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Conserved domains on  [gi|164607156|ref|NP_113615|]
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dynein axonemal light chain 1 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-181 6.17e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 6.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  37 IEKMDaSLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE--------------------------- 89
Cdd:cd21340   36 ITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprs 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  90 --AVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEA 166
Cdd:cd21340  115 laALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKI 190

                        170
                 ....*....|....*
gi 164607156 167 TKRVPKLKKLDGTPV 181
Cdd:cd21340  191 ILASKSLEVLDGKEI 205
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-181 6.17e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 6.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  37 IEKMDaSLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE--------------------------- 89
Cdd:cd21340   36 ITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprs 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  90 --AVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEA 166
Cdd:cd21340  115 laALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKI 190

                        170
                 ....*....|....*
gi 164607156 167 TKRVPKLKKLDGTPV 181
Cdd:cd21340  191 ILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-154 2.74e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 2.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  36 PIEKMDASLSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHI 113
Cdd:COG4886  147 QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLAN 226

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 164607156 114 MKKLKILYMSNNLVKDWAEfvkLAELPCLEDLVFVGNPLEE 154
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTD 264
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 49-89 8.47e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 8.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 164607156   49 NCEKLSLSTNCIEKIANLNGLKNLRILSLGRNN-IKNLNGLE 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-181 6.17e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 6.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  37 IEKMDaSLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE--------------------------- 89
Cdd:cd21340   36 ITKIE-NLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprs 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  90 --AVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEA 166
Cdd:cd21340  115 laALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKI 190

                        170
                 ....*....|....*
gi 164607156 167 TKRVPKLKKLDGTPV 181
Cdd:cd21340  191 ILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-154 2.74e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 2.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  36 PIEKMDASLSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHI 113
Cdd:COG4886  147 QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLAN 226

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 164607156 114 MKKLKILYMSNNLVKDWAEfvkLAELPCLEDLVFVGNPLEE 154
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-177 1.07e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  44 LSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNglEAVGD--TLEELWISYNFIEKL-KGIHIMKKLKI 119
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLP--EPLGNltNLKSLDLSNNQLTDLpEELGNLTNLKE 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 164607156 120 LYMSNNLVKDWAEFvkLAELPCLEDLVFVGNPLEEkhsaennwIEEATKRVPKLKKLD 177
Cdd:COG4886  187 LDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTD--------LPEPLANLTNLETLD 234
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-125 4.45e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164607156  53 LSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAvGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNN 125
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGN 78
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-173 8.78e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  29 KLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVgDTLEELWISYNFIE-- 106
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTdl 287

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 164607156 107 KLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAENNWIEEATKRVPKL 173
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-154 1.36e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  41 DASLSMLANCEKLSLSTNciekiANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHIMKKLKI 119
Cdd:COG4886   89 LTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKS 163

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 164607156 120 LYMSNNLVKDWAEFvkLAELPCLEDLVFVGNPLEE 154
Cdd:COG4886  164 LDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITD 196
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 49-89 8.47e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 8.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 164607156   49 NCEKLSLSTNCIEKIANLNGLKNLRILSLGRNN-IKNLNGLE 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_9 pfam14580
Leucine-rich repeat;
73-154 4.57e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156   73 RILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAeLPCLEDLVFVGNPL 152
Cdd:pfam14580  22 RELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEA-LPNLTELILTNNNL 100


                  ..
gi 164607156  153 EE 154
Cdd:pfam14580 101 QE 102
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-177 2.02e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156  52 KLSLSTNCIEKIANLNGLKNLRILSLGRNNikNLNGLEAvgdtLEELWISYNFIEKL-KGIHIMKKLKILYMSNNLVKDW 130
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE--ELSNLTN----LESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164607156 131 AEFvkLAELPCLEDLVFVGNPLEEkhsaennwIEEATKRVPKLKKLD 177
Cdd:COG4886  152 PEP--LGNLTNLKSLDLSNNQLTD--------LPEELGNLTNLKELD 188
LRR_9 pfam14580
Leucine-rich repeat;
33-177 3.04e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 36.67  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607156   33 QIPPIEKMDASLSMLancEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNlngleaVGDTLEElwisynfieklkgih 112
Cdd:pfam14580  30 KIPIIENLGATLDQF---DTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR------IGEGLGE--------------- 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164607156  113 IMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLeekhSAENNWIEEATKRVPKLKKLD 177
Cdd:pfam14580  86 ALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPV----TNKPHYRLYVIYKVPQLRLLD 146
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 95-125 4.04e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 4.04e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 164607156   95 LEELWISYNFIEKLKGIHIMKKLKILYMSNN 125
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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