BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  23 HTDVLVKPGEEapPIPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYL 102
Cdd:cd18186   1 LCDVTLVVGGR--EFPAHRAVLAARSPYFRAMFSSG-MKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLA 77

                ....*
gi 15223447 103 AADKY 107
Cdd:cd18186  78 AADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  23 HTDVLVKPGEEapPIPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYL 102
Cdd:cd18186   1 LCDVTLVVGGR--EFPAHRAVLAARSPYFRAMFSSG-MKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLA 77

                ....*
gi 15223447 103 AADKY 107
Cdd:cd18186  78 AADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447     37 IPTHKAVLAARSKVFRNMLDSDECKTSPEEsITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVC 116
Cdd:smart00225  11 FHAHKAVLAAHSPYFKALFSSDFKESDKSE-IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELC 89

                   ....*...
gi 15223447    117 RNHFIASL 124
Cdd:smart00225  90 EEFLLKLL 97

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                        10        20        30
                ....*....|....*....|....*....|...
gi 15223447 128 NVLDILELASIPCDTILKDAAINHIVKHMEEVV 160
Cdd:cd14733   4 NCLGILELADLYNLEELKEKALKFILENFEEVS 36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  23 HTDVLVKPGEEapPIPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYL 102
Cdd:cd18186   1 LCDVTLVVGGR--EFPAHRAVLAARSPYFRAMFSSG-MKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLA 77

                ....*
gi 15223447 103 AADKY 107
Cdd:cd18186  78 AADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447     37 IPTHKAVLAARSKVFRNMLDSDECKTSPEEsITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVC 116
Cdd:smart00225  11 FHAHKAVLAAHSPYFKALFSSDFKESDKSE-IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELC 89

                   ....*...
gi 15223447    117 RNHFIASL 124
Cdd:smart00225  90 EEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447   6 QKAAFLGGLVVSFKEQMHTDVLVKPGEEAppIPTHKAVLAARSKVFRNMLDSDEcKTSPEESITLPDLSHDELKSLLEFL 85
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHE--IPAHRAVLACASPYLFELFSSDS-DGESILTVKLDGLDPDAVEVLVNYA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15223447  86 YSGNLKAPYNQYRSLYLAADKYDISYLQDVCRNHFIASLSSRNVLDI 132
Cdd:cd18306  78 YTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15223447  37 IPTHKAVLAARSKVFRNMLDSDECKTSPEesITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAA 104
Cdd:cd18315  13 LKAHKLVLAAASPYFAALLKETPPDEHPV--IILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  11 LGGLvvsFKEQMHTDV-LVKPGEEappIPTHKAVLAARSKVFRNMLDSdECKTSPEESITLPDLSHDELKSLLEFLYSGn 89
Cdd:cd18279   9 LGNL---WENSRFTDCcLCVGGQE---FQAHKAILAARSPVFSAMFEH-EMEESKKNRVEINDVDPEVFKEMMRFIYTG- 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223447  90 lKAPYNQYRS--LYLAADKYDISYLQDVCRNHFIASLSSRN 128
Cdd:cd18279  81 -KAPNLDKMAddLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15223447  40 HKAVLAARSKVFRNMLdSDECKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVC 116
Cdd:cd18314  21 HRIVLCARSPVFRSML-TGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  18 FKEQMHTDV-LVKPGEEapPIPTHKAVLAARSKVFRNMLdSDECKtspeesITL-PDLSHDELKSLLEFLYSGNLKAPYN 95
Cdd:cd18299   7 LHSPSCADVvFILQGGV--RIFAHRIVLAAASSVFADLF-LMMTV------VTLdSDITPEAFRRVLEFLYTGVLDENED 77

                        90       100
                ....*....|....*....|....
gi 15223447  96 QYRSLYLAADKYDISYLQDVCRNH 119
Cdd:cd18299  78 DLKELKDAAELLELFDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  18 FKEQMHTDV--LVKPGEEAPPIPTHKAVLAARSKVFRNMLDSDECKTSPEesITLPDLSHDELKSLLEFLYSGNLK-APY 94
Cdd:cd18282   2 FNNELMADVhfIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNE--IEIPDVEPAAFLNLLRYLYCDEIDlEPD 79

