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Conserved domains on  [gi|1937369614|ref|NP_113986|]
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solute carrier family 12 member 2 [Rattus norvegicus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
207-1203 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1623.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  207 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVTYTAESKGVVKFGW 278
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  279 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 358
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  359 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLLAI 437
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  438 ADFVIGTFISLDSKKPKGFFGYKSEIFSENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 516
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  517 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 596
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  597 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 676
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  677 YALINFSVFHASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 756
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  757 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRW 836
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  837 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEG 916
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  917 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSdqdafkasgekpitqkDEEEDGKTSTQPLLKkeskgpvaplnvad 996
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS----------------IELNDGKISTQPDMH-------------- 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  997 qklLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFS 1075
Cdd:TIGR00930  748 ---LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAE 824
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1076 DIMVLGDINTKPKKENIVAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTA 1154
Cdd:TIGR00930  825 VIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDA 904
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*....
gi 1937369614 1155 NIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1203
Cdd:TIGR00930  905 ALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
207-1203 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1623.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  207 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVTYTAESKGVVKFGW 278
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  279 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 358
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  359 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLLAI 437
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  438 ADFVIGTFISLDSKKPKGFFGYKSEIFSENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 516
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  517 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 596
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  597 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 676
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  677 YALINFSVFHASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 756
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  757 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRW 836
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  837 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEG 916
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  917 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSdqdafkasgekpitqkDEEEDGKTSTQPLLKkeskgpvaplnvad 996
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS----------------IELNDGKISTQPDMH-------------- 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  997 qklLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFS 1075
Cdd:TIGR00930  748 ---LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAE 824
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1076 DIMVLGDINTKPKKENIVAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTA 1154
Cdd:TIGR00930  825 VIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDA 904
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*....
gi 1937369614 1155 NIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1203
Cdd:TIGR00930  905 ALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
792-1203 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 663.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  792 RPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSidQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMK 871
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  872 PNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKS 951
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  952 DQDAFKASGEK------------PITQKDEEEDGKTSTQPLLKKESKGPVAPLNvADQKLLEASTQFQKKQGKNTIDVWW 1019
Cdd:pfam03522  159 SNSKQDDDKSKlskkdsnlslspDKSTKNPSGKDSSKSDKLKKKSPSIILRTAS-NEKEILNNITQFQKKQKKGTIDVWW 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1020 LFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIVAFDDM 1098
Cdd:pfam03522  238 LYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDEL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1099 IEPYRLHEDDKEQDIAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWL 1178
Cdd:pfam03522  318 IEPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWL 389
                          410       420
                   ....*....|....*....|....*
gi 1937369614 1179 EALSKDLPPILLVRGNHQSVLTFYS 1203
Cdd:pfam03522  390 ETLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
289-744 1.30e-43

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 165.07  E-value: 1.30e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  289 NIWGVMLFIRLSWIVGQAGiGLSVLVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 368
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  369 VAVAMYVVGFAETVVELLKEHSILmideindirIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLlaiadFVIGTFISL 448
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFIVV 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  449 dskkpkGFFGYKSEIFSeNFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIA 528
Cdd:COG0531    169 ------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  529 VSVGSCVVRDATGNVNDTItteltnctsaacklnfdfsycesntcsyglmnnFQVMSMVSG--FAPLISAGIFSATLSSA 606
Cdd:COG0531    242 LALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGAL 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  607 LASLVSAPKIFQALCKDNIYPAFqmFAKGYGKNNEPLRGYILTFLIALGFILI--AELNVIAPIISNFFLASYALINFSV 684
Cdd:COG0531    289 NASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAV 366
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937369614  685 FhASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 744
Cdd:COG0531    367 I-VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
207-1203 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1623.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  207 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVTYTAESKGVVKFGW 278
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  279 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 358
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  359 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLLAI 437
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  438 ADFVIGTFISLDSKKPKGFFGYKSEIFSENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 516
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  517 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 596
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  597 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 676
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  677 YALINFSVFHASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 756
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  757 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRW 836
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  837 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEG 916
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  917 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSdqdafkasgekpitqkDEEEDGKTSTQPLLKkeskgpvaplnvad 996
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS----------------IELNDGKISTQPDMH-------------- 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  997 qklLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFS 1075
Cdd:TIGR00930  748 ---LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAE 824
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1076 DIMVLGDINTKPKKENIVAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTA 1154
Cdd:TIGR00930  825 VIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDA 904
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*....
gi 1937369614 1155 NIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1203
Cdd:TIGR00930  905 ALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
792-1203 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 663.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  792 RPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSidQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMK 871
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  872 PNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVNVDYSKKS 951
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  952 DQDAFKASGEK------------PITQKDEEEDGKTSTQPLLKKESKGPVAPLNvADQKLLEASTQFQKKQGKNTIDVWW 1019
Cdd:pfam03522  159 SNSKQDDDKSKlskkdsnlslspDKSTKNPSGKDSSKSDKLKKKSPSIILRTAS-NEKEILNNITQFQKKQKKGTIDVWW 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1020 LFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIVAFDDM 1098
Cdd:pfam03522  238 LYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDEL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614 1099 IEPYRLHEDDKEQDIAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWL 1178
Cdd:pfam03522  318 IEPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWL 389
                          410       420
                   ....*....|....*....|....*
gi 1937369614 1179 EALSKDLPPILLVRGNHQSVLTFYS 1203
Cdd:pfam03522  390 ETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
281-783 1.73e-132

