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Conserved domains on  [gi|825706201|ref|NP_114005|]
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osteomodulin precursor [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-293 5.79e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 5.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  93 IQQLNLQFNDieavtadSFINATHLKEINLSHNKIKSQKIDygvFAKLSNLQQLHLDHNNLEEFPFPLP--KSLERLLLG 170
Cdd:COG4886   98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 171 YNEISTLPThAMDGLVNVTMLDLCYNHLSDStlkGKILSKLEKLMQLNLCNNRLESMPPGLP--SSLMYLSLENNSISSI 248
Cdd:COG4886  168 NNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL 243
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 825706201 249 PEdyFQKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLK 293
Cdd:COG4886  244 PE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLT 285
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 1.07e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 825706201    61 GCAKECFCPtnfPTSMYCDNRKLKTIP-DIPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPlDLPPDTT 32
LRR_8 super family cl38440
Leucine rich repeat;
280-342 6.77e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 825706201  280 SNLIELNVGHNKL----KQAFYIPRNLEHLYLQNNEIQSINVTmmcpSLDPLhhHHLTYLRVDQNKL 342
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLSNLKVLDLSNNLLTTLSPG----AFSGL--PSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-293 5.79e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 5.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  93 IQQLNLQFNDieavtadSFINATHLKEINLSHNKIKSQKIDygvFAKLSNLQQLHLDHNNLEEFPFPLP--KSLERLLLG 170
Cdd:COG4886   98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 171 YNEISTLPThAMDGLVNVTMLDLCYNHLSDStlkGKILSKLEKLMQLNLCNNRLESMPPGLP--SSLMYLSLENNSISSI 248
Cdd:COG4886  168 NNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL 243
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 825706201 249 PEdyFQKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLK 293
Cdd:COG4886  244 PE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 4.60e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  68 CPTNFPTSMYCDNRKLKTIP-DIPMHIQQLNLQFNDIEAVTADSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 146 LHLDHNNLEEFPFPLPKSLERLLLGYNEISTLPTHAMDGLvnvTMLDLCYNHLsdSTLKGKILSkleKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 825706201 226 SMPPGLPSSLMYLSLENNSISSIPEDYfqkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
LRR_8 pfam13855
Leucine rich repeat;
96-153 1.29e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 825706201   96 LNLQFNDIEAVTADSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLDHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
136-342 5.11e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 5.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 136 VFAKLSNLQQLHLDHNNL--EEFPF-----PLPKSLERLLLGYNEISTLPT------HAMDGLVNVTMLDLCYNHLSDST 202
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLgeEAAKAlasalRPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 203 LKG-KILSKLEKLMQLNLCNNRLESMP--------PGLPSSLMYLSLENNSISSIP----EDYFQKLPKLHALRISHNKL 269
Cdd:cd00116   98 CGVlESLLRSSSLQELKLNNNGLGDRGlrllakglKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGI 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 825706201 270 EDipydifnlsnlielnVGHNKLKQAFYIPRNLEHLYLQNNEIQSINVTMMCPSLdpLHHHHLTYLRVDQNKL 342
Cdd:cd00116  178 GD---------------AGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL--ASLKSLEVLNLGDNNL 233
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 1.07e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 825706201    61 GCAKECFCPtnfPTSMYCDNRKLKTIP-DIPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPlDLPPDTT 32
LRR_8 pfam13855
Leucine rich repeat;
280-342 6.77e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 825706201  280 SNLIELNVGHNKL----KQAFYIPRNLEHLYLQNNEIQSINVTmmcpSLDPLhhHHLTYLRVDQNKL 342
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLSNLKVLDLSNNLLTTLSPG----AFSGL--PSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-293 5.79e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 5.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  93 IQQLNLQFNDieavtadSFINATHLKEINLSHNKIKSQKIDygvFAKLSNLQQLHLDHNNLEEFPFPLP--KSLERLLLG 170
Cdd:COG4886   98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 171 YNEISTLPThAMDGLVNVTMLDLCYNHLSDStlkGKILSKLEKLMQLNLCNNRLESMPPGLP--SSLMYLSLENNSISSI 248
