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Conserved domains on  [gi|448824838|ref|NP_116007|]
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mitochondrial import inner membrane translocase subunit Tim22 [Rattus norvegicus]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 family protein( domain architecture ID 10493815)

Tim17/Tim22/Tim23/Pmp24 family protein such as the mitochondrial import inner membrane translocase subunit Tim22, an essential core component of the TIM22 complex, which mediates the insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane

Gene Ontology:  GO:0016020
PubMed:  27760563|33297490

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 67-182 2.77e-31

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


:

Pssm-ID: 460567  Cd Length: 109  Bit Score: 109.57  E-value: 2.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   67 CAFKAVLACVGGFVLGGAFGVFTAGIDTnvgfdPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRG 146
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNR-----PPPLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRG 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 448824838  147 KSDWKNSVISGCITGGAigFRAGVKAGAIGCGGFAA 182
Cdd:pfam02466  76 KEDPWNSIAAGALTGAL--LRGGPRAAAVGGAVGAA 109
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 67-182 2.77e-31

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 109.57  E-value: 2.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   67 CAFKAVLACVGGFVLGGAFGVFTAGIDTnvgfdPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRG 146
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNR-----PPPLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRG 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 448824838  147 KSDWKNSVISGCITGGAigFRAGVKAGAIGCGGFAA 182
Cdd:pfam02466  76 KEDPWNSIAAGALTGAL--LRGGPRAAAVGGAVGAA 109
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 65-192 6.82e-20

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 82.60  E-value: 6.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838  65 ESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKDP--------------YRTPTA---REVLKDMGQRGMSYAKNF 127
Cdd:COG5596   44 YSCIGKSALSGLKGFRLGGPSGGFSSSLAYGTGLVHLLGlnfggvwgglfstiDCTPFRlqlKEQLNNAGKRGFFTGKNL 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 448824838 128 AIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR 192
Cdd:COG5596  124 GVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQAMPMGGAGFAAFSAGITLAMK 188
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 126-176 1.46e-08

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 51.58  E-value: 1.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 448824838 126 NFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAG----VKAGAIG 176
Cdd:PTZ00236  65 NFAIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGwrsaVRNAIFG 119
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 59-178 1.46e-08

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 51.76  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   59 MIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDtnvGF--DPKDPYRTPTAREVLKDMGQRGMsyakNFAIVGAMFSC 136
Cdd:TIGR00980   1 MEEYTREPCPYRILDDFGGAFAMGTIGGSIFQAFK---GFrnSPKGEKLVGAMRAIKTRAPVLGG----NFAVWGGLFST 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 448824838  137 TECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKA---GAIGCG 178
Cdd:TIGR00980  74 IDCAVVAIRKKEDPWNSIISGFLTGAALAVRGGPRAmrgSAILGA 118
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 67-182 2.77e-31

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 109.57  E-value: 2.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   67 CAFKAVLACVGGFVLGGAFGVFTAGIDTnvgfdPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRG 146
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNR-----PPPLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRG 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 448824838  147 KSDWKNSVISGCITGGAigFRAGVKAGAIGCGGFAA 182
Cdd:pfam02466  76 KEDPWNSIAAGALTGAL--LRGGPRAAAVGGAVGAA 109
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 65-192 6.82e-20

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 82.60  E-value: 6.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838  65 ESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKDP--------------YRTPTA---REVLKDMGQRGMSYAKNF 127
Cdd:COG5596   44 YSCIGKSALSGLKGFRLGGPSGGFSSSLAYGTGLVHLLGlnfggvwgglfstiDCTPFRlqlKEQLNNAGKRGFFTGKNL 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 448824838 128 AIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR 192
Cdd:COG5596  124 GVLGLIYAGINSIITALRAKHDIANAIAAGAFTGAALASSAGPQAMPMGGAGFAAFSAGITLAMK 188
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 126-176 1.46e-08

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 51.58  E-value: 1.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 448824838 126 NFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAG----VKAGAIG 176
Cdd:PTZ00236  65 NFAIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGwrsaVRNAIFG 119
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 59-178 1.46e-08

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 51.76  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   59 MIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDtnvGF--DPKDPYRTPTAREVLKDMGQRGMsyakNFAIVGAMFSC 136
Cdd:TIGR00980   1 MEEYTREPCPYRILDDFGGAFAMGTIGGSIFQAFK---GFrnSPKGEKLVGAMRAIKTRAPVLGG----NFAVWGGLFST 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 448824838  137 TECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKA---GAIGCG 178
Cdd:TIGR00980  74 IDCAVVAIRKKEDPWNSIISGFLTGAALAVRGGPRAmrgSAILGA 118
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 74-176 4.34e-07

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 47.53  E-value: 4.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 448824838   74 ACVGGFVLGGAFGVFTAGIDTnvgfdPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNS 153
Cdd:TIGR00983  41 CYLTGLAIGALNGLRLGLKET-----QSMPWTKLRLNQILNMVTRRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNS 115

                          90       100
                  ....*....|....*....|...
gi 448824838  154 VISGCITGGAIGFRAGVKAGAIG 176
Cdd:TIGR00983 116 VAAGALTGALYKSTRGLRGMARS 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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