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Conserved domains on  [gi|31982634|ref|NP_081302|]
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leucine-rich repeat-containing protein 46 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-146 3.27e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 75.98  E-value: 3.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  60 ITCIGNLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSEN--------LIETLKL 131
Cdd:cd21340  36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQrlppgeklTFDPRSL 115

                        90
                ....*....|....*
gi 31982634 132 DELPESLLILNLCGN 146
Cdd:cd21340 116 AALSNSLRVLNISGN 130
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-146 3.27e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.98  E-value: 3.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  60 ITCIGNLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSEN--------LIETLKL 131
Cdd:cd21340  36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQrlppgeklTFDPRSL 115

                        90
                ....*....|....*
gi 31982634 132 DELPESLLILNLCGN 146
Cdd:cd21340 116 AALSNSLRVLNISGN 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-143 1.63e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  47 LGELETVRLDGEGITCIG-NLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSENL 125
Cdd:COG4886 204 LTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                        90
                ....*....|....*...
gi 31982634 126 IETLKLDELPESLLILNL 143
Cdd:COG4886 284 LTDLKLKELELLLGLNSL 301
LRR_9 pfam14580
Leucine-rich repeat;
55-173 1.31e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.06  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634    55 LDGEGITCIGNL-EKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLD--LQYLQFLDLSENLIETL-K 130
Cdd:pfam14580  26 LRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNNLQELgD 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 31982634   131 LDELPE--SLLILNLCGNPCTNQEGYRKMVIGALPLLLDLDKQPI 173
Cdd:pfam14580 106 LDPLASlkKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-146 3.27e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.98  E-value: 3.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  60 ITCIGNLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSEN--------LIETLKL 131
Cdd:cd21340  36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQrlppgeklTFDPRSL 115

                        90
                ....*....|....*
gi 31982634 132 DELPESLLILNLCGN 146
Cdd:cd21340 116 AALSNSLRVLNISGN 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-143 1.63e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  47 LGELETVRLDGEGITCIG-NLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSENL 125
Cdd:COG4886 204 LTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                        90
                ....*....|....*...
gi 31982634 126 IETLKLDELPESLLILNL 143
Cdd:COG4886 284 LTDLKLKELELLLGLNSL 301
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-150 7.78e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 7.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  47 LGELETVRLDGEGITCIG-NLEKLRNIHSLYLQSNKIQRI-ENLACITSLRFLSLARNQIRHV-ENLLDLQYLQFLDLSE 123
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSN 191

                        90       100
                ....*....|....*....|....*....
gi 31982634 124 NLIETLK--LDELPeSLLILNLCGNPCTN 150
Cdd:COG4886 192 NQITDLPepLGNLT-NLEELDLSGNQLTD 219
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-146 4.05e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 4.05e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31982634  69 LRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSENLIETLK-LDELPeSLLILNLCGN 146
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEnLENLV-NLKKLYLGGN 78
LRR_9 pfam14580
Leucine-rich repeat;
55-173 1.31e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.06  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634    55 LDGEGITCIGNL-EKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLD--LQYLQFLDLSENLIETL-K 130
Cdd:pfam14580  26 LRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNNLQELgD 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 31982634   131 LDELPE--SLLILNLCGNPCTNQEGYRKMVIGALPLLLDLDKQPI 173
Cdd:pfam14580 106 LDPLASlkKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-126 2.30e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634   4 DEQEAKKAAQRTEEGVHITEALITKRNLTFPGDEDLSEKMFHTlGELETVRLDGEGITCIG------NLEKLRNIHSLYL 77
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGaialakALQENTTLHSLDL 355

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  78 QSNKIQR------IENLACITSLRFLSLARNQI--RHVENLLD-LQY--LQFLDLSENLI 126
Cdd:COG5238 356 SDNQIGDegaialAKYLEGNTTLRELNLGKNNIgkQGAEALIDaLQTnrLHTLILDGNLI 415
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 71-110 3.29e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 3.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31982634    71 NIHSLYLQSNKIQRIENLACITSLRFLSLARN-QIRHVENL 110
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
70-126 5.67e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 5.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31982634    70 RNIHSLYLQSNKIQRIE-----NLaciTSLRFLSLARNQIRHVEN--LLDLQYLQFLDLSENLI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafkGL---SNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
92-147 2.64e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634    92 TSLRFLSLARNQIRHV--ENLLDLQYLQFLDLSENLIETLKLDEL--PESLLILNLCGNP 147
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 42-151 6.50e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 6.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982634  42 KMFHTLGeLETVRLDGEGITCIGN-LEKLRNIHSLYLQSNKIQR------IENLACITSLRFLSLARNQIRH------VE 108
Cdd:COG5238 236 KSLTTLD-LSNNQIGDEGVIALAEaLKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAE 314

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 31982634 109 NLLDLQYLQFLDLSEN---------LIETLKLDelpESLLILNLCGNPCTNQ 151
Cdd:COG5238 315 GLQGNKTLHTLNLAYNgigaqgaiaLAKALQEN---TTLHSLDLSDNQIGDE 363
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-136 8.66e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 8.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 31982634    92 TSLRFLSLARNQIRHVENLLDLQYLQFLDLSENLIETlKLDELPE 136
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT-DLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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