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Conserved domains on  [gi|47271457|ref|NP_085116|]
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zinc finger protein ZFP2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048 111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048 351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410       420       430
                ....*....|....*....|....*....|
gi 47271457 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048 111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048 351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410       420       430
                ....*....|....*....|....*....|
gi 47271457 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 47271457   200 SLIQHERIHTGEKPYKCNECGKAFTQ 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 184-232 2.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 47271457 184 KPYqCKECGKAFHKNSSLIQHERIHTgekpYKCNECGKAFTQSMNLTVH 232
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 6.63e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  132 CNVCgKHFIERSSLTVHQ-------------------RIHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086 410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  193 KAFHKNsSLIQHERIHTGEKPYKCNECG---KAFTQSM-------NLTVHQRThTGEKPYECNECGKAF---SQSMHLI- 258
Cdd:PLN03086 485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                 ....*
gi 47271457  259 VHQRS 263
Cdd:PLN03086 563 VHQKS 567
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048 111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048 351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410       420       430
                ....*....|....*....|....*....|
gi 47271457 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-461 4.75e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 128 KPYKCNVCGKHFIERSSLTVHQRIHTGEKPYKCN--ECGKAFSQSMNLTVHQRTHTGEKPY-QCKECGKAFHKNSSLIQH 204
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 205 ERIHTGEKPYKCNECGKAFTQ--SMNLTVHQRTHTGEKPYE-CNECGKAFSQS--MHLIVHQRSHTGEKpyecsqcgkaf 279
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSrdPQLPDLLSISNLRNNPLPgNNSSSVNTPQSnsLHPPLPANSLSKDP----------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 280 SKSSTLTLHQRNHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFSK------NSSLTQHRRIHTGEKP 353
Cdd:COG5048 181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASES 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 354 YECMVCGKHFTGRSSLTVHQVIHTG-EKPYECNECGKAFSQSAYLIEHQR--IHTGEkpyecdqcgkafiknssltvhqr 430
Cdd:COG5048 261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE----------------------- 317

                       330       340       350
                ....*....|....*....|....*....|...
gi 47271457 431 thtGEKPYQCNE--CGKAFSRSTNLTRHQRTHT 461
Cdd:COG5048 318 ---SLKPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-460 5.66e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 156 KPYKCNECGKAFSQSMNLTVHQRTHTGEKPYQC--KECGKAFHKNSSLIQHERIHTGEKPYKC----------------N 217
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 218 ECGKAF---TQSMNLTVHQRTHTGEKPYECNEC--GKAFSQSMHLIVHQRSHTGEKPYECSQ--CGKAFSKSSTLTLHQR 290
Cdd:COG5048 112 SSSSNSndnNLLSSHSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPAnsLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 291 NHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFSK------NSSLTQHRRIHTGEKPYECMVCGKHFT 364
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 365 GRSSLTVHQVIHTG-EKPYECNECGKAFSQSAYLIEHQR--IHTGE--KPYECD--QCGKAFIKNSSLTVHQRTHTGEKP 437
Cdd:COG5048 272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                       330       340
                ....*....|....*....|....*
gi 47271457 438 YQC--NECGKAFSRSTNLTRHQRTH 460
Cdd:COG5048 352 AKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-336 3.18e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  71 KRPHNCNSHGEDATQNSELIKTQRMFVGKKIYECNQCSKTFSQSSSllkhqriHTGEKPYKCNVCGKHFIERSSLTVHQR 150
Cdd:COG5048 209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS-------SSASESPRSSLPTASSQSSSPNESDSS 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 151 IHTG-EKPYKCNECGKAFSQSMNLTVHQRT--HTGE--KPYQCKE--CGKAFHKNSSLIQHERIHTGEKPYKCNecgkaf 223
Cdd:COG5048 282 SEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK------ 355

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 224 tqsmnLTVHQRTHTGEKPYECNECgkafsqsmhlIVHQRSHTGEKPYEC--SQCGKAFSKSSTLTLHQRNHTGEKP--YK 299
Cdd:COG5048 356 -----LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47271457 300 CNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFS 336
Cdd:COG5048 421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 47271457   200 SLIQHERIHTGEKPYKCNECGKAFTQ 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 47271457   228 NLTVHQRTHTGEKPYECNECGKAFSQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 3.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 47271457   144 SLTVHQRIHTGEKPYKCNECGKAFSQ 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-195 4.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.24e-04
                          10        20
                  ....*....|....*....|....
gi 47271457   172 NLTVHQRTHTGEKPYQCKECGKAF 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 5.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 47271457   424 SLTVHQRTHTGEKPYQCNECGKAFSR 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 438-460 6.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.78e-04
                          10        20
                  ....*....|....*....|...
gi 47271457   438 YQCNECGKAFSRSTNLTRHQRTH 460
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 154-237 6.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 6.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 154 GEKPYKCN--ECGKAFSQSMNLTVHqRTHtgekpyqcKECGKAFHKNSSLIQHERIHTGEKPYKCNECGKAFTQSMNLTV 231
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 47271457 232 HqRTHT 237
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 8.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.27e-04
                          10        20
                  ....*....|....*....|....
gi 47271457   396 YLIEHQRIHTGEKPYECDQCGKAF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 47271457   285 LTLHQRNHTGEKPYKCNKCGKSFSQ 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 47271457   256 HLIVHQRSHTGEKPYECSQCGKAFSK 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-139 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....
gi 47271457   116 SLLKHQRIHTGEKPYKCNVCGKHF 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 184-232 2.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 47271457 184 KPYqCKECGKAFHKNSSLIQHERIHTgekpYKCNECGKAFTQSMNLTVH 232
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-364 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*
gi 47271457   340 SLTQHRRIHTGEKPYECMVCGKHFT 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 158-180 3.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|...
gi 47271457   158 YKCNECGKAFSQSMNLTVHQRTH 180
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 214-236 4.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|...
gi 47271457   214 YKCNECGKAFTQSMNLTVHQRTH 236
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 4.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 47271457   368 SLTVHQVIHTGEKPYECNECGKAFSQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 334-433 6.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 334 AFSKNSSL---TQHRRIHT-GEKPYECMV--CGKHFTGRSSLTVHQvIHtgekpyecNECGKAFSQSAYLIEHQRIHTGE 407
Cdd:COG5189 326 KLAHGGERnidTPSRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKD 396

                        90       100
                ....*....|....*....|....*.
gi 47271457 408 KPYECDQCGKAFIKNSSLTVHqRTHT 433
Cdd:COG5189 397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 6.63e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  132 CNVCgKHFIERSSLTVHQ-------------------RIHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086 410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457  193 KAFHKNsSLIQHERIHTGEKPYKCNECG---KAFTQSM-------NLTVHQRThTGEKPYECNECGKAF---SQSMHLI- 258
Cdd:PLN03086 485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                 ....*
gi 47271457  259 VHQRS 263
Cdd:PLN03086 563 VHQKS 567
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-372 9.96e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 9.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271457 294 GEKPYKCN--KCGKSFSQSTYLIEHqRLHSgvkpfecnECGKAFSKNSSLTQHRRIHTGEKPYECMVCGKHFTGRSSLTV 371
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 47271457 372 H 372
Cdd:COG5189 417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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