvkdedk 980
Cdd:smart00487   70 WAEELKKLG---PSLGLKVVGLYGGDSKR-----EQLRKLESGKTDI-------------LVTT----PGRL-------- 116

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145335142    981 ktkmvrevkpdkeLDDIRE--ILMGRPGLLVLDEAH-TPRNQRSCIWKTLSKV--ETQKRILLSGTPFQN--NFLEL 1050
Cdd:smart00487  117 -------------LDLLENdkLSLSNVDLVILDEAHrLLDGGFGDQLEKLLKLlpKNVQLLLLSATPPEEieNLLEL 180
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 819-1104 2.62e-11

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 64.89  E-value: 2.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  819 VKSQMYPHQQEGFEfiWknlagtimLNELKD--FensdetGGCI---MshapGTGKTRLTIIFLQAYLQCFPDcKPV-II 892
Cdd:cd18012     1 LKATLRPYQKEGFN--W--------LSFLRHygL------GGILaddM----GLGKTLQTLALLLSRKEEGRK-GPSlVV 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  893 APASLLLTWAEEFKKWNISipfhnLSSLDFTGkensaalgllmqknatarSNNEIRMVKIyswIKSKSILGISYNLYEKL 972
Cdd:cd18012    60 APTSLIYNWEEEAAKFAPE-----LKVLVIHG------------------TKRKREKLRA---LEDYDLVITSYGLLRRD 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  973 AgvkdedkktkmvrEVKPDKELDdireilmgrpgLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCN 1052
Cdd:cd18012   114 I-------------ELLKEVKFH-----------YLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWS 169

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1053 VLGLARPKYLERLTSTLKKSGMTVTKRGkknlgneiNNRGIEELKAVMLPFV 1104
Cdd:cd18012   170 IFDFLNPGLLGSYKRFKKRFAKPIEKDG--------DEEALEELKKLISPFI 213
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 823-1071 7.36e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 63.93  E-value: 7.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGF---EFIWKNLAGTIMLNELkdfensdetggcimshapGTGKTRLTIIFLQAYLQCFPDCKPVII-APASLL 898
Cdd:cd18057     1 LHPYQLEGLnwlRFSWAQGTDTILADEM------------------GLGKTVQTIVFLYSLYKEGHSKGPYLVsAPLSTI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  899 LTWAEEFKKWNisipfHNLSSLDFTGKENSAALgllMQKNATARSNNEIRMVKIYSWIKSKS-----ILGISYnlyekla 973
Cdd:cd18057    63 INWEREFEMWA-----PDFYVVTYTGDKESRSV---IRENEFSFEDNAIRSGKKVFRMKKEAqikfhVLLTSY------- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  974 gvkdedkktkmvrevkpdkELDDIREILMGRP--GLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELC 1051
Cdd:cd18057   128 -------------------ELITIDQAILGSIewACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELF 188

                         250       260
                  ....*....|....*....|
gi 145335142 1052 NVLGLARPKYLERLTSTLKK 1071
Cdd:cd18057   189 HLLNFLTPERFNNLEGFLEE 208
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 860-1104 1.31e-10

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 63.10  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  860 IMSHAPGTGKTRLTIIFLQAYLQCFPDCKP-VIIAPASLLLTWAEEFKKW--NISIPFHnlssldftgkensaaLGLLMQ 936
Cdd:cd18054    43 ILADEMGLGKTIQTISFLSYLFHQHQLYGPfLLVVPLSTLTSWQREFEIWapEINVVVY---------------IGDLMS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  937 KNAtarsnneirmVKIYSWIKSKSiLGISYNL----YEKLAgvkdedkKTKMVrevkpdkeLDDIREILMGrpgllvLDE 1012
Cdd:cd18054   108 RNT----------IREYEWIHSQT-KRLKFNAlittYEILL-------KDKTV--------LGSINWAFLG------VDE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1013 AHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSGmtvtkRGKKNlgneinnrG 1092
Cdd:cd18054   156 AHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHG-----KGREN--------G 222

                         250
                  ....*....|..
gi 145335142 1093 IEELKAVMLPFV 1104
Cdd:cd18054   223 YQSLHKVLEPFL 234
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 1008-1104 1.18e-09

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 60.06  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1008 LVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYL--ER----------LTSTLKKSGMT 1075
Cdd:cd17999   130 CVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLgtEKqfqrrflkpiLASRDSKASAK 209

