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Conserved domains on  [gi|16418335|ref|NP_084072|]
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leucine-rich alpha-2-glycoprotein precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-272 7.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  66 LSVEFSNLTQLPAAaLQGCPGLRELHLSSNRLQALsPELLAPVPRLRALDLTRNALRSLPPGLFSTSaNLSTLVLRENQL 145
Cdd:COG4886 118 LDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 146 REVSAqWLQGLDALGHLDLAENQLSSLPSGlLASLGALHTLDLGYNLLESLPEglLRGPRRLQRLHLEGNRLQRLEDSLL 225
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN 270

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 16418335 226 APQpfLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGL 272
Cdd:COG4886 271 LTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 259-341 8.14e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.85  E-value: 8.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335    259 DLSNNSLSSTPPGLWAFLGRPTRdmqdgFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAE 338
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSE-----IDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75


                   ...
gi 16418335    339 LGS 341
Cdd:TIGR00864   76 LDS 78
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-272 7.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  66 LSVEFSNLTQLPAAaLQGCPGLRELHLSSNRLQALsPELLAPVPRLRALDLTRNALRSLPPGLFSTSaNLSTLVLRENQL 145
Cdd:COG4886 118 LDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 146 REVSAqWLQGLDALGHLDLAENQLSSLPSGlLASLGALHTLDLGYNLLESLPEglLRGPRRLQRLHLEGNRLQRLEDSLL 225
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN 270

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 16418335 226 APQpfLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGL 272
Cdd:COG4886 271 LTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-293 3.48e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.60  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   55 FPSSLPADTVHLSVEFSNLTQLPAAalqgCPG-LRELHLSSNRLQALsPELLAPVprLRALDLTRNALRSLPPGLfstSA 133
Cdd:PRK15370 214 LPENLQGNIKTLYANSNQLTSIPAT----LPDtIQEMELSINRITEL-PERLPSA--LQSLDLFHNKISCLPENL---PE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  134 NLSTLVLRENQLREVSAQWLQGLDalgHLDLAENQLSSLPSGLLASlgaLHTLDLGYNLLESLPEGLlrgPRRLQRLHLE 213
Cdd:PRK15370 284 ELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASL---PPELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  214 GNRLQRLEDSLlapQPFLRVLFLNDNQLVGVATGSFQGLQHLDMldlSNNSLSSTPPGLWAFLG---RPTRDMqdgfdIS 290
Cdd:PRK15370 355 KNQITVLPETL---PPTITTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLPESLPHFRGegpQPTRII-----VE 423


                 ...
gi 16418335  291 HNP 293
Cdd:PRK15370 424 YNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-267 9.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 9.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 110 RLRALDLTRNALRSLppGLFSTSANLSTLVLRENQLREVSAqwLQGLDALGHLDLAENQLSSLPSglLASLGALHTLDLG 189
Cdd:cd21340   3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 190 YNLLESLpEGLlRGPRRLQRLHLEGNRLQRLE------DSLLAPQPFLRVLFLNDNQLVGVAtgSFQGLQHLDMLDLSNN 263
Cdd:cd21340  77 GNRISVV-EGL-ENLTNLEELHIENQRLPPGEkltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152


                ....
gi 16418335 264 SLSS 267
Cdd:cd21340 153 QISD 156
LRR_8 pfam13855
Leucine rich repeat;
109-169 3.73e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 3.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16418335   109 PRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWLQGLDALGHLDLAENQL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 259-341 8.14e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.85  E-value: 8.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335    259 DLSNNSLSSTPPGLWAFLGRPTRdmqdgFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAE 338
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSE-----IDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75


                   ...
gi 16418335    339 LGS 341
Cdd:TIGR00864   76 LDS 78
LRRCT smart00082
Leucine rich repeat C-terminal domain;
292-338 9.87e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 9.87e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 16418335    292 NPWICDKNLADLCRWLVANRNKMfSQNDTRCAGPEAMKGQRLLDVAE 338
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRGPLLELLHS 46
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-272 7.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  66 LSVEFSNLTQLPAAaLQGCPGLRELHLSSNRLQALsPELLAPVPRLRALDLTRNALRSLPPGLFSTSaNLSTLVLRENQL 145
Cdd:COG4886 118 LDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 146 REVSAqWLQGLDALGHLDLAENQLSSLPSGlLASLGALHTLDLGYNLLESLPEglLRGPRRLQRLHLEGNRLQRLEDSLL 225
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN 270