Cdd:COG4886  168 NNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL 243
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 825706201 249 PEdyFQKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLK 293
Cdd:COG4886  244 PE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
151-344 1.85e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 1.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 151 NNLEEFPFPLPKSLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNhlsdstlkgKILSKLEKLMQLNLCNNRLESMPPG 230
Cdd:COG4886   61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEE 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 231 LPS--SLMYLSLENNSISSIPEDyFQKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLK---QAFYIPRNLEHL 305
Cdd:COG4886  132 LANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITdlpEPLGNLTNLEEL 210
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 825706201 306 YLQNNEIQSINvtmmcPSLDPLhhHHLTYLRVDQNKLKE 344
Cdd:COG4886  211 DLSGNQLTDLP-----EPLANL--TNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-316 2.35e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 2.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  74 TSMYCDNRKLKTIPD-IPM--HIQQLNLQFNDIEAVTAdSFINATHLKEINLSHNKIKSQKidyGVFAKLSNLQQLHLDH 150
Cdd:COG4886  139 KELDLSNNQLTDLPEpLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSG 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 151 NNLEEFPFPLP--KSLERLLLGYNEISTLPthAMDGLVNVTMLDLCYNHLSDSTlkgkILSKLEKLMQLNLCNNR----- 223
Cdd:COG4886  215 NQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQltdlk 288
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 224 LESMPPGLPSSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLE 303
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368
                        250
                 ....*....|...
gi 825706201 304 HLYLQNNEIQSIN 316
Cdd:COG4886  369 LGLLGLLEATLLT 381
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 4.60e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  68 CPTNFPTSMYCDNRKLKTIP-DIPMHIQQLNLQFNDIEAVTADSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 146 LHLDHNNLEEFPFPLPKSLERLLLGYNEISTLPTHAMDGLvnvTMLDLCYNHLsdSTLKGKILSkleKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 825706201 226 SMPPGLPSSLMYLSLENNSISSIPEDYfqkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
LRR_8 pfam13855
Leucine rich repeat;
96-153 1.29e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.29e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 825706201   96 LNLQFNDIEAVTADSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLDHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
92-310 1.54e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  92 HIQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIkSQKIDYGVFAKLSNLQQLHLDHNNleeFPFPLPKS----LERL 167
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNN---FTGSIPRGsipnLETL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 168 LLGYNEISTLPTHAMDGLVNVTMLDLCYNhlsdsTLKGKI---LSKLEKLMQLNLCNNRLESMPP--------------- 229
Cdd:PLN00113 146 DLSNNMLSGEIPNDIGSFSSLKVLDLGGN-----VLVGKIpnsLTNLTSLEFLTLASNQLVGQIPrelgqmkslkwiylg 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 230 ------GLP------SSLMYLSL-ENNSISSIPEDyFQKLPKLHALRISHNKLED-IPYDIFNLSNLIELNVGHNKLKQA 295
Cdd:PLN00113 221 ynnlsgEIPyeigglTSLNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGE 299
                        250       260
                 ....*....|....*....|.
gi 825706201 296 fyIP------RNLEHLYLQNN 310
Cdd:PLN00113 300 --IPelviqlQNLEILHLFSN 318
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
83-323 1.03e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.56  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  83 LKTIPD-IPMHIQQLNLQFNDIEAVTAdsfiNATHLKEINLSHNKIKSQKIdygvfaKLSNLQQLHLDHNNLEEFPfPLP 161
Cdd:PRK15387 213 LTTLPDcLPAHITTLVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLPV------LPPGLLELSIFSNPLTHLP-ALP 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 162 KSLERLLLGYNEISTLPTHAmDGLVNVTMLDlcyNHLSdstlkgKILSKLEKLMQLNLCNNRLESMPPgLPSSLMYLSLE 241
Cdd:PRK15387 282 SGLCKLWIFGNQLTSLPVLP-PGLQELSVSD---NQLA------SLPALPSELCKLWAYNNQLTSLPT-LPSGLQELSVS 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 242 NNSISSIPedyfqKLP-KLHALRISHNKLEDIPYdifNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIQSINvtmM 320
Cdd:PRK15387 351 DNQLASLP-----TLPsELYKLWAYNNRLTSLPA---LPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---M 419

                 ...
