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Conserved domains on  [gi|13386376|ref|NP_083479|]
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reproductive homeobox 2A isoform 1 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 134-186 1.93e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 1.93e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 13386376 134 QQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 134-186 1.93e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 1.93e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 13386376 134 QQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 135-186 7.08e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 7.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 13386376    135 QSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
135-186 8.11e-12

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 57.51  E-value: 8.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 13386376   135 QSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
141-191 1.76e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 40.11  E-value: 1.76e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 13386376 141 QLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL 191
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG 112
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 134-186 1.93e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 1.93e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 13386376 134 QQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 135-186 7.08e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 7.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 13386376    135 QSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
135-186 8.11e-12

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 57.51  E-value: 8.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 13386376   135 QSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYR 186
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
141-191 1.76e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 40.11  E-value: 1.76e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 13386376 141 QLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL 191
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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