                          90       100
                  ....*....|....*....|....*....
gi 145335142 1076 VTKRGKKnlgneinnrGIEELKAVMLPFV 1104
Cdd:cd17999   210 EQEAGAL---------ALEALHKQVLPFL 229
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 860-1071 3.00e-09

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 58.87  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  860 IMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVII-APASLLLTWAEEFKKWNisipfHNLSSLDFTGKENSAALgllMQKN 938
Cdd:cd18055    23 ILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVsAPLSTIINWEREFQMWA-----PDFYVVTYTGDKDSRAI---IREN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  939 ATARSNNeirmvkiyswiksksilgisynlyeklaGVKDEDKKTKMVREVK-------PDKELDDIREILMG--RPGLLV 1009
Cdd:cd18055    95 EFSFDDN----------------------------AVKGGKKAFKMKREAQvkfhvllTSYELVTIDQAALGsiRWACLV 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1010 LDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKK 1071
Cdd:cd18055   147 VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEE 208
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 859-1054 3.54e-09

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 58.52  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  859 CIMSHAPGTGKTRLTIIFLqAYLqcFPDCK---P-VIIAPASLLLTWAEEFKKWnisIPFHNLSSldFTGkensaalgll 934
Cdd:cd17993    23 GILADEMGLGKTVQTISFL-SYL--FHSQQqygPfLVVVPLSTMPAWQREFAKW---APDMNVIV--YLG---------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  935 mqkNATARSnneirMVKIYSWIKSKSiLGISYNL----YEKLagVKDEdkktkmvrevkpdKELDDIREILMGrpgllvL 1010
Cdd:cd17993    85 ---DIKSRD-----TIREYEFYFSQT-KKLKFNVllttYEII--LKDK-------------AFLGSIKWQYLA------V 134

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 145335142 1011 DEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVL 1054
Cdd:cd17993   135 DEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALL 178
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 823-1060 7.92e-09

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 57.21  E-value: 7.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNlAGTIMLNelkdfensDEtggcimshaPGTGKTrltiifLQA--YLQCFPDCKPV-IIAPASLLL 899
Cdd:cd18010     1 LLPFQREGVCFALRR-GGRVLIA--------DE---------MGLGKT------VQAiaIAAYYREEWPLlIVCPSSLRL 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  900 TWAEEFKKWnisipFHNLSSLDFtgkensaalgllmqknatarsnNEIRMVKIYSWIKSKSILGISYNLYEKLagvkded 979
Cdd:cd18010    57 TWADEIERW-----LPSLPPDDI----------------------QVIVKSKDGLRDGDAKVVIVSYDLLRRL------- 102

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  980 kktkmvrevkpdkelddiREILMGRP-GLLVLDEAH---TPRNQRS-CIWKTLSKveTQKRILLSGTPFQNNFLELCNVL 1054
Cdd:cd18010   103 ------------------EKQLLARKfKVVICDESHylkNSKAKRTkAALPLLKR--AKRVILLSGTPALSRPIELFTQL 162


                  ....*.
gi 145335142 1055 GLARPK 1060
Cdd:cd18010   163 DALDPK 168
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 858-1050 9.90e-09

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 57.26  E-value: 9.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  858 GCIMSHAPGTGKTRLTIIFLQaYLQCFPDCKP--VIIAPASLLLTWAEEFKKWNisipfhNLSSLDFTGKENSAALGLLM 935
Cdd:cd17995    21 NCILADEMGLGKTIQSIAFLE-HLYQVEGIRGpfLVIAPLSTIPNWQREFETWT------DMNVVVYHGSGESRQIIQQY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  936 Q---KNATARSNNEIrmvkiyswIKSKSILgisyNLYEklagvkdedkktkMVreVKPDKELDDIREilmgrpGLLVLDE 1012
Cdd:cd17995    94 EmyfKDAQGRKKKGV--------YKFDVLI----TTYE-------------MV--IADAEELRKIPW------RVVVVDE 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 145335142 1013 AHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLEL 1050
Cdd:cd17995   141 AHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEEL 178
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 866-1059 1.48e-08