gi 825706201 321 CPS 323
Cdd:PRK15387 420 LPS 422
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
92-292 1.19e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  92 HIQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIkSQKIDYGvFAKLSNLQQLHLDHNNL----EEFPFPLPkSLERL 167
Cdd:PLN00113 381 NLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SGELPSE-FTKLPLVYFLDISNNNLqgriNSRKWDMP-SLQML 457
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 168 LLGYNEIS-TLPTHAmdGLVNVTMLDLCYNHLSDSTLKGkiLSKLEKLMQLNLCNNRLESMPPGLPSS---LMYLSLENN 243
Cdd:PLN00113 458 SLARNKFFgGLPDSF--GSKRLENLDLSRNQFSGAVPRK--LGSLSELMQLKLSENKLSGEIPDELSSckkLVSLDLSHN 533
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 825706201 244 SISSIPEDYFQKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNKL 292
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
141-319 3.81e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 3.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 141 SNLQQLHLDHNNLEEFPFPLPKSLERLLLGYNEISTLPthamdglvnvtmldlcynhlsdSTLKGKIlskleklMQLNLC 220
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLP----------------------ENLQGNI-------KTLYAN 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 221 NNRLESMPPGLPSSLMYLSLENNSISSIPEdyfqKLPK-LHALRISHNKLEDIPYDIFNlsNLIELNVGHNKLKQ-AFYI 298
Cdd:PRK15370 229 SNQLTSIPATLPDTIQEMELSINRITELPE----RLPSaLQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTlPAHL 302
                        170       180
                 ....*....|....*....|.
gi 825706201 299 PRNLEHLYLQNNEIQSINVTM 319
Cdd:PRK15370 303 PSGITHLNVQSNSLTALPETL 323
LRR_8 pfam13855
Leucine rich repeat;
141-198 2.42e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.42e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 825706201  141 SNLQQLHLDHNNLEEFP---FPLPKSLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHL 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
233-292 3.80e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 3.80e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 825706201  233 SSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKLEDI-PYDIFNLSNLIELNVGHNKL 292
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
138-302 1.69e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 138 AKLSNLQQLHLDHNNLE-EFPFPLP--KSLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHLSdstlkGKI---LSKL 211
Cdd:PLN00113 185 TNLTSLEFLTLASNQLVgQIPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLT-----GPIpssLGNL 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 212 EKLMQLNLCNNRLE-SMPPGLPS--SLMYLSLENNSIS-SIPEDYFQkLPKLHALRISHNKLE-DIPYDIFNLSNLIELN 286
Cdd:PLN00113 260 KNLQYLFLYQNKLSgPIPPSIFSlqKLISLDLSDNSLSgEIPELVIQ-LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQ 338
                        170
                 ....*....|....*.
gi 825706201 287 VGHNKLKQAfyIPRNL 302
Cdd:PLN00113 339 LWSNKFSGE--IPKNL 352
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
136-342 5.11e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 5.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 136 VFAKLSNLQQLHLDHNNL--EEFPF-----PLPKSLERLLLGYNEISTLPT------HAMDGLVNVTMLDLCYNHLSDST 202
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLgeEAAKAlasalRPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 203 LKG-KILSKLEKLMQLNLCNNRLESMP--------PGLPSSLMYLSLENNSISSIP----EDYFQKLPKLHALRISHNKL 269
Cdd:cd00116   98 CGVlESLLRSSSLQELKLNNNGLGDRGlrllakglKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGI 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 825706201 270 EDipydifnlsnlielnVGHNKLKQAFYIPRNLEHLYLQNNEIQSINVTMMCPSLdpLHHHHLTYLRVDQNKL 342
Cdd:cd00116  178 GD---------------AGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL--ASLKSLEVLNLGDNNL 233
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
89-312 5.36e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 5.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  89 IPMHIQQL-NLQF-----NDIEAVTADSFINATHLKEINLSHNKIKSQKIDygVFAKLSNLQQLHLDHNNLE-EFPF--- 158