                        90       100       110
                ....*....|....*....|....*....|
gi 15223447  95 NQYRSLYlAADKYDISYLQDVCRNHFIASL 124
Cdd:cd18282  80 TVLATLY-AAKKYLVPHLARACVQFLETSL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  18 FKEQMHTDVLVKPGEEAppIPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQY 97
Cdd:cd18336  14 LQHKQLCDVLLIAGNLK--IPAHRLVLSAVSDYFAAMFTND-VREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTI 90

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15223447  98 RSLYLAADKYDISYLQDVCRNHFIASLSSRNVLDI 132
Cdd:cd18336  91 ESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  40 HKAVLAARSKVFRNMLDSdECKTSPEESITLPDLSHDELKSLLEFLYSGnlKAPY--NQYRSLYLAADKYDISYLQDVCR 117
Cdd:cd18343  36 HKSILAARSPVFNAMFEH-EMEESKKNRVEINDVDPEVFKEMMRFIYTG--KAPNldKMADNLLAAADKYALERLKVMCE 112

                        90
                ....*....|.
gi 15223447 118 NHFIASLSSRN 128
Cdd:cd18343 113 EALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  30 PGEEAPPIPTHKAVLAARSKVFRNMLDSDECKTSPEesITLPDLSHDELKSLLEFLYSGNLK-APYNQYRSLYlAADKYD 108
Cdd:cd18346  37 PGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE--IELPDVEPAAFLALLRFLYSDEVQiGPETVMTTLY-TAKKYA 113

                        90       100
                ....*....|....*....|
gi 15223447 109 ISYLQDVCRNHFIASLSSRN 128
Cdd:cd18346 114 VPALEAHCVEFLTKHLRADN 133

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447   37 IPTHKAVLAARSKVFRNMLdsdeCKTSPEESITLPDlSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVC 116
Cdd:PHA03098  23 IKVHKIILSSSSEYFKKMF----KNNFKENEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLC 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15223447  117 RNHFIASLSSRNVLDILELASIPCDTILKDAAINHIVKHME 157
Cdd:PHA03098  98 INYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIE 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  33 EAPPIPTHKAVLAARSKVFRNMLDSDECKTSPEEsITLPDLSHDELKSLLEFLYSG---NLKAPYNQYRSLYLAADKYDI 109
Cdd:cd18297  20 EGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPV-IEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLRAASFFQL 98

                ....*....
gi 15223447 110 SYLQDVCRN 118
Cdd:cd18297  99 DGLKRHCEI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  24 TD-VLVKPGEEappIPTHKAVLAARSKVFRNMLDSdECKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYL 102
Cdd:cd18265  24 TDvVLLVDGKD---FPCHRATLSANSAYFRAMFGG-HLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLE 99

                        90
                ....*....|....
gi 15223447 103 AADKYDISYLQDVC 116
Cdd:cd18265 100 ASDLLQVSKLREAC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  37 IPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVC 116
Cdd:cd18271  36 IPCHRCVLAACSDFFRAMFEVN-MKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKAC 114

                        90
                ....*....|....*.
gi 15223447 117 RNHFIASLSSRNVLDI 132
Cdd:cd18271 115 SDFLIKSIDLTNCLQL 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  25 DVLVKPGEEAppIPTHKAVLAARSKVFRNMLDSD--ECKtspEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYL 102
Cdd:cd18238  17 DVTLKVGEKS--IHCHRLVLACVSPYFRAMFTSEmaESK---QDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLY 91

                        90       100
                ....*....|....*....|..
gi 15223447 103 AADKYDISYLQDVC----RNHF 120
Cdd:cd18238  92 AASLLQVEEVAKACcefmKDHL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15223447  37 IPTHKAVLAARSKVFRNMLDSDECKTSPEEsITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKY 107
Cdd:cd01165  10 FHVNKELLAQSSEYFRALFRGGFRESGQAE-INLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  40 HKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVCRNH 119
Cdd:cd18272  47 HRLVLSAQSCFFRSMFTSN-LKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRF 125

