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Conserved domains on  [gi|149274655|ref|NP_115560|]
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rho GTPase-activating protein SYDE2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 814-1028 9.63e-91

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04379:

Pssm-ID: 470621  Cd Length: 207  Bit Score: 290.52  E-value: 9.63e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVL 893
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSPlkmssngcENDP-GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04379    81 KDYLRELPEPLITPQLYEMVLEALAVAL--------PNDVqTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNK 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 149274655  973 MTCQNLAVCFGPVLLSQRQEPSTHnNRVFTDSEELASALDFKKHIEVLHYLLQLWP 1028
Cdd:cd04379   153 MTPQNLAVCFGPVLMFCSQEFSRY-GISPTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
C2 super family cl14603
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
 679-794 9.82e-05

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


The actual alignment was detected with superfamily member cd04014:

Pssm-ID: 472691 [Multi-domain]  Cd Length: 132  Bit Score: 43.42  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  679 SGLMSVHFYGAEDLKP-----------PRIDSKDVFCAIQVDSVNKARTAllTCRTTFldmDHTFN----IEIENAQHLK 743
Cdd:cd04014     3 TGTLKIKICEAVDLKPtdwstrhavpkKGSQLLDPYVSIDVDDTHIGKTS--TKPKTN---SPVWNeeftTEVHNGRNLE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149274655  744 LVVFSWEPTPRKNRVCcHGTVVLPTLFRVTKTHQ-LAVKLEPRGLIYVKVTL 794
Cdd:cd04014    78 LTVFHDAAIGPDDFVA-NCTISFEDLIQRGSGSFdLWVDLEPQGKLHVKIEL 128
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 814-1028 9.63e-91

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 290.52  E-value: 9.63e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVL 893
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSPlkmssngcENDP-GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04379    81 KDYLRELPEPLITPQLYEMVLEALAVAL--------PNDVqTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNK 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 149274655  973 MTCQNLAVCFGPVLLSQRQEPSTHnNRVFTDSEELASALDFKKHIEVLHYLLQLWP 1028
Cdd:cd04379   153 MTPQNLAVCFGPVLMFCSQEFSRY-GISPTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 830-1025 3.89e-49

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 172.07  E-value: 3.89e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655    830 MVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQypDINVITGVLKDYLRELPSPLITKQL 909
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEY--DVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655    910 YEAVLDAMAKSPLKMSSNGCEndpgdskytvDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSq 989
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALR----------ELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLR- 148

                           170       180       190
                    ....*....|....*....|....*....|....*.
gi 149274655    990 rqepsthnnrvfTDSEELASALDFKKHIEVLHYLLQ 1025
Cdd:smart00324  149 ------------PPDGEVASLKDIRHQNTVIEFLIE 172
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 832-991 6.26e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 167.72  E-value: 6.26e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655   832 PLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQypDINVITGVLKDYLRELPSPLITKQLYE 911
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEE--DVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655   912 AVLDAMAKSPLKMSSNGCendpgdskytVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQRQ 991
Cdd:pfam00620   79 EFIEAAKLPDEEERLEAL----------RELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
C2_PKC_epsilon cd04014
C2 domain in Protein Kinase C (PKC) epsilon; A single C2 domain is found in PKC epsilon. The ...
 679-794 9.82e-05

C2 domain in Protein Kinase C (PKC) epsilon; A single C2 domain is found in PKC epsilon. The PKC family of serine/threonine kinases regulates apoptosis, proliferation, migration, motility, chemo-resistance, and differentiation. There are 3 groups: group 1 (alpha, betaI, beta II, gamma) which require phospholipids and calcium, group 2 (delta, epsilon, theta, eta) which do not require calcium for activation, and group 3 (xi, iota/lambda) which are atypical and can be activated in the absence of diacylglycerol and calcium. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-II topology.