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 16418335 226 APQpfLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGL 272
Cdd:COG4886 271 LTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-267 1.79e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  80 ALQGCPGLRELHLSSNRLQALsPELLAPVPRLRALDLTRNALRSLPPGLFStSANLSTLVLRENQLREVSAqWLQGLDAL 159
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPE-ELGNLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 160 GHLDLAENQLSSLPSGlLASLGALHTLDLGYNLLESLPEGlLRGPRRLQRLHLEGNRLQRLEDslLAPQPFLRVLFLNDN 239
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                       170       180
                ....*....|....*....|....*...
gi 16418335 240 QLVGVatGSFQGLQHLDMLDLSNNSLSS 267
Cdd:COG4886 261 QLTDL--PPLANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-293 3.48e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.60  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   55 FPSSLPADTVHLSVEFSNLTQLPAAalqgCPG-LRELHLSSNRLQALsPELLAPVprLRALDLTRNALRSLPPGLfstSA 133
Cdd:PRK15370 214 LPENLQGNIKTLYANSNQLTSIPAT----LPDtIQEMELSINRITEL-PERLPSA--LQSLDLFHNKISCLPENL---PE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  134 NLSTLVLRENQLREVSAQWLQGLDalgHLDLAENQLSSLPSGLLASlgaLHTLDLGYNLLESLPEGLlrgPRRLQRLHLE 213
Cdd:PRK15370 284 ELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASL---PPELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  214 GNRLQRLEDSLlapQPFLRVLFLNDNQLVGVATGSFQGLQHLDMldlSNNSLSSTPPGLWAFLG---RPTRDMqdgfdIS 290
Cdd:PRK15370 355 KNQITVLPETL---PPTITTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLPESLPHFRGegpQPTRII-----VE 423


                 ...
gi 16418335  291 HNP 293
Cdd:PRK15370 424 YNP 426
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-306 2.97e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  53 TEFPSSLPADT--VHLSVEFSNLTQLPAAaLQGCPGLRELHLSSNRLQALSPElLAPVPRLRALDLTRNALRSLPPGLfS 130
Cdd:COG4886 149 TDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPL-A 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 131 TSANLSTLVLRENQLREVSaqWLQGLDALGHLDLAENQLSSLPSglLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRL 210
Cdd:COG4886 226 NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 211 HLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFLGRPTRDMQDGFDIS 290
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                       250
                ....*....|....*.
gi 16418335 291 HNPWICDKNLADLCRW 306
Cdd:COG4886 382 LALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-270 4.40e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 4.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  97 LQALSPELLAPVPRLRALDLTRNALrslppglFSTSANLSTLVLRENQLREVSAqWLQGLDALGHLDLAENQLSSLPSGL 176
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPL 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 177 ----------------------LASLGALHTLDLGYNLLESLPEGlLRGPRRLQRLHLEGNRLQRLEDSlLAPQPFLRVL 234
Cdd:COG4886 156 gnltnlksldlsnnqltdlpeeLGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP-LANLTNLETL 233

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16418335 235 FLNDNQLVGVAtgSFQGLQHLDMLDLSNNSLSSTPP 270
Cdd:COG4886 234 DLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
106-314 1.86e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.18  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  106 APVP-RLRALDLTRNALRSLPPGLfstSANLSTLVLRENQLREVSAQWLqglDALGHLDLAENQLSSLPSGLLAslgALH 184
Cdd:PRK15370 195 ACIPeQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATLP---DTIQEMELSINRITELPERLPS---ALQ 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  185 TLDLGYNLLESLPEGLlrgPRRLQRLHLEGNRLQRL--------------EDSLLA-PQ---PFLRVLFLNDNQLVGVAT 246
Cdd:PRK15370 266 SLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLpahlpsgithlnvqSNSLTAlPEtlpPGLKTLEAGENALTSLPA 342