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 56.95  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  866 GTGKTRLTIIFLqAYLQCFPDCK-P-VIIAPASLLLTWAEEFKKWnisIPFhnlssldftgkensaalgllmqknatars 943
Cdd:cd17997    32 GLGKTLQTISLL-GYLKHYKNINgPhLIIVPKSTLDNWMREFKRW---CPS----------------------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  944 nneIRMVKiyswiksksilgisynlyekLAGVKDEDKKtkMVREVKPDKELDDI---REILMGRPGLL--------VLDE 1012
Cdd:cd17997    79 ---LRVVV--------------------LIGDKEERAD--IIRDVLLPGKFDVCitsYEMVIKEKTVLkkfnwryiIIDE 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 145335142 1013 AHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd17997   134 AHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLP 180
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 820-1103 3.83e-08

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 55.86  E-value: 3.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  820 KSQMYPHQQEGFEF---IWKNLAGTIMLNELkdfensdetggcimshapGTGKTRLTIIFLqAYLQCFPDCKPV-IIAPA 895
Cdd:cd18009     1 GGVMRPYQLEGMEWlrmLWENGINGILADEM------------------GLGKTIQTIALL-AHLRERGVWGPFlVIAPL 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  896 SLLLTWAEEFKKWNISIPfhnlssldftgkensaalglLMQKNATARSNNEIRMvKIYSWIKSKSILGISYNLYEklagV 975
Cdd:cd18009    62 STLPNWVNEFARFTPSVP--------------------VLLYHGTKEERERLRK-KIMKREGTLQDFPVVVTSYE----I 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  976 KDEDKKTKMVREVKpdkelddireilmgrpgLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLG 1055
Cdd:cd18009   117 AMRDRKALQHYAWK-----------------YLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLN 179

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 145335142 1056 LARPKYLERLTSTLK---KSGMTVTKRGKKNLGNEINNRGIEELKAVMLPF 1103
Cdd:cd18009   180 FLLPDVFDDLSSFESwfdFSSLSDNAADISNLSEEREQNIVHMLHAILKPF 230
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 825-1059 1.63e-07

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 53.60  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  825 PHQQEGFEFIWKNLAGTimlnelkdfensdetGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKP-VIIAPASLLLTWAE 903
Cdd:cd18006     3 PYQLEGVNWLLQCRAEQ---------------HGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPfLVLCPLSVLDNWKE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  904 EFKKWNIsipfhNLSSLDFTG-KENSAAlgllMQKNatarsnneirmvkiyswIKSKSILGISYNLYEKLagVKDEDKKT 982
Cdd:cd18006    68 ELNRFAP-----DLSVITYMGdKEKRLD----LQQD-----------------IKSTNRFHVLLTTYEIC--LKDASFLK 119

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145335142  983 KMVREVkpdkelddireilmgrpglLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18006   120 SFPWAS-------------------LVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEP 177
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 824-1050 2.02e-07

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 53.83  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  824 YPHQQEGFEF-IWKnlagtimlnelkdfensdetGGcIMSHAPGTGKTRLTIIFLQAYLQCFPD---------------- 886
Cdd:cd18008     2 LPYQKQGLAWmLPR--------------------GG-ILADEMGLGKTIQALALILATRPQDPKipeeleenssdpkkly 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  887 -CKP-VIIAPASLLLTWAEEFKKwniSIPFHNLSSLDFTGKENSAALGLLMQKNatarsnneirMVkiyswIKSKSILGI 964
Cdd:cd18008    61 lSKTtLIVVPLSLLSQWKDEIEK---HTKPGSLKVYVYHGSKRIKSIEELSDYD----------IV-----ITTYGTLAS 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  965 SYNlyeklagvkdedKKTKMVREVKPDKELDDIREILMGRpglLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQ 1044
Cdd:cd18008   123 EFP------------KNKKGGGRDSKEKEASPLHRIRWYR---VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQ 187


                  ....*.
gi 145335142 1045 NNFLEL 1050
Cdd:cd18008   188 NSLDDL 193
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 859-1073 3.74e-07

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 52.75  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  859 CIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPASLLLTWAEEFKKWNisipfhNLSSLDFTGkenSAALGLLMQKn 938
Cdd:cd18060    22 CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT------EMNTIVYHG---SLASRQMIQQ- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  939 atarsnneirmvkiyswiksksilgisYNLYEKlagvkdEDKKTKMVREVKPDKELDDIREILMGRPGL-------LVLD 1011
Cdd:cd18060    92 ---------------------------YEMYCK------DSRGRLIPGAYKFDALITTFEMILSDCPELreiewrcVIID 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1012 EAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSG 1073
Cdd:cd18060   139 EAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG 200
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 1008-1071 4.60e-07