Pssm-ID: 175981 [Multi-domain]  Cd Length: 132  Bit Score: 43.42  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  679 SGLMSVHFYGAEDLKP-----------PRIDSKDVFCAIQVDSVNKARTAllTCRTTFldmDHTFN----IEIENAQHLK 743
Cdd:cd04014     3 TGTLKIKICEAVDLKPtdwstrhavpkKGSQLLDPYVSIDVDDTHIGKTS--TKPKTN---SPVWNeeftTEVHNGRNLE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149274655  744 LVVFSWEPTPRKNRVCcHGTVVLPTLFRVTKTHQ-LAVKLEPRGLIYVKVTL 794
Cdd:cd04014    78 LTVFHDAAIGPDDFVA-NCTISFEDLIQRGSGSFdLWVDLEPQGKLHVKIEL 128
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 814-1028 9.63e-91

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 290.52  E-value: 9.63e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVL 893
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSPlkmssngcENDP-GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04379    81 KDYLRELPEPLITPQLYEMVLEALAVAL--------PNDVqTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNK 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 149274655  973 MTCQNLAVCFGPVLLSQRQEPSTHnNRVFTDSEELASALDFKKHIEVLHYLLQLWP 1028
Cdd:cd04379   153 MTPQNLAVCFGPVLMFCSQEFSRY-GISPTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 830-1025 3.89e-49

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 172.07  E-value: 3.89e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655    830 MVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQypDINVITGVLKDYLRELPSPLITKQL 909
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEY--DVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655    910 YEAVLDAMAKSPLKMSSNGCEndpgdskytvDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSq 989
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALR----------ELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLR- 148

                           170       180       190
                    ....*....|....*....|....*....|....*.
gi 149274655    990 rqepsthnnrvfTDSEELASALDFKKHIEVLHYLLQ 1025
Cdd:smart00324  149 ------------PPDGEVASLKDIRHQNTVIEFLIE 172
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 832-991 6.26e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 167.72  E-value: 6.26e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655   832 PLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQypDINVITGVLKDYLRELPSPLITKQLYE 911
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEE--DVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655   912 AVLDAMAKSPLKMSSNGCendpgdskytVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQRQ 991
Cdd:pfam00620   79 EFIEAAKLPDEEERLEAL----------RELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 832-1025 1.64e-42

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 152.84  E-value: 1.64e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  832 PLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLcenQYPDINVITGVLKDYLRELPSPLITKQLYE 911
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDL---EDYDVHDVASLLKLYLRELPEPLIPFELYD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  912 AVLDAMAKSPLKMSSNGCEndpgdskytvDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQrq 991
Cdd:cd00159    78 EFIELAKIEDEEERIEALK----------ELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRP-- 145

                         170       180       190
                  ....*....|....*....|....*....|....
gi 149274655  992 epsthnnrvftDSEELASALDFKKHIEVLHYLLQ 1025
Cdd:cd00159   146 -----------PDSDDELLEDIKKLNEIVEFLIE 168
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 814-1026 4.15e-36

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 135.83  E-value: 4.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYpDINVITGVL 893
Cdd:cd04387     1 FGVKISTVTKRERS--KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEM-DVNAIAGTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSplkmssngcenDP-GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04387    78 KLYFRELPEPLFTDELYPNFAEGIALS-----------DPvAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNK 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 149274655  973 MTCQNLAVCFGPVLLsqrqEPSTHNNRVFTDSEELASALDFKKHIEVLHYLLQL 1026
Cdd:cd04387   147 MSLHNLATVFGPTLL----RPSEKESKIPTNTMTDSWSLEVMSQVQVLLYFLQL 196
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-992 6.53e-35

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 132.26  E-value: 6.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGLmvPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVL 893
Cdd:cd04372     1 YGCDLTTLVKAHNTQR--PMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISATVYPDINVITGAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAM--AKSPLKMSSngcendpgdskyTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVN 971
Cdd:cd04372    79 KLYFRDLPIPVITYDTYPKFIDAAkiSNPDERLEA------------VHEALMLLPPAHYETLRYLMEHLKRVTLHEKDN 146

                         170       180
                  ....*....|....*....|.
gi 149274655  972 KMTCQNLAVCFGPVLLSQRQE 992
Cdd:cd04372   147 KMNAENLGIVFGPTLMRPPED 167
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 814-994 1.49e-33

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 127.89  E-value: 1.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKaVGLCENQYPDINVITGVL 893
Cdd:cd04403     1 FGCHLEALCQRENS--TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEK-LDLDDSKWEDIHVITGAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSplkmssngcenDPGDSKYTV-DLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04403    78 KLFFRELPEPLFPYSLFNDFVAAIKLS-----------DYEQRVSAVkDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNR 146

                         170       180
                  ....*....|....*....|..
gi 149274655  973 MTCQNLAVCFGPVLLSQRQEPS 994
Cdd:cd04403   147 MTTQNLAIVFGPTLLRPEQETG 168
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 814-995 7.78e-33