Cdd:PLN00113 252 IPSSLGNLkNLQYlflyqNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLFSNNFTgKIPValt 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 159 PLPKsLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHLSdstlkGKI---LSKLEKLMQLNLCNNRLES-MPPGLP-- 232
Cdd:PLN00113 330 SLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT-----GEIpegLCSSGNLFKLILFSNSLEGeIPKSLGac 403
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 233 SSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNK----LKQAFYiPRNLEHLYL 307
Cdd:PLN00113 404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKffggLPDSFG-SKRLENLDL 482

                 ....*
gi 825706201 308 QNNEI 312
Cdd:PLN00113 483 SRNQF 487
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 1.07e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 825706201    61 GCAKECFCPtnfPTSMYCDNRKLKTIP-DIPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPlDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
96-316 3.17e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  96 LNLQFNDIEAVtaDSFINATHLKEINLSHNKIksQKIDygVFAKLSNLQQLHLDHNNLEEFPF--PLPKsLERLLLGYNE 173
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKI--TKIE--NLEFLTNLTHLYLQNNQIEKIENleNLVN-LKKLYLGGNR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 174 ISTLpthamdglvnvtmldlcynhlsdstlKGkiLSKLEKLMQLNLCNNRLesmPPGLPsslmyLSLENNSISSIpedyf 253
Cdd:cd21340   80 ISVV--------------------------EG--LENLTNLEELHIENQRL---PPGEK-----LTFDPRSLAAL----- 118
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 825706201 254 qkLPKLHALRISHNKLEDIpYDIFNLsnlielnvghnklkqafyipRNLEHLYLQNNEIQSIN 316
Cdd:cd21340  119 --SNSLRVLNISGNNIDSL-EPLAPL--------------------RNLEQLDASNNQISDLE 158
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
117-250 1.63e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.08  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 117 LKEINLSHNKIKSqkidygVFAKLSNLQQLHLDHNNLEEFPfPLPKSLERLLLGYNEISTLPT-----HAMDGLVN-VTM 190
Cdd:PRK15387 304 LQELSVSDNQLAS------LPALPSELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselYKLWAYNNrLTS 376
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 825706201 191 LDLCYNHLSDSTLKGKILSKL----EKLMQLNLCNNRLESMPPgLPSSLMYLSLENNSISSIPE 250
Cdd:PRK15387 377 LPALPSGLKELIVSGNRLTSLpvlpSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPE 439
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
142-302 2.56e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 142 NLQQLHLDHNNLE-EFPFPLP--KSLERLLLGYNEISTLPTHAMDGLVNVTMLDLcynhlSDSTLKGKI----------- 207
Cdd:PLN00113 381 NLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI-----SNNNLQGRInsrkwdmpslq 455
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 208 ---------------LSKLEKLMQLNLCNNRLESMPP---GLPSSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKL 269
Cdd:PLN00113 456 mlslarnkffgglpdSFGSKRLENLDLSRNQFSGAVPrklGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
                        170       180       190
                 ....*....|....*....|....*....|....
gi 825706201 270 E-DIPYDIFNLSNLIELNVGHNKLKQAfyIPRNL 302
Cdd:PLN00113 536 SgQIPASFSEMPVLSQLDLSQNQLSGE--IPKNL 567
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
92-361 2.62e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  92 HIQQLNLQFNDIEAVTADSFINA----THLKEINLSHNKIKSQKIdYGVFAKLSNLQQLH-LD-HNN------LEEFPFP 159
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPIGDEGA-EILAEALKGNKSLTtLDlSNNqigdegVIALAEA 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 160 L--PKSLERLLLGYNEIS-----TLPTHaMDGLVNVTMLDLCYNHLSDSTLKGkILSKLEKlmqlnlcNNRLESMppglp 232
Cdd:COG5238  260 LknNTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIGDEGAIA-LAEGLQG-------NKTLHTL----- 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 233 sSLMYLSLENNSISSIPEdYFQKLPKLHALRISHNKLEDIPYD-----IFNLSNLIELNVGHNKLKqafyiprNLEHLYL 307
Cdd:COG5238  326 -NLAYNGIGAQGAIALAK-ALQENTTLHSLDLSDNQIGDEGAIalakyLEGNTTLRELNLGKNNIG-------KQGAEAL 396
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 825706201 308 qnneiqsinvtmmcpsLDPLHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIY 361