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 51.67  E-value: 4.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145335142 1008 LVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKK 1071
Cdd:cd17994   109 LVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEE 172
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
814-1403 5.75e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 53.88  E-value: 5.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  814 DKIPGVKSQMYPHQQEgfefiwknlagtiMLNELKDFENSDETGGCIMShAPGTGKtrlTIIFLQAYLQCFPDCKPVIIA 893
Cdd:COG1061    72 DEASGTSFELRPYQQE-------------ALEALLAALERGGGRGLVVA-PTGTGK---TVLALALAAELLRGKRVLVLV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  894 P-ASLLLTWAEEFKKWNISIPFHNlssldftGKENSAALGLLmqknATarsnneirmvkiyswiksksilgisynlYEKL 972
Cdd:COG1061   135 PrRELLEQWAEELRRFLGDPLAGG-------GKKDSDAPITV----AT----------------------------YQSL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  973 AGvkdedkktkmvrevkpDKELDDIREilmgRPGLLVLDEAH---TPRNQRsciwkTLSKVETQKRILLSGTPFQNNfle 1049
Cdd:COG1061   176 AR----------------RAHLDELGD----RFGLVIIDEAHhagAPSYRR-----ILEAFPAAYRLGLTATPFRSD--- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1050 lcnvlglARPKYLERLTstlkksgmtvtkrgkknlgneinnrgieelkavmlpfvhvhkgsilqsslpglrECVVVLNPP 1129
Cdd:COG1061   228 -------GREILLFLFD------------------------------------------------------GIVYEYSLK 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1130 ELQRR-VLESIEVthnrktknvfetehklslVSVHPSLvsrckisEKERLSIDEalLAQLKKVRLDPNQSVKTRFLMEFV 1208
Cdd:COG1061   247 EAIEDgYLAPPEY------------------YGIRVDL-------TDERAEYDA--LSERLREALAADAERKDKILRELL 299

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1209 ELcEVIKEKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFndpKSKAKVFLASTKACSEGIS 1288
Cdd:COG1061   300 RE-HPDDRKTLVFCSSVDHAEALAELLNEA-----GIRAAVVTGDTPKKEREEILEAF---RDGELRILVTVDVLNEGVD 370

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1289 LVGASRVILLDVVWNPAVERQAISRAYRIGQ-KRIVYTYHLVAKGTPEGPKYCKQAQKDRISELVFACSSRhDKGKEKIA 1367
Cdd:COG1061   371 VPRLDVAILLRPTGSPREFIQRLGRGLRPAPgKEDALVYDFVGNDVPVLEELAKDLRDLAGYRVEFLDEEE-SEELALLI 449

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 145335142 1368 EAVTEDKVLDTMVEHSKLGDMFDNLIVQPKEADLVE 1403
Cdd:COG1061   450 AVKPALEVKGELEEELLEELELLEDALLLVLAELLL 485
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 859-1060 8.38e-07

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 51.97  E-value: 8.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  859 CIMSHAPGTGKTRLTIIFLQAYLQCFPDCKP-VIIAPASLLLTWAEEFKKWnisIPFHNLSsldftgkensAALGLLMQK 937
Cdd:cd18053    42 CILADEMGLGKTIQTISFLNYLFHEHQLYGPfLLVVPLSTLTSWQREIQTW---APQMNAV----------VYLGDINSR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  938 NatarsnneirMVKIYSWIKSKSI---LGISYNLYEKLagvkdedkktkmvreVKPDKELDDIREILMGrpgllvLDEAH 1014
Cdd:cd18053   109 N----------MIRTHEWMHPQTKrlkFNILLTTYEIL---------------LKDKSFLGGLNWAFIG------VDEAH 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 145335142 1015 TPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPK 1060
Cdd:cd18053   158 RLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE 203
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 859-1084 2.07e-06