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 126.38  E-value: 7.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGlmVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDInviTGVL 893
Cdd:cd04378     1 FGVDFSQVPRDFPDE--VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDI---SSVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLdAMAKSPLKMSSNGCE-NDPGDSKYTV----DLLDCLPEIEKATLKMLLDHLKLVASYH 968
Cdd:cd04378    76 KLFLRQLPEPLILFRLYNDFI-ALAKEIQRDTEEDKApNTPIEVNRIIrklkDLLRQLPASNYNTLQHLIAHLYRVAEQF 154

                         170       180
                  ....*....|....*....|....*..
gi 149274655  969 EVNKMTCQNLAVCFGPVLLSQRQEPST 995
Cdd:cd04378   155 EENKMSPNNLGIVFGPTLIRPRPGDAD 181
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-989 2.73e-32

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 124.44  E-value: 2.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKEniGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLC--ENQYPDINVITG 891
Cdd:cd04398     1 FGVPLEDLILRE--GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLIspEDYESDIHSVAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  892 VLKDYLRELPSPLITKQLYEAVLDAmAKSplkmssngcENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVN 971
Cdd:cd04398    79 LLKLFFRELPEPLLTKALSREFIEA-AKI---------EDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVN 148

                         170
                  ....*....|....*...
gi 149274655  972 KMTCQNLAVCFGPVLLSQ 989
Cdd:cd04398   149 RMSVNNLAIIWGPTLMNA 166
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 831-1003 8.19e-32

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 122.80  E-value: 8.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  831 VPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYpDINVITGVLKDYLRELPSPLITKQLY 910
Cdd:cd04385    15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDARSVQLREGEY-TVHDVADVLKRFLRDLPDPLLTSELH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  911 EAVLDAmakSPLKMSSNGCEndpgdsKYTvDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQ- 989
Cdd:cd04385    94 AEWIEA---AELENKDERIA------RYK-ELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTd 163

                         170
                  ....*....|....*.
gi 149274655  990 --RQEPSTHNNRVFTD 1003
Cdd:cd04385   164 ehSVGQTSHEVKVIED 179
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 814-987 6.11e-30

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 117.54  E-value: 6.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENiglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLceNQYPdINVITGVL 893
Cdd:cd04377     1 FGVSLSSLTSEDR---SVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNL--EDYP-IHVITSVL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSplkmssngcenDPGDSKYTV-DLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04377    75 KQWLRELPEPLMTFELYENFLRAMELE-----------EKQERVRALySVLEQLPRANLNTLERLIFHLVRVALQEEVNR 143

                         170
                  ....*....|....*
gi 149274655  973 MTCQNLAVCFGPVLL 987
Cdd:cd04377   144 MSANALAIVFAPCIL 158
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 831-986 4.19e-27

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 109.80  E-value: 4.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  831 VPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLY 910
Cdd:cd04395    18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149274655  911 EAVLDAmaksplkmssNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVL 986
Cdd:cd04395    98 PDFIEA----------NRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTL 163
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-995 2.77e-26

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 107.97  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGlmVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDInviTGVL 893
Cdd:cd04409     1 FGADFAQVAKKSPDG--IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDI---SNVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDaMAKSPLKMSSNGCENDPGDSKY-------------TVDLLDCLPEIEKATLKMLLDH 960
Cdd:cd04409    76 KLYLRQLPEPLILFRLYNEFIG-LAKESQHVNETQEAKKNSDKKWpnmctelnrillkSKDLLRQLPAPNYNTLQFLIVH 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 149274655  961 LKLVASYHEVNKMTCQNLAVCFGPVLLSQRQEPST 995
Cdd:cd04409   155 LHRVSEQAEENKMSASNLGIIFGPTLIRPRPTDAT 189
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 826-997 4.81e-26

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 106.61  E-value: 4.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  826 NIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFeRDSKAVGLCENQypDINVITGVLKDYLRELPSPLI 905
Cdd:cd04382    12 STSPMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKF-LRGKTVPNLSKV--DIHVICGCLKDFLRSLKEPLI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  906 TKQLYEAVLDAMaksplkmssngcEN-DPGDSKYTV-DLLDCLPEIEKATLKMLLDHLKLVASyHEVNKMTCQNLAVCFG 983
Cdd:cd04382    89 TFALWKEFMEAA------------EIlDEDNSRAALyQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFG 155

