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Conserved domains on  [gi|15217826|ref|NP_171767|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 121-658 1.27e-117

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 367.24  E-value: 1.27e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 121 AEAAEQPLDLIIPLLKYQKEFLAWAtiQELSAVR-GGILADEMGMGKTIQAISLVLARREvdraksREAVGHTLVLVPPV 199
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWL--LFLRRLGlGGLLADDMGLGKTIQALALLLELKE------RGLARPVLIVAPTS 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 200 ALSQWLDEISRLTspGSTRVLQYHGP-KRDKNVQKLMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAH 278
Cdd:COG0553 301 LVGNWQRELAKFA--PGLRVLVLDGTrERAKGANPFEDADLVITSYGLL----RRDIEL------LAAVDWDLVILDEAQ 368

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 279 DIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSysFLN--FFYSTYAsfaFRHTHITFARNVTVKF------ 350
Cdd:COG0553 369 HIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLD--FLNpgLLGSLKA---FRERFARPIEKGDEEAlerlrr 443

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 351 LIGGNILplsipvR------IENVPAVLIMQINTSLGGKrrdalsvvEADFYESLYKvsktTFDGYIQAGTLMNNYAHIF 424
Cdd:COG0553 444 LLRPFLL------RrtkedvLKDLPEKTEETLYVELTPE--------QRALYEAVLE----YLRRELEGAEGIRRRGLIL 505

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 425 GLLIRLRQAVDHPYLVsysspsgananlldanknekecgfghdpskdyfvtssehqasktkLKGFRASSIlnrinlddfk 504
Cdd:COG0553 506 AALTRLRQICSHPALL---------------------------------------------LEEGAELSG---------- 530

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 505 TSTKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEPDCRVLLMSL 584
Cdd:COG0553 531 RSAKLEALLELLEELLAEG--EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217826 585 QAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIGQCKPVRVVRFIMEKTVEEKILTLQKKKEDLFESTLG 658
Cdd:COG0553 609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 121-658 1.27e-117

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 367.24  E-value: 1.27e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 121 AEAAEQPLDLIIPLLKYQKEFLAWAtiQELSAVR-GGILADEMGMGKTIQAISLVLARREvdraksREAVGHTLVLVPPV 199
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWL--LFLRRLGlGGLLADDMGLGKTIQALALLLELKE------RGLARPVLIVAPTS 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 200 ALSQWLDEISRLTspGSTRVLQYHGP-KRDKNVQKLMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAH 278
Cdd:COG0553 301 LVGNWQRELAKFA--PGLRVLVLDGTrERAKGANPFEDADLVITSYGLL----RRDIEL------LAAVDWDLVILDEAQ 368

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 279 DIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSysFLN--FFYSTYAsfaFRHTHITFARNVTVKF------ 350
Cdd:COG0553 369 HIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLD--FLNpgLLGSLKA---FRERFARPIEKGDEEAlerlrr 443

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 351 LIGGNILplsipvR------IENVPAVLIMQINTSLGGKrrdalsvvEADFYESLYKvsktTFDGYIQAGTLMNNYAHIF 424
Cdd:COG0553 444 LLRPFLL------RrtkedvLKDLPEKTEETLYVELTPE--------QRALYEAVLE----YLRRELEGAEGIRRRGLIL 505

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 425 GLLIRLRQAVDHPYLVsysspsgananlldanknekecgfghdpskdyfvtssehqasktkLKGFRASSIlnrinlddfk 504
Cdd:COG0553 506 AALTRLRQICSHPALL---------------------------------------------LEEGAELSG---------- 530

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 505 TSTKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEPDCRVLLMSL 584
Cdd:COG0553 531 RSAKLEALLELLEELLAEG--EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217826 585 QAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIGQCKPVRVVRFIMEKTVEEKILTLQKKKEDLFESTLG 658
Cdd:COG0553 609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 134-342 3.19e-81

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 257.22  E-value: 3.19e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATiqelsaVRGGILADEMGMGKTIQAISLVLARREVDRAKSREAVGH------------TLVLVPPVAL 201
Cdd:cd18008   1 LLPYQKQGLAWML------PRGGILADEMGLGKTIQALALILATRPQDPKIPEELEENssdpkklylsktTLIVVPLSLL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 202 SQWLDEISRLTSPGSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKDEGVDETM------SPLHSIKWNRIIVD 275
Cdd:cd18008  75 SQWKDEIEKHTKPGSLKVYVYHGSKRIKSIEELSDYDIVITTYGTLASEFPKNKKGGGRDskekeaSPLHRIRWYRVILD 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15217826 276 EAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVsySFLNFfySTYASFAFRHTHITF 342
Cdd:cd18008 155 EAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLL--RFLRV--EPFGDYPWFNSDISK 217
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 137-440 7.41e-46

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 164.78  E-value: 7.41e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   137 YQKEFLAWATIQELSAVRGGILADEMGMGKTIQAISLVLARREVDRAKSreavGHTLVLVPPVALSQWLDEISRLTSPGS 216
Cdd:pfam00176   1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWG----GPTLIVVPLSLLHNWMNEFERWVSPPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   217 TRVLQYHGPKRD----KNVQKLMN-YDFVLTTSPIVeneyRKDEgvdetmSPLHSIKWNRIIVDEAHDIKNRSSRTAKAV 291
Cdd:pfam00176  77 LRVVVLHGNKRPqerwKNDPNFLAdFDVVITTYETL----RKHK------ELLKKVHWHRIVLDEGHRLKNSKSKLSKAL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   292 FALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYSTYasfafrhthiTFARNVTVKFLIGGN---------------- 355
Cdd:pfam00176 147 KSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLS----------TFRNWFDRPIERGGGkkgvsrlhkllkpfll 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   356 -----ILPLSIPVRIENVpavlimqintslggkRRDALSVVEADFYESlyKVSKTTFDgYIQAGTLMNNYAH-IFGLLIR 429
Cdd:pfam00176 217 rrtkkDVEKSLPPKVEYI---------------LFCRLSKLQRKLYQT--FLLKKDLN-AIKTGEGGREIKAsLLNILMR 278

                         330
                  ....*....|.
gi 15217826   430 LRQAVDHPYLV 440
Cdd:pfam00176 279 LRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 156-649 4.92e-43

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 167.28  E-value: 4.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   156 GILADEMGMGKTIQAISLVLARREvdrakSREAVGHTLVLVPPVALSQWLDEISRLTSpgSTRVLQYHGPKRDKNVQK-- 233
Cdd:PLN03142  191 GILADEMGLGKTLQTISLLGYLHE-----YRGITGPHMVVAPKSTLGNWMNEIRRFCP--VLRAVKFHGNPEERAHQRee 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   234 LM---NYDFVLTTSPIVENEyrkdegvdetMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQND 310
Cdd:PLN03142  264 LLvagKFDVCVTSFEMAIKE----------KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNN 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   311 VDELYSLvsysfLNFFYSTYASFAFrhthiTFARnvtvKFLIGGNILPLSIPVRIENV--PAVL---IMQINTSLGGKRR 385
Cdd:PLN03142  334 LHELWAL-----LNFLLPEIFSSAE-----TFDE----WFQISGENDQQEVVQQLHKVlrPFLLrrlKSDVEKGLPPKKE 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   386 DALSV----VEADFYESLYKVSKTTFDGYIQAGTLMNnyahifgLLIRLRQAVDHPYLVSysspsgananlldankneke 461
Cdd:PLN03142  400 TILKVgmsqMQKQYYKALLQKDLDVVNAGGERKRLLN-------IAMQLRKCCNHPYLFQ-------------------- 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   462 cgfGHDPSKDYFvtSSEHQasktklkgfrassilnrinlddFKTSTKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLI 541
Cdd:PLN03142  453 ---GAEPGPPYT--TGEHL----------------------VENSGKMVLLDKLLPKLKERD--SRVLIFSQMTRLLDIL 503