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16418335  247 GSFQGLQhldMLDLSNNSLSSTPPGLwaflgRPTrdMQDgFDISHNPWI-CDKNLADLCRWLVANRNKM 314
Cdd:PRK15370 343 SLPPELQ---VLDVSKNQITVLPETL-----PPT--ITT-LDVSRNALTnLPENLPAALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-267 9.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 9.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 110 RLRALDLTRNALRSLppGLFSTSANLSTLVLRENQLREVSAqwLQGLDALGHLDLAENQLSSLPSglLASLGALHTLDLG 189
Cdd:cd21340   3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 190 YNLLESLpEGLlRGPRRLQRLHLEGNRLQRLE------DSLLAPQPFLRVLFLNDNQLVGVAtgSFQGLQHLDMLDLSNN 263
Cdd:cd21340  77 GNRISVV-EGL-ENLTNLEELHIENQRLPPGEkltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152


                ....
gi 16418335 264 SLSS 267
Cdd:cd21340 153 QISD 156
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-239 2.55e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 2.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  65 HLSVEFSNLTQLPAaaLQGCPGLRELHLSSNRLQALspELLAPVPRLRALDLTRNALRSLPPglFSTSANLSTLVLRENQ 144
Cdd:cd21340   6 HLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 145 LREVSAqwLQGLDALGHLDLaENQlsSLPSG---------LLASLGALHTLDLGYNLLESLPEglLRGPRRLQRLHLEGN 215
Cdd:cd21340  80 ISVVEG--LENLTNLEELHI-ENQ--RLPPGekltfdprsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*.
gi 16418335 216 RLQRLED--SLLAPQPFLRVLFLNDN 239
Cdd:cd21340 153 QISDLEEllDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-253 4.80e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   53 TEFPSSLPADTVHLSVEFSNLTQLPAAAlqgCPGLRELHLSSNRLQALsPELLApvPRLRALDLTRNALRSLPPGLFSTs 132
Cdd:PRK15370 296 RTLPAHLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSL-PASLP--PELQVLDVSKNQITVLPETLPPT- 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  133 anlstlvlrenqlrevsaqwlqgldaLGHLDLAENQLSSLPSGLLAslgALHTLDLGYNLL----ESLPEGLLRGPRRlQ 208
Cdd:PRK15370 369 --------------------------ITTLDVSRNALTNLPENLPA---ALQIMQASRNNLvrlpESLPHFRGEGPQP-T 418

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16418335  209 RLHLEGN--------RLQRLEDSLLAPQPflRVLF-LNDNQLVGVATGSFQGLQ 253
Cdd:PRK15370 419 RIIVEYNpfsertiqNMQRLMSSVGYQGP--RVLFaMGDFSIVRVTRPLHQAVQ 470
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-272 6.38e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 6.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   75 QLPAAALQGCPGLRELHLSSNRLQALSPEllAPVPRLRALDLTRNALRSLPP---GLFStsaNLSTLVLRENQLREVSAQ 151
Cdd:PLN00113 108 PIPDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPndiGSFS---SLKVLDLGGNVLVGKIPN 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  152 WLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAPQPFL 231
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNL 262

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 16418335  232 RVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGL 272
Cdd:PLN00113 263 QYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPEL 303
LRR_8 pfam13855
Leucine rich repeat;
109-169 3.73e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 3.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16418335   109 PRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWLQGLDALGHLDLAENQL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
205-265 9.87e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 9.87e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16418335   205 RRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSL 265
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-270 1.57e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   70 FSN-LTQLPAAALQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREV 148
Cdd:PLN00113 316 FSNnFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGE 395

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  149 SAQWLQGLDALGHLDLAENQLS-SLPSGlLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNR-LQRLEDSLLA 226
Cdd:PLN00113 396 IPKSLGACRSLRRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPDSFGS 474

