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Conserved domains on  [gi|254692936|ref|NP_083591|]
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POU domain, class 5, transcription factor 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
112-181 2.25e-38

Pou domain - N-terminal to homeobox domain;


:

Pssm-ID: 459692  Cd Length: 72  Bit Score: 130.86  E-value: 2.25e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692936  112 QKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVD 181
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain super family cl47488
Homeodomain;
214-250 2.75e-09

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 52.50  E-value: 2.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 254692936  214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
 
Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
112-181 2.25e-38

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 130.86  E-value: 2.25e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692936  112 QKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVD 181
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
POU smart00352
Found in Pit-Oct-Unc transcription factors;
107-181 3.29e-32

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 114.84  E-value: 3.29e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254692936   107 DVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVD 181
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
214-250 2.75e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 52.50  E-value: 2.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 254692936  214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 214-250 1.03e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 1.03e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 254692936 214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:cd00086   15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 214-250 1.61e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.33  E-value: 1.61e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 254692936   214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:smart00389  16 LEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 104-188 4.41e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.85  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692936 104 LPEDVSAIQKEMEqLAKELRQKRMTLGYSQADVGFAVGamfgkvLSQTTICRFEA--QQLSLANMWKLRPLLKMWLEEV- 180
Cdd:COG3620    5 MSRDVVTVSPDDT-LGEALRLMRKELGLSQLPVAELVG------VSQSDILRIESgkRDPTVSTLEKIAEALGKELSAVl 77

                         90
                 ....*....|
gi 254692936 181 --DEKNLLGI 188
Cdd:COG3620   78 vvDDGKLVGI 87
 
Name Accession Description Interval E-value
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
112-181 2.25e-38

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 130.86  E-value: 2.25e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692936  112 QKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVD 181
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
POU smart00352
Found in Pit-Oct-Unc transcription factors;
107-181 3.29e-32

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 114.84  E-value: 3.29e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254692936   107 DVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLRPLLKMWLEEVD 181
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
214-250 2.75e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 52.50  E-value: 2.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 254692936  214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 214-250 1.03e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 1.03e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 254692936 214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:cd00086   15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 214-250 1.61e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.33  E-value: 1.61e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 254692936   214 LEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNR 250
Cdd:smart00389  16 LEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 104-188 4.41e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.85  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692936 104 LPEDVSAIQKEMEqLAKELRQKRMTLGYSQADVGFAVGamfgkvLSQTTICRFEA--QQLSLANMWKLRPLLKMWLEEV- 180
Cdd:COG3620    5 MSRDVVTVSPDDT-LGEALRLMRKELGLSQLPVAELVG------VSQSDILRIESgkRDPTVSTLEKIAEALGKELSAVl 77

                         90
                 ....*....|
gi 254692936 181 --DEKNLLGI 188
Cdd:COG3620   78 vvDDGKLVGI 87
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
115-180 2.28e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 35.98  E-value: 2.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254692936 115 MEQLAKELRQKRMTLGYSQADVGFAVGamfgkvLSQTTICRFEA--QQLSLANMWKLRPLLKMWLEEV 180
Cdd:COG1476    2 KKKLGNRLKELRKERGLTQEELAELLG------VSRQTISAIENgkYNPSLELALKIARALGVSLEEL 63
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
113-169 2.38e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.51  E-value: 2.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254692936 113 KEMEQLAKELRQKRMTLGYSQADVGFAVGamfgkvLSQTTICRFEAQQ--LSLANMWKL 169
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLG------VSRSTISRIERGRrnPSLETLLKL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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