                         170
                  ....*....|....*
gi 149274655  984 PVLLSQ-RQEPSTHN 997
Cdd:cd04382   156 PTIVGYsVPNPDPMT 170
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 831-987 3.17e-25

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 104.51  E-value: 3.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  831 VPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDinvITGVLKDYLRELPSPLITKQLY 910
Cdd:cd04408    16 VPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHD---ITSVLKHFLKELPEPVLPFQLY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  911 EAVLdAMAKSPLKMSSNGCE-NDPGDS--KYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLL 987
Cdd:cd04408    93 DDFI-ALAKELQRDSEKAAEsPSIVENiiRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLL 171
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-995 4.42e-25

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 103.74  E-value: 4.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVVEkeNIGLMVPLLIQKCIMEIEKRGCqVVGLYRLCGSAAVKKELREAFerDSKAV-GLCENQY-PDINVIT 890
Cdd:cd04384     2 VFGCDLTEHLL--NSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEF--DSEQIpDLTKDVYiQDIHSVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  891 GVLKDYLRELPSPLITKQLYEAVLDAMAKSPlkmssngcenDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEV 970
Cdd:cd04384    77 SLCKLYFRELPNPLLTYQLYEKFSEAVSAAS----------DEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSI 146

                         170       180
                  ....*....|....*....|....*
gi 149274655  971 NKMTCQNLAVCFGPVLLSQRQEPST 995
Cdd:cd04384   147 TNMHAKNLAIVWAPNLLRSKQIESA 171
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 835-992 1.58e-24

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 102.47  E-value: 1.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  835 IQKCIMEIEKRGCQVVGLYRLCG-SAAVKKELREAFER---DSKAVGLCENQYpDINVITGVLKDYLRELPSPLITKQLY 910
Cdd:cd04374    32 VRKCIEAVETRGINEQGLYRVVGvNSKVQKLLSLGLDPktsTPGDVDLDNSEW-EIKTITSALKTYLRNLPEPLMTYELH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  911 EAVLDAmAKSplkmssngcendpGDSKYTVD----LLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVL 986
Cdd:cd04374   111 NDFINA-AKS-------------ENLESRVNaihsLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176


                  ....*.
gi 149274655  987 LSQRQE 992
Cdd:cd04374   177 LRPQEE 182
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 813-986 7.20e-24

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 100.13  E-value: 7.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVVE---KENIGLMVPLLIQKCIMEIEKRGC-QVVGLYRLCGSAAVKKELREAFErDSKAVGLCE-NQYPDIN 887
Cdd:cd04400     1 IFGSPLEEAVElssHKYNGRDLPSVVYRCIEYLDKNRAiYEEGIFRLSGSASVIKQLKERFN-TEYDVDLFSsSLYPDVH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  888 VITGVLKDYLRELPSPLITKQLYEAVLDAMAKSPlkmssngcenDPGDSKYTV-DLLDCLPEIEKATLKMLLDHLKLVAS 966
Cdd:cd04400    80 TVAGLLKLYLRELPTLILGGELHNDFKRLVEENH----------DRSQRALELkDLVSQLPQANYDLLYVLFSFLRKIIE 149

                         170       180
                  ....*....|....*....|
gi 149274655  967 YHEVNKMTCQNLAVCFGPVL 986
Cdd:cd04400   150 HSDVNKMNLRNVCIVFSPTL 169
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 814-987 9.94e-24

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 99.68  E-value: 9.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENiglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLcENqYPdINVITGVL 893
Cdd:cd04407     1 FGVRVGSLTSNKT---SVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKL-EN-YP-IHAITGLL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMaKSPLKmssngceNDPGDSKYTVdlLDCLPEIEKATLKMLLDHLKLVASYHEVNKM 973
Cdd:cd04407    75 KQWLRELPEPLMTFAQYNDFLRAV-ELPEK-------QEQLQAIYRV--LEQLPTANHNTLERLIFHLVKVALEEDVNRM 144

                         170
                  ....*....|....
gi 149274655  974 TCQNLAVCFGPVLL 987
Cdd:cd04407   145 SPNALAIVFAPCLL 158
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-987 3.08e-23

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 98.56  E-value: 3.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERdskavGLCEN--QYPDINVITG 891
Cdd:cd04404     6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNM-----GEPVDfdQYEDVHLPAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  892 VLKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNgcendpgdskyTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVN 971
Cdd:cd04404    81 ILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVER-----------VKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQN 149

