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Conserved domains on  [gi|13399330|ref|NP_085047|]
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uroplakin-3b isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UP_III_II super family cl06408
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 84-209 6.44e-59

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


The actual alignment was detected with superfamily member cd09969:

Pssm-ID: 471435  Cd Length: 184  Bit Score: 187.21  E-value: 6.44e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13399330  84 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 163
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13399330 164 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYR 209
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYR 121
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 84-209 6.44e-59

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 187.21  E-value: 6.44e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13399330  84 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 163
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13399330 164 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYR 209
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYR 121
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 84-209 6.44e-59

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 187.21  E-value: 6.44e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13399330  84 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 163
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13399330 164 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYR 209
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYR 121
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 84-209 3.21e-56

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 180.27  E-value: 3.21e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13399330  84 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLASASDTVWLVVAFSNASRGFQNPETLAD-IPASPQLLTDGHYMTL 162
Cdd:cd09968   1 EAVSYVPQLASTFLEGNPTSTTFTLEQPRCVFDSSASDTDDVWLVVAVSNATNNFNAPQNSTDpISTYSQFSGGQYYLTL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 13399330 163 PLSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQPFCNAPLPGPGPYR 209
Cdd:cd09968  81 RASRDLYPCGNP---SLNAYVLRVGADGNCTDNGNCNGPLPGPGPYR 124
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 86-209 9.49e-47

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 156.05  E-value: 9.49e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13399330  86 VPYTPQITAWDLEGKVTATTFSLEQPRCVFDGlaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLPLS 165
Cdd:cd09966   1 LSYVPQLTASTGAGNPTLSTFTLEQPPCMFDS--SSTDDVWLVVALPNATLAFQNVTLSTDISTYLTFTTGNYYKTLRAS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 13399330 166 PDQLPCGDPMAgSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYR 209
Cdd:cd09966  79 FDLPPCRNRRD-IVSAYVLRVGNTTTCLSG-YCNTPLPGPGPYR 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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