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   542 S-YALGKSGVSCvQLVGSMSKAAKDAALKNF-KEEPDCRVLLMSLQAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIH 619
Cdd:PLN03142  504 EdYLMYRGYQYC-RIDGNTGGEDRDASIDAFnKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAH 582

                         490       500       510
                  ....*....|....*....|....*....|
gi 15217826   620 RIGQCKPVRVVRFIMEKTVEEKILTLQKKK 649
Cdd:PLN03142  583 RIGQKKEVQVFRFCTEYTIEEKVIERAYKK 612
DEXDc smart00487
DEAD-like helicases superfamily;
130-319 6.04e-23

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 97.18  E-value: 6.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826    130 LIIPLLKYQKEFLAWAtiqeLSAVRGGILADEMGMGKTIQAISLVLarrevdRAKSREAVGHTLVLVPPVAL-SQWLDEI 208
Cdd:smart00487   5 GFEPLRPYQKEAIEAL----LSGLRDVILAAPTGSGKTLAALLPAL------EALKRGKGGRVLVLVPTRELaEQWAEEL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826    209 SRLTSP-GSTRVLQYHGPKRDKNVQKLMN--YDFVLTTSPIVENEYRKDegvdetmsPLHSIKWNRIIVDEAHDIKN--R 283
Cdd:smart00487  75 KKLGPSlGLKVVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND--------KLSLSNVDLVILDEAHRLLDggF 146

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 15217826    284 SSRTAKAVFALE-ATYRWALSGTPLQNDVDELYSLVS 319
Cdd:smart00487 147 GDQLEKLLKLLPkNVQLLLLSATPPEEIENLLELFLN 183
DpdE NF041062
protein DpdE;
158-209 1.11e-04

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 45.73  E-value: 1.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15217826   158 LADEMGMGKTIQAiSLVLarREV--DRAKSReavghTLVLVPPVALSQWLDEIS 209
Cdd:NF041062  175 LADEVGLGKTIEA-GLVI--RQHllDNPDAR-----VLVLVPDALVRQWRRELR 220
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 121-658 1.27e-117

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 367.24  E-value: 1.27e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 121 AEAAEQPLDLIIPLLKYQKEFLAWAtiQELSAVR-GGILADEMGMGKTIQAISLVLARREvdraksREAVGHTLVLVPPV 199
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWL--LFLRRLGlGGLLADDMGLGKTIQALALLLELKE------RGLARPVLIVAPTS 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 200 ALSQWLDEISRLTspGSTRVLQYHGP-KRDKNVQKLMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAH 278
Cdd:COG0553 301 LVGNWQRELAKFA--PGLRVLVLDGTrERAKGANPFEDADLVITSYGLL----RRDIEL------LAAVDWDLVILDEAQ 368

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 279 DIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSysFLN--FFYSTYAsfaFRHTHITFARNVTVKF------ 350
Cdd:COG0553 369 HIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLD--FLNpgLLGSLKA---FRERFARPIEKGDEEAlerlrr 443

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 351 LIGGNILplsipvR------IENVPAVLIMQINTSLGGKrrdalsvvEADFYESLYKvsktTFDGYIQAGTLMNNYAHIF 424
Cdd:COG0553 444 LLRPFLL------RrtkedvLKDLPEKTEETLYVELTPE--------QRALYEAVLE----YLRRELEGAEGIRRRGLIL 505

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 425 GLLIRLRQAVDHPYLVsysspsgananlldanknekecgfghdpskdyfvtssehqasktkLKGFRASSIlnrinlddfk 504
Cdd:COG0553 506 AALTRLRQICSHPALL---------------------------------------------LEEGAELSG---------- 530

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 505 TSTKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEPDCRVLLMSL 584
Cdd:COG0553 531 RSAKLEALLELLEELLAEG--EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISL 608

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217826 585 QAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIGQCKPVRVVRFIMEKTVEEKILTLQKKKEDLFESTLG 658
Cdd:COG0553 609 KAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 134-342 3.19e-81

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 257.22  E-value: 3.19e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATiqelsaVRGGILADEMGMGKTIQAISLVLARREVDRAKSREAVGH------------TLVLVPPVAL 201
Cdd:cd18008   1 LLPYQKQGLAWML------PRGGILADEMGLGKTIQALALILATRPQDPKIPEELEENssdpkklylsktTLIVVPLSLL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 202 SQWLDEISRLTSPGSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKDEGVDETM------SPLHSIKWNRIIVD 275
Cdd:cd18008  75 SQWKDEIEKHTKPGSLKVYVYHGSKRIKSIEELSDYDIVITTYGTLASEFPKNKKGGGRDskekeaSPLHRIRWYRVILD 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15217826 276 EAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVsySFLNFfySTYASFAFRHTHITF 342
Cdd:cd18008 155 EAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLL--RFLRV--EPFGDYPWFNSDISK 217
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 506-633 4.08e-55

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 184.22  E-value: 4.08e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 506 STKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEPDCRVLLMSLQ 585
Cdd:cd18793  10 SGKLEALLELLEELREPG--EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTK 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15217826 586 AGGVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIGQCKPVRVVRFI 633
Cdd:cd18793  88 AGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 134-324 2.43e-51

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 178.06  E-value: 2.43e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAVRGGILADEMGMGKTIQAISLVLARREvDRAKSREAVGH------------------TLVL 195
Cdd:cd18072   1 LLLHQKQALAWLLWRERQKPRGGILADDMGLGKTLTMIALILAQKN-TQNRKEEEKEKalteweskkdstlvpsagTLVV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 196 VPPVALSQWLDEISRLTSPGSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKDeGVDETMSPLHSIKWNRIIVD 275
Cdd:cd18072  80 CPASLVHQWKNEVESRVASNKLRVCLYHGPNRERIGEVLRDYDIVITTYSLVAKEIPTY-KEESRSSPLFRIAWARIILD 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15217826 276 EAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVsySFLN 324
Cdd:cd18072 159 EAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLL--KFLR 205
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 134-325 1.60e-48

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 170.34  E-value: 1.60e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELS----------------------------AVRGGILADEMGMGKTIQAISLVLARRevdraks 185
Cdd:cd18071   1 LLPHQKQALAWMVSRENSqdlppfweeavglflntitnfsqkkrpeLVRGGILADDMGLGKTLTTISLILANF------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 186 reavghTLVLVPPVALSQWLDEISRLTSPGSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKDEGvdetmSPLH 265
Cdd:cd18071  74 ------TLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLLSKYDIVLTTYNTLASDFGAKGD-----SPLH 142

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 266 SIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVsySFLNF 325
Cdd:cd18071 143 TINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLL--SFLHL 200
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 134-324 6.27e-48

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 166.59  E-value: 6.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtIQELSAVRGGILADEMGMGKTIQAISLVLARRevdraKSREAVGHTLVLVPPVALSQWLDEISRLTs 213
Cdd:cd17919   1 LRPYQLEGLNFL-LELYENGPGGILADEMGLGKTLQAIAFLAYLL-----KEGKERGPVLVVCPLSVLENWEREFEKWT- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pGSTRVLQYHGPKRDKNVQ----KLMNYDFVLTTSPIVENEYRKdegvdetmspLHSIKWNRIIVDEAHDIKNRSSRTAK 289
Cdd:cd17919  74 -PDLRVVVYHGSQRERAQIrakeKLDKFDVVLTTYETLRRDKAS----------LRKFRWDLVVVDEAHRLKNPKSQLSK 142

