extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312316  20 ALQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNG 96
Cdd:cd23573   2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312316  20 ALQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNG 96
Cdd:cd23573   2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316     21 LQCYSCTAQmNNRDCLNVQNCSLDQHSCFTSRIRAI--GLVTVISKGCSSQ--C---EDDSENYYLGKKNITCCYSDLCN 93
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVIsdSRGSVVYKGCATSpiCpgsHGYEINLTIAFLKVSCCQTDLCN 79

                   ....
gi 21312316     94 VNGA 97
Cdd:smart00134  80 AAGP 83

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312316  20 ALQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNG 96
Cdd:cd23573   2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312316    23 CYSCTAQmNNRDCLNVQNCSLDQHSCFTSRIRAIG---LVTVISKGCS-SQC---EDDSENYYLGKKNITCCYSDLCN 93
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEgnlRGTVVSKGCArSSCprlLSDFINGGIISVSESCCQSDLCN 77

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312316  21 LQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRA------IGLVTVIsKGCSSQCEDDSENYYLGKKNITCCYSDLCN 93
Cdd:cd23560   1 LRCYTCPEPTDSSLCTTIVNCSPNETACKTTLYSVdsgypfFGNITVT-RGCASECIPSDPDGIGETHPISCCNTDLCN 78

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316     21 LQCYSCTAQmNNRDCLNVQNCSLDQHSCFTSRIRAI--GLVTVISKGCSSQ--C---EDDSENYYLGKKNITCCYSDLCN 93
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVIsdSRGSVVYKGCATSpiCpgsHGYEINLTIAFLKVSCCQTDLCN 79

                   ....
gi 21312316     94 VNGA 97
Cdd:smart00134  80 AAGP 83

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316  21 LQCYSCTAQMNNRDCLN---VQNCSLDQHSCFTSRIRAIGLVTVISKGC--SSQCEDDSENYYLGKKNIT---------- 85
Cdd:cd23539   1 LSCWTCDNASSNEECLAngtLVTCQSNEESCQTEVRRRGGGVYLISKGCkqRQACENNKKQNFKAAWNPTqcnpespnsv 80

                        90
                ....*....|.
gi 21312316  86 ---CCYSDLCN 93
Cdd:cd23539  81 crcCCSTDLCN 91

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316  21 LQCYSCTAqmnNRDCLNVQNCSLDQHSCFTSRIRAI---GLVTVISKGCSSQCEDDSENYYLGKKNI-----TCCYSDLC 92
Cdd:cd23556   1 LRCYSCKS---NGDCRVEEVCALGQDLCRTTVMTLWeegEELELVVKGCDVSGKTNASSSYRTGLNInslqeTVCSSDLC 77

                .
gi 21312316  93 N 93
Cdd:cd23556  78 N 78

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21312316  21 LQCYSCtaqmNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENyylgkKNITCCYSDLCN 93
Cdd:cd00206   1 LICYNC----PSSTCPTTKTCPPGENLCYKKWWRDGPRGKRIERGCAATCPKPKPG-----EKVKCCSTDKCN 64

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312316  17 PGAALQCYSCTAqmnNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYylGKKNITCCYSDLCN 93
Cdd:cd23552   3 SAQALKCHECKG---IEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESL--ANSKASCCNTDLCN 74

extracellular domain (ECD) found in Drosophila melanogaster Saxophone and similar proteins; Saxophone (Sax) is the Drosophila bone morphogenetic protein (BMP) type I receptor that transmits signal through Mad. It functions as a Dpp (Decapentaplegic) receptor in Drosophila embryos, but that its activity is normally inhibited by the O-linked glycosyltransferase Sxc (Super sex combs). Saxophone is the ortholog of the human activin receptor-like kinase (ALK)-1/2. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316  21 LQCYSCtaqmNNRDCLNVQNCSlDQHSCFTSRIRAIGLVTVISKGCSSqcEDDSENYYLGKK---------------NIT 85
Cdd:cd23600   4 FKCYSC----EPPDCDPTTVCS-NAIQCWKSRVRDSDGKERVSRGCIT--EPDQVPFTCNTKshsgsskkkpnsgqySVE 76

                ....*...
gi 21312316  86 CCYSDLCN 93
Cdd:cd23600  77 CCQGDFCN 84

extracellular domain (ECD) found in the bone morphogenetic protein receptor type-2 (BMPR2)-like family; The BMPR2-like family includes BMPR2, activin receptor type-2A (ACTR-IIA), activin receptor type-2B (ACTR-IIB), and anti-Muellerian hormone type-2 receptor (AMHR2). On ligand binding, they form a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR2 binds to BMP7, BMP2, and less efficiently, BMP4. ACTR-IIA is the receptor for activin A, activin B, and inhibin A. It also interacts with type I receptor ACVR1 and bone morphogenetic protein 7 (BMP7). ACTR-IIB interacts with vacuolar protein sorting 39 (Vps39), dynein light chain Tctex-type 1 (DYNLT1), bone morphogenetic protein 2 (BMP2), and bone morphogenetic protein 3 (BMP3). AMHR2 is the receptor for anti-Muellerian hormone. Members in this family contain an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312316  22 QCYSCTAQMNNRDCLNVQNCSLDQHSCFTS-RIRAIGLVTVISKGC-----SSQCEDDS-ENYYLGKKNIT---CCYSDL 91
Cdd:cd23533  10 VSLSSTDESDITSCNTTETCKSGSSYCFALwREDSNGNIEILLQGCwdssgPNECDSSEcIASKSPSLNNTkfcCCSGDL 89

                ....
gi 21312316  92 CNVN 95
Cdd:cd23533  90 CNAN 93