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Conserved domains on  [gi|14249119|ref|NP_115887|]
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rhox homeobox family member 2 [Homo sapiens]

Protein Classification

homeodomain and DUF367 domain-containing protein( domain architecture ID 11982726)

homeodomain and DUF367 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
139-191 7.75e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 7.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 14249119   139 HAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRR 191
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PRK02287 super family cl47099
DUF367 family protein;
183-232 3.26e-03

DUF367 family protein;


The actual alignment was detected with superfamily member PRK02287:

Pssm-ID: 235024 [Multi-domain]  Cd Length: 171  Bit Score: 37.55  E-value: 3.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 14249119  183 ENRRAKWRRHQRALmarnmlPFMAVGQPV------MVTAAEAITAPLFISGMRDDY 232
Cdd:PRK02287  77 RVFFKLLRGHHRRL------PFLVAANPVnygkpfKLSSVEALAAALYILGFKEEA 126
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
139-191 7.75e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 7.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 14249119   139 HAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRR 191
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 141-193 4.40e-19

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 78.82  E-value: 4.40e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 14249119 141 FTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQ 193
Cdd:cd00086   7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 140-190 8.06e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 8.06e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 14249119    140 AFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWR 190
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
142-199 1.42e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 58.60  E-value: 1.42e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14249119 142 TPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMAR 199
Cdd:COG5576  59 TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQ 116
PRK02287 PRK02287
DUF367 family protein;
183-232 3.26e-03

DUF367 family protein;


Pssm-ID: 235024 [Multi-domain]  Cd Length: 171  Bit Score: 37.55  E-value: 3.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 14249119  183 ENRRAKWRRHQRALmarnmlPFMAVGQPV------MVTAAEAITAPLFISGMRDDY 232
Cdd:PRK02287  77 RVFFKLLRGHHRRL------PFLVAANPVnygkpfKLSSVEALAAALYILGFKEEA 126
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
139-191 7.75e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 7.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 14249119   139 HAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRR 191
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 141-193 4.40e-19

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 78.82  E-value: 4.40e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 14249119 141 FTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQ 193
Cdd:cd00086   7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 140-190 8.06e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 8.06e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 14249119    140 AFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWR 190
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
142-199 1.42e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 58.60  E-value: 1.42e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14249119 142 TPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMAR 199
Cdd:COG5576  59 TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQ 116
PRK02287 PRK02287
DUF367 family protein;
183-232 3.26e-03

DUF367 family protein;


Pssm-ID: 235024 [Multi-domain]  Cd Length: 171  Bit Score: 37.55  E-value: 3.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 14249119  183 ENRRAKWRRHQRALmarnmlPFMAVGQPV------MVTAAEAITAPLFISGMRDDY 232
Cdd:PRK02287  77 RVFFKLLRGHHRRL------PFLVAANPVnygkpfKLSSVEALAAALYILGFKEEA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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