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15217826 290 AVFALEATYRWALSGTPLQNDVDELYSLVsySFLN 324
Cdd:cd17919 143 ALKALRAKRRLLLTGTPLQNNLEELWALL--DFLD 175
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 137-440 7.41e-46

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 164.78  E-value: 7.41e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   137 YQKEFLAWATIQELSAVRGGILADEMGMGKTIQAISLVLARREVDRAKSreavGHTLVLVPPVALSQWLDEISRLTSPGS 216
Cdd:pfam00176   1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWG----GPTLIVVPLSLLHNWMNEFERWVSPPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   217 TRVLQYHGPKRD----KNVQKLMN-YDFVLTTSPIVeneyRKDEgvdetmSPLHSIKWNRIIVDEAHDIKNRSSRTAKAV 291
Cdd:pfam00176  77 LRVVVLHGNKRPqerwKNDPNFLAdFDVVITTYETL----RKHK------ELLKKVHWHRIVLDEGHRLKNSKSKLSKAL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   292 FALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYSTYasfafrhthiTFARNVTVKFLIGGN---------------- 355
Cdd:pfam00176 147 KSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLS----------TFRNWFDRPIERGGGkkgvsrlhkllkpfll 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   356 -----ILPLSIPVRIENVpavlimqintslggkRRDALSVVEADFYESlyKVSKTTFDgYIQAGTLMNNYAH-IFGLLIR 429
Cdd:pfam00176 217 rrtkkDVEKSLPPKVEYI---------------LFCRLSKLQRKLYQT--FLLKKDLN-AIKTGEGGREIKAsLLNILMR 278

                         330
                  ....*....|.
gi 15217826   430 LRQAVDHPYLV 440
Cdd:pfam00176 279 LRKICNHPGLI 289
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 134-333 7.00e-44

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 156.96  E-value: 7.00e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWatiqeLSAVR----GGILADEMGMGKTIQAISLVLARREVDRAKSreavghTLVLVPPVALSQWLDEIS 209
Cdd:cd18012   5 LRPYQKEGFNW-----LSFLRhyglGGILADDMGLGKTLQTLALLLSRKEEGRKGP------SLVVAPTSLIYNWEEEAA 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 210 RLTSpgSTRVLQYHGPKRDKNVQKLM-NYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAHDIKNRSSRTA 288
Cdd:cd18012  74 KFAP--ELKVLVIHGTKRKREKLRALeDYDLVITSYGLL----RRDIEL------LKEVKFHYLVLDEAQNIKNPQTKTA 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15217826 289 KAVFALEATYRWALSGTPLQNDVDELYSLvsYSFLN--FFYStYASF 333
Cdd:cd18012 142 KAVKALKADHRLALTGTPIENHLGELWSI--FDFLNpgLLGS-YKRF 185
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 134-320 3.99e-43

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 155.96  E-value: 3.99e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtiqelsAVRGGILADEMGMGKTIQAISLVLARR--------------------EVDRAKSREAVGHTL 193
Cdd:cd18070   1 LLPYQRRAVNWM------LVPGGILADEMGLGKTVEVLALILLHPrpdndldaadddsdemvccpDCLVAETPVSSKATL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 194 VLVPPVALSQWLDEISRLTsPGSTRVLQYHGPKRDK-----NVQKLMNYDFVLTTSPIVENE--YRKDEG---------- 256
Cdd:cd18070  75 IVCPSAILAQWLDEINRHV-PSSLKVLTYQGVKKDGalaspAPEILAEYDIVVTTYDVLRTElhYAEANRsnrrrrrqkr 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217826 257 VDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18070 154 YEAPPSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSF 217
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 156-649 4.92e-43

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 167.28  E-value: 4.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   156 GILADEMGMGKTIQAISLVLARREvdrakSREAVGHTLVLVPPVALSQWLDEISRLTSpgSTRVLQYHGPKRDKNVQK-- 233
Cdd:PLN03142  191 GILADEMGLGKTLQTISLLGYLHE-----YRGITGPHMVVAPKSTLGNWMNEIRRFCP--VLRAVKFHGNPEERAHQRee 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   234 LM---NYDFVLTTSPIVENEyrkdegvdetMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQND 310
Cdd:PLN03142  264 LLvagKFDVCVTSFEMAIKE----------KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNN 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   311 VDELYSLvsysfLNFFYSTYASFAFrhthiTFARnvtvKFLIGGNILPLSIPVRIENV--PAVL---IMQINTSLGGKRR 385
Cdd:PLN03142  334 LHELWAL-----LNFLLPEIFSSAE-----TFDE----WFQISGENDQQEVVQQLHKVlrPFLLrrlKSDVEKGLPPKKE 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   386 DALSV----VEADFYESLYKVSKTTFDGYIQAGTLMNnyahifgLLIRLRQAVDHPYLVSysspsgananlldankneke 461
Cdd:PLN03142  400 TILKVgmsqMQKQYYKALLQKDLDVVNAGGERKRLLN-------IAMQLRKCCNHPYLFQ-------------------- 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   462 cgfGHDPSKDYFvtSSEHQasktklkgfrassilnrinlddFKTSTKIEALREEIRFMVERDwsAKAIVFSQFTSFLDLI 541
Cdd:PLN03142  453 ---GAEPGPPYT--TGEHL----------------------VENSGKMVLLDKLLPKLKERD--SRVLIFSQMTRLLDIL 503

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   542 S-YALGKSGVSCvQLVGSMSKAAKDAALKNF-KEEPDCRVLLMSLQAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIH 619
Cdd:PLN03142  504 EdYLMYRGYQYC-RIDGNTGGEDRDASIDAFnKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAH 582

                         490       500       510
                  ....*....|....*....|....*....|
gi 15217826   620 RIGQCKPVRVVRFIMEKTVEEKILTLQKKK 649
Cdd:PLN03142  583 RIGQKKEVQVFRFCTEYTIEEKVIERAYKK 612
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 134-323 1.64e-32

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 125.54  E-value: 1.64e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWatiqeLSAVRG----GILADEMGMGKTIQAISlVLARREVDRAKSREAVGH-TLVLVPPVALSQWLDEI 208
Cdd:cd17999   1 LRPYQQEGINW-----LAFLNKynlhGILCDDMGLGKTLQTLC-ILASDHHKRANSFNSENLpSLVVCPPTLVGHWVAEI 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 209 SRLTSPGSTRVLQYHGP--KRDKNVQKLMNYDFVLTTSPIVENEYRKdegvdetmspLHSIKWNRIIVDEAHDIKNRSSR 286
Cdd:cd17999  75 KKYFPNAFLKPLAYVGPpqERRRLREQGEKHNVIVASYDVLRNDIEV----------LTKIEWNYCVLDEGHIIKNSKTK 144

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 15217826 287 TAKAVFALEATYRWALSGTPLQNDVDELYSLvsYSFL 323
Cdd:cd17999 145 LSKAVKQLKANHRLILSGTPIQNNVLELWSL--FDFL 179
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 134-317 2.36e-31

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 122.49  E-value: 2.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKE---FLAWatiqELSAVRGGILADEMGMGKTIQAISLVLA--------------RREVDRAKSREAVGHT-LVL 195
Cdd:cd18005   1 LRDYQREgveFMYD----LYKNGRGGILGDDMGLGKTVQVIAFLAAvlgktgtrrdrennRPRFKKKPPASSAKKPvLIV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 196 VPPVALSQWLDEISRLtspGSTRVLQYHGPKRDKNVQ---KLMNYDFVLTTspivENEYRKDegVDEtmspLHSIKWNRI 272
Cdd:cd18005  77 APLSVLYNWKDELDTW---GHFEVGVYHGSRKDDELEgrlKAGRLEVVVTT----YDTLRRC--IDS----LNSINWSAV 143