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 412.87  E-value: 1.73e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  281 GVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIAMATVVTTITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGAIG 360
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  361 LIFAFanavavaMYVVGFA-ETVVELLKEHSILMIDEINDIRIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLLAIAD 439
Cdd:pfam00324   80 WNYWL-------SWITVLAlELTAASILIQFWELVPDIPYLWVWGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  440 FVIGTFISLDSKKPK---GFFGYKSEIFSENFGPDFreEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 516
Cdd:pfam00324  153 FIIVGIILLSGGNPNdgaIFRYLGDNGGKNNFPPGF--GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQV 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  517 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltnctsaacklnfdfsycesntcsYGLMNNFQVMSMVSGFAPLISA 596
Cdd:pfam00324  231 IWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLAPLINA 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  597 GIFSATLSSALASLVSAPKIFQALCKDNIYPafqMFAKGYGKNNEPLRGYILTFLIALGFILIAELNviAPIISNFFLAS 676
Cdd:pfam00324  286 VILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLN--PAIVFNFLLAI 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  677 YALINFSVFHASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 756
Cdd:pfam00324  361 SGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAA 440
                          490       500
                   ....*....|....*....|....*..
gi 1937369614  757 TYLSALQHSIRLSGVEDHVKNFRPQCL 783
Cdd:pfam00324  441 AYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
289-744 1.30e-43

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 165.07  E-value: 1.30e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  289 NIWGVMLFIRLSWIVGQAGiGLSVLVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 368
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  369 VAVAMYVVGFAETVVELLKEHSILmideindirIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLlaiadFVIGTFISL 448
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFIVV 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  449 dskkpkGFFGYKSEIFSeNFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIA 528
Cdd:COG0531    169 ------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  529 VSVGSCVVRDATGNVNDTItteltnctsaacklnfdfsycesntcsyglmnnFQVMSMVSG--FAPLISAGIFSATLSSA 606
Cdd:COG0531    242 LALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGAL 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  607 LASLVSAPKIFQALCKDNIYPAFqmFAKGYGKNNEPLRGYILTFLIALGFILI--AELNVIAPIISNFFLASYALINFSV 684
Cdd:COG0531    289 NASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAV 366
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937369614  685 FhASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 744
Cdd:COG0531    367 I-VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
193-255 1.10e-32

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 121.01  E-value: 1.10e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  193 DTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK-------EPFEDGFANGEE 255
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKnsalavaEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
306-726 1.04e-14

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 77.74  E-value: 1.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  306 AGIGLSVLVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVEL 385
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  386 LKEhsiLMIDEINDIRIIGAITVVVLLGISVAGMEWEAKAQIVLLVILLLAIADFVIGTFIsldskkPKGFFGYKSEIFS 465
Cdd:pfam13520  107 LGP---DLVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGL------VTADGGGFNLLSG 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  466 E--NFGPDFreEETFFSVFAIFFPAATGILAGANISGDlaDPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDATGNV 543
Cdd:pfam13520  178 EwhTFFPDG--WPGVFAGFLGVLWSFTGFESAANVSEE--VKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALS 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  544 NDTITTeltnctsaacklnfdfsycesntcsYGLMnnFQvMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKD 623
Cdd:pfam13520  254 SGLGQV-------------------------AALL--FQ-AVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALARD 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369614  624 NIYPAFQMFAKgYGKNNEPLRGYILTFLIALGFILIAelnVIAPIISNFFLASYALINFSVFHASLA-------KSPGWR 696
Cdd:pfam13520  306 GVLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLF---LLSPAAYNALLSLSAYGYLLSYLLPIIgllilrkKRPDLG 381
                          410       420       430
                   ....*....|....*....|....*....|
gi 1937369614  697 pafKYYNMWISLTGAILCCIVMFVINWWAA 726
Cdd:pfam13520  382 ---RIPGRWPVAIFGILFSLFLIVALFFPP 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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