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Conserved domains on  [gi|261862275|ref|NP_082146|]
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armadillo repeat-containing X-linked protein 3 [Mus musculus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 12058521)

armadillo/beta-catenin-like repeat-containing protein similar to armadillo repeat-containing protein and armadillo repeat-containing X-linked protein

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 118-338 1.91e-116

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


:

Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 337.46  E-value: 1.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  118 LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQ 197
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  198 RRLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMT 277
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261862275  278 RELLRAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLFFFLK 338
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 118-338 1.91e-116

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 337.46  E-value: 1.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  118 LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQ 197
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  198 RRLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMT 277
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261862275  278 RELLRAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLFFFLK 338
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 155-191 4.50e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.71  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 261862275   155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLS 191
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 118-338 1.91e-116

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 337.46  E-value: 1.91e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  118 LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQ 197
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261862275  198 RRLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMT 277
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261862275  278 RELLRAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLFFFLK 338
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 155-191 4.50e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.71  E-value: 4.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 261862275   155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLS 191
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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