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15217826 273 IVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSL 317
Cdd:cd18005 144 IADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCL 188
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 134-317 3.71e-31

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 121.71  E-value: 3.71e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWatIQEL-SAVRGGILADEMGMGKTIQAISLV--LARREvdraksreAVGHTLVLVPPVALSQWLDEISR 210
Cdd:cd18001   1 LYPHQREGVAW--LWSLhDGGKGGILADDMGLGKTVQICAFLsgMFDSG--------LIKSVLVVMPTSLIPHWVKEFAK 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 211 LTsPGsTRVLQYHGPK---RDKNVQKLMN-YDFVLTTSPIVEN--EYRKDEGVDEtmsplhsIKWNRIIVDEAHDIKNRS 284
Cdd:cd18001  71 WT-PG-LRVKVFHGTSkkeRERNLERIQRgGGVLLTTYGMVLSntEQLSADDHDE-------FKWDYVILDEGHKIKNSK 141

                       170       180       190
                ....*....|....*....|....*....|...
gi 15217826 285 SRTAKAVFALEATYRWALSGTPLQNDVDELYSL 317
Cdd:cd18001 142 TKSAKSLREIPAKNRIILTGTPIQNNLKELWAL 174
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 134-333 1.69e-30

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 119.80  E-value: 1.69e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAW-ATIQElsavRG--GILADEMGMGKTIQAISLVLARREvdraksREAVGHTLVLVPPVALSQWLDEISR 210
Cdd:cd18009   4 MRPYQLEGMEWlRMLWE----NGinGILADEMGLGKTIQTIALLAHLRE------RGVWGPFLVIAPLSTLPNWVNEFAR 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 211 LTSpgSTRVLQYHGPK--RDKNVQKLMNYDFVLTTSPIVENEYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTA 288
Cdd:cd18009  74 FTP--SVPVLLYHGTKeeRERLRKKIMKREGTLQDFPVVVTSY---EIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLI 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15217826 289 KAVFALEATYRWALSGTPLQNDVDELYSLvsysfLNFF----YSTYASF 333
Cdd:cd18009 149 QELKTFNSDNRLLLTGTPLQNNLSELWSL-----LNFLlpdvFDDLSSF 192
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 137-329 1.23e-27

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 111.26  E-value: 1.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 137 YQKEFLAW-ATIQElsavRG--GILADEMGMGKTIQAISLVLARREVdraksREAVGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd17997   7 YQIRGLNWlISLFE----NGinGILADEMGLGKTLQTISLLGYLKHY-----KNINGPHLIIVPKSTLDNWMREFKRWCP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pgSTRVLQYHGPKRDKN--VQKLM---NYDFVLTTSPIVENEyrkdegvdetMSPLHSIKWNRIIVDEAHDIKNRSSRTA 288
Cdd:cd17997  78 --SLRVVVLIGDKEERAdiIRDVLlpgKFDVCITSYEMVIKE----------KTVLKKFNWRYIIIDEAHRIKNEKSKLS 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 15217826 289 KAVFALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYST 329
Cdd:cd17997 146 QIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSS 186
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 134-320 9.54e-27

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 108.68  E-value: 9.54e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWaTIQELSAVRGGILADEMGMGKTIQAISL--VLARREVDRaksreavGHTLVLVPPVALSQWLDEISRL 211
Cdd:cd18006   1 LRPYQLEGVNW-LLQCRAEQHGCILGDEMGLGKTCQTISLlwYLAGRLKLL-------GPFLVLCPLSVLDNWKEELNRF 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 212 TSpgSTRVLQYHGPKRD-----KNVQKLMNYDFVLTTSPIVeneyRKDEgvdetmSPLHSIKWNRIIVDEAHDIKNRSSR 286
Cdd:cd18006  73 AP--DLSVITYMGDKEKrldlqQDIKSTNRFHVLLTTYEIC----LKDA------SFLKSFPWASLVVDEAHRLKNQNSL 140

                       170       180       190
                ....*....|....*....|....*....|....
gi 15217826 287 TAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18006 141 LHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSF 174
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 156-325 3.00e-26

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 107.45  E-value: 3.00e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 156 GILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEISRLtSPgSTRVLQYHGPK--RDKNVQK 233
Cdd:cd17996  25 GILADEMGLGKTIQTISLITYLMEKKKNN-----GPYLVIVPLSTLSNWVSEFEKW-AP-SVSKIVYKGTPdvRKKLQSQ 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 234 L--MNYDFVLTTSpivenEY-RKDEGVdetmspLHSIKWNRIIVDEAHDIKNRSSRTAKAV-FALEATYRWALSGTPLQN 309
Cdd:cd17996  98 IraGKFNVLLTTY-----EYiIKDKPL------LSKIKWKYMIIDEGHRMKNAQSKLTQTLnTYYHARYRLLLTGTPLQN 166

                       170
                ....*....|....*.
gi 15217826 310 DVDELYSLvsysfLNF 325
Cdd:cd17996 167 NLPELWAL-----LNF 177
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 134-322 3.77e-26

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 105.87  E-value: 3.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWatIQELSAVR-GGILADEMGMGKTIQAISLVLARREvdrakSREAVGHTLVLVPPVALSQWLDEISR-- 210
Cdd:cd18000   1 LFKYQQTGVQW--LWELHCQRvGGILGDEMGLGKTIQIIAFLAALHH-----SKLGLGPSLIVCPATVLKQWVKEFHRww 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 211 -------LTSPGSTRVLQYHGPKRDKNVQKLmnyDFVLTTSPIVENEYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNR 283
Cdd:cd18000  74 ppfrvvvLHSSGSGTGSEEKLGSIERKSQLI---RKVVGDGGILITTY---EGFRKHKDLLLNHNWQYVILDEGHKIRNP 147

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15217826 284 SSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSYSF 322
Cdd:cd18000 148 DAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVF 186
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 134-320 6.07e-26

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 105.16  E-value: 6.07e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATI---QELSavrgGILADEMGMGKTIQAISLVLARREVDRAksreavGHTLVLVPPVALSQWLDEISR 210
Cdd:cd17998   1 LKDYQLIGLNWLNLlyqKKLS----GILADEMGLGKTIQVIAFLAYLKEIGIP------GPHLVVVPSSTLDNWLREFKR 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 211 LTSpgSTRVLQYHGPK------RDKNVQKLMNYDFVLTTspiveneYRKDEGVDETMSPLHSIKWNRIIVDEAHDIKNRS 284
Cdd:cd17998  71 WCP--SLKVEPYYGSQeerkhlRYDILKGLEDFDVIVTT-------YNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMT 141

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15217826 285 SRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd17998 142 SERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNF 177
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 137-325 9.85e-26

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 105.79  E-value: 9.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 137 YQKEFLAWaTIQELSAVRGGILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEISRLTspgS 216
Cdd:cd17995   4 YQLEGVNW-LLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIR-----GPFLVIAPLSTIPNWQREFETWT---D 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 217 TRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKD------EGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKA 290
Cdd:cd17995  75 MNVVVYHGSGESRQIIQQYEMYFKDAQGRKKKGVYKFDvlittyEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQG 154

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15217826 291 VFALEATYRWALSGTPLQNDVDELYSLvsysfLNF 325
Cdd:cd17995 155 LKKLTLEHKLLLTGTPLQNNTEELWSL-----LNF 184
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 154-324 1.81e-24