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 16418335  227 PQpfLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPP 270
Cdd:PLN00113 475 KR--LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP 516
LRR_8 pfam13855
Leucine rich repeat;
85-145 3.50e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.50e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16418335    85 PGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQL 145
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-266 8.09e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 8.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   65 HLSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQ 144
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  145 LREVSAQWLQGLDALGHLDLAENQLSslpSGLLASLGA---LHTLDLGYNLLES-LPEGLLRGPrRLQRLHLEGNRLQ-R 219
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSNKFS---GEIPKNLGKhnnLTVLDLSTNNLTGeIPEGLCSSG-NLFKLILFSNSLEgE 395

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 16418335  220 LEDSLLAPQPFLRVLfLNDNQLVGVATGSFQGLQHLDMLDLSNNSLS 266
Cdd:PLN00113 396 IPKSLGACRSLRRVR-LQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
LRR_8 pfam13855
Leucine rich repeat;
66-121 1.60e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 1.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16418335    66 LSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNAL 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
134-193 2.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   134 NLSTLVLRENQLREVSAQWLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
162-217 4.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.41e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16418335   162 LDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRL 217
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
51-269 6.65e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.93  E-value: 6.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   51 GPTEFPSSLPADTVHLSVEFSNLTQLPAAAlqgcPGLRELHLSSNRLQALspellaPV--PRLRALDLTRNALRSLPpgl 128
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSL------PVlpPGLLELSIFSNPLTHLP--- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  129 fSTSANLSTLVLRENQLREVSAQwlqgLDALGHLDLAENQLSSLPSgLLASLGALHTLDLGYNLLESLPEGLLR------ 202
Cdd:PRK15387 279 -ALPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASLPA-LPSELCKLWAYNNQLTSLPTLPSGLQElsvsdn 352

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16418335  203 -------GPRRLQRLHLEGNRLQrledSLLAPQPFLRVLFLNDNQLVGVATGSfqglQHLDMLDLSNNSLSSTP 269
Cdd:PRK15387 353 qlaslptLPSELYKLWAYNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLP 418
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 259-341 8.14e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.85  E-value: 8.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335    259 DLSNNSLSSTPPGLWAFLGRPTRdmqdgFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAE 338
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSE-----IDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75


                   ...
gi 16418335    339 LGS 341
Cdd:TIGR00864   76 LDS 78
LRRCT smart00082
Leucine rich repeat C-terminal domain;
292-338 9.87e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 9.87e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 16418335    292 NPWICDKNLADLCRWLVANRNKMfSQNDTRCAGPEAMKGQRLLDVAE 338
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRGPLLELLHS 46
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-292 1.71e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   87 LRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTlvlrenqlrevsaqwlqgldalghLDLAE 166
Cdd:PLN00113 310 LEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTV------------------------LDLST 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  167 NQLSS-LPSGLLASlGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVA 245
Cdd:PLN00113 366 NNLTGeIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI 444

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 16418335  246 TGSFQGLQHLDMLDLSNNSLSSTPPGLWAflgrptRDMQDGFDISHN 292
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFGGLPDSFG------SKRLENLDLSRN 485
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 74-294 3.63e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 3.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  74 TQLPAAALQGCPGLRELHLSSNRLQALSPELLAPV---PRLRALDLTRN-----ALRSLPPGLFSTSANLSTLVL----R 141
Cdd:cd00116  70 LQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLgrnrL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 142 ENQLREVSAQWLQGLDALGHLDLAENQLssLPSGL------LASLGALHTLDLGYNLLE----SLPEGLLRGPRRLQRLH 211
Cdd:cd00116 150 EGASCEALAKALRANRDLKELNLANNGI--GDAGIralaegLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLN 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 212 LEGNRL-----QRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQH----LDMLDLSNNSLSSTPPGLWAFLGRPTRD 282
Cdd:cd00116 228 LGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAekesLLELDLRGNKFGEEGAQLLAESLLEPGN 307

                       250
                ....*....|..
gi 16418335 283 MQDGFDISHNPW 294
Cdd:cd00116 308 ELESLWVKDDSF 319
LRR_8 pfam13855
Leucine rich repeat;
231-276 5.39e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.39e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 16418335   231 LRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFL 276
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL 48
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-276 7.70e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 7.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   70 FSNL--TQLPAAaLQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLRE 147
Cdd:PLN00113 388 FSNSleGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG 466