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 50.43  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  859 CIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPASLLLTWAEEFKKWNisipfhNLSSLDFTGKENSAALglLMQKN 938
Cdd:cd18058    22 CILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT------EMNAIVYHGSQISRQM--IQQYE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  939 ATARSNNEIRMVKIYSWiksksilGISYNLYEKLagvkdedkktkmvrevkpdkeLDDIREILMGRPGLLVLDEAHTPRN 1018
Cdd:cd18058    94 MYYRDEQGNPLSGIFKF-------QVVITTFEMI---------------------LADCPELKKINWSCVIIDEAHRLKN 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145335142 1019 QRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSGMTVTKRGKKNL 1084
Cdd:cd18058   146 RNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKTEEQVKKL 211
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 860-1059 2.56e-06

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 50.20  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  860 IMSHAPGTGKTRLTIIFLqAYLQCFPDC-KP-VIIAPASLLLTWAEEFKKWnisIPfhNLSSLDFTG--KENSAALGLLM 935
Cdd:cd18002    23 ILADEMGLGKTVQSIAVL-AHLAEEHNIwGPfLVIAPASTLHNWQQEISRF---VP--QFKVLPYWGnpKDRKVLRKFWD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  936 QKNATARSNneirmvkiyswikSKSILGISYNLYeklagVKDEdkktKMVREVKPDkelddireilmgrpgLLVLDEAHT 1015
Cdd:cd18002    97 RKNLYTRDA-------------PFHVVITSYQLV-----VQDE----KYFQRVKWQ---------------YMVLDEAQA 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 145335142 1016 PRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18002   140 IKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMP 183
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 823-1050 2.75e-06

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 50.04  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNLAGTIMLNelkdfensdetggcimshaPGTGKTrLTIIFLQAYLQCFPDCKPV-IIAPASLL-LT 900
Cdd:cd18013     1 PHPYQKVAINFIIEHPYCGLFLD-------------------MGLGKT-VTTLTALSDLQLDDFTRRVlVIAPLRVArST 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  901 WAEEFKKWNIsipFHNL--SSLDFTGKENSAALgllmQKNATarsnneirmvkIYSwiksksilgISYNLYEKLAGVKDE 978
Cdd:cd18013    61 WPDEVEKWNH---LRNLtvSVAVGTERQRSKAA----NTPAD-----------LYV---------INRENLKWLVNKSGD 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145335142  979 DKKTKMVrevkpdkelddireilmgrpgllVLDEAHTPRNQRSCIWKTLSKVETQ-KR-ILLSGTPFQNNFLEL 1050
Cdd:cd18013   114 PWPFDMV-----------------------VIDELSSFKSPRSKRFKALRKVRPViKRlIGLTGTPSPNGLMDL 164
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 860-1059 1.71e-05

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 47.70  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  860 IMSHAPGTGKTRLTIIFLqAYLQCFPDCKP--VIIAPASLLLTWAEEFKKWnisIPfhNLSSLDFTGKENSAALGLlmqK 937
Cdd:cd18065    38 ILADEMGLGKTLQTIALL-GYLKHYRNIPGphMVLVPKSTLHNWMNEFKRW---VP--SLRAVCLIGDKDARAAFI---R 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  938 NATARSNNEIRMVKIYSWIKSKSILGISYNLYeklagvkdedkktkmvrevkpdkelddireilmgrpglLVLDEAHTPR 1017
Cdd:cd18065   109 DVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRY--------------------------------------LVIDEAHRIK 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 145335142 1018 NQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18065   151 NEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP 192
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 856-1073 2.23e-05

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 47.33  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  856 TGGCIMSHAPGTGKTRLTIIFL-QAYLQCFPDcKPVIIAPASLLLTWAEEFKKWNisipfhNLSSLDFTGKEnsaalgll 934
Cdd:cd18059    19 TRNCILADEMGLGKTIQSITFLyEIYLKGIHG-PFLVIAPLSTIPNWEREFRTWT------ELNVVVYHGSQ-------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  935 mqknataRSNNEIRMVKIYSWIKSKSILGISYNLYEKLAGVKdedkktkMVrevkpdkeLDDIREILMGRPGLLVLDEAH 1014
Cdd:cd18059    84 -------ASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFE-------MI--------LTDCPELRNIPWRCVVIDEAH 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 145335142 1015 TPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSG 1073
Cdd:cd18059   142 RLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFG 200
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 1008-1059 2.56e-05

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 47.35  E-value: 2.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145335142 1008 LVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18064   141 LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP 192
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 1256-1329 3.21e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 43.46  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1256 QKQRQTLIneFNDPKSKAKV------FLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKriVYTYHLV 1329
Cdd:cd18785     1 VMVVKIIV--FTNSIEHAEEiassleILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD--EGEVILF 76
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 866-1060 5.71e-05