                         170
                  ....*....|....*.
gi 149274655  972 KMTCQNLAVCFGPVLL 987
Cdd:cd04404   150 KMTNSNLAVVFGPNLL 165
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-1023 2.75e-22

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 95.60  E-value: 2.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENiglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKaVGLCENQYPdINVITGVL 893
Cdd:cd04373     1 FGVPLANVVTSEK---PIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHN-LDLVSKDFT-VNAVAGAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNGCEndpgdskytvDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKM 973
Cdd:cd04373    76 KSFFSELPDPLIPYSMHLELVEAAKINDREQRLHALK----------ELLKKFPPENFDVFKYVITHLNKVSQNSKVNLM 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 149274655  974 TCQNLAVCFGPVLLSQrqepsthnnrVFTDSEELASALDFKKHIEVLHYL 1023
Cdd:cd04373   146 TSENLSICFWPTLMRP----------DFTSMEALSATRIYQTIIETFIQQ 185
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-994 5.74e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 95.22  E-value: 5.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQ---KVVEKEniglmVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFerDSKAVGLCENQ-YPDINV 888
Cdd:cd04386     4 VFGTPLEehlKRTGRE-----IALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAAL--DAGTFSLPLDEfYSDPHA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  889 ITGVLKDYLRELPSPLITKQLYEAVLDAMaksplkmssngceNDPGDSKYTVDLLDC---LPEIEKATLKMLLDHLKLVA 965
Cdd:cd04386    77 VASALKSYLRELPDPLLTYNLYEDWVQAA-------------NKPDEDERLQAIWRIlnkLPRENRDNLRYLIKFLSKLA 143

                         170       180
                  ....*....|....*....|....*....
gi 149274655  966 SYHEVNKMTCQNLAVCFGPVLLSQRQEPS 994
Cdd:cd04386   144 QKSDENKMSPSNIAIVLAPNLLWAKNEGS 172
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 814-987 2.52e-20

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 90.06  E-value: 2.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENiglMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLceNQYpDINVITGVL 893
Cdd:cd04406     1 FGVELSRLTSEDR---SVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNL--DDY-NIHVIASVF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  894 KDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNGCendpgdskYTVdlLDCLPEIEKATLKMLLDHLKLVASYHEVNKM 973
Cdd:cd04406    75 KQWLRDLPNPLMTFELYEEFLRAMGLQERRETVRGV--------YSV--IDQLSRTHLNTLERLIFHLVRIALQEETNRM 144

                         170
                  ....*....|....
gi 149274655  974 TCQNLAVCFGPVLL 987
Cdd:cd04406   145 SANALAIVFAPCIL 158
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-1029 2.62e-20

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 90.87  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVVE---KENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDskavgLCENQYPDINV- 888
Cdd:cd04391     1 LFGVPLSTLLErdqKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAK-----FYEGTFLWDQVk 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  889 ---ITGVLKDYLRELPSPLITKQLyeavLDAMAKsplkmssngCENDPgDSKYTVDLLD----CLPEIEKATLKMLLDHL 961
Cdd:cd04391    76 qhdAASLLKLFIRELPQPLLTVEY----LPAFYS---------VQGLP-SKKDQLQALNllvlLLPEANRDTLKALLEFL 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149274655  962 KLVASYHEVNKMTCQNLAVCFGPVLLSQRqepSTHNNRVFTDSEELASALDFKKHIEVL-HYLLQLWPV 1029
Cdd:cd04391   142 QKVVDHEEKNKMNLWNVAMIMAPNLFPPR---GKHSKDNESLQEEVNMAAGCANIMRLLiRYQDLLWTV 207
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 827-994 6.76e-19

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 86.34  E-value: 6.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  827 IGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERdSKAVGLCENQYPdiNVITGVLKDYLRELPSPLIT 906
Cdd:cd04376     5 IARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVVLDENHSV--HDVAALLKEFFRDMPDPLLP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  907 KQLYEAVLDAMAKSplkmssngcendPGDSKYTVDLL-DCLPEIEKATLKMLLDHLKLVASY---------HEV--NKMT 974
Cdd:cd04376    82 RELYTAFIGTALLE------------PDEQLEALQLLiYLLPPCNCDTLHRLLKFLHTVAEHaadsidedgQEVsgNKMT 149