Cdd:COG5238  397 ----------------IDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_8 pfam13855
Leucine rich repeat;
163-224 5.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 825706201  163 SLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHLsdSTLKGKILSKLEKLMQLNLCNNRL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
187-245 5.72e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.72e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 825706201  187 NVTMLDLCYNHLSDstLKGKILSKLEKLMQLNLCNNRLESMPP----GLPsSLMYLSLENNSI 245
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
93-246 1.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  93 IQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIKSQKIDYgvFAKLSNLQQLHLDHNNLE-EFPfplpkslerllLGY 171
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE--LSSCKKLVSLDLSHNQLSgQIP-----------ASF 543
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 825706201 172 NEISTLpthamdglvnvTMLDLCYNHLSdstlkGKI---LSKLEKLMQLNLCNNRLESmppGLPSSLMYLSLENNSIS 246
Cdd:PLN00113 544 SEMPVL-----------SQLDLSQNQLS-----GEIpknLGNVESLVQVNISHNHLHG---SLPSTGAFLAINASAVA 602
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
217-342 1.64e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 217 LNLCNNRLESMPPGLPSSLMYLSLENNSISSIPedyfQKLPKLHALRISHNKLEDIPydiFNLSNLIELNVGHNKLKQAF 296
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLP---VLPPGLLELSIFSNPLTHLP 278
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 825706201 297 YIPRNLEHLYLQNNEIQSInvtmmcPSLDPlhhhHLTYLRVDQNKL 342
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTSL------PVLPP----GLQELSVSDNQL 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
211-315 3.01e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 211 LEKLMQLNLCNNRLESMP-PGLPSSLMYLSLENNSISSIPEdyFQKLPKLHALRISHNKLEDIPydifNLSNLielnvgh 289
Cdd:cd21340    1 LKRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENL------- 67
                         90       100
                 ....*....|....*....|....*.
gi 825706201 290 nklkqafyipRNLEHLYLQNNEIQSI 315
Cdd:cd21340   68 ----------VNLKKLYLGGNRISVV 83
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
115-153 1.41e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 825706201  115 THLKEINLSHNKIKsqkiDYGVFAKLSNLQQLHLDHNNL 153
Cdd:pfam12799   1 PNLEVLDLSNNQIT----DIPPLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
79-220 3.29e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201  79 DNRKLK-TIP-DIPM--HIQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIKSQKIDygVFAKLSNLQQLHLDHNNLE 154
Cdd:PLN03150 426 DNQGLRgFIPnDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPE--SLGQLTSLRILNLNGNSLS 503
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 825706201 155 EfpfPLPKSLERLLLgYNEISTLPTHAmdGLVNVTMLDLCYNHLSDSTLKGKILSKLEKLMQLNLC 220
Cdd:PLN03150 504 G---RVPAALGGRLL-HRASFNFTDNA--GLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFLVIC 563
PLN03150 PLN03150
hypothetical protein; Provisional
198-264 3.72e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 3.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 825706201 198 LSDSTLKGKI---LSKLEKLMQLNLCNNRLE-SMPPGLPS--SLMYLSLENNSIS-SIPEdyfqKLPKLHALRI 264
Cdd:PLN03150 425 LDNQGLRGFIpndISKLRHLQSINLSGNSIRgNIPPSLGSitSLEVLDLSYNSFNgSIPE----SLGQLTSLRI 494
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
238-328 4.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 825706201 238 LSLENNSISSIPEdyFQKLPKLHALRISHNKLEDIPydifNLSNLielnvghnklkqafyipRNLEHLYLQNNEIQSINV 317
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE----NLEFL-----------------TNLTHLYLQNNQIEKIEN 63
                         90
                 ....*....|.
gi 825706201 318 TMMCPSLDPLH 328
Cdd:cd21340   64 LENLVNLKKLY 74
LRR_8 pfam13855
Leucine rich repeat;
280-342 6.77e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 825706201  280 SNLIELNVGHNKL----KQAFYIPRNLEHLYLQNNEIQSINVTmmcpSLDPLhhHHLTYLRVDQNKL 342
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLSNLKVLDLSNNLLTTLSPG----AFSGL--PSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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