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 102.75  E-value: 1.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 154 RGGILADEMGMGKTIQAISLV---LARREVDRAKSREAVghtlvLVPPVAL-SQWLDEISRLTSPGSTRVLQYHGpkRDK 229
Cdd:cd18004  25 GGAILADEMGLGKTLQAIALVwtlLKQGPYGKPTAKKAL-----IVCPSSLvGNWKAEFDKWLGLRRIKVVTADG--NAK 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 230 NVQKLMNYDFVLTTSPIVENEYRKDEGVDETMSPLHSIkwNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQN 309
Cdd:cd18004  98 DVKASLDFFSSASTYPVLIISYETLRRHAEKLSKKISI--DLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQN 175

                       170
                ....*....|....*
gi 15217826 310 DVDELYSLVsySFLN 324
Cdd:cd18004 176 DLDEFFALV--DFVN 188
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 134-318 1.63e-23

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 99.35  E-value: 1.63e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAW-ATIQELSAvrGGILADEMGMGKTIQAISLvLARRevdrAKSREAVGHTLVLVPPVALSQWLDEISRLt 212
Cdd:cd18003   1 LREYQHIGLDWlATLYEKNL--NGILADEMGLGKTIQTIAL-LAHL----ACEKGNWGPHLIVVPTSVMLNWEMEFKRW- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 213 SPGsTRVLQYHGPK--RDKNVQKLMNYD--FVLTTSpiveneYRKdegVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTA 288
Cdd:cd18003  73 CPG-FKILTYYGSAkeRKLKRQGWMKPNsfHVCITS------YQL---VVQDHQVFKRKKWKYLILDEAHNIKNFKSQRW 142

                       170       180       190
                ....*....|....*....|....*....|
gi 15217826 289 KAVFALEATYRWALSGTPLQNDVDELYSLV 318
Cdd:cd18003 143 QTLLNFNTQRRLLLTGTPLQNSLMELWSLM 172
DEXDc smart00487
DEAD-like helicases superfamily;
130-319 6.04e-23

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 97.18  E-value: 6.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826    130 LIIPLLKYQKEFLAWAtiqeLSAVRGGILADEMGMGKTIQAISLVLarrevdRAKSREAVGHTLVLVPPVAL-SQWLDEI 208
Cdd:smart00487   5 GFEPLRPYQKEAIEAL----LSGLRDVILAAPTGSGKTLAALLPAL------EALKRGKGGRVLVLVPTRELaEQWAEEL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826    209 SRLTSP-GSTRVLQYHGPKRDKNVQKLMN--YDFVLTTSPIVENEYRKDegvdetmsPLHSIKWNRIIVDEAHDIKN--R 283
Cdd:smart00487  75 KKLGPSlGLKVVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND--------KLSLSNVDLVILDEAHRLLDggF 146

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 15217826    284 SSRTAKAVFALE-ATYRWALSGTPLQNDVDELYSLVS 319
Cdd:smart00487 147 GDQLEKLLKLLPkNVQLLLLSATPPEEIENLLELFLN 183
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 508-622 3.06e-22

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 91.89  E-value: 3.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   508 KIEALREEIRFMVERdwsaKAIVFSQFTSFLDlISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEpDCRVLLmSLQAG 587
Cdd:pfam00271   2 KLEALLELLKKERGG----KVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-ATDVA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15217826   588 GVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIG 622
Cdd:pfam00271  75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 156-320 6.83e-22

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 94.73  E-value: 6.83e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 156 GILADEMGMGKTIQAISLVLARRevdraKSREAVGHTLVLVPPVALSQWLDEIsRLTSPGsTRVLQYHGPKRDKNV---- 231
Cdd:cd17993  23 GILADEMGLGKTVQTISFLSYLF-----HSQQQYGPFLVVVPLSTMPAWQREF-AKWAPD-MNVIVYLGDIKSRDTirey 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 232 ------QKLMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGT 305
Cdd:cd17993  96 efyfsqTKKLKFNVLLTTYEII----LKDKAF------LGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGT 165

                       170
                ....*....|....*
gi 15217826 306 PLQNDVDELYSLVSY 320
Cdd:cd17993 166 PLQNSLKELWALLHF 180
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 134-328 1.86e-20

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 90.64  E-value: 1.86e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAW-ATIQELSAvrGGILADEMGMGKTIQAISlVLARRevdrAKSREAVGHTLVLVPPVALSQWLDEISRLT 212
Cdd:cd18002   1 LKEYQLKGLNWlANLYEQGI--NGILADEMGLGKTVQSIA-VLAHL----AEEHNIWGPFLVIAPASTLHNWQQEISRFV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 213 SpgSTRVLQYHGPKRDKNV------QKLMNYD-----FVLTTSPIVENEYRKdegvdetmspLHSIKWNRIIVDEAHDIK 281
Cdd:cd18002  74 P--QFKVLPYWGNPKDRKVlrkfwdRKNLYTRdapfhVVITSYQLVVQDEKY----------FQRVKWQYMVLDEAQAIK 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15217826 282 NRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18002 142 SSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDS 188
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 133-328 1.57e-19

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 88.15  E-value: 1.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 133 PLLKYQKEFLAWATIQELSAVRGgILADEMGMGKTIQAISLVLARREVdraksREAVGHTLVLVPPVALSQWLDEISRLT 212
Cdd:cd18065  15 TLRDYQVRGLNWMISLYENGVNG-ILADEMGLGKTLQTIALLGYLKHY-----RNIPGPHMVLVPKSTLHNWMNEFKRWV 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 213 SpgSTRVLQYHGpkrDKNVQKLMNYDFVLTTS-PIVENEYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAV 291
Cdd:cd18065  89 P--SLRAVCLIG---DKDARAAFIRDVMMPGEwDVCVTSY---EMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 15217826 292 FALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18065 161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNS 197
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 151-320 2.12e-19

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 87.73  E-value: 2.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 151 SAVRGGILADEMGMGKTIQAISLVLArreVDRAKSREAvgHTLVLVPPVALSQWLDEISRLTSPGSTRVLQYHGPKRDKN 230
Cdd:cd18007  24 DEGGGCILAHTMGLGKTLQVITFLHT---YLAAAPRRS--RPLVLCPASTLYNWEDEFKKWLPPDLRPLLVLVSLSASKR 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 231 VQK---------------LMNYD-FVLTTSPIVENEYRKDEGVDETMSPLHSIkwnrIIVDEAHDIKNRSSRTAKAVFAL 294
Cdd:cd18007  99 ADArlrkinkwhkeggvlLIGYElFRNLASNATTDPRLKQEFIAALLDPGPDL----LVLDEGHRLKNEKSQLSKALSKV 174

                       170       180
                ....*....|....*....|....*.
gi 15217826 295 EATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18007 175 KTKRRILLTGTPLQNNLKEYWTMVDF 200
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 155-320 2.88e-19

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 87.59  E-value: 2.88e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 155 GGILADEMGMGKTIQAISLV--LARREVDRAKSreAVGHTLVLVPPVALSQWLDEISRLTspGSTRVlQYHGPKRDKNVQ 232
Cdd:cd18066  26 GAILADEMGLGKTLQCISLIwtLLRQGPYGGKP--VIKRALIVTPGSLVKNWKKEFQKWL--GSERI-KVFTVDQDHKVE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 233 KLMNYDF--VLTTSpiveneYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQND 310
Cdd:cd18066 101 EFIASPLysVLIIS------Y---EMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQND 171