                         170       180
                  ....*....|....*....|
gi 149274655  975 CQNLAVCFGPVLLsQRQEPS 994
Cdd:cd04376   150 SLNLATIFGPNLL-HKQKSG 168
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 830-995 4.54e-18

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 83.65  E-value: 4.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  830 MVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAF---ERDSKavglceNQYPDINVITGVLKDYLRELPSPLIT 906
Cdd:cd04390    21 LVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFdagERPSF------DSDTDVHTVASLLKLYLRELPEPVIP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  907 KQLYEAVLDAmAKSPLKMSSNGCENdpgdskyTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVL 986
Cdd:cd04390    95 WAQYEDFLSC-AQLLSKDEEKGLGE-------LMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNI 166

                         170
                  ....*....|
gi 149274655  987 L-SQRQEPST 995
Cdd:cd04390   167 LrPKVEDPAT 176
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-999 4.63e-18

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 83.50  E-value: 4.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVVEKENiglmVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREafERDSKAVGLCENQypDINVITGV 892
Cdd:cd04402     1 LFGQPLSNICEDDN----LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKE--KLNSGVEVDLKAE--PVLLLASV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  893 LKDYLRELPSPLITKQLYEAVLDAMAKsplkmssngcENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04402    73 LKDFLRNIPGSLLSSDLYEEWMSALDQ----------ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNK 142

                         170       180
                  ....*....|....*....|....*..
gi 149274655  973 MTCQNLAVCFGPVLLsQRQEPSTHNNR 999
Cdd:cd04402   143 MDAFNLAVCIAPSLL-WPPASSELQNE 168
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-984 9.86e-18

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 82.51  E-value: 9.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVvekENIGLM---VPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFErDSKAVGLCENQypDINVI 889
Cdd:cd04393     2 VFGVPLQEL---QQAGQPengVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLD-SGEEVDLSKEA--DVCSA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  890 TGVLKDYLRELPSPLITkqlyeavlDAMAKSPLKMSSNGCENDPGDSKYTvDLLDCLPEIEKATLKMLLDHLKLVASYHE 969
Cdd:cd04393    76 ASLLRLFLQELPEGLIP--------ASLQIRLMQLYQDYNGEDEFGRKLR-DLLQQLPPVNYSLLKFLCHFLSNVASQHH 146

                         170
                  ....*....|....*
gi 149274655  970 VNKMTCQNLAVCFGP 984
Cdd:cd04393   147 ENRMTAENLAAVFGP 161
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 824-1000 1.41e-17

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 82.08  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  824 KENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYpDINVITGVLKDYLRELPSP 903
Cdd:cd04383    11 IQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNDH-DINSVAGVLKLYFRGLENP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  904 LITKQLYEAVldamaksplkMSSNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFG 983
Cdd:cd04383    90 LFPKERFEDL----------MSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFG 159

                         170
                  ....*....|....*....
gi 149274655  984 PVLLS--QRQEPSTHNNRV 1000
Cdd:cd04383   160 PTLMPvpEGQDQVSCQAHV 178
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 814-990 8.28e-16

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 76.71  E-value: 8.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENI--GLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAvglCENQYpDINVITG 891
Cdd:cd04381     1 FGASLSLAVERSRChdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESP---NLEEY-EPPTVAS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  892 VLKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNGCENdpgdskytvdLLDCLPEIEKATLKMLLDHLKLVASYHEVN 971
Cdd:cd04381    77 LLKQYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQR----------LLKELPECNRLLLAWLIVHMDHVIAQELET 146

                         170       180
                  ....*....|....*....|
gi 149274655  972 KMTCQNLAVCFGPVL-LSQR 990
Cdd:cd04381   147 KMNIQNISIVLSPTVqISNR 166
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 831-989 6.04e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 75.52  E-value: 6.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  831 VPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSK-AVGLCENQYpDINVITGVLKDYLRELPSPLITKQL 909
Cdd:cd04396    32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDyGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPLDL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  910 YEAVLDAMAKSP-LKMSSNGCENDPGDS------KYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCF 982
Cdd:cd04396   111 YEEFRNPLRKRPrILQYMKGRINEPLNTdidqaiKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIF 190


                  ....*..
gi 149274655  983 GPVLLSQ 989
Cdd:cd04396   191 QPGILSH 197
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 814-1024 1.21e-14

