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Conserved domains on  [gi|15147219|ref|NP_150093|]
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transcriptional regulator protein Pur-beta [Homo sapiens]

Protein Classification

Pur family transcription activator( domain architecture ID 12058637)

Pur family transcription activator such as Pur-alpha (PurA), Pur-beta (PurB), and Pur-gamma (PurG), which bind preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 31-279 1.76e-115

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


:

Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 332.18  E-value: 1.76e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219    31 TQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLaagAE 110
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHL---PE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   111 EGggpRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRggggfgagpgPGGLQSGQTIALPAQGLIEFRDALAKLI 190
Cdd:pfam04845  78 DG---SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMR----------GNPRGQRQQIALPAQGMIEFRDALTDLI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   191 DDYGGEDDElaggpgggaggpggGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGG 270
Cdd:pfam04845 145 EDYGEGDEN--------------DIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRD 210


                  ....*....
gi 15147219   271 AFCRYADEM 279
Cdd:pfam04845 211 IFDKYIEKM 219
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 31-279 1.76e-115

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 332.18  E-value: 1.76e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219    31 TQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLaagAE 110
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHL---PE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   111 EGggpRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRggggfgagpgPGGLQSGQTIALPAQGLIEFRDALAKLI 190
Cdd:pfam04845  78 DG---SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMR----------GNPRGQRQQIALPAQGMIEFRDALTDLI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   191 DDYGGEDDElaggpgggaggpggGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGG 270
Cdd:pfam04845 145 EDYGEGDEN--------------DIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRD 210


                  ....*....
gi 15147219   271 AFCRYADEM 279
Cdd:pfam04845 211 IFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 33-95 7.95e-26

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 97.29  E-value: 7.95e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15147219     33 ELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYA 95
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGGRSSITVPEQGAAEFRDALTKLIEKYG 63
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 31-279 1.76e-115

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 332.18  E-value: 1.76e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219    31 TQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLaagAE 110
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHL---PE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   111 EGggpRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRggggfgagpgPGGLQSGQTIALPAQGLIEFRDALAKLI 190
Cdd:pfam04845  78 DG---SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMR----------GNPRGQRQQIALPAQGMIEFRDALTDLI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15147219   191 DDYGGEDDElaggpgggaggpggGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGG 270
Cdd:pfam04845 145 EDYGEGDEN--------------DIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRD 210


                  ....*....
gi 15147219   271 AFCRYADEM 279
Cdd:pfam04845 211 IFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 33-95 7.95e-26

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 97.29  E-value: 7.95e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15147219     33 ELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYA 95
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGGRSSITVPEQGAAEFRDALTKLIEKYG 63
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 119-194 3.96e-20

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 82.27  E-value: 3.96e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15147219    119 LKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGgggfgagpgpgglqSGQTIALPAQGLIEFRDALAKLIDDYG 194
Cdd:smart00712   2 LASKKLTVENKRFYFDVKENRRGRFLRISEVKNNG--------------GRSSITVPEQGAAEFRDALTKLIEKYG 63
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 219-280 2.17e-18

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 77.65  E-value: 2.17e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15147219    219 LPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSY-RNAITVPFKAWGKFGGAFCRYADEMK 280
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGgRSSITVPEQGAAEFRDALTKLIEKYG 63
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 25-92 1.20e-06

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 48.67  E-value: 1.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15147219    25 GGGEQETQELA-SKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAgGSKSRLTLSMAVAAEFRDSLGDFIE 92
Cdd:pfam04845 150 GDENDIPQELPeGTSLTVDNKRFYFDVGSNKRGVFLRISEVKP-NYRNSITVPEKAWTRFRDIFDKYIE 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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