                       170
                ....*....|
gi 15217826 311 VDELYSLVSY 320
Cdd:cd18066 172 LQEFFALIDF 181
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 134-320 8.19e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 85.88  E-value: 8.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAvRGGILADEMGMGKTIQAISLVlarREVDRAKSReavGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd18060   1 LREYQLEGVNWLLFNWYNR-QNCILADEMGLGKTIQSIAFL---QEVYNVGIH---GPFLVIAPLSTITNWEREFNTWTE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pgsTRVLQYHGPKRDKnvQKLMNYDFVLTTSP--IVENEYRKD------EGVDETMSPLHSIKWNRIIVDEAHDIKNRSS 285
Cdd:cd18060  74 ---MNTIVYHGSLASR--QMIQQYEMYCKDSRgrLIPGAYKFDalittfEMILSDCPELREIEWRCVIIDEAHRLKNRNC 148

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15217826 286 RTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18060 149 KLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHF 183
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 134-328 9.09e-19

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 86.26  E-value: 9.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAVrGGILADEMGMGKTIQAISLVLARREVdraksREAVGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd18064  16 LRDYQVRGLNWLISLYENGI-NGILADEMGLGKTLQTISLLGYMKHY-----RNIPGPHMVLVPKSTLHNWMAEFKRWVP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 PGSTRVLQYHGPKRDKNVQKLM---NYDFVLTTSPIVENEyrkdegvdetMSPLHSIKWNRIIVDEAHDIKNRSSRTAKA 290
Cdd:cd18064  90 TLRAVCLIGDKDQRAAFVRDVLlpgEWDVCVTSYEMLIKE----------KSVFKKFNWRYLVIDEAHRIKNEKSKLSEI 159

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15217826 291 VFALEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18064 160 VREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNS 197
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 132-320 6.48e-18

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 83.52  E-value: 6.48e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 132 IPLLKYQKEFLAWATiQELSAVRGGILADEMGMGKTIQAISLVLARREvdrakSREAVGHTLVLVPPVALSQWLDEISrL 211
Cdd:cd18054  19 LELRDYQLEGLNWLA-HSWCKNNSVILADEMGLGKTIQTISFLSYLFH-----QHQLYGPFLLVVPLSTLTSWQREFE-I 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 212 TSPgSTRVLQYHGPKRDKNV----------QKLMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAHDIK 281
Cdd:cd18054  92 WAP-EINVVVYIGDLMSRNTireyewihsqTKRLKFNALITTYEIL----LKDKTV------LGSINWAFLGVDEAHRLK 160

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15217826 282 NRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18054 161 NDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF 199
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 134-320 1.51e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 82.00  E-value: 1.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAvRGGILADEMGMGKTIQAISLVLarrevdRAKSREAVGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd18059   1 LREYQLEGVNWLLFNWYNT-RNCILADEMGLGKTIQSITFLY------EIYLKGIHGPFLVIAPLSTIPNWEREFRTWTE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pgsTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYR------KDEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRT 287
Cdd:cd18059  74 ---LNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKfhaiitTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKL 150

                       170       180       190
                ....*....|....*....|....*....|...
gi 15217826 288 AKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18059 151 LEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHF 183
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 134-320 2.07e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 81.63  E-value: 2.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAvRGGILADEMGMGKTIQAISLVlarREVDRAKSReavGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd18058   1 LREYQLEGMNWLLFNWYNR-KNCILADEMGLGKTIQSITFL---SEIFLMGIR---GPFLIIAPLSTITNWEREFRTWTE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pgsTRVLQYHGPKRDKnvQKLMNYDFVLTTSP--IVENEYrKDEGVDETMS-------PLHSIKWNRIIVDEAHDIKNRS 284
Cdd:cd18058  74 ---MNAIVYHGSQISR--QMIQQYEMYYRDEQgnPLSGIF-KFQVVITTFEmiladcpELKKINWSCVIIDEAHRLKNRN 147

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15217826 285 SRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18058 148 CKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNF 183
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 134-319 9.76e-17

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 79.26  E-value: 9.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLawatiqeLSAVRGG----ILADEMGMGKTIQA---ISLVLARREVDRAksreavghtLVLVPPVALSQWLD 206
Cdd:cd18011   1 PLPHQIDAV-------LRALRKPpvrlLLADEVGLGKTIEAgliIKELLLRGDAKRV---------LILCPASLVEQWQD 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 207 EISRLTSPGSTRVlqyhgpkRDKNVQKLMN-YDFVLTTSPIVENEYRKDEGVDETMSPLHSIKWNRIIVDEAHDIKNR-- 283
Cdd:cd18011  65 ELQDKFGLPFLIL-------DRETAAQLRRlIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSgg 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15217826 284 --SSRTAKAVFAL--EATYRWALSGTPLQNDVDELYSLVS 319
Cdd:cd18011 138 gkETKRYKLGRLLakRARHVLLLTATPHNGKEEDFRALLS 177
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 134-320 1.35e-16

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 79.28  E-value: 1.35e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWATIQELSAvRGGILADEMGMGKTIQAISLVlarREVDRAKSReavGHTLVLVPPVALSQWLDEISRLTS 213
Cdd:cd18061   1 LREYQLEGLNWLLFNWYNR-RNCILADEMGLGKTIQSITFL---YEILLTGIR---GPFLIIAPLSTIANWEREFRTWTD 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 pgsTRVLQYHGPKRDKnvQKLMNYDFVLTTSP--IVENEYRKD------EGVDETMSPLHSIKWNRIIVDEAHDIKNRSS 285
Cdd:cd18061  74 ---LNVVVYHGSLISR--QMIQQYEMYFRDSQgrIIRGAYRFQaiittfEMILGGCPELNAIDWRCVIIDEAHRLKNKNC 148

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15217826 286 RTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18061 149 KLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHF 183
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 155-321 6.61e-16

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 77.90  E-value: 6.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 155 GGILADEMGMGKTIQAISLV--------LARREVDRAksreavghtLVLVPPVALSQWLDEISRLTSPGSTrVLQYHGPK 226
Cdd:cd18067  26 GCIMADEMGLGKTLQCITLMwtllrqspQCKPEIDKA---------IVVSPSSLVKNWANELGKWLGGRLQ-PLAIDGGS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 227 RDKNVQKL---MNYDFVLTTSPIVENEYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALS 303
Cdd:cd18067  96 KKEIDRKLvqwASQQGRRVSTPVLIISY---ETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLS 172

                       170
                ....*....|....*...
gi 15217826 304 GTPLQNDVDELYSLVSYS 321
Cdd:cd18067 173 GTPIQNDLSEYFSLVNFV 190
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 134-325 8.11e-16

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 76.32  E-value: 8.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtiqELSAVRG--GILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEIsRL 211
Cdd:cd17994   1 LHPYQLEGLNWL---RFSWAQGtdTILADEMGLGKTIQTIVFLYSLYKEGHSK-----GPFLVSAPLSTIINWEREF-EM 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 212 TSPgSTRVLQYHGpkrdknvqklmnyDFVLTTSpiveneYrkdEGVDETMSPLHSIKWNRIIVDEAHDIKNRSSRTAKAV 291
Cdd:cd17994  72 WAP-DFYVVTYVG-------------DHVLLTS------Y---ELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRIL 128

                       170       180       190
                ....*....|....*....|....*....|....
gi 15217826 292 FALEATYRWALSGTPLQNDVDELYSLvsysfLNF 325
Cdd:cd17994 129 NSYKIGYKLLLTGTPLQNNLEELFHL-----LNF 157
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 120-328 1.45e-15

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 77.03  E-value: 1.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 120 IAEAAEQPLDLII--PLLKYQKEFLAWaTIQELSAVRGGILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVP 197
Cdd:cd18063   8 ITERVEKQSSLLIngTLKHYQLQGLEW-MVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLN-----GPYLIIVP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 198 PVALSQWLDEISRLtSPGSTRVLQYHGPKRDKNVQKLM---NYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIV 274
Cdd:cd18063  82 LSTLSNWTYEFDKW-APSVVKISYKGTPAMRRSLVPQLrsgKFNVLLTTYEYI----IKDKHI------LAKIRWKYMIV 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15217826 275 DEAHDIKNRSSRTAKAVFA-LEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18063 151 DEGHRMKNHHCKLTQVLNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKS 205
HELICc smart00490
helicase superfamily c-terminal domain;
539-622 3.94e-15