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 74.32  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVEKENI---------GLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYP 884
Cdd:cd04397     1 FGVPLEILVEKFGAdstlgvgpgKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  885 DInvITGVLKDYLRELPSPLITKQLYEavldamakspLKMSSNGCEnDPGDSKYTVDLLDC-LPEIEKATLKMLLDHLKL 963
Cdd:cd04397    81 VQ--LAALLKKFLRELPDPLLTFKLYR----------LWISSQKIE-DEEERKRVLHLVYClLPKYHRDTMEVLFSFLKW 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149274655  964 VASYHEV-----NKMTCQNLAVCFGP-VLLSQRQEPSTHNNRVftdseeLAsaldfkkhIEVLHYLL 1024
Cdd:cd04397   148 VSSFSHIdeetgSKMDIHNLATVITPnILYSKTDNPNTGDEYF------LA--------IEAVNYLI 200
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 851-1003 8.16e-14

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 71.35  E-value: 8.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  851 GLYRLCGSAAVKKELREAFERDskavGLCENQYPDINViTGVLKDYLRELPSPLITKQLYEAVLDAMaksplkmssngcE 930
Cdd:cd04394    39 GLFRKSGSVVRQKELKAKLEGG----EACLSSALPCDV-AGLLKQFFRELPEPLLPYDLHEALLKAQ------------E 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  931 NDPGDSKYTVDLLDC--LPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLL--SQRQEPSTHNN----RVFT 1002
Cdd:cd04394   102 LPTDEERKSATLLLTclLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFqsEEGGEKMSSSTekrlRLQA 181


                  .
gi 149274655 1003 D 1003
Cdd:cd04394   182 A 182
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 813-1011 8.43e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 72.07  E-value: 8.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  813 IFGVDIQKVVEKenIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDInviTGV 892
Cdd:cd04375     4 VFGVPLLVNLQR--TGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDV---ADM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  893 LKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSngcendpgDSKYTVDLLdcLPEIEKATLKMLLDHLKLVASYHEVNK 972
Cdd:cd04375    79 LKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRL--------EAVQCAILL--LPDENREVLQTLLYFLSDVAANSQENQ 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 149274655  973 MTCQNLAVCFGPVL---LSQRQEPSTHNNRVFT-------DSEELASAL 1011
Cdd:cd04375   149 MTATNLAVCLAPSLfhlNTSRRENSSPARRMQRkkslgkpDQKELSENK 197
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 851-1013 3.17e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 67.10  E-value: 3.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  851 GLYRLCGSAAVKKELREAFERDsKAVGLCENQYpDINVITGVLKDYLRELPSPLITKQLYEAVLDAmakSPLkmssngCE 930
Cdd:cd04392    28 GLFRKPGNSARQQELRDLLNSG-TDLDLESGGF-HAHDCATVLKGFLGELPEPLLTHAHYPAHLQI---ADL------CQ 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  931 NDPGDSKYTVD-----------LLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQRQEPSthnNR 999
Cdd:cd04392    97 FDEKGNKTSAPdkerllealqlLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTP---ED 173

                         170
                  ....*....|....
gi 149274655 1000 VFTDSEELASALDF 1013
Cdd:cd04392   174 LHENAQKLNSIVTF 187
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 832-998 2.49e-08

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 55.27  E-value: 2.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  832 PLLIqKCIMEIEKRGCQVVGLYRlCGSAAVKKELREAFERDSKAVGLceNQYpDINVITGVLKDYLRELPSPLITKQLYE 911
Cdd:cd04388    17 PLLI-KLVEAIEKKGLESSTLYR-TQSSSSLTELRQILDCDAASVDL--EQF-DVAALADALKRYLLDLPNPVIPAPVYS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  912 AVLDAmakSPLKMSSNGCendpgdSKYTVDLLDC--LPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLsq 989
Cdd:cd04388    92 EMISR---AQEVQSSDEY------AQLLRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLF-- 160


                  ....*....
gi 149274655  990 RQEPSTHNN 998
Cdd:cd04388   161 RFQPASSDS 169
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 814-987 1.56e-06

