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Conserved domains on  [gi|110625829|ref|NP_081934|]
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protein HEXIM2 [Mus musculus]

Protein Classification

HEXIM domain-containing protein( domain architecture ID 10633900)

HEXIM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 101-226 4.61e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


:

Pssm-ID: 464638  Cd Length: 136  Bit Score: 188.43  E-value: 4.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625829  101 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVLHGPSHSGSGGENEAGDS--- 177
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 110625829  178 -------DGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQA 226
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
COG4026 super family cl26606
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 203-275 1.55e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


The actual alignment was detected with superfamily member COG4026:

Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 39.71  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625829 203 SLQG-RSKQELVRDYLDLERRLSQAEQETRRLRQlqgcssrqpcqQVEELAAEVERLRTENQRLRQENEMWNRE 275
Cdd:COG4026  123 SLQNiPEYNELREELLELKEKIDEIAKEKEKLTK-----------ENEELESELEELREEYKKLREENSILEEE 185
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 101-226 4.61e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 188.43  E-value: 4.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625829  101 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVLHGPSHSGSGGENEAGDS--- 177
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 110625829  178 -------DGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQA 226
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 203-275 1.55e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 39.71  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625829 203 SLQG-RSKQELVRDYLDLERRLSQAEQETRRLRQlqgcssrqpcqQVEELAAEVERLRTENQRLRQENEMWNRE 275
Cdd:COG4026  123 SLQNiPEYNELREELLELKEKIDEIAKEKEKLTK-----------ENEELESELEELREEYKKLREENSILEEE 185
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
170-274 1.96e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.75  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625829 170 GENEAGDSDGQGRAHGEFQQRDFSEAYERYhteSLQGRSKQELVRDYLDLERRLSQAEQETRRLRQLQgcssrqpcQQVE 249
Cdd:COG4717   30 GPNEAGKSTLLAFIRAMLLERLEKEADELF---KPQGRKPELNLKELKELEEELKEAEEKEEEYAELQ--------EELE 98

                         90       100
                 ....*....|....*....|....*
gi 110625829 250 ELAAEVERLRTENQRLRQENEMWNR 274
Cdd:COG4717   99 ELEEELEELEAELEELREELEKLEK 123
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 101-226 4.61e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 188.43  E-value: 4.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625829  101 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVLHGPSHSGSGGENEAGDS--- 177
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 110625829  178 -------DGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQA 226
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 203-275 1.55e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 39.71  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625829 203 SLQG-RSKQELVRDYLDLERRLSQAEQETRRLRQlqgcssrqpcqQVEELAAEVERLRTENQRLRQENEMWNRE 275
Cdd:COG4026  123 SLQNiPEYNELREELLELKEKIDEIAKEKEKLTK-----------ENEELESELEELREEYKKLREENSILEEE 185
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
170-274 1.96e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.75  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625829 170 GENEAGDSDGQGRAHGEFQQRDFSEAYERYhteSLQGRSKQELVRDYLDLERRLSQAEQETRRLRQLQgcssrqpcQQVE 249
Cdd:COG4717   30 GPNEAGKSTLLAFIRAMLLERLEKEADELF---KPQGRKPELNLKELKELEEELKEAEEKEEEYAELQ--------EELE 98

                         90       100
                 ....*....|....*....|....*
gi 110625829 250 ELAAEVERLRTENQRLRQENEMWNR 274
Cdd:COG4717   99 ELEEELEELEAELEELREELEKLEK 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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