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 70.70  E-value: 3.94e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826    539 DLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEPdcRVLLMSLQAGGVALNLTAASHVFMMDPWWNPAVERQAQDRI 618
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78


                   ....
gi 15217826    619 HRIG 622
Cdd:smart00490  79 GRAG 82
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 134-306 4.95e-15

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 74.55  E-value: 4.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtIQelsavRGG--ILADEMGMGKTIQAISLVLARREvdraksreaVGHTLVLVPPVALSQWLDEISR- 210
Cdd:cd18010   1 LLPFQREGVCFA-LR-----RGGrvLIADEMGLGKTVQAIAIAAYYRE---------EWPLLIVCPSSLRLTWADEIERw 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 211 LTSPGSTRVLQYHGPKRDKNVqklMNYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAHDIKNRSSRTAKA 290
Cdd:cd18010  66 LPSLPPDDIQVIVKSKDGLRD---GDAKVVIVSYDLL----RRLEKQ------LLARKFKVVICDESHYLKNSKAKRTKA 132

                       170
                ....*....|....*...
gi 15217826 291 VFAL--EATYRWALSGTP 306
Cdd:cd18010 133 ALPLlkRAKRVILLSGTP 150
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 134-328 1.34e-14

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 74.31  E-value: 1.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWaTIQELSAVRGGILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEISRLtS 213
Cdd:cd18062  24 LKQYQIKGLEW-LVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRIN-----GPFLIIVPLSTLSNWVYEFDKW-A 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 PGSTRVLQYHGPKRDKNVQKLM---NYDFVLTTSPIVeneyRKDEGVdetmspLHSIKWNRIIVDEAHDIKNRSSRTAKA 290
Cdd:cd18062  97 PSVVKVSYKGSPAARRAFVPQLrsgKFNVLLTTYEYI----IKDKQI------LAKIRWKYMIVDEGHRMKNHHCKLTQV 166

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15217826 291 VFA-LEATYRWALSGTPLQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18062 167 LNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKS 205
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 157-328 2.45e-14

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 73.16  E-value: 2.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 157 ILADEMGMGKTIQAISLVLARREvdrakSREAVGHTLVLVPPVALSQWLDEIsRLTSPgSTRVLQYHGPKRDKNV----- 231
Cdd:cd18053  43 ILADEMGLGKTIQTISFLNYLFH-----EHQLYGPFLLVVPLSTLTSWQREI-QTWAP-QMNAVVYLGDINSRNMirthe 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 232 -----QKLMNYDFVLTTSPIVeneyRKDEgvdetmSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTP 306
Cdd:cd18053 116 wmhpqTKRLKFNILLTTYEIL----LKDK------SFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTP 185

                       170       180
                ....*....|....*....|..
gi 15217826 307 LQNDVDELYSLVSYSFLNFFYS 328
Cdd:cd18053 186 LQNSLKELWSLLHFIMPEKFSS 207
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 134-320 3.70e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 69.32  E-value: 3.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtiqELSAVRGG--ILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEIsRL 211
Cdd:cd18057   1 LHPYQLEGLNWL---RFSWAQGTdtILADEMGLGKTVQTIVFLYSLYKEGHSK-----GPYLVSAPLSTIINWEREF-EM 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 212 TSPgSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYR-KDEG---------------VDETMspLHSIKWNRIIVD 275
Cdd:cd18057  72 WAP-DFYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFRmKKEAqikfhvlltsyelitIDQAI--LGSIEWACLVVD 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15217826 276 EAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18057 149 EAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNF 193
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 137-320 3.57e-12

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 66.57  E-value: 3.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 137 YQKEFLAWAtiqELSAVRGG--ILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEIsRLTSP 214
Cdd:cd18055   4 YQLEGLNWL---RFSWAQGTdtILADEMGLGKTIQTIVFLYSLYKEGHTK-----GPFLVSAPLSTIINWEREF-QMWAP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 215 gSTRVLQYHGPKRDKNVQKLMNYDFVLTTSPIVENEYRKD--------------EGVDETMSPLHSIKWNRIIVDEAHDI 280
Cdd:cd18055  75 -DFYVVTYTGDKDSRAIIRENEFSFDDNAVKGGKKAFKMKreaqvkfhvlltsyELVTIDQAALGSIRWACLVVDEAHRL 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15217826 281 KNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18055 154 KNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNF 193
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 141-320 1.26e-11

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 64.84  E-value: 1.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 141 FLAWATIQELSAVR-----GGILADEMGMGKTIQAISLVLARREVDRAKSreavghTLVLVPPVALSQWLDEISRLTSPG 215
Cdd:cd18069  11 FLYDNIIESLERYKgssgfGCILAHSMGLGKTLQVISFLDVLLRHTGAKT------VLAIVPVNTLQNWLSEFNKWLPPP 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 216 STRvlqyhGPKRDKNVQKLMNYDFVLTTSPIVE--NEYRKDEGVdetMSPLHSIKWNR-----IIVDEAHDIKNRSSRTA 288
Cdd:cd18069  85 EAL-----PNVRPRPFKVFILNDEHKTTAARAKviEDWVKDGGV---LLMGYEMFRLRpgpdvVICDEGHRIKNCHASTS 156

                       170       180       190
                ....*....|....*....|....*....|..
gi 15217826 289 KAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18069 157 QALKNIRSRRRIVLTGYPLQNNLIEYWCMVDF 188
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 155-336 1.29e-11

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 65.29  E-value: 1.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 155 GGILADEMGMGKTIQAISLVlarREVDRAKSREAVGHTLVLVPPVALSQWLDE------------------ISRLTSPgS 216
Cdd:cd18068  30 GCILAHCMGLGKTLQVVTFL---HTVLLCEKLENFSRVLVVCPLNTVLNWLNEfekwqeglkdeekievneLATYKRP-Q 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 217 TRVLQYHGPKRDKNVQkLMNYDF--VLTtspiVENEYRKDEGVDET-MSPLHSIKWNRIIVDEAHDIKNRSSRTAKAVFA 293
Cdd:cd18068 106 ERSYKLQRWQEEGGVM-IIGYDMyrILA----QERNVKSREKLKEIfNKALVDPGPDFVVCDEGHILKNEASAVSKAMNS 180

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 15217826 294 LEATYRWALSGTPLQNDVDELYSLVSYSFLNFFySTYASFAFR 336
Cdd:cd18068 181 IRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLL-GTIKEFRNR 222
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 134-320 5.84e-11

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 63.16  E-value: 5.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 134 LLKYQKEFLAWAtiqELSAVRGG--ILADEMGMGKTIQAISLVLARREVDRAKsreavGHTLVLVPPVALSQWLDEIsRL 211
Cdd:cd18056   1 LHPYQLEGLNWL---RFSWAQGTdtILADEMGLGKTVQTAVFLYSLYKEGHSK-----GPFLVSAPLSTIINWEREF-EM 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 212 TSPgSTRVLQYHGPKRDKNVQKLMNYDF-----------------------VLTTSPiveneyrkdEGVDETMSPLHSIK 268
Cdd:cd18056  72 WAP-DMYVVTYVGDKDSRAIIRENEFSFednairggkkasrmkkeasvkfhVLLTSY---------ELITIDMAILGSID 141

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15217826 269 WNRIIVDEAHDIKNRSSRTAKAVFALEATYRWALSGTPLQNDVDELYSLVSY 320
Cdd:cd18056 142 WACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNF 193
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 137-306 2.50e-09

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 56.16  E-value: 2.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 137 YQKEFL--AWATIQElsavRGGILADEMGMGKTIQAISLVLARREvdraksreavGHTLVLVPPVAL-SQWLDEISRLTS 213
Cdd:cd17926   4 YQEEALeaWLAHKNN----RRGILVLPTGSGKTLTALALIAYLKE----------LRTLIVVPTDALlDQWKERFEDFLG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 214 PGSTRVLQYhGPKRDKNVQKLmnydfVLTTspiveneYRKDEGVDETMSPLHSiKWNRIIVDEAHDIknrSSRTAKAVFA 293
Cdd:cd17926  70 DSSIGLIGG-GKKKDFDDANV-----VVAT-------YQSLSNLAEEEKDLFD-QFGLLIVDEAHHL---PAKTFSEILK 132

                       170
                ....*....|....
gi 15217826 294 -LEATYRWALSGTP 306
Cdd:cd17926 133 eLNAKYRLGLTATP 146
ResIII pfam04851
Type III restriction enzyme, res subunit;
131-306 1.36e-08

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 54.60  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   131 IIPLLKYQKEFLAwATIQELSAV-RGGILADEMGMGKTIQAISLVlarrevDRAKSREAVGHTLVLVPPVAL-SQWLDEI 208
Cdd:pfam04851   1 KLELRPYQIEAIE-NLLESIKNGqKRGLIVMATGSGKTLTAAKLI------ARLFKKGPIKKVLFLVPRKDLlEQALEEF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   209 SRLTSPGSTRVLQYHGpkrDKNVQKLMNYDFVLTTspiVENEYRKDEGVDETMSPLHsikWNRIIVDEAHdiknRSSRTA 288
Cdd:pfam04851  74 KKFLPNYVEIGEIISG---DKKDESVDDNKIVVTT---IQSLYKALELASLELLPDF---FDVIIIDEAH----RSGASS 140

                         170       180
                  ....*....|....*....|
gi 15217826   289 -KAVF-ALEATYRWALSGTP 306
Cdd:pfam04851 141 yRNILeYFKPAFLLGLTATP 160
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 136-316 8.62e-07

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 50.43  E-value: 8.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 136 KYQKEFLAWAtiqeLSAVRGGILADeMGMGKTIQAISLVLARREVDRaksreaVGHTLVLVP-PVALSQWLDEISRLTSP 214
Cdd:cd18013   3 PYQKVAINFI----IEHPYCGLFLD-MGLGKTVTTLTALSDLQLDDF------TRRVLVIAPlRVARSTWPDEVEKWNHL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 215 GSTRVLQYHGPKRDKNvqKLMNYDFVLTTSPIvENEYRKDEGVDETMSplhsikWNRIIVDEAHDIKNRSSRTAKAVFAL 294
Cdd:cd18013  72 RNLTVSVAVGTERQRS--KAANTPADLYVINR-ENLKWLVNKSGDPWP------FDMVVIDELSSFKSPRSKRFKALRKV 142

                       170       180
                ....*....|....*....|....
gi 15217826 295 EATYRW--ALSGTPLQNDVDELYS 316
Cdd:cd18013 143 RPVIKRliGLTGTPSPNGLMDLWA 166
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 527-622 7.23e-06

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 45.96  E-value: 7.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 527 KAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKDAALKNFKEEpDCRVLLmslqAGGVA---LNLTAASHVFMMD 603
Cdd:cd18787  29 KAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSG-KVRVLV----ATDVAargLDIPGVDHVINYD 103

                        90
                ....*....|....*....
gi 15217826 604 PwwnPaveRQAQDRIHRIG 622
Cdd:cd18787 104 L---P---RDAEDYVHRIG 116
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 163-280 5.00e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 44.16  E-value: 5.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826   163 GMGKTIQAISLVLARREVDRAKSReavghTLVLVPPVALS-QWLDEISRLTSPGSTRV-LQYHGPKRDKNVQKLMNYDFV 240
Cdd:pfam00270  24 GSGKTLAFLLPALEALDKLDNGPQ-----ALVLAPTRELAeQIYEELKKLGKGLGLKVaSLLGGDSRKEQLEKLKGPDIL 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15217826   241 LTTSPIVENEYRKDEGvdetmspLHSIKWnrIIVDEAHDI 280
Cdd:pfam00270  99 VGTPGRLLDLLQERKL-------LKNLKL--LVLDEAHRL 129
DpdE NF041062
protein DpdE;
158-209 1.11e-04

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 45.73  E-value: 1.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15217826   158 LADEMGMGKTIQAiSLVLarREV--DRAKSReavghTLVLVPPVALSQWLDEIS 209
Cdd:NF041062  175 LADEVGLGKTIEA-GLVI--RQHllDNPDAR-----VLVLVPDALVRQWRRELR 220
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 155-280 2.03e-04

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 42.01  E-value: 2.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 155 GGILADEMGMGKTIQAiSLVLARREVDRAKSreavghTLVLVPPVAL-SQWLDEISRLTSPG-STRVLQYHGPKRDKNVQ 232
Cdd:cd00046   3 NVLITAPTGSGKTLAA-LLAALLLLLKKGKK------VLVLVPTKALaLQTAERLRELFGPGiRVAVLVGGSSAEEREKN 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15217826 233 KLMNYDFVLTTSPIVENEYRKDEgvdetmsPLHSIKWNRIIVDEAHDI 280
Cdd:cd00046  76 KLGDADIIIATPDMLLNLLLRED-------RLFLKDLKLIIVDEAHAL 116
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 580-633 1.15e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 38.07  E-value: 1.15e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15217826 580 LLMSLQAGGVALNLTAASHVFMMDPWWNPAVERQAQDRIHRIGQcKPVRVVRFI 633
Cdd:cd18785  25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGK-DEGEVILFV 77
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
 154-278 1.29e-03

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 39.98  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826 154 RGGILADEMGMGKTIQAISLVLarrevdRAKSReavghTLVLVPP-VALSQWLDEISRLTSPGSTRVLQYHGPKRDKnvq 232
Cdd:cd18029  27 RSGVIVLPCGAGKTLVGITAAC------TIKKS-----TLVLCTSaVSVEQWRRQFLDWTTIDDEQIGRFTSDKKEI--- 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15217826 233 kLMNYDFVLTTSPIVENEYRKDEGVDETMSPLHSIKWNRIIVDEAH 278
Cdd:cd18029  93 -FPEAGVTVSTYSMLANTRKRSPESEKFMEFITEREWGLIILDEVH 137
PRK13766 PRK13766
Hef nuclease; Provisional
 508-675 2.90e-03

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 41.01  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826  508 KIEALREEIRFMVERDWSAKAIVFSQFTSFLDLISYALGKSGVSCVQLVGSMSKAAKD--------AALKNFKEEpDCRV 579
Cdd:PRK13766 348 KLEKLREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDGDKgmsqkeqiEILDKFRAG-EFNV 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217826  580 LLmslqAGGVA---LNLTAASHVFMMDPWwnPAVERQAQdRIHRIGQCKPVRVVRFIMEKTVEEKILTLQKKKEDLFEST 656
Cdd:PRK13766 427 LV----STSVAeegLDIPSVDLVIFYEPV--PSEIRSIQ-RKGRTGRQEEGRVVVLIAKGTRDEAYYWSSRRKEKKMKEE 499

                        170
                 ....*....|....*....
gi 15217826  657 LGDSEEAVVQKLGEDDIKS 675
Cdd:PRK13766 500 LKNLKGILNKKLQELDEEQ 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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