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Conserved domains on  [gi|18079254|ref|NP_110442|]
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p53 and DNA damage-regulated protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 26-111 4.25e-36

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


:

Pssm-ID: 467471  Cd Length: 103  Bit Score: 119.54  E-value: 4.25e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079254  26 DKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEA 105
Cdd:cd22860  18 DKQELVDLDRRRNKNREALRALKKSKKEESKVWICLGDMFIKLPKEKAKKMLEKDQKELDKEINKLRSELKEKVNKLRDL 97


                ....*.
gi 18079254 106 QGKPEL 111
Cdd:cd22860  98 EGKPEL 103
 
Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 26-111 4.25e-36

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467471  Cd Length: 103  Bit Score: 119.54  E-value: 4.25e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079254  26 DKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEA 105
Cdd:cd22860  18 DKQELVDLDRRRNKNREALRALKKSKKEESKVWICLGDMFIKLPKEKAKKMLEKDQKELDKEINKLRSELKEKVNKLRDL 97


                ....*.
gi 18079254 106 QGKPEL 111
Cdd:cd22860  98 EGKPEL 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 27-108 9.00e-04

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 36.43  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079254    27 KRQIVDLDTKRNQNREGLRALQ---KDLSLSEDVMVCF---GNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVN 100
Cdd:pfam01920   8 QQQLQLLAQQIKQLETQLKELElalEELELLDEDTKVYkliGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQLEKLEK 87


                  ....*...
gi 18079254   101 RLFEAQGK 108
Cdd:pfam01920  88 ELEELKEE 95
 
Name Accession Description Interval E-value
PDRG1 cd22860
p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a ...
 26-111 4.25e-36

p53 and DNA damage-regulated protein 1; p53 and DNA damage-regulated protein 1 (PDRG1) is a beta-type subunit of the prefoldin-like complex that is part of the PAQosome (Particle for Arrangement of Quaternary structure) complex. The PAQosome is a cochaperone that assists the chaperone HSP90 in assembly of large protein complexes. PDRG1 acts as a tumor marker in multiple cancer types, including testicular cancer, lung cancer, colorectal cancer, liver cancer, etc. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467471  Cd Length: 103  Bit Score: 119.54  E-value: 4.25e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079254  26 DKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEA 105
Cdd:cd22860  18 DKQELVDLDRRRNKNREALRALKKSKKEESKVWICLGDMFIKLPKEKAKKMLEKDQKELDKEINKLRSELKEKVNKLRDL 97


                ....*.
gi 18079254 106 QGKPEL 111
Cdd:cd22860  98 EGKPEL 103
Prefoldin cd00890
prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and ...
 26-100 1.47e-16

prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits; the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes, there are two or more paralogous genes encoding each subunit, adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467470  Cd Length: 79  Bit Score: 68.90  E-value: 1.47e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18079254  26 DKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVN 100
Cdd:cd00890   5 LSQQIEQLNRQINELEEALDELSNLDKDTEEVYRSVGGVFIEKSKEETKEELEEKLDELQKEIKKLEQQLEAKTK 79
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 26-100 4.91e-15

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 65.06  E-value: 4.91e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18079254  26 DKRQIVDLDTKRNQNREGLRALQKdLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVN 100
Cdd:cd00632   5 LKSQKEELERKINEQKVVLDELSN-LKKNRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKEK 78
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 54-102 2.72e-04

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 37.52  E-value: 2.72e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 18079254  54 SEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRL 102
Cdd:cd23165  45 DEPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEIEKLEEEIDEIEEEM 93
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 27-108 9.00e-04

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 36.43  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079254    27 KRQIVDLDTKRNQNREGLRALQ---KDLSLSEDVMVCF---GNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVN 100
Cdd:pfam01920   8 QQQLQLLAQQIKQLETQLKELElalEELELLDEDTKVYkliGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQLEKLEK 87


                  ....*...
gi 18079254   101 RLFEAQGK 108
Cdd:pfam01920  88 ELEELKEE 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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