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  148 VSAQwLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAP 227
Cdd:PLN00113 467 GLPD-SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 16418335  228 QPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFL 276
Cdd:PLN00113 546 MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFL 594
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 33-266 1.06e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  33 LKECLILQSAEGSTVSCHGPTEFPSSL-------PADTVHLSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSPELL 105
Cdd:COG5238  97 AEEVSPVALAETATAVATPPPDLRRIMaktledsLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKA 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 106 APVPRLRALDLTRNALRSLPPGLF----STSANLSTLVLRENQLREVSA----QWLQGLDALGHLDLAENQLSSlpSGLL 177
Cdd:COG5238 177 LQNNSVETVYLGCNQIGDEGIEELaealTQNTTVTTLWLKRNPIGDEGAeilaEALKGNKSLTTLDLSNNQIGD--EGVI 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 178 AslgalhtldlgynLLESlpeglLRGPRRLQRLHLEGNRLQ----RLEDSLLAPQPFLRVLFLNDNQLVGV-ATGSFQGL 252
Cdd:COG5238 255 A-------------LAEA-----LKNNTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEgAIALAEGL 316

                       250
                ....*....|....*..
gi 16418335 253 QH---LDMLDLSNNSLS 266
Cdd:COG5238 317 QGnktLHTLNLAYNGIG 333
LRR_8 pfam13855
Leucine rich repeat;
183-241 4.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 4.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16418335   183 LHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQL 241
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 87-272 4.59e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.17  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335    87 LRELHLSSNRLQALSpELLAPVPRLRALDLTRNA-LRSLPPglFSTSANLSTLVLRE-NQLREV--SAQWLQGLDALgHL 162
Cdd:PLN03210  613 LVKLQMQGSKLEKLW-DGVHSLTGLRNIDLRGSKnLKEIPD--LSMATNLETLKLSDcSSLVELpsSIQYLNKLEDL-DM 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   163 DLAENqLSSLPSGL-LASLGALH------------------TLDLGYNLLESLPEGLlrgprRLQRL---HLEGNRLQRL 220
Cdd:PLN03210  689 SRCEN-LEILPTGInLKSLYRLNlsgcsrlksfpdistnisWLDLDETAIEEFPSNL-----RLENLdelILCEMKSEKL 762

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335   221 ED--SLLAP-----QPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSN-NSLSSTPPGL 272
Cdd:PLN03210  763 WErvQPLTPlmtmlSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTGI 822
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 78-201 4.73e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  78 AAALQGCPGLRELHLSSNRLQALSPELLAPVPR----LRALDLTRNAL-----RSLPPGLfSTSANLSTLVLRENQLREV 148
Cdd:COG5238 285 AKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQgnktLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLSDNQIGDE 363

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 149 SA----QWLQGLDALGHLDLAENQLSSL-PSGLLASL--GALHTLDLGYNLLESLPEGLL 201
Cdd:COG5238 364 GAialaKYLEGNTTLRELNLGKNNIGKQgAEALIDALqtNRLHTLILDGNLIGAEAQQRL 423
PLN03150 PLN03150
hypothetical protein; Provisional
 205-296 3.21e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  205 RRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGlwAFLGRPTRDMQ 284
Cdd:PLN03150 442 RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA--ALGGRLLHRAS 519

                         90
                 ....*....|..
gi 16418335  285 dgFDISHNPWIC 296
Cdd:PLN03150 520 --FNFTDNAGLC 529
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-246 4.68e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 4.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335  65 HLSVEFSNLTQLPAaaLQGCPGLRELHLSSNRLQALSPelLAPVPRLRALDLTRNALRSLP----PGLFSTSANLSTLVL 140
Cdd:COG4886 232 TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLL 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418335 141 RENQLREVSAQWLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRL 220
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                       170       180
                ....*....|....*....|....*.
gi 16418335 221 EDSLLAPQPFLRVLFLNDNQLVGVAT 246
Cdd:COG4886 388 TLLLLLLTTTAGVLLLTLALLDAVNT 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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