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 49.70  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  814 FGVDIQKVVE--KENI-GLMVPLLIQKCIMEI-EKRGCQVVGLYRLCGSAAVKKELREAFER-DSKAVGLcenqyPDINV 888
Cdd:cd04389     1 FGSSLEEIMDrqKEKYpELKLPWILTFLSEKVlALGGFQTEGIFRVPGDIDEVNELKLRVDQwDYPLSGL-----EDPHV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  889 ITGVLKDYLRELPSPLITKQLYEAVLDAmaksplkmssngcENDPGDSKYTVDLldcLPEIEKATLKMLLDHLKLVA--S 966
Cdd:cd04389    76 PASLLKLWLRELEEPLIPDALYQQCISA-------------SEDPDKAVEIVQK---LPIINRLVLCYLINFLQVFAqpE 139

                         170       180
                  ....*....|....*....|.
gi 149274655  967 YHEVNKMTCQNLAVCFGPVLL 987
Cdd:cd04389   140 NVAHTKMDVSNLAMVFAPNIL 160
C2_PKC_epsilon cd04014
C2 domain in Protein Kinase C (PKC) epsilon; A single C2 domain is found in PKC epsilon. The ...
 679-794 9.82e-05

C2 domain in Protein Kinase C (PKC) epsilon; A single C2 domain is found in PKC epsilon. The PKC family of serine/threonine kinases regulates apoptosis, proliferation, migration, motility, chemo-resistance, and differentiation. There are 3 groups: group 1 (alpha, betaI, beta II, gamma) which require phospholipids and calcium, group 2 (delta, epsilon, theta, eta) which do not require calcium for activation, and group 3 (xi, iota/lambda) which are atypical and can be activated in the absence of diacylglycerol and calcium. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-II topology.


Pssm-ID: 175981 [Multi-domain]  Cd Length: 132  Bit Score: 43.42  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  679 SGLMSVHFYGAEDLKP-----------PRIDSKDVFCAIQVDSVNKARTAllTCRTTFldmDHTFN----IEIENAQHLK 743
Cdd:cd04014     3 TGTLKIKICEAVDLKPtdwstrhavpkKGSQLLDPYVSIDVDDTHIGKTS--TKPKTN---SPVWNeeftTEVHNGRNLE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149274655  744 LVVFSWEPTPRKNRVCcHGTVVLPTLFRVTKTHQ-LAVKLEPRGLIYVKVTL 794
Cdd:cd04014    78 LTVFHDAAIGPDDFVA-NCTISFEDLIQRGSGSFdLWVDLEPQGKLHVKIEL 128
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 800-988 1.08e-03

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 41.94  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  800 NSLHGLDINQEPIIFGVDIQKVVEKENIGLMVPLLIQK----CIMEIEKRGCQVVGLYRLCGSAAVKKELREAFeRDSKA 875
Cdd:cd04380    15 SSLETLIRLPDPGIRNLIDQLELGDNPDYSEVPLSIPKeiwrLVDYLYTRGLAQEGLFEEPGLPSEPGELLAEI-RDALD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274655  876 VGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVLDAMaksplkmssngceNDPGDSKYTVdLLDCLPEIEKATLK 955
Cdd:cd04380    94 TGSPFNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLEAV-------------ANNEEDKRQV-IRISLPPVHRNVFV 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 149274655  956 MLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLS 988
Cdd:cd04380   160 YLCSFLRELLSESADRGLDENTLATIFGRVLLR 192
C2_ABR cd08686
C2 domain in the Active BCR (Breakpoint cluster region) Related protein; The ABR protein is ...
 699-748 4.61e-03

C2 domain in the Active BCR (Breakpoint cluster region) Related protein; The ABR protein is similar to the breakpoint cluster region protein. It has homology to guanine nucleotide exchange proteins and GTPase-activating proteins (GAPs). ABR is expressed primarily in the brain, but also includes non-neuronal tissues such as the heart. It has been associated with human diseases such as Miller-Dieker syndrome in which mental retardation and malformations of the heart are present. ABR contains a RhoGEF domain and a PH-like domain upstream of its C2 domain and a RhoGAP domain downstream of this domain. A few members also contain a Bcr-Abl oncoprotein oligomerization domain at the very N-terminal end. Splice variants of ABR have been identified. ABR is found in a wide variety of organisms including chimpanzee, dog, mouse, rat, fruit fly, and mosquito. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176068  Cd Length: 118  Bit Score: 38.26  E-value: 4.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 149274655  699 SKDVFCAIQVDS----VNKARTAllTCRTTFL-DMDHTFNIEIENAQHLKLVVFS 748
Cdd:cd08686    14 SANLYCTLEVDSfgyfVKKAKTR--VCRDTTEpNWNEEFEIELEGSQTLRILCYE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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