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Conserved domains on  [gi|198278501|ref|NP_082155|]
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pre-mRNA-processing factor 17 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 1.25e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.25e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGDRrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200  156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198278501 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 1.25e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.25e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGDRrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200  156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198278501 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 4.11e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 4.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319  266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 198278501 516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 306-488 3.46e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 3.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 306 SCSMDCKIKLWEVygDRRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 383
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 384 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 462
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 198278501 463 SMPA-------VTLSPNGKWLACQSMDNQILIF 488
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-360 1.10e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 198278501   321 DRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
322-360 2.03e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 198278501  322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 1.25e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 1.25e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGDRrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200  156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198278501 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 4.11e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 4.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319  266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 198278501 516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
279-539 8.52e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 8.52e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 359 WDTETGQCISRFT-NRKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319  231 WDLATGKLLRTLTgHSGSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319  308 DDGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKTLASGSDDGTVRLWDLATGELL---RTLTGH--TGAVTSVA 379

                        250       260
                 ....*....|....*....|....
gi 198278501 516 FSPDMSYVISGDGNGKLNIWDWKT 539
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 9.15e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 9.15e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 279 KQIHVWSGHTKGVSAVRLFPLsGHLLLSCSMDCKIKLWEVyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 359 WDTETGQCISRFT-NRKVPYCVKFNPDEdkqNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319  147 WDLATGKLLRTLTgHSGAVTSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319  224 ADGTVRLWDLA---TGKLLRTLTGHSGSvrSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGH--SGGVNSVA 295

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 198278501 516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 579
Cdd:COG2319  296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
280-579 2.45e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.00  E-value: 2.45e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEvyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLW 359
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 360 DTETGQCISRFT-NRKVPYCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD 438
Cdd:COG2319  106 DLATGLLLRTLTgHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 439 DKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVDF 516
Cdd:COG2319  183 DGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKLLASGSADGTVRLWDLATGKLL---RTLTGH--SGSVRSVAF 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198278501 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-446 1.82e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 1.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 279 KQIHVWSGHTKGVSAVRlFPLSGHLLLSCSMDCKIKLWEVYGDRrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:cd00200  126 KCLTTLRGHTDWVNSVA-FSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGvNSVAFSPD---GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*....
gi 198278501 438 DDKSLRVWE 446
Cdd:cd00200  281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
278-448 3.57e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 3.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 278 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLK 357
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 358 LWDTETGQCISRFTNrkvpycvkfnpdedkqnlfvagmsdkkivqwdirsgeivqeydrHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319  356 LWDLATGELLRTLTG--------------------------------------------HTGAVTSVAFSPDGRTLASGS 391

                        170
                 ....*....|.
gi 198278501 438 DDKSLRVWEWD 448
Cdd:COG2319  392 ADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 306-488 3.46e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 3.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 306 SCSMDCKIKLWEVygDRRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 383
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 384 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 462
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 198278501 463 SMPA-------VTLSPNGKWLACQSMDNQILIF 488
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-360 1.10e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 198278501   321 DRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
322-360 2.03e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 198278501  322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-317 3.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 198278501   277 PKKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 317
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-317 2.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 198278501  278 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 407-446 1.54e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 198278501   407 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 539-579 1.54e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 198278501   539 TTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 579
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
408-446 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 198278501  408 GEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 286-423 3.90e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV---------YGDRRCLrtFIGHSKAVRDICFNTAGTQFL-SAAYDRY 355
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkeIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198278501 356 LKLWDTETGQCISRFTNRKVPYCVKFNPdedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 423
Cdd:PTZ00420 150 VNIWDIENEKRAFQINMPKKLSSLKWNI---KGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNT 214
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 497-536 5.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 198278501   497 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
Cdd:smart00320   3 ELLKTLKGH--TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
347-476 1.61e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198278501 347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDrhLGA-VNTIV 425
Cdd:COG3391   83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPD--GGRLYVADSGNGRVSVIDTATGKVVATIP--VGAgPHGIA 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 198278501 426 FVDENRR-FVSTSDDKSLRVW--EWDiPVDFKYIAEPSMHSMP-AVTLSPNGKWL 476
Cdd:COG3391  159 VDPDGKRlYVANSGSNTVSVIvsVID-TATGKVVATIPVGGGPvGVAVSPDGRRL 212
WD40 pfam00400
WD domain, G-beta repeat;
541-579 4.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 4.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 198278501  541 KLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
497-536 8.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 8.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 198278501  497 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
Cdd:pfam00400   2 KLLKTLEGH--TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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