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 46.21  E-value: 5.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  866 GTGKTRLTIIFLqAYLQCFP-DCKP-VIIAPASLLLTWAEEFKKWNISIpfhnlSSLDFTGKensaalgllmqKNATARS 943
Cdd:cd17996    32 GLGKTIQTISLI-TYLMEKKkNNGPyLVIVPLSTLSNWVSEFEKWAPSV-----SKIVYKGT-----------PDVRKKL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  944 NNEIRMVKiyswiksksiLGISYNLYEKLagVKDEDKKTKmvrevkpdkelddIREILMgrpgllVLDEAHTPRNQRSCI 1023
Cdd:cd17996    95 QSQIRAGK----------FNVLLTTYEYI--IKDKPLLSK-------------IKWKYM------IIDEGHRMKNAQSKL 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 145335142 1024 WKTLSK-VETQKRILLSGTPFQNNFLELCNVLGLARPK 1060
Cdd:cd17996   144 TQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPK 181
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 988-1059 7.59e-05

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 45.36  E-value: 7.59e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145335142  988 VKPDKELDDirEILMGRPGLLVLDEAH-------TPRNQRSCIWKTLSKVeTQKRILLSGTPFQNNFLELCNVLGLARP 1059
Cdd:cd18011   106 LKRSEERRG--LLLSEEWDLVVVDEAHklrnsggGKETKRYKLGRLLAKR-ARHVLLLTATPHNGKEEDFRALLSLLDP 181
ResIII pfam04851
Type III restriction enzyme, res subunit;
820-908 2.55e-04

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 43.04  E-value: 2.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142   820 KSQMYPHQQEgfefiwknlagtiMLNELKDFENSDETGGCImSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAP-ASLL 898
Cdd:pfam04851    1 KLELRPYQIE-------------AIENLLESIKNGQKRGLI-VMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLL 66

                           90
                   ....*....|
gi 145335142   899 LTWAEEFKKW 908
Cdd:pfam04851   67 EQALEEFKKF 76
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 884-1058 2.09e-03

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 41.31  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  884 FPDCKPVIIAPASLLLTWAEEFKKwnisipfhnlssldftgKENSAALGLLmqknaTARSNNEIRMVKIYSwikSKSILG 963
Cdd:cd18072    71 VPSAGTLVVCPASLVHQWKNEVES-----------------RVASNKLRVC-----LYHGPNRERIGEVLR---DYDIVI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  964 ISYNLyeklagvkdedkktkMVREVKPDKELDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPF 1043
Cdd:cd18072   126 TTYSL---------------VAKEIPTYKEESRSSPLFRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPI 190

                         170
                  ....*....|....*
gi 145335142 1044 QNNFLELCNVLGLAR 1058
Cdd:cd18072   191 QNNLLDMYSLLKFLR 205
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 1210-1325 2.60e-03

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 39.41  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142 1210 LCEVIKEKVLVFSQYIDPLKLIMKHLVSRfkwnpGEEVLYMHGKLEQKQRQTLINEFNDPKSKakvFLASTKACSEGISL 1289
Cdd:cd18787    22 LEKLKPGKAIIFVNTKKRVDRLAELLEEL-----GIKVAALHGDLSQEERERALKKFRSGKVR---VLVATDVAARGLDI 93

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 145335142 1290 VGASRVILLDVVWNPA--VERqaISRAYRIGQKRIVYT 1325
Cdd:cd18787    94 PGVDHVINYDLPRDAEdyVHR--IGRTGRAGRKGTAIT 129
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 823-927 6.71e-03

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 38.44  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145335142  823 MYPHQQEGFEFIWKNlagtimlnelkdfeNSDETGgcIMSHAPGTGKTrLTIIFLQAYLQCFpdcKPVIIAPASLLLT-W 901
Cdd:cd17926     1 LRPYQEEALEAWLAH--------------KNNRRG--ILVLPTGSGKT-LTALALIAYLKEL---RTLIVVPTDALLDqW 60

                          90       100
                  ....*....|....*....|....*.
gi 145335142  902 AEEFKKWNISIPFHNLSSLDFTGKEN 927
Cdd:cd17926    61 KERFEDFLGDSSIGLIGGGKKKDFDD 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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