                        90
                ....*....|....
gi 15223447 120 FIASLSSRNVLDIL 133
Cdd:cd18272 126 LARTVQVRNCLQVM 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  26 VLVKPGEEappIPTHKAVLAARSKVFRNMLDSDECKTSPE-ESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAA 104
Cdd:cd18245  18 TLVVGGEE---IPVQKNVLAAASPYFRAKLNYNPPKDDGStYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAA 94

                        90
                ....*....|..
gi 15223447 105 DKYDISYLQDVC 116
Cdd:cd18245  95 DLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  24 TDVLVKPGEEAppIPTHKAVLAARSKVFRNMLDSDEcKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLA 103
Cdd:cd18253  19 TDVIICVEGRE--FPCHRAILSACSSYFRAMFCNDH-RESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFET 95

                        90
                ....*....|...
gi 15223447 104 ADKYDISYLQDVC 116
Cdd:cd18253  96 SSLFQISPLRDAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  18 FKEQMHTDVLVKPGEEAppIPTHKAVLAARSKVFRNMLDSDecktspEESITLPDLSHDELKSLLEFLYSG--NLKAPYN 95
Cdd:cd18303  13 FDKELYSDITIKLADKS--IPAHKFVLAARSEKWSNENLAS------TNELDLSDISYEVVLALLRWLYTDelDLTLDDE 84

                        90       100       110
                ....*....|....*....|....*....|...
gi 15223447  96 QYRSLYLAADKYDISYLQDVCRNHFIASLSSRN 128
Cdd:cd18303  85 FLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  19 KEQMHTDVLVKPGeeAPPIPTHKAVLAARSKVFRNMLdSDECKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYR 98
Cdd:cd18250  17 AERKFFDVTLCAG--GREFPCHRTVLAAASSYFRAMF-AGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVE 93

                        90
                ....*....|....*...
gi 15223447  99 SLYLAADKYDISYLQDVC 116
Cdd:cd18250  94 ALLRAADLFQFPSVKEAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  11 LGGLVVSFKEQMHTDVLVKPgEEAPPIPTHKAVLAARSKVFRNMLDSDECKTSPEEsITLPDLSHDELKSLLEFLYSGNL 90
Cdd:cd18274  10 LQQLKAMYDEGQLTDIVVEV-DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE-VRIVGVEAESMHLVLDYAYTSRV 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15223447  91 KAPYNQYRSLYLAADKYDISYLQDVCRNHFIASLSSRNVLDI 132
Cdd:cd18274  88 TLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  18 FKEQMHTDVLVKPgeEAPPIPTHKAVLAARSKVFRNMLDSDECKTspeESITLP--DLSHDELKSLLEFLYSGN-LKAPY 94
Cdd:cd18360   5 FNSPLLADVVFKI--QGTTVPAHRAVLVARCEVMAAMFNGNYAEA---KSFLVPiyGVSKDTFLSFLEYLYTDScCPASI 79

                        90       100       110
                ....*....|....*....|....*....|
gi 15223447  95 NQYRSLYLAADKYDISYLQDVCRNHFIASL 124
Cdd:cd18360  80 LQAMALLICAEMYQVSRLQHICELYIITQL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447  23 HTDV-LVKPGEEappIPTHKAVLAARSKVFRNML-----DSDECKtspeesITLPDLSHDELKSLLEFLYSGNLKapynq 96
Cdd:cd18287  22 YSDVtFVVEEKR---FPAHRVILAARSEYFRALLyggmrESQQSE------IELKDTNAEAFKALLKYIYTGRLT----- 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15223447  97 yrslylaadkydisylqdvcrnhfIASLSSRNVLDILELA 136
Cdd:cd18287  88 ------------------------LTDLKEDVLLDVLGLA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223447   5 EQKAAFLGGLVVSFKEQMHTD-VLVKPGEEappIPTHKAVLAARSKVFRNMLDSDeCKTSPEESITLPDLSHDELKSLLE 83
Cdd:cd18270   8 EYAVSLLEQLKFFYEQQLLTDiVLIVEGTE---FPCHKMVLATCSSYFRAMFMSG-LSESKQTHVHLRNVDAATLQIIIT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15223447  84 FLYSGNLKAPYNQYRSLYLAADKYDISYLQDVCRNHFIASLSSRNVLDIL 133
Cdd